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| 1 | Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study显示文摘Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors(FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designing a hybrid between the FGFR-selectivity-enhancing motif dimethoxybenzene group and our previously identified novel scaffold, we discovered a new series of potent FGFR inhibitors, with the best one showing sub-nanomolar enzymatic activity. After several round of optimization and with the solved crystal structure, detailed structure–activity relationship was elaborated. Together with in vitro metabolic stability tests and in vivo pharmacokinetic profiling, a representative compound(35) was selected and tested in xenograft mouse model, and the result demonstrated that inhibitor 35 was effective against tumors with FGFR genetic alterations, exhibiting potential for further development. | Peng Wei Bo Liu Ruifeng Wang Yinglei Gao Lanlan Li Yuchi Ma Zhiwei Qian Yuelei Chen Maosheng Cheng Meiyu Geng Jingkang Shen Dongmei Zhao Jing Ai Bing Xiong | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 2 | Molecular characterization of the genome of duck enteritis virus显示文摘 | Yufeng Li Bing Huang Xiuli Ma Jing Wu Feng Li Wu Ai Minxun Song Hanchun Yang | 2009 | Virology2009，，2： | 2 |
| 3 | Genetic Diversity and Drug Susceptibility of Mycobacterium tuberculosis Isolates in a Remote Mountain Area of China显示文摘Objective We determined the genetic diversity of Mycobacterium tuberculosis(MTB) in a remote mountainous area of southwest China and evaluated the resolving ability of single nucleotide polymorphism(SNP) genotyping combined with variable number tandem repeat(VNTR) genotyping for Beijing family strains in association with drug resistance status.Methods Three hundred thirty-one MTB strains were isolated from patients living in mountainous regions of southwest China,and 8-loci SNP,VNTR-15 genotyping assays,and drug susceptibility testing of 9 drugs were performed.Results A total of 183 [55.29%(183/331)] strains were classified into the Beijing family.Of the 183 strains,111(60.66%) were defined as modern Beijing strains.The most predominant modern Beijing sub-lineage and ancient Beijing sub-lineage were Bmyc10 [39.34%(72/183)] and Bmyc25 [20.77%(38/183)],respectively.Of the isolates,19.64%(65/331) were resistant to at least 1 of the 9 anti-TB drugs and 17 [4.98%(17/331)] MTB isolates were multi-drug resistant tuberculosis(MDR-TB).Two hundred sixty-one isolates showed a clustering rate of 14.18%(37/261) and a discriminatory index of 0.9990.The Beijing lineage exhibited a significantly higher prevalence of MDR-TB,as well as resistance to isoniazid(INH),rifampin(RIF),and para-aminosalicylic acid(PAS) when analyzed independently(P = 0.005,P = 0.017,P = 0.014,and P = 0.006 respectively).The Beijing lineage was not associated with genetic clustering or resistance to any drug.In addition,genetic clustering was not associated with drug resistance.Conclusion MTB strains demonstrate high genetic diversity in remote mountainous areas of southwest China.Beijing strains,especially modern Beijing strains,are predominant in remote mountainous area of China.The combination of 8-loci SNPs and VNTR-15 genotyping is a useful tool to study the molecular epidemiology of MTB strains in this area. | ma ai jing wang sheng fen fan jia le zhao bing he guang xue zhao yan lin | 2018 | Biomedical and Environmental Sciences2018，31，5： | 2 |
| 4 | Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo transfers显示文摘 | Ye Yin Ge Chen Kezhen Li Qiuyue Liao Sijia Zhang Nieying Ma Jing Chen Yan Zhang Jihui Ai | 2017 | Frontiers of Medicine2017，11，4： | 2 |
| 5 | Lactate anions participate in T cell cytokine production and function显示文摘After antigen stimulation, T cells preferentially increase aerobic glycolysis to meet the bioenergetic and biosynthetic demands of T cell activation, proliferation, and effector functions. Lactate, a by-product of glycolysis, has been reported to function as an important energy source and signaling molecule. Here, we found that lactate anions are involved in cytokine production in Tcells after TCR activation. During ex vivo T cell activation, the addition of excess sodium lactate(Na L) increased the production of cytokines(such as IFNγ/IL-2/TNFα) more than the addition of sodium chloride(NaCl). This enhanced cytokine production was dependent on TCR/CD3 activation but not CD28 activation. In vivo, Na L treatment inhibited tumour growth in subcutaneously transplanted tumour models in a T cell-dependent manner, which was consistent with increased T cell cytokine production in the Na L treatment group compared to the Na Cl treatment group. Furthermore, a mechanistic experiment showed that this enhanced cytokine production was regulated by GAPDH-mediated post-transcriptional regulation. Taken together, our findings indicate a new regulatory mechanism involved in glycolysis that promotes T cell function. | Jing Wen Shipeng Cheng Yaguang Zhang Ran Wang Jiefang Xu Zhiyang Ling Liyan Ma Xinghao Ai Bing Sun | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 6 | Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations显示文摘 | Zhe YU Yu-chi MA Jing AI Dan-qi CHEN Dong-mei ZHAO Xin WANG Yue-lei CHEN Mei-yu GENG Bing XIONG Mao-sheng CHENG Jing-kang SHEN | 2013 | Acta Pharmacologica Sinica2013，34，11： | 2 |
| 7 | Application of plant growth regulator TDZ in strawberry anther culture 显示文摘 | WANG Jing dong ZHANG Li MA Hong ai | 2010 | Agricultural Science and Technology2010，11，910： | 1 |
| 8 | Contracting with demand uncertainty under supply chain competition显示文摘 | Ai Xingzheng Che Jing Ma Jianhua | 2012 | Annals of Operations Research2012，201，1： | 1 |
| 9 | Nurse Staffing Levels Make a Difference on Patient Outcomes: A Multisite Study in Chinese Hospitals显示文摘 | Xiao‐wen Zhu Li‐ming You Jing Zheng Ke Liu Jin‐bo Fang Shu‐xiao Hou Min‐min Lu Ai‐li Lv Wei‐guang Ma Hong‐hong Wang Zi‐jing Wu Li‐feng Zhang | 2012 | Journal of Nursing Scholarship2012，，3： | 1 |
| 10 | Simultaneous determination of 118 pesticide residues in Chinese teas by gas chromatography-mass spectrometry显示文摘 | Xin Yang De Chang Xu Jian Wei Qiu Hua Zhang Ying Chun Zhang Ai Jun Dong Ying Ma Jing Wang | 2009 | Chemical Papers2009，，1： | 1 |
| 11 | Discovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors显示文摘瞄准:异常遇见 c 的激活在癌症形成,前进和传播,以及在抵抗的开发起一个关键作用到 anticancer 药。因此,遇见 c 为癌症作为一个吸引人的目标出现了治疗。这研究的目的是开发新遇见 c 的禁止者并且详细描述识别 inhibitors.Methods 的结构活动关系:基于 5 和 14 在停靠学习的混合物的预言的有约束力的模式,遇见 c 的怀有禁止者的 3- 的一个新系列((1H-pyrrolo [3,2-c ] pyridin-1-yl ) sulfonyl ) imidazo [1,2-a ] pyridine 脚手架被发现。有势力禁止者通过与酶、细胞的试金相结合的广泛的优化被识别。有希望的混合物进一步关于它的选择,它遇见 c 的发信号上的效果,房间增长和在 vitro.Results 散布的房间被调查:有 12.8 nmol/L 的 IC 50 值的大多数有势力化合物 31 禁止的遇见 c 的 kinase 活动,是 >, 16 不同酷氨酸 kinases 的一块面板的比那些高的 78 褶层。化合物 31 (8, 40, 200 nmol/L ) dose-dependently 禁止了 phosphorylation 遇见 c 并且它在遇见 c 的异常人的 EBC-1 癌症房间的关键下游的 Akt 和英皇家空军之阶级最低之兵发信号串联。在怀有遇见 c 的表示 / 激活的不同背景层次的 12 根人的癌症房间线,加重 31 potently 禁止的 c-Met-driven 房间增长。而且,加重 MDCK cells.Conclusion 散布的 31 dose-dependently 损害的 c-Met-mediated 房间:遇见 c 的禁止者的这个系列是为新奇 anticancer 药的开发的有希望的领先。 | Tong-chao LIU Xia PENG Yu-chi MA Yin-chun JI Dan-qi CHEN Ming-yue ZHENG Dong-mei ZHAO Mao-sheng CHENG Mei-yu GENG Jing-kang SHEN Jing AI Bing XIONG | 2016 | Acta Pharmacologica Sinica2016，37，5： | 1 |
| 12 | A Novel Robust Watermarking Algorithm for Encrypted Medical Image Based on DTCWT-DCT and Chaotic Map显示文摘In order to solve the problem of patient information security protection in medical images,whilst also taking into consideration the unchangeable particularity of medical images to the lesion area and the need for medical images themselves to be protected,a novel robust watermarking algorithm for encrypted medical images based on dual-tree complex wavelet transform and discrete cosine transform(DTCWT-DCT)and chaotic map is proposed in this paper.First,DTCWT-DCT transformation was performed on medical images,and dot product was per-formed in relation to the transformation matrix and logistic map.Inverse transformation was undertaken to obtain encrypted medical images.Then,in the low-frequency part of the DTCWT-DCT transformation coefficient of the encrypted medical image,a set of 32 bits visual feature vectors that can effectively resist geometric attacks are found to be the feature vector of the encrypted medical image by using perceptual hashing.After that,different logistic initial values and growth parameters were set to encrypt the watermark,and zero-watermark technology was used to embed and extract the encrypted medical images by combining cryptography and third-party concepts.The proposed watermarking algorithm does not change the region of interest of medical images thus it does not affect the judgment of doctors.Additionally,the security of the algorithm is enhanced by using chaotic mapping,which is sensitive to the initial value in order to encrypt the medical image and the watermark.The simulation results show that the pro-posed algorithm has good homomorphism,which can not only protect the original medical image and the watermark information,but can also embed and extract the watermark directly in the encrypted image,eliminating the potential risk of decrypting the embedded watermark and extracting watermark.Compared with the recent related research,the proposed algorithm solves the contradiction between robustness and invisibility of the watermarking algorithm for encrypted medical images,and it has good results against both conventional attacks and geometric attacks.Under geometric attacks in particular,the proposed algorithm performs much better than existing algorithms. | Jing Liu Jingbing Li Jieren Cheng Jixin Ma Naveed Sadiq Baoru Han Qiang Geng Yang Ai | 2019 | Computers, Materials & Continua2019，，8： | 1 |
| 13 | Molecular characterization of the genome of duck enteritis virus显示文摘 | Yufeng Li Bing Huang Xiuli Ma Jing Wu Feng Li Wu Ai Minxun Song Hanchun Yang | 2009 | Virology2009，，2： | 1 |
| 14 | Fertility outcome analysis after modified laparoscopic microsurgical tubal anastomosis显示文摘Modified laparoscopic microsurgical tubal anastomosis is an alternative for microsurgical anastomosis via laparotomy to reverse sterilization in women with renewed child wish.The current study aims to evaluate the fertility outcome after modified laparoscopic microsurgical tubal anastomosis.A retrospective study was performed.Fifty-eight women who underwent modified laparoscopic microsurgical tubal anastomosis were monitored to investigate the fertility outcome and characteristics of this new technology.Of the 58 patients,the cumulative pregnancy rate(PR)in the 42 patients with follow-up data was 23.8%(10/42),57.1%(24/42),66.7%(28/42),and 73.8%(31/42)within 6,12,24,and 36 months after surgery,respectively.The intrauterine PR was 69.0%(29/42).Two patients(4.8%)had ectopic pregnancies that occurred within 24 months of surgery;three cases ended in spontaneous abortion.The delivery rate was 83.9%(26/31).The length of operating time was 1.20.3 h,with a range of 1.0–2.5 h(60–145 min),and the mean time was approximately 75 min.The blood loss was relatively small,between 10 and 50 ml with an average amount of 22 ml.Thus,the modified laparoscopic tubal anastomosis is a highly successful procedure and a viable alternative to open abdominal microsurgical approaches.Compared with the traditional laparoscopic tubal sterilization reversal,this modified approach has three advantages:(1)less invasive approach via a trocar reduction;(2)remodeling of tube is better performing tied together after 3–4 sutures;and(3)faster operating time. | Jihui Ai Pei Zhang Lei Jin Yufeng Li Jing Yue Ding Ma Hanwang Zhang | 2011 | Frontiers of Medicine2011，5，3： | 0 |
| 15 | Monitoring rock desert formation caused by two different origins(ice-snow melting and drying)in the Qinghai-Tibet Plateau of China by considering topographic and meteorological elements显示文摘Monitoring rock desert formation caused by two different origins(ice-snow melting and drying)through remote sensing is crucial to our understanding of the interaction between the underlying surface of different rock desert and land-atmosphere types,as well as the relationship between bare land and soil erosion.A number of achievements have been made in remote sensing monitoring of desert areas,but there is a lack of accurate classification and remote sensing identification of rock desert types based on formation mechanism.In this study,the north and south sides of the eastern Kunlun Mountains in the northern part of the Qinghai-Tibet Plateau of China were taken as the study areas.Landsat operational landscape imager,digital elevation model,and precipitation and temperature grid data were used as data sources.By identifying the bare areas based on the normalized difference vegetation index(NDVI),we used the multi-element fusion method of contours,isotherms,and isohyets to identify the rock desert types in the ice-snow melting and dry areas.The results showed that:(1)the rock desert areas identified by remote sensing based on topographic and meteorological elements were highly accurate,with an overall accuracy of 88.45%and kappa coefficient of 0.77.The multi-element fusion method of contours,isotherms,and isohyets could effectively identify the rock desert types in the ice-snow melting and dry areas;(2)the optimal segmentation range of the ice-snow melting and dry areas was 3600 m contour,-2°C-2°C isotherms,and 100-130 mm isohyets.The areas with elevation less than 3600 m,annual average temperature higher than 2°C,and average annual precipitation less than 100 mm were rock desert in the dry areas.The range of-2°C-2°C isotherms and 100-130 mm isohyets was the transition area between the ice-snow melting and dry areas.The areas with elevation higher than 3600 m,annual average temperature less than-2°C,and average annual precipitation higher than 130 mm were rock desert in the ice-snow melting areas;and(3)the identification accuracy of the bare areas based on the NDVI method was better,specifically,the identification accuracy of plain bare areas was generally better than that of mountain bare areas.The remote sensing identification method considers not only the topographic factors that have great influence on the spatial distribution of the two types of rock desert areas,but also the meteorological factors,which can provide a scientific reference for the effective identification of the two types of rock desert areas. | JIA Wei SHI Peijun WANG Jing'ai MA Weidong XIA Xingsheng ZHOU Yuantao | 2022 | Journal of Arid Land2022，14，8： | 0 |
| 16 | Dietary Sodium Intake and Its Impact Factors in Adults of Shandong Province显示文摘Dietary sodium intake and its impact factors in2 140 adults aged 18-69 years were analyzed.The mean daily sodium intake was 5 745.0(5 427.6-6 062.5)mg per day,which was higher in males than in females(P<0.01).After having been adjusted for gender,age and urban/city areas,the mean daily sodium intake was significantly higher in participants with a lower education level,drinkers and smokers than in those with a higher education level, | LI Jian Hong XU Ai Qiang LU Zi Long YAN Liu Xia GUO Xiao Lei WANG Hui Cheng MA Ji Xiang ZHANG Ji Yu DONG Jing WANG Lin Hong | 2014 | Biomedical and Environmental Sciences2014，27，7： | 0 |
| 17 | CLINICAL REPORT OF MODIFIED MAZE PROCEDURE显示文摘CLINICALREPORTOFMODIFIEDMAZEPROCEDURECLINICALREPORTOFMODIFIEDMAZEPROCEDUREZhuJiaGuang;HeZhongLiang;LuoWei;DongAiQiang;XuShiWe... | Zhu Jia Guang He Zhong Liang Luo Wei Dong Ai Qiang Xu Shi Wei Chen Fang Zhang Chang Ming Shang Jing Ma lie Xian Tang Chao He Qi Cai.(The Second Affiliated Hospital, Zhe Jiang Medical University 68 Jianfang Rood, Hangzhou 310009, China) | 1994 | Chinese Journal of Biomedical Engineering(English Edition)1994，3，3： | 0 |
| 18 | Characterization of Highly Pathogenic Avian Influenza H5N1 Viruses Isolated from Domestic Poultry in China显示文摘高度病原的鸟的流行性感冒(HPAI ) H5N1 病毒在国内家禽引起了几爆发。尽管有控制这个病毒的传播的大努力,它继续演变并且因为高死亡率,形成实质的威胁到公共健康。在这研究,我们定序在东方中国从国内家禽孤立并且典型流行性感冒病毒紧张把他们与那些作比较的八个 H5N1 鸟的流行性感冒病毒的整个染色体。种系发生的分析证明所有八个染色体属于 clade 2.3.2.1 并且 clade 7.2,在中国的二主要传播 clades。那在 2.3.2.1 分享了的 clade 聚类的病毒有 H5N1 的相同的高度孤立在东方亚洲人定位了。孤立在 7.2 被发现在整个中国传播的 clade 聚类那,与一个 east-to-west 密度坡度。在老鼠的致病力研究显示出那这些孤立在肺,和 clade 复制 2.3.2.1 病毒展览与 clade 相比的毒力的尤其是更高的度 7.2 个病毒。我们的结果贡献 HPAI H5N1 病毒的生物描述和致病力的说明。 | LAI Cheng Cai WANG Ke Yu CHEN Rui ZHANG Ai Jun GU Hong Jing YIN Yan Bo WANG Dong Dong LIU Lin Lin XING Li TONG Yi Gang MA Zong Juan YANG Peng Hui WANG Xi Liang | 2017 | Biomedical and Environmental Sciences2017，30，1： | 0 |
| 19 | COVID-19 mortality in ICUs associated with critical care staffing显示文摘To the Editor Coronavirus disease 2019(COVID-19)has been around for over a year since December 2019,and the global outlook is not optimistic.Because of its high transmissibility and high mortality,management of the COVID-19 pandemic has become a major challenge for health systems globally,especially for critical care. | Jingjing Xi Lin Zeng Shusheng Li Yuhang Ai Xiandi He Yan Kang Yimin Li Yanping Mo Yue Peng Kejian Qian Bingyu Qin Chunting Wang Jing Yan Fachun Zhou Hua Zhang Penglin Ma | 2021 | Burns & Trauma2021，9，1： | 0 |
| 20 | Mapping the Global-Scale Maize Drought Risk Under Climate Change Based on the GEPIC-Vulnerability-Risk Model显示文摘Drought is projected to become more frequent and increasingly severe under climate change in many agriculturally important areas.However,few studies have assessed and mapped the future global crop drought risk—defined as the occurrence probability and likelihood of yield losses from drought—at high resolution.With support of the GEPIC-Vulnerability-Risk model,we propose an analytical framework to quantify and map the future global-scale maize drought risk at a 0.5°resolution.In this framework,the model can be calibrated and validated using datasets from in situ observations(for example,yield statistics,losses caused by drought)and the literature.Water stress and drought risk under climate change can then be simulated.To evaluate the applicability of the framework,a global-scale assessment of maize drought risk under 1.5℃warming was conducted.At 1.5℃warming,the maize drought risk is projected to be regionally variable(high in the midlatitudes and low in the tropics and subtropics),with only a minor negative(-0.93%)impact on global maize yield.The results are consistent with previous studies of drought impacts on maize yield of major agricultural countries around the world.Therefore,the framework can act as a practical tool for global-scale,future-oriented crop drought risk assessment,and the results provide theoretical support for adaptive planning strategies for drought. | Yuanyuan Yin Yuan Gao Degen Lin Lei Wang Weidong Ma Jing’ai Wang | 2021 | International Journal of Disaster Risk Science2021，12，3： | 0 |
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