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| 1 | PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15显示文摘Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer patients.Recently,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse models.Herein,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer patients.Single-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)TILs.Furthermore,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)TILs.Transcriptionally and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 expression.Notably,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)TILs.Taken together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies. | Kyung Hwan Kim Hong Kwan Kim Hyung-Don Kim Chang Gon Kim Hoyoung Lee Ji Won Han Seong Jin Choi Seongju Jeong Minwoo Jeon Hyunglae Kim Jiae Koh Bo Mi Ku Su-Hyung Park Myung-Ju Ahn Eui-Cheol Shin | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 2 | Increased expression of the nitric oxide synthase gene and protein in corpus cavernosum by repeated dosing of udenafil in a rat model of chemical diabetogenesis显示文摘可勃起的机能障碍(编辑) 是糖尿病 mellitus (DM ) 的主要复杂并发症。这研究在糖尿病的老鼠的阴茎海绵体(CC ) 调查在编辑和组成的氮的氧化物 synthase (cNOS ) 的 downregulation 之间的关系。它也检验 udenafil 的效果,一种 phosphodiesterase 类型 5 (PDE5 ) 禁止者,在编辑和 cNOS 表示层次上。在 16 星期有在糖尿病的老鼠的 udenafil 的每日的口头的处理以后, intracavernous 压力 / 平均数动脉的压力(ICP/MAP ) 比率被记录测量可勃起的功能,并且 cNOS 表示用反向的 transcriptase (RT ) 被测量 -PCR 和 immunoblots。尽管 ICP/MAP 比率和 endothelial NOS (eNOS ) 和在 CC 的 neuronal NOS (nNOS ) 的表达式层次显著地在糖尿病的老鼠被减少,长期的 udenafil 处理改进了可勃起的函数并且与糖尿病的控制相比增加了 cNOS 表示。这些调查结果建议在 DM 的编辑是仔细,与减少的 cNOS 有关,在 CC 和那 udenafil 的表示有能力由 modulating cNOS 补偿这个病理学的变化表示。Udenafil 也在 cGMP (周期的 guanosine monophosphate ) 有一个禁止的角色降级。 | GJ Ahn HK Chung CH Lee KK Kang BO Ahn | 2009 | Asian Journal of Andrology2009，11，4： | 2 |
| 3 | Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large‐volume center显示文摘 | Sung‐Gyu Lee Shin Hwang Deok‐Bog Moon Chul‐Soo Ahn Ki‐Hun Kim Kyu‐Bo Sung Gi‐Young Ko Kwang‐Min Park Tae‐Yong Ha Gi‐Won Song | 2008 | Liver Transpl2008，，7： | 1 |
| 4 | CO 2 absorption and regeneration of alkali metal-based solid sorbents显示文摘 | Soo Chool Lee Bo Yun Choi Tae Jin Lee Chong Kul Ryu Young Soo Ahn Jae Chang Kim | 2005 | Catalysis Today2005，，3： | 1 |
| 5 | Long‐term incidence, risk factors, and management of biliary complications after adult living donor liver transplantation显示文摘 | Shin Hwang Sung‐Gyu Lee Kyu‐Bo Sung Kwang‐Min Park Ki‐Hun Kim Chul‐Soo Ahn Young‐Joo Lee Sung‐Koo Lee Gyu‐Sam Hwang Deok‐Bog Moon Tae‐Yong Ha Dong‐Sik Kim Jae‐Pil Jung Gi‐Won Song | 2006 | Liver Transpl2006，，5： | 1 |
| 6 | Efficient transient expression and transformation of PEG-mediated gene uptake into mesophyll protoplasts of pepper (Capsicum annuum L.)显示文摘 | Joo Mi Jeon Nam Young Ahn Bo Hwa Son Cha Young Kim Chang-deok Han Gun-Do Kim Sang Wan Gal Sung-Ho Lee | 2007 | Plant Cell Tissue and Organ Culture2007，，2： | 1 |
| 7 | Malignancy rate in sonograph-ically suspicious thyroid nodules of less than a centimeter in sizedoes not decrease with decreasing size 显示文摘 | BO Y H AHN H Y LEE Y H | 2011 | J Korean Med Sic2011，26，2： | 1 |
| 8 | Maiignancy ratein zoographically suspicious thyroid noduies of less than a centimeter in size does not decrease with decreasin size 显示文摘 | Bo YH Ahn HY Lee YH | 2011 | J Korean Med Sic2011，26，2： | 1 |
| 9 | Surgical treatment of hilar cholangiocarcinoma in the new era: the Asan experience显示文摘 | Sung Gyu Lee Gi Won Song Shin Hwang Tae Yong Ha Deok Bog Moon Dong Hwan Jung Ki Hun Kim Chul Soo Ahn Myung Hwan Kim Sung Koo Lee Kyu Bo Sung Gi Young Ko | 2010 | Journal of Hepato-Biliary-Pancreatic Sciences2010，，： | 1 |
| 10 | Topological structure of Y-junction carbon nanotubes显示文摘 | Gan Bo Ahn J Zhang Q | 2000 | Materials Letters2000，45，： | 1 |
| 11 | Efficacy of DA-8159, a new PDE5 inhibitor, for inducing penile erection in rabbits with acute spinal cord injury显示文摘 | Ahn BO Kang KK Ahn GJ etal | 2003 | Int J Impot Res2003，15，6： | 1 |
| 12 | Fluorescence energy transfer inhibition bioassay for cholera toxin based on galactose-stabilized gold nanoparticles and amine-terminated quantum dots显示文摘 | Kwang-Soo Ahn Kyung Rae Lim Daeho Jeong Bo Young Lee Kwan Soo Kim Won-Yong Lee | 2016 | Microchemical Journal2016，，： | 1 |
| 13 | Antidiabetic effects of extracts from Psidium guajava显示文摘 | Won Keun Oh Chul Ho Lee Myung Sun Lee Eun Young Bae Cheon Bae Sohn Hyuncheol Oh Bo Yeon Kim Jong Seog Ahn | 2004 | Journal of Ethnopharmacology2004，，3： | 1 |
| 14 | Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages显示文摘 | Hyun Ah Jung Seong Eun Jin Bo Ra Ahn Chan Mi Lee Jae Sue Choi | 2013 | Food and Chemical Toxicology2013，，： | 1 |
| 15 | Oxidative damages are critical in pathogenesis of reflux esophagitis: implication of antioxidants in its treatment显示文摘 | Oh TY Lee JS Ahn BO | 2001 | Free Radic Biol Med2001，30，8： | 1 |
| 16 | ( - ) - Syringaresinol inhibits proliferation of human promyelocytic HL - 60leukemia cells via G1 arrest and apoptosis显示文摘 | Bo - Young Park Sei - Ryang Oh Kyung - Seop Ahn | 2008 | International Immunop- harmacology2008，8，7： | 1 |
| 17 | Daphnane diterpene esters isolated from flower buds of Daphne genk- wainduce apoptosis in human myelocytic HL -60 cells and suppress tumor growth in Lewis lung carcinoma ( LLC ) - inoculated mouse model 显示文摘 | Bo - Young Park Byung - Sun Min Kyung - Seop Ahn | 2007 | Journal of Ethnopharmacology2007，111，3： | 1 |
| 18 | Clinical significance of the BRAF V600E mutation in multifocal papillary thyroid carcinoma in Korea显示文摘 | Hwa Young Ahn Yun Jae Chung Byung Seup Kim Kyung Ho Kang Ju Won Seok Hee Sung Kim Sung Jun Park Bo Youn Cho | 2013 | Surgery2013，，： | 1 |
| 19 | Effects of taurine on cerulein - induced acute pancreatitis in the rat显示文摘 | Ahn BO Kim KH Lee G | 2001 | Pharmacology2001，63，1： | 1 |
| 20 | In vitro antioxidant and anti-inflammatory activities of Angelica decursiva显示文摘 | Dafang Zhao Md. Nurul Islam Bo Ra Ahn Hyun Ah Jung Byung-Woo Kim Jae Sue Choi | 2012 | Archives of Pharmacal Research2012，，： | 1 |
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