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| 1 | Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies显示文摘Coronavirus disease 2019(COVID-19),caused by the novel human coronavirus SARS-CoV-2,is currently a major threat to public health worldwide.The viral spike protein binds the host receptor angiotensin-converting enzyme 2(ACE2)via the receptor-binding domain(RBD),and thus is believed to be a major target to block viral entry.Both SARS-CoV-2 and SARS-CoV share this mechanism.Here we functionally analyzed the key amino acid residues located within receptor binding motif of RBD that may interact with human ACE2 and available neutralizing antibodies.The in vivo experiments showed that immunization with either the SARS-CoV RBD or SARS-CoV-2 RBD was able to induce strong clade-specific neutralizing antibodies in mice;however,the cross-neutralizing activity was much weaker,indicating that there are distinct antigenic features in the RBDs of the two viruses.This finding was confirmed with the available neutralizing monoclonal antibodies against SARS-CoV or SARS-CoV-2.It is worth noting that a newly developed SARS-CoV-2 human antibody,HA001,was able to neutralize SARS-CoV-2,but failed to recognize SARS-CoV.Moreover,the potential epitope residues of HA001 were identified as A475 and F486 in the SARS-CoV-2 RBD,representing new binding sites for neutralizing antibodies.Overall,our study has revealed the presence of different key epitopes between SARS-CoV and SARSCoV-2,which indicates the necessity to develop new prophylactic vaccine and antibody drugs for specific control of the COVID-19 pandemic although the available agents obtained from the SARS-CoV study are unneglectable. | Chunyan Yi Xiaoyu Sun Jing Ye Longfei Ding Meiqin Liu Zhuo Yang Xiao Lu Yaguang Zhang Liyang Ma Wangpeng Gu Aidong Qu Jianqing Xu Zhengli Shi Zhiyang Ling Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，6： | 13 |
| 2 | Hierarchical MoS2 intercalated clay hybrid nanosheets with enhanced catalytic activity显示文摘新兴的层次瞬间 2/pillared-montmorillonite (瞬间 2/PMMT) 混血儿 nanosheets 成功地在 cetyltrimethylammonium 溴化物 PMMT 的夹层以内通过瞬间 2 的灵巧的在原处热水的合成被准备,并且他们的催化表演被 4-nitrophenol (4-NP ) 的减小反应作为 reductant 用 NaBH 4 评估。微观结构和形态学描述显示瞬间 2/PMMT 与 1.29 nm,和瞬间 2 nanosheets 的夹层间距展出了叠混血儿的分层的结构在 montmorillonite (MMT ) 以内被设置层,与大多数暴露于外面的边。瞬间 2/PMMT 的催化活动和稳定性被 MMT 两个都提高。与是的瞬间 2/PMMT 催化剂, 4-NP 减小的明显的反应率常数是 0.723 min 1 并且在 ~ 被维持在五反应以后的 0.679 min 1 骑车。为 4-NP 的减小反应的瞬间 2/PMMT 和可能的催化作用机制的结构的进化被调查。同样准备的瞬间 2/PMMT 混血儿 nanosheets 在水处理和生物医学的域为催化申请正在答应候选人。在这研究开发的策略能为设计混合 nanosheets 与提供卓见多样异构二维(2D ) nanomaterials。 | Kang Peng Liangjie Fu Huaming Yang Jing Ouyang Aidong Tang | 2017 | Nano Research2017，10，2： | 6 |
| 3 | Simultaneous determination of ivabradine and N-desmethylivabradine in human plasma and urine using a LC-MS/MS method: application to a pharmacokinetic study显示文摘A sensitive and specific liquid-chromatography tandem mass spectrometry(LC-MS/MS)assay has been developed and validated for the simultaneous quantification of ivabradine and its active metabolite N-desmethylivabradine in human plasma and urine.The assay employed a single liquid–liquid extraction of the analytes from plasma and urine samples,and diazepam was used as internal standard(IS).The chromatographic separation was achieved on a Diamonsil C18 column(150 mm4.6 mm,5 mm,Dikma)using a mixture of methanol and aqueous 5 mM ammonium acetate buffer containing 0.2%formic acid(80:20,v/v)as mobile phase.The assay for ivabradine and N-desmethylivabradine in plasma showed good linearity(r≥0.99)over the ranges 0.1013–101.3 ng/mL and 0.085–25.5 ng/mL,respectively.The assay for ivabradine and N-desmethylivabradine in urine showed good linearity(r≥0.99)over the ranges 10.13–6078 ng/mL and 8.5–850 ng/mL,respectively.The intra-and inter-day accuracy and precision values were found to be within the assay variability limits(RSD<15%)in accordance with FDA guidelines.The methods were successfully used for evaluating the pharmacokinetic properties of ivabradine and N-desmethylivabradine in human plasma and urine in Chinese healthy volunteers. | Chengtao Lu Yanyan Jia Jing Yang Xin Jin Ying Songa Wenxing Liu Yi Ding Xiaoli Sun Aidong Wen | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 3 |
| 4 | Engineering a tubular mesoporous silica nanocontainer with well-preserved clay shell from natural halloysite显示文摘在里面从自然矿物质的 mesoporous nanotubes 的 situ 合成仍然是大挑战。此处,我们与一个变化报导 mesoporous 硅石 nanotubes (MNT ) 的成功的合成内部壳的厚度和保存泥土从 natural-halloysite nanotubes (HNT ) 的外部壳。在由酸的沥滤的管状的铝矽酸盐泥土的腔直径的增大以后,一致 mesopores 被一条修改 pseudomorphic 转变途径介绍,当时泥土外部壳保存得很好。用密度在沥滤的艾尔和 Si 期间的功能的理论计算,原子结构进化和 energetics -- 哦冷凝作用详细被学习。在从 HNT 艾尔离子沥滤以后,从艾尔的本地结构的变化(哦) 到在中等沥滤水平的艾尔(V) 并且到在沥滤的高度的艾尔(Td ) ,水平被证实。在沥滤酸的 HNT (在内部壳的弄歪的二维的硅石来源和在外部壳的未经触动的铝矽酸盐结构)的二种硅石部件的计算 hydroxylation 精力比体积硅石的高是更低的 0.5 eV 或 1.0 eV ,它在热水的过程澄清硅石部件的不同行为。从 HNT 的反应 MNT 的成功的合成用自然矿物质与特殊形态学为 mesoporous nanocontainers 的合成介绍新策略。特别地, MNT 与众多的反应艾尔(V) 种类和一个特定的表面区域取样直到 583 m 2/g (由 10 的一个因素增加了) 正在答应装载药的 nanocontainers 和 nanoreactors。 | Liangjie Fu Huaming Yang Aidong Tang Yuehua Hu | 2017 | Nano Research2017，10，8： | 3 |
| 5 | A novel visual attention method for target detection from SAR images显示文摘Synthetic Aperture Radar(SAR) imaging systems have been widely used in civil and military fields due to their all-weather and all-day abilities and various other advantages. However, due to image data exponentially increasing, there is a need for novel automatic target detection and recognition technologies. In recent years, the visual attention mechanism in the visual system has helped humans effectively deal with complex visual signals. In particular, biologically inspired top-down attention models have garnered much attention recently. This paper presents a visual attention model for SAR target detection, comprising a bottom-up stage and top-down process.In the bottom-up step, the Itti model is improved based on the difference between SAR and optical images. The top-down step fully utilizes prior information to further detect targets. Extensive detection experiments carried out on the benchmark Moving and Stationary Target Acquisition and Recognition(MSTAR) dataset show that, compared with typical visual models and other popular detection methods, our model has increased ability and robustness for SAR target detection, under a range of Signal to Clutter Ratio(SCR) conditions and scenes. In addition, results obtained using only the bottom-up stage are inferior to those of the proposed method, further demonstrating the effectiveness and rationality of a top-down strategy. In summary, our proposed visual attention method can be considered a potential benchmark resource for the SAR research community. | Fei GAO Aidong LIU Kai LIU Erfu YANG Amir HUSSAIN | 2019 | Chinese Journal of Aeronautics2019，32，8： | 3 |
| 6 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 7 | Intercalated 2D nanoclay for emerging drug delivery in cancer therapy显示文摘自然二维(2D ) kaolinite nanoclay 被合并了到一个新兴的药交货系统。kaolinite nanoclay 的基础间距通过不同的链长度的各种各样的器官的客人种类的置闰从 0.72 ~ 4.16 nm 被扩展,它能在药交货增加效率并且减少 doxorubicin (纪录影片) 的毒性。原来的 kaolinite (白陶土) 和白陶土置闰混合物向胰腺的癌症,胃的癌症,前列腺癌症,乳癌, colorectal 癌症,食道的癌症,和区分的甲状腺的房间展出了 biocompatibility 和很低的毒性的高水平癌症。然而,肺癌症和 hepatocellular 癌症房间为药交货搬运人需要更严格的组合、结构、词法的调整。纪录影片白陶土和纪录影片白陶土置闰混合物比处于中立状况在中等酸的答案显示出戏剧性地更快的药版本,并且以一种剂量依赖者方式对十种模型癌症房间文化展出了提高的治疗学的效果。为一个新奇的药交货系统的 2D nanoclay 材料的使用能 feasibly 向高效的 nanotherapeutics 铺平一条道路,与优异 antitumor 功效并且显著地减少副作用。 | Yi Zhang Mei Long Peng Huang Huaming Yang Shi Chang Yuehua Hu Aidong Tang Linfeng Mao | 2017 | Nano Research2017，10，8： | 2 |
| 8 | Determination of ifenprodil by LC–MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers显示文摘This paper reports the development and validation of an assay for ifenprodil based on liquid chromatography–tandem mass spectrometry(LC–MS/MS)and its application to a pharmacokinetic study involving single and multiple intravenous infusions to healthy Chinese volunteers.After sample preparation of plasma by liquid–liquid extraction with ethyl acetate,the analyte and internal standard,urapidil,were separated by reversed phase chromatography in a run time of 4 min and detected by positive ion electrospray ionization followed by multiple reaction monitoring of the precursor-to-product ion transitions at m/z 326.2-308.1 for ifenprodil and m/z 388.4-205.3 for IS.The assay was linear in the concentration range 0.2–50.0 ng/mL with recovery 476.4%.In the pharmacokinetic study of single intravenous infusions of 5,10 and 15 mg ifenprodil,peak plasma concentrations and areas under the plasma concentration–time curve were both linearly related to dose.In the pharmacokinetic study of multiple once daily intravenous infusions of 10 mg ifenprodil for 7 days,pharmacokinetic parameters were similar to those after the single dose showing that ifenprodil does not accumulate on repeated administration. | Jing Yang Chengtao Lu Wei Song Jiankang Li Yi Ding Yanrong Zhu Jinyi Cao Likun Ding Yanyan Jia Aidong Wen | 2013 | Acta Pharmaceutica Sinica B2013，3，3： | 2 |
| 9 | Modular dynamic simulation for integrated particulate processes by means of tool integration 显示文摘 | Viateheslav Kulikov Heiko Briesen Robert Grosch Aidong Yang Lars von Wedel Wolfgang Marquardt | 2005 | Chemical Engineering Science2005，60，7： | 1 |
| 10 | Upcycling of phosphogypsum waste for efficient zinc-ion batteries显示文摘Zinc metal is a promising anode material for next-generation aqueous batteries,but its practical application is limited by the formation of zinc dendrite.To prevent zinc dendrite growth,various Zn^(2+)-conducting but water-isolating solid-electrolyte interphase(SEI)films have been developed,however,the required high-purity chemical materials are extremely expensive.In this work,phosphogypsum(PG),an industrial byproduct produced from the phosphoric acid industry,is employed as a multifunctional protective layer to navigate uniform zinc deposition.Theoretical and experimental results demonstrate that PG-derived CaSO_(4)2H_(2)O can act as an artificial SEI layer to provide fast channels for Zn^(2+)transport.Moreover,CaSO_(4)2H_(2)O could release calcium ions(Ca^(2+))due to its relatively high Kspvalue,which have a higher binding energy than that of Zn^(2+)on the Zn surface,thus preferentially adsorbing to the tips of the protuberances to force zinc ions to nucleate at inert region.As a result,the Zn@PG anode achieves a high Coulombic efficiency of 99.5%during 500 cycles and long-time stability over 1000 hours at 1 m A cm^(-2).Our findings will not only construct a low-cost artificial SEI film for practical metal batteries,but also achieve a high-value utilization of phosphogypsum waste. | Huanwen Wang Can Luo Yinyin Qian Caihong Yang Xiaojun Shi Yansheng Gong Rui Wang Beibei He Jun Jin Aidong Tang Edison Huixiang Ang Huaming Yang | 2023 | Journal of Energy Chemistry2023，，6： | 1 |
| 11 | Animal stem cells: the engineering development front of 2018显示文摘The Engineering Fronts reports are important guidelines for the future development directions of engineering science and technology. The Chinese Academy of Engineering (CAE) has been conducting studies relevant to Engineering Fronts for two years since 2017. | Wenye YUAN Jianxiang XU Chenying LI Lijuan SHI Aidong YANG Yan WANG Lu XING Shaozhong KANG | 2019 | Frontiers of Agricultural Science and Engineering2019，6，1： | 1 |
| 12 | A nuclear localized protein ZCCHC9 is expressed in cerebral cortex and suppresses the MAPK signal pathway显示文摘The CCHC-type zinc finger motif has numerous biological activities (such as DNA binding and RNA binding) and can also mediate protein-protein interaction. This article gives a primary report about the human ZCCHC9 gene. Protein ZCCHC9 contains four CCHC motifs and is highly conserved in humans, mice, and rats. The whole cDNA sequence of the ZCCHC9 gene has been amplified by PCR and a number of plasmids have been constructed for further study. The results show that ZCCHC9 is localized in the nucleus, and especially concentrated in the nucleolus. It is highly expressed in the brain and testicles of the mouse. This has been confirmed by real-time reverse transcription polymerase chain reaction (RT-PCR). In situ hybridization of the mouse brain indicates that ZCCHC9 is mainly expressed in the cerebral cortex. Reporter gene assay shows that ZCCHC9 suppresses the transcription activities of NF-kappa B and SRE, and may play roles in the Mitogen-Activated Protein Kinase (MAPK) signaling transduction pathway. | Aidong Zhou Jianlin Zhou Liping Yang Mingjun Liu Hong Li Su Xu Mei Han Jian Zhang | 2008 | Journal of Genetics and Genomics2008，35，8： | 1 |
| 13 | In2O3 nanoparticles synthesized by mechanochemical processing显示文摘 | Yang Huaming Tang Aidong Zhang Xiangchao | 2004 | Scripta Material2004，50，： | 1 |
| 14 | nanoparticles synthesized by mechanochemical processing显示文摘 | Huaming Yang Aidong Tang etc | 2004 | Scripta Materialia2004，，11： | 1 |
| 15 | A formulation of the collaboration mechanism for integrated abnormal situation management 显示文摘 | Yang Aidong Lu Ming L | 2000 | Computers & Chem Eng2000，24，27： | 1 |
| 16 | Sulfur vs. tellurium: the heteroatom effects on the nonfullerene acceptors显示文摘The effect of chalcogen heteroatom variation on donor materials has been systematically investigated. However, this effect on acceptors has rarely been explored. Herein, nonfullerene acceptors BFPSP and BFPTP were reported by simply changing the chalcogen atoms from S to Te. The differences between BFPSP and BFPTP in light absorption, energy levels, excited-state lifetimes, energy loss, charge mobilities, morphology, and photovoltaic properties were systematically investigated to understand the heteroatom effects. More importantly, the electroluminescence spectra, external quantum efficiency of photovoltaics and TDDFTcalculations revealed that the triplet excited state(T1) in energy of BFPTP equals to the charge transfer(CT) state in PBDBT:BFPTP, which allows T1 excitons, generated by intersystem crossing, to split into free charges to contribute to the efficiency.This contribution provides a strategy for tuning the photophysical properties of nonfullerene acceptors and designing high performance triplet materials for OSCs. | Lei Yang Linqing Qin Yunxiao Xu Huotian Zhang Lei Lv Kepeng Chen Xinyu Sui Yangguang Zhong Yuan Guo Feng Gao Jianzhang Zhao Yuhao Li Xinfeng Liu Yuanping Yi Xinhui Lu Aidong Peng Hui Huang | 2019 | Science China Chemistry2019，62，7： | 1 |
| 17 | Lu,A formulation of the collaboration mechanism for integrated abnormal situation management显示文摘 | Yang Aidong Ming L | 2000 | Computers & Chem Eng2000，，24： | 1 |
| 18 | A formulation of the collaboration mechanism for integrated abnormal situation management显示文摘 | Yang Aidong Lu Ming L | 2000 | Computers & Chem Eng2000，24，27： | 1 |
| 19 | Electrochemical synthesis and photocatalytic property of cuprous oxide nanoparticles 显示文摘 | Yang Huaming Ouyang Jing Tang Aidong | 2006 | Mater Res Bull2006，41，7： | 1 |
| 20 | Synthesis of WO 3 /TiO 2 nanocomposites via sol–gel method显示文摘 | Huaming Yang Rongrong Shi Ke Zhang Yuehua Hu Aidong Tang Xianwei Li | 2005 | Journal of Alloys and Compounds2005，，1： | 1 |
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