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| 1 | Construction, expression and characterization of the engineered antibody against tumor surface antigen, p185^(c-erbB-2)显示文摘The c-erbB-2 proto-oncogene encodes a 185kDa protein p185, which belongs to epidermal growth factorreceptor family. Amplification of this gene has been shown to correlate with poor clinical prognosis forcertain cancer patients. The monoclonal antibody A21 which directed against p185 specifically inhibitsproliferation of tumor cells overexpressing p185, hence allows it to be a candidate for targeted therapy. Inorder to overcome several drawbacks of murine MAb, we cloned its VH and VL genes and constructed thesingle-chain Fv (scFv) through a peptide linker. The recombinant scFvA21 was expressed in Escherichiacoli and purified by the affinity column. Subsequently it was characterized by ELISA, Western blot, cellimmunohistochemistry and FACS. All these assays showed the binding activity to extracellular domain(ECD) of p185. Based on those properties of scFvA21, we further constructed the scFv-Fc fusion moleculewith a homodimer form and the recombinant product was expressed in mammalian cells. In a series ofsubsequent analysis this fusion protein showed identical antigen binding site and activity with the parentantibody. These anti-p185 engineered antibodies have promised to be further modified as a tumor targetingdrugs, with a view of application in the diagnosis and treatment of human breast cancer. | LIAN SHENG CHENG, AI PING LIU, JIA HONG YANG, YAN QIU DONG, LIANG WEI LI, JING WANG, CHAO CHEN WANG, JING LIUSchool of Life Science, University of Science and Technology of China, Hefei 230027, China | 2003 | Cell Research2003，13，1： | 24 |
| 2 | Estrogen reduces CCL_4-induced liver fibrosis in rats显示文摘AIM: Chronic liver diseases, such as fibrosis or cirrhosis,are more common in men than in women. This genderdifference may be related to the effects of sex hormones onthe liver. The aim of the present work was to investigatethe effects of estrogen on CCL4-induced fibrosis of the liverin rats.METHODS: Liver fibrosis was induced in male, female andovariectomized rats by CCL4 administration. All the groupswere treated with estradiol(1 mg/kg) twice weekly. Andtamoxifen wasgiven to male fibrosis model. At the end of 8weeks, all therats were killed to study serum indicators andthe livers.RESULTS: Estradiol treatment reduced aspartateaminotransferase(AST), alanine aminotransferase (ALT),hyaluronic acid(HA) and type IV collagen(CIV) in sera,suppressed hepatic collagen content, decreased the areas ofhepatic stellate cells (HSC) positive for α-smooth muscle actin(α-SMA), and lowered the synthesis of hepatic type I collagensignificantly in both sexes and ovariectomy fibrotic rats inducedby CCL4 administration. Whereas, tamoxifen had the oppositeeffect. The fibrotic response of the female liver to CCL4treatment was significantly weaker than that of male liver.CONCLUSION: Estradiol reduces CCL4-induced hepaticfibrosis in rats. The antifibrogenic role of estrogen in theliver may be one reason for the sex associated differencesin the progression from hepatic fibrosis to cirrhosis. | Jun-Wang Xu Jun Gong Xin-Ming Chang Jin-Yan Luo Lei Dong Zhi-Ming Hao Ai Jia Gui-Ping Xu | 2002 | World Journal of Gastroenterology2002，8，5： | 14 |
| 3 | 3D Geometry-Based UAV-MIMO Channel Modeling and Simulation显示文摘A more general narrowband regular-shaped geometry-based statistical model(RS-GBSM) combined with the line of sight(LoS) and single bounce(SB) rays for unmanned aerial vehicle(UAV) multiple-input multiple-output(MIMO) channel is proposed in this paper. The channel characteristics, including space-time correlation function(STCF), Doppler power spectral density(DPSD), level crossing rate(LCR) and average fade duration(AFD), are derived based on the single sphere reference model for a non-isotropic environment. The corresponding sum-of-sinusoids(SoS) simulation models including both the deterministic model and statistical model with finite scatterers are also proposed for practicable implementation. The simulation results illustrate that the simulation models well reproduce the channel characteristics of the single sphere reference model with sufficient simulation scatterers. And the statistical model has a better approximation of the reference model in comparison with the deterministic one when the simulation trials of the stochastic model are sufficient. The effects of the parameters such as flight height, moving direction and Rice factor on the characteristics are also studied. | Rubing Jia Yiran Li Xiang Cheng Bo Ai | 2018 | China Communications2018，15，12： | 11 |
| 4 | A Green Paradigm for Internet of Things: Ambient Backscatter Communications显示文摘Internet of Things (IoT) has attracted extensive interest from both academia and industries, and is recognized as an ultimate infrastructure to connect everything at anytime and anywhere. The implementation of IoT generally faces the challenges from energy constraint and implementation cost. In this paper, we will introduce a new green communication paradigm, the ambient backscatter (AmBC), that could utilize the environmental wireless signals for both powering a tiny-cost device and backscattering the information symbols. Specifically, we will present the basic principles of AmBC, analyze its features and advantages, suggest its open problems, and predict its potential applications for our future IoT. | Wei Zhang Yao Qin Wenjing Zhao Minzheng Jia Qiang Liu Ruisi He Bo Ai | 2019 | China Communications2019，16，7： | 9 |
| 5 | Survey of coverage,strategy and cost of hepatitis B vaccination in rural and urban areas of China显示文摘INTRODUCTIONSomestudiesdemonstratedthatHBsAgandantiHBcpositiveratesoftheimmunizedpopulationsafterhepatitisB(HB)vaccination... | ZENG Xian Jia 1, YANG Gong Huan 2, LIAO Su Su 1, CHEN Ai Ping 2, TAN Jian 2, HUANG Zheng Jing 2 and LI Hui 1 | 1999 | World Journal of Gastroenterology1999，5，4： | 8 |
| 6 | Proton pump inhibitor for non-erosive reflux disease:A meta-analysis显示文摘AIM:To evaluate the efficacy,safety and influential factors of proton pump inhibitor(PPI)treatment for non-erosive reflux disease(NERD).METHODS:PubMed,MEDLINE,EMBASE and the Cochrane Library were searched up to April 2013 to identify eligible randomized controlled trials(RCTs)that probed into the efficacy,safety and influential factors of PPI treatment for NERD.The rates of symptomatic relief and adverse events were measured as the outcomes.After RCT selection,assessment and data collection,the pooled RRs and 95%CI were calculated.This meta-analysis was performed using the Stata 12.0 software(Stata Corporation,College Station,Texas,United States).The level of evidence was estimated by the Grading of Recommendations Assessment,Development and Evaluation system.RESULTS:Seventeen RCTs including 6072 patients met the inclusion criteria.The results of the metaanalysis showed that PPI treatment was significantly superior to H2receptor antagonists(H2RA)treatment(RR=1.629,95%CI:1.422-1.867,P=0.000)and placebo(RR=1.903,95%CI:1.573-2.302,P=0.000)for the symptomatic relief of NERD.However,there were no obvious differences between PPI and H2RA(RR=0.928,95%CI:0.776-1.110,P=0.414)or PPI and the placebo(RR=1.000,95%CI:0.896-1.116,P=0.997)regarding the rate of adverse events.The overall rate of symptomatic relief of PPI against NERD was 51.4%(95%CI:0.433-0.595,P=0.000),and relief was influenced by hiatal hernia(P=0.030).The adverse rate of PPI against NERD was 21.0%(95%CI:0.152-0.208,P=0.000),and was affected by hiatal hernia(P=0.081)and drinking(P=0.053).CONCLUSION:PPI overmatched H2RA on symptomatic relief rate but not on adverse rate for NERD.Its relief rate and adverse rate were influenced by hiatal hernia and drinking. | Ji-Xiang Zhang Meng-Yao Ji Jia Song Hong-Bo Lei Shi Qiu Jing Wang Ming-Hua Ai Jun Wang Xiao-Guang Lv Zi-Rong Yang Wei-Guo Dong | 2013 | World Journal of Gastroenterology2013，19，45： | 8 |
| 7 | Trajectory optimization of multiple quad-rotor UAVs in collaborative assembling task显示文摘A hierarchic optimization strategy based on the offline path planning process and online trajectory planning process is presented to solve the trajectory optimization problem of multiple quad-rotor unmanned aerial vehicles in the collaborative assembling task. Firstly, the path planning process is solved by a novel parallel intelligent optimization algorithm, the central force optimization-genetic algorithm(CFO-GA), which combines the central force optimization(CFO)algorithm with the genetic algorithm(GA). Because of the immaturity of the CFO, the convergence analysis of the CFO is completed by the stability theory of the linear time-variant discrete-time systems. The results show that the parallel CFO-GA algorithm converges faster than the parallel CFO and the central force optimization-sequential quadratic programming(CFO-SQP) algorithm. Then,the trajectory planning problem is established based on the path planning results. In order to limit the range of the attitude angle and guarantee the flight stability, the optimized object is changed from the ordinary six-degree-of-freedom rigid-body dynamic model to the dynamic model with an inner-loop attitude controller. The results show that the trajectory planning process can be solved by the mature SQP algorithm easily. Finally, the discussion and analysis of the real-time performance of the hierarchic optimization strategy are presented around the group number of the waypoints and the equal interval time. | Chen Yongbo Yu Jianqiao Mei Yuesong Zhang Siyu Ai Xiaolin Jia Zhenyue | 2016 | Chinese Journal of Aeronautics2016，29，1： | 7 |
| 8 | Hierarchical Content Caching in Fog Radio Access Networks:Ergodic Rate and Transmit Latency显示文摘In order to alleviate capacity constraints on the fronthaul and decrease the transmit latency, a hierarchical content caching paradigm is applied in the fog radio access networks(F-RANs). In particular, a specific cluster of remote radio heads is formed through a common centralized cloud at the baseband unit pool, while the local content is directly delivered at fog access points with edge cache and distributed radio signal processing capability. Focusing on a downlink F-RAN, the explicit expressions of ergodic rate for the hierarchical paradigm is derived. Meanwhile, both the waiting delay and latency ratio for users requiring a single content are exploited. According to the evaluation results of ergodic rate on waiting delay, the transmit latency can be effectively reduced through improving the capacity of both fronthaul and radio access links. Moreover, to fully explore the potential of hierarchical content caching, the transmit latency for users requiring multiple content objects is optimized as well in three content transmission cases with different radio access links. The simulation results verify the accuracy of the analysis, further show the latency decreases significantly due to the hierarchical paradigm. | Shiwei Jia Yuan Ai Zhongyuan Zhao Mugen Peng Chunjing Hu | 2016 | China Communications2016，13，12： | 6 |
| 9 | Experimental investigation of propagation mechanisms and fracture morphology for coalbed methane reservoirs显示文摘Fracture propagation mechanisms in coalbed methane(CBM) reservoirs are very complex due to the development of the internal cleat system. In this paper, the characteristics of initiation and propagation of hydraulic fractures in coal specimens at different angles between the face cleat and the maximum horizontal principal stress were investigated with hydraulic fracturing tests. The results indicate that the interactions between the hydraulic fractures and the cleat system have a major effect on fracture networks. 'Step-like'' fractures were formed in most experiments due to the existence of discontinuous butt cleats. The hydraulic fractures were more likely to divert or propagate along the butt cleat with an increase in the angles and a decrease in the horizontal principal stress difference. An increase in the injection rate and a decrease in the fracturing fluid viscosity were more conducive to fracture networks. In addition, the influence on fracture propagation of the residual coal fines in the wellbore was also studied. The existence of coal fines was an obstacle in fracturing, and no effective connection can be formed between fractures. The experimental investigation revealed the fracture propagation mechanisms and can provide guidance for hydraulic fracturing design of CBM reservoirs. | Chi Ai Xiao-Xuan Li Jun Zhang Dan Jia Wen-Jing Tan | 2018 | Petroleum Science2018，15，4： | 5 |
| 10 | Rapid Identification of Legionella Pathogenicity by Surface-Enhanced Raman Spectroscopy显示文摘Objective To establish Surface-enhanced Raman Spectroscopy(SERS) can be used as a rapid and reliable method to distinguish virulent strain and mild strain of L. pneumophila. Methods We isolated and characterized of bacterial strains from ATCC and water samples strains, while we analyzed data from SERS technology using gold nanoparticles as a base and cell infections were employed to rapidly detect L. pneumophila strains. Origin 8.0 was used to collect Raman spectra, smooth and homogenize data, and to contrast spectra. Principal component analysis(PCA) was conducted to discriminate differences between groups using the multivariate analysis package Py Chem 3.0.5. Results Our results indicated that the peaks of high virulence strains reached ≥4000. This criterion was verified by subsequent cell experiments. In addition, we also conducted SERS rapid identification on the virulence of several collected clinical strains and obtained accurate results. Conclusion The present study indicates that the established SERS protocol can be used as a rapid and reliable method to distinguish virulent and mildly virulent strains of L. pneumophila, which can be further used in clinical samples. | LI Jing QIN Tian JIA Xiao Xiao DENG Ai Hua ZHANG Xu FAN Wen Hui HUO Shuai Dong WEN Ting Yi LIU Wen Jun | 2015 | Biomedical and Environmental Sciences2015，28，6： | 4 |
| 11 | Hugl-1 induces apoptosis in esophageal carcinoma cells both in vitro and in vivo显示文摘AIM: To determine whether the human giant larvae homolog 1 gene (Hugl-1/Llg1/Lgl1) exerts tumor suppressor effects in esophageal cancer. METHODS: We constructed a Hugl-1 expression plasmid, pEZ-M29-Hugl1, for gene transfection. We transfected the pEZ-M29-Hugl1 plasmid into Eca109 esophageal cancer cell lines with Lipofectamine 2000 to overexpress Hugl-1. Real-time reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting were performed to determine the effects of the plasmid on Hugl-1 expression. In vitro cell proliferation and apoptosis were examined separately by cell counting Kit-8 (CCK-8) assay, flow cytometry, and Western blotting before and after the transfection of the plasmid into Eca109 cells. Cell cycle distribution was assessed with flow cytometry. The effect of Hugl-1 overexpressing on tumor growth in vivo was performed with a xenograft tumor model in nude mice. Expression of Hugl-1 in xenograft tumor was analyzed by immunohistochemistry.The transferase-mediated dUTP nick end-labeling (TUNEL) technique was performed to detect and quantitate apoptotic cell. RESULTS: The transfection efficiency was confirmed with real-time RT-PCR and Western blotting. Our results show that compared with control groups the mRNA levels and protein levels of Hugl-1 in pEZ-M29-Hugl1-treated group were remarkably increased (P < 0.05). The CCK-8 assay demonstrated that the growth of cells overexpressing Hugl-1 was significantly lower than control cells. Cell cycle distribution showed there was a G 0 /G 1 cell cycle arrest in cells overexpressing Hugl-1 (64.09% ± 3.14% vs 50.32% ± 4.60%, 64.09% ± 3.14% vs 49.13% ± 2.24%). Annexin V-fluorescein isothiocyanate revealed that apoptosis was significantly increased in cells overexpressing Hugl-1 compared with control group (17.33% ± 4.76% vs 6.90% ± 1.61%, 17.33% ± 4.76% vs 6.27% ± 0.38%). Moreover, we found that Hugl-1 changes the level of the anti-apoptotic protein Bcl-2 and the proapoptotic protein Bax and the activation of both caspase-3 and caspase-9. With a TUNEL assay, we found that Hugl-1 markedly increased the apoptosis rate of Eca109 cells in vivo (60.50% ± 9.11% vs 25.00% ± 12.25%). It was shown that Hugl-1 represents a significantly more effective tumor suppressor gene alone in a xenograft tumor mouse model. This data suggest that Hugl-1 inhibited tumor growth and induced cell apoptosis in vivo . CONCLUSION: These results suggest that Hugl-1 induces growth suppression and apoptosis in a human esophageal squamous cell carcinoma cell line both in vitro and in vivo . | Jia Song Xiu-Lan Peng Meng-Yao Ji Ming-Hua Ai Ji-Xiang Zhang Wei-Guo Dong | 2013 | World Journal of Gastroenterology2013，19，26： | 4 |
| 12 | High-performance oxygen reduction and evolution carbon catalysis: From mechanistic studies to device integration显示文摘能容易集成于存在的高效、便宜的氧减小和进化催化剂的发展设备为利用 O 2-H2 O 化学,例如再生燃料房间和金属空气电池。此处,我们报导 NH 3-activated 做 N 的层次碳(NHC ) 催化剂经由一条可伸缩的线路综合了,并且表明它的设备集成。NHC 催化剂为氧减小反应(ORR ) 和氧进化反应(OER ) 展出了好性能,当综合时,借助于电气化学的研究和评估示威了进一个再生燃料房间的氧电极。为 ORR 和 OER 观察的活动比得上最先进的磅和红外催化剂在碱的环境完成的那些。我们进一步通过密度为电气化学的活动作为活跃地点识别了碳缺点的关键角色功能的理论计算和高分辨率的 TEM 可视化。这个工作加亮 NHC 的潜力在再生燃料房间并且可能代替商业宝贵金属为断断续续的可更新的精力的划算的存储的金属空气电池。 | John W. F. To Jia Wei Desmond Ng Samira Siahrostami Ai Leen Koh Yangjin Lee Zhihua Chen Kara D. Fong Shucheng Chen Jiajun He Won-Gyu Bae Jennifer Wilcox Hu Young Jeong Kwanpyo Kim Felix Studt Jens K. Nфrskov Thomas F. Jaramillo Zhenan Bao | 2017 | Nano Research2017，10，4： | 4 |
| 13 | Observer-based adaptive sliding mode backstepping output-feedback DSC for spin-stabilized canard-controlled projectiles显示文摘This article presents a complete nonlinear controller design for a class of spin-stabilized canard-controlled projectiles.Uniformly ultimate boundedness and tracking are achieved,exploiting a heavily coupled,bounded uncertain and highly nonlinear model of longitudinal and lateral dynamics.In order to estimate unmeasurable states,an observer is proposed for an augmented multiple-input-multiple-output(MIMO) nonlinear system with an adaptive sliding mode term against the disturbances.Under the frame of a backstepping design,an adaptive sliding mode output-feedback dynamic surface control(DSC) approach is derived recursively by virtue of the estimated states.The DSC technique is adopted to overcome the problem of ‘‘explosion of complexity' and relieve the stress of the guidance loop.It is proven that all signals of the MIMO closed-loop system,including the observer and controller,are uniformly ultimately bounded,and the tracking errors converge to an arbitrarily small neighborhood of the origin.Simulation results for the observer and controller are provided to illustrate the feasibility and effectiveness of the proposed approach. | Yuanchuan SHEN Jianqiao YU Guanchen LUO Xiaolin AI Zhenyue JIA Fangzheng CHEN | 2017 | Chinese Journal of Aeronautics2017，30，3： | 4 |
| 14 | Gene expression dynamics during the gonocyte to spermatogonia transition and spermatogenesis in the domestic yak显示文摘Background:Spermatogenesis is a cellular differentiation process that includes three major events:mitosis of spermatogonia,meiosis of spermatocytes and spermiogenesis.Steady-state spermatogenesis relies on functions of spermatogonial stem cells(SSCs).Establishing and maintaining a foundational SSC pool is essential for continued spermatogenesis in mammals.Currently,our knowledge about SSC and spermatogenesis is severely limited in domestic animals.Results:In the present study,we examined transcriptomes of testes from domestic yaks at four different stages(3,5,8 and 24 months of age)and attempted to identify genes that are associated with key developmental events of spermatogenesis.Histological analyses showed that the most advanced germ cells within seminiferous tubules of testes from 3,5,8 and 24 months old yaks were gonocytes,spermatogonia,spermatocytes and elongated spermatids,respectively.RNA-sequencing(RNA-seq)analyses revealed that 11904,4381 and 2459 genes were differentially expressed during the gonocyte to spermatogonia transition,the mitosis to meiosis transition and the meiosis to post-meiosis transition.Further analyses identified a list of candidate genes than may regulate these important cellular processes.CXCR4,a previously identified SSC niche factor in mouse,was one of the up-regulated genes in the 5 months old yak testis.Results of immunohistochemical staining confirmed that CXCR4 was exclusively expressed in gonocytes and a subpopulation of spermatogonia in the yak testis.Conclusions:Together,these findings demonstrated histological changes of postnatal testis development in the domestic yak.During development of spermatogonial lineage,meiotic and haploid germ cells are supported by dynamic transcriptional regulation of gene expression.Our transcriptomic analyses provided a list of candidate genes that potentially play crucial roles in directing the establishment of SSC and spermatogenesis in yak. | Guowen Wang Yongchang Li Qilin Yang Shangrong Xu Shike Ma Rongge Yan Ruina Zhang Gongxue Jia Deqiang Ai Qi’en Yang | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 15 | Enantioseparation of Aminoglutethimide by High-speed Countercurrent Chromatography Using Carboxymethly-β-cyclodextrin as Chiral Selector显示文摘Enantioseparation of aminoglutethimide was performed by high-speed counter-current chromatography with a two-phase system composed of ethyl acetate: methanol: water = 10: 1: 9. The lower phase contained 20 mmol/L of carboxymethly-β-cyclodextrin as chiral selector. The enantiomers were separated in 1.2 h and identified by chiral HPLC. This method was very efficient for the chiral preparative separation. | Ping AI Jia Chuan LIU Min ZI Zhi Hua DENG Zhi Hong YAN Li Ming YUAN | 2006 | Chinese Chemical Letters2006，17，6： | 3 |
| 16 | New Minor Cyclopeptides from Arenaria oreophila (Caryophyllaceae)显示文摘新次要的周期的肽,命名 arenariphilin C 1 和 arenariphilin D 2,从 Arenaria oreophila (石竹科) 的整个植物被孤立。他们的结构我们 redetermined 作为出租机动三轮车(Pro^1-Pro^2-Leu^1-Leu^2-Phe-Ser-Gly-Thr ) 和出租机动三轮车(Ser-Cys ) 根据分光镜的数据,特别由二尺寸的 NMR (2D NMR ) 技术。 | Ai Qun JIA Ning Hua TAN Jun ZHOU | 2006 | Chinese Chemical Letters2006，17，4： | 3 |
| 17 | Infection with severe fever with thrombocytopenia virus in healthy population:a cohort study in a high endemic region,China显示文摘Background: Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region.Methods: A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates.Results: Totally 886 individuals were recruited. The baseline seroprevalence that was tested before the epidemic season was 11.9% (70/587) for IgG and 6.8% (40/587) for NAb, which was increased to 13.4% (47/350) and 7.7% (27/350) during the epidemic season, and further to 15.8% (80/508) and 9.8% (50/508) post epidemic. The IgG antibody-based seropositivity was significantly related to the patients aged ≥ 70 years old [adjusted odds ratio (OR) = 2.440, 95% confidence interval (CI): 1.334-4.461 compared to the group of < 50 years old,P = 0.004], recent contact with cats (adjustedOR = 2.195, 95%CI: 1.261-3.818,P = 0.005), and working in tea garden (adjustedOR = 1.698, 95%CI: 1.002-2.880,P = 0.049) by applying multivariate logistic regression model. The NAb based seropositivity was similarly related to the patients aged ≥ 70 years old (adjustedOR = 2.691, 95%CI: 1.271-5.695 compared to the group of < 50 years old,P = 0.010), and recent contact with cats (OR = 2.648, 95%CI: 1.419-4.941,P = 0.002). For a cohort of individuals continually sampled with 1-year apart, the anti-SFTSV IgG were maintained at a stable level, while the NAb level reduced.Conclusions: Subclinical infection might not provide adequate immunity to protect reinfection of SFTSV, thus highlighting the ongoing threats of SFTS in endemic regions, which called for an imperative need for vaccine development. Identification of risk factors might help to target high-risk population for public health education and vaccination in the future. | Xiao‑Lei Ye Ke Dai Qing‑Bin Lu Yan‑Qin Huang Shou‑Ming Lv Pan‑He Zhang Jia‑Chen Li Hai‑Yang Zhang Zhen‑Dong Yang Ning Cui Chun Yuan Kun Liu Xiao‑Ai Zhang Jiu‑Song Zhang Hao Li Yang Yang Li‑Qun Fang Wei Liu | 2021 | Infectious Diseases of Poverty2021，10，6： | 3 |
| 18 | The Discovery of Deep Potassium and Lithium Resources in the Huangjinkou Anticline, Northeast of Sichuan显示文摘Important clues have been found for potassiumprospecting in the Huangjinkou anticline of the northeastSichuan Basin in the 1970s (Zheng et al., 2015; Lin et al.,2004). In 2008, China Geological Survey launched aprospective investigation of potash resources in thewestern region of China, and the local governments andprivate-owned enterprises also responded positively. Then,during 2015-2016, the Land and Resources Department ofSichuan Province deployed potash prospecting drilling(borehole ZK601) in the Huangjinkou anticline, andobtained deep potassium and lithium resources. Theseresults may give a direction of marine potash prospectingin the Sichuan Basin. | ZHONG Jia'ai ZHENG Mianping TANG Xueyuan TANG Xue Yuan QI Wen ZHANG Zhen LIU Zhu WANG Fuming PANG Bo | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 2 |
| 19 | Neoadjuvant chemotherapy with FOLFOX: Improved outcomes in Chinese patients with locally advanced gastric cancer显示文摘 | Zi‐YuLi Cherry E.Koh Zhao‐DeBu Ai‐WenWu Lian‐HaiZhang Xiao‐JiangWu QiWu Xiang‐LongZong HuiRen LeiTang Xiao‐PengZhang Ji‐YouLi YingHu LinShen Jia‐FuJi | 2012 | J Surg Oncol2012，，8： | 2 |
| 20 | Genetic Diversity and Drug Susceptibility of Mycobacterium tuberculosis Isolates in a Remote Mountain Area of China显示文摘Objective We determined the genetic diversity of Mycobacterium tuberculosis(MTB) in a remote mountainous area of southwest China and evaluated the resolving ability of single nucleotide polymorphism(SNP) genotyping combined with variable number tandem repeat(VNTR) genotyping for Beijing family strains in association with drug resistance status.Methods Three hundred thirty-one MTB strains were isolated from patients living in mountainous regions of southwest China,and 8-loci SNP,VNTR-15 genotyping assays,and drug susceptibility testing of 9 drugs were performed.Results A total of 183 [55.29%(183/331)] strains were classified into the Beijing family.Of the 183 strains,111(60.66%) were defined as modern Beijing strains.The most predominant modern Beijing sub-lineage and ancient Beijing sub-lineage were Bmyc10 [39.34%(72/183)] and Bmyc25 [20.77%(38/183)],respectively.Of the isolates,19.64%(65/331) were resistant to at least 1 of the 9 anti-TB drugs and 17 [4.98%(17/331)] MTB isolates were multi-drug resistant tuberculosis(MDR-TB).Two hundred sixty-one isolates showed a clustering rate of 14.18%(37/261) and a discriminatory index of 0.9990.The Beijing lineage exhibited a significantly higher prevalence of MDR-TB,as well as resistance to isoniazid(INH),rifampin(RIF),and para-aminosalicylic acid(PAS) when analyzed independently(P = 0.005,P = 0.017,P = 0.014,and P = 0.006 respectively).The Beijing lineage was not associated with genetic clustering or resistance to any drug.In addition,genetic clustering was not associated with drug resistance.Conclusion MTB strains demonstrate high genetic diversity in remote mountainous areas of southwest China.Beijing strains,especially modern Beijing strains,are predominant in remote mountainous area of China.The combination of 8-loci SNPs and VNTR-15 genotyping is a useful tool to study the molecular epidemiology of MTB strains in this area. | ma ai jing wang sheng fen fan jia le zhao bing he guang xue zhao yan lin | 2018 | Biomedical and Environmental Sciences2018，31，5： | 2 |
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