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| 1 | Validation of the chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer显示文摘AIM To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29(EORTC QLQ-CR29) in Chinese patients with colorectal cancer(CRC). METHODS From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire(EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale(KPS). The reliability and validity of the questionnaires were assessed by Cronbach's α coefficient, the Spearman correlation test and Wilcoxon rank sum test.RESULTS The EORTC QLQ-CR29 showed satisfactory reliability(α > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability(α = 0.608). The multitrait scaling analyses showed good convergent(r > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups(KPS ≤ 80; KPS > 80). body image and most single-item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients. CONCLUSION The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients. | Jin-bo Lin Lei Zhang Dong-Wen Wu Zhou-Huan xi xue-Jun Wang Yun-Shou Lin Wakana Fujiwara Jing-Ru Tian Min Wang Peng Peng Ai Guo Zhen Yang Le Luo Ling-Ya Jiang Qia-Qia Li xue-Ying Zhang Yun-Feng Zhang Hou-Wei xu bing Yang xun-Lin Li Yi-xiong Lei | 2017 | World Journal of Gastroenterology2017，23，10： | 12 |
| 2 | Seroepidemiology and genetic characterization of hepatitis E virus in western Yunnan Province显示文摘Objective:To investigate the seroepidemiology and genetic characterization of hepatitis E virus(HEV) in western Yunnan Province.Methods:Questionnaire survey was conducted among1638 residents in western Yunnan Province using stratified sampling method.Enzyme-linked immunosorbent assay was used to detect serum anti-HEV IgG and IgM.HEV RNA was extracted from patients with serum anti-HEV IgM positive.The open reading flame 2(ORF2) of HEV that was amplified by nested RT-PCR was sequenced and compared with standard HEV genotypes 1-4.Results:Serum anti-HEV positive was found in 13.929(228/1638) residents.The HEV infection rate in males was significantly higher than that in females with a ratio of 1.47(P<0.01).20-30 and30-40 years old young men showed the highest incidence.20.57%and 20.78%.respectively.While10-20 and 20-30 years old young women exhibited the highest infection rate,11.85%and 15.60%,respectively.According to occupation,the highest HEV infection rate was observed in farmers(20.35%) and migrants(16.50%).We isolated 10 individual HEV isolates from 31 patients with serum anti-HEV IgM positive.Homology analysis and phylogenetic analysis indicated that these10 HEV isolates belonged to HEV genotype 4 with the homology of 78.65%-94.71%.Conclusions:The HEV infection rate is high in western Yunnan Province.HEV genotype 4 is the leading cause of HEV infection and young farmers and migrants are the main infected population. | Li-Juan Li Yuan-Ying Shen Zhi-Qiong Ai Le Guo Cheng-Rui Geng | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，11： | 2 |
| 3 | Genetic Diversity and Drug Susceptibility of Mycobacterium tuberculosis Isolates in a Remote Mountain Area of China显示文摘Objective We determined the genetic diversity of Mycobacterium tuberculosis(MTB) in a remote mountainous area of southwest China and evaluated the resolving ability of single nucleotide polymorphism(SNP) genotyping combined with variable number tandem repeat(VNTR) genotyping for Beijing family strains in association with drug resistance status.Methods Three hundred thirty-one MTB strains were isolated from patients living in mountainous regions of southwest China,and 8-loci SNP,VNTR-15 genotyping assays,and drug susceptibility testing of 9 drugs were performed.Results A total of 183 [55.29%(183/331)] strains were classified into the Beijing family.Of the 183 strains,111(60.66%) were defined as modern Beijing strains.The most predominant modern Beijing sub-lineage and ancient Beijing sub-lineage were Bmyc10 [39.34%(72/183)] and Bmyc25 [20.77%(38/183)],respectively.Of the isolates,19.64%(65/331) were resistant to at least 1 of the 9 anti-TB drugs and 17 [4.98%(17/331)] MTB isolates were multi-drug resistant tuberculosis(MDR-TB).Two hundred sixty-one isolates showed a clustering rate of 14.18%(37/261) and a discriminatory index of 0.9990.The Beijing lineage exhibited a significantly higher prevalence of MDR-TB,as well as resistance to isoniazid(INH),rifampin(RIF),and para-aminosalicylic acid(PAS) when analyzed independently(P = 0.005,P = 0.017,P = 0.014,and P = 0.006 respectively).The Beijing lineage was not associated with genetic clustering or resistance to any drug.In addition,genetic clustering was not associated with drug resistance.Conclusion MTB strains demonstrate high genetic diversity in remote mountainous areas of southwest China.Beijing strains,especially modern Beijing strains,are predominant in remote mountainous area of China.The combination of 8-loci SNPs and VNTR-15 genotyping is a useful tool to study the molecular epidemiology of MTB strains in this area. | ma ai jing wang sheng fen fan jia le zhao bing he guang xue zhao yan lin | 2018 | Biomedical and Environmental Sciences2018，31，5： | 2 |
| 4 | Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease显示文摘在 vitro 的一种服的 organoid 文化的发展提供一个机会产生人的像大脑的器官调查对光线的 glial ( RG )和外部光线的 glial ( oRG )的神经发生特定的人的疾病的机制在室的地区( VZ )和 subventricular 地区( SVZ )的细胞发展中的 neocortex 。为在开发的早阶段期间生产成熟 subcortical 神经原子类型的 neuronal 祖先和组织建模为学习人的大脑是必要的发展疾病。几个以前的努力出现了成功地在文化盘子中种神经 organoid,然而,我们表明与 VZ, OSVZ 形成和外皮的层结构的迭合组织概括 neocortical 发展过程的一个新范例。用有从一个主要头小畸型病人的 Aspm 基因的机能障碍的病人特定的导致的 pluripotent 干细胞(iPSCs ) ,另外,我们证明神经发生缺点在耐心的 organoids 导致有缺点的 neuronal 活动,建议新策略学习在中央神经系统的人的发展疾病。 | Rui Li Le Sun Ai Fang Peng Li Qian Wu Xiaoqun Wang | 2017 | Protein & Cell2017，8，11： | 2 |
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| 7 | Case-based reasoning and TRIZ: A coupling for innovative conception in Chemical Engineering显示文摘 | CORTES R GUILLERMO LE L et ai | 2009 | Chemical Engineering and Processing2009，48，： | 1 |
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| 9 | Activation of canonical wnt pathway promotes differentiation of mouse bone marrow‐derived MSCs into type II alveolar epithelial cells, confers resistance to oxidative stress, and promotes their migration to injured lung tissue in vitro显示文摘 | Ai‐ran Liu Le Liu Song Chen Yi Yang Hong‐jie Zhao Ling Liu Feng‐mei Guo Xiao‐min Lu Hai‐bo Qiu | 2013 | J Cell Physiol2013，，6： | 1 |
| 10 | A simplified diagnostic test for ambulatory screening of peripheral diabetic neuropathy显示文摘 | Lunetta M Le Moil R Grasso G et ai | 1998 | Diabetes Res Clin Pract1998，39，3： | 1 |
| 11 | The Retrospective Diagnostic Potential of Gene Xpert MTB/RIF for the Analysis of Formalin-Fixed Paraffin-Embedded Tissue from Extrapulmonary Tuberculosis Patients显示文摘Tuberculosis(TB)is a chronic disease caused by infection with Mycobacterium tuberculosis.Laboratory confirmation of this infection is challenging due to the paucibacillary nature of extrapulmonary tuberculosis(EPTB). | JIA Qing Jun ZENG Mei Chun CHENG Qing Lin HUANG Yin Yan WU Yi Fei LI Qing Chun WANG Le AI Li Yun FANG Zi Jian CHENG Shi SHU Li Ping | 2023 | Biomedical and Environmental Sciences2023，36，3： | 1 |
| 12 | Eftfect of exercise training on interleukin-6, tumour necrosis factor alpha and function- al capacity in heart failure 显示文摘 | Smart NA Larsen AI Le Maitre JP Ferraz AS | 2011 | Cardiol Res Pract2011，27，53： | 1 |
| 13 | A randomized clinical study of eefoperazone and sulbactam versus gentamyein and elindamyein in the treatment of intra-abdominal infeetion显示文摘 | Jauregni LE Appelbaum PC Fabian TC et aI | 1990 | J Antimierob Chemother1990，25，： | 1 |
| 14 | Infrared neural stimulation:Beam path in the guinea pig cochlea显示文摘 | Moreno LE Rajguru SM Matic AI | | 0，，1： | 1 |
| 15 | A unique clonal JAK2 muta- tion leading to constitutive signaling causes polycythemia vera显示文摘 | James C Ugo V Le Cou e dic J P et aI | 2005 | Nature2005，434，7037： | 1 |
| 16 | Interleukin-33: a mediator of inflammation targeting hematopoietic stem and progenitor cells and their progenies显示文摘 | Le H Kim K Kim J et aI | 2013 | Front Immunol2013，4，： | 1 |
| 17 | Vitamin C as effective as combinations of antioxidant nutrients in reducing sympotoms of upper respiratory tract infection in ultramarathom runners显示文摘 | Peters EM Goetzsche JM Joseph LE et aI | 1996 | S Afr Sports Med1996，11，3： | 1 |
| 18 | Prognostic value of brain natriuretic peptide in acute pulmonary embolism显示文摘 | Coutance G Le Page O Lo T et aI | 2008 | Crit Care2008，12，4： | 1 |
| 19 | Modeling oncogene addiction using RNA interference 显示文摘 | ROTHENBERG SM ENGELMAN JA LE S et aI | 2008 | Proc Nat! Acad Sci USA2008，105，12： | 1 |
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