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| 1 | Exosome-guided bone targeted delivery of Antagomir-188 as an anabolic therapy for bone loss显示文摘The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal stem cells(BMSCs)characterizes many pathological bone loss conditions.Stromal cell-derived factor-1(SDF1)is highly enriched in the bone marrow for C-X-C motif chemokine receptor 4(CXCR4)-positive hematopoietic stem cell(HSC)homing and tumor bone metastasis.In this study,we displayed CXCR4 on the surface of exosomes derived from genetically engineered NIH-3T3 cells.CXCR4+exosomes selectively accumulated in the bone marrow.Then,we fused CXCR4+exosomes with liposomes carrying antagomir-188 to produce hybrid nanoparticles(NPs).The hybrid NPs specifically gathered in the bone marrow and released antagomir-188,which promoted osteogenesis and inhibited adipogenesis of BMSCs and thereby reversed age-related trabecular bone loss and decreased cortical bone porosity in mice.Taken together,this study presents a novel way to obtain bone-targeted exosomes via surface display of CXCR4 and a promising anabolic therapeutic approach for age-related bone loss. | Yan Hu Xiaoqun Li Qin Zhang Zhengrong Gu Ying Luo Jiawei Guo Xiuhui Wang Yingying Jing Xiao Chen Jiacan Su | 2021 | Bioactive Materials2021，6，9： | 12 |
| 2 | Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis显示文摘人的大脑开发的细胞的复杂性强烈地被调查了,尽管全部人的服的外皮的地区性的描述没基于单个房间的 transcriptome 分析被报导。这里,我们从人的中间怀孕期的胚胎的 22 个大脑区域在超过 4,000 个单个房间上执行了 RNA-seq。我们识别了 29 房间亚簇,它证明在每个区域和脑桥的不同比例显示出星形细胞的特别高的百分比。胚胎的神经原不象成年神经原一样多样,尽管他们在成年人拥有了他们的命运的重要特征。神经原开发是在服的外皮的 unsynchronized,当背面的区域看起来比在这个阶段的腹的区域更成熟。区域特定的基因包括地在每 neuronal 亚簇被识别,并且这些基因的一个大比例是联系的神经疾病。我们的结果介绍区域化的基因表示的一处系统的风景和人的服的外皮的神经原成熟。 | Xiaoying Fan Ji Dong Suijuan Zhong Yuan Wei Qian Wu Liying Yan Jun Yong Le Sun Xiaoye Wang Yangyu Zhao Wei Wang Jie Yan Xiaoqun Wang Jie Qiao Fuchou Tang | 2018 | Cell Research2018，28，7： | 11 |
| 3 | Telomere-dependent and telomereindependent roles of RAP1 in regulating human stem cell homeostasis显示文摘RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclea匚 Here we generated RAP1 -deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cells (hNSCs) via directed differentiation. In both hMSCs and hNSCs, RAP1 not only negatively regulated telomere length but also acted as a transcriptional regulator of RELN by tuning the methylation status of its gene promoter. RAP1 deficiency enhanced self-renewal and delayed senescence in hMSCs, but not in hNSCs, suggesting complicated lineage-specific effects of RAP1 in adult stem cells.Altogether, these results demonstrate for the first time that RAP1 plays both telomeric and nontelomeric roles in regulating human stem cell homeostasis. | Xing Zhang Zunpeng Liu Xiaoqian Liu Si Wang Yiyuan Zhang Xiaojuan He Shuhui Sun Shuai Ma Ng Shyh-Chang Feng Liu Qiang Wang Xiaoqun Wang Lin Liu Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu | 2019 | Protein & Cell2019，10，9： | 7 |
| 4 | Prevention and Control of Perioperative Incision Infection in Patients Undergoing Day Cataract Surgery显示文摘Purpose:To explore the effects of the prevention and control of perioperative incision infection on the quality of day cataract surgery.Methods:.The nursing care and efficacy of 5087 patients undergoing day cataract surgery between October 2012 and October 2013 were retrospectively reviewed. The disinfection and isolation guidance was established for perioperative prevention and control of infection,.topical administration of ocular agents, reexamination and healthcare instruction, and alternative measures were taken.Results: All 5087 patients successfully underwent day surgery of phacoemulsification combined with intraocular lens implantation. All cases recovered without incision infection.Conclusion: Preoperative preparation, and intraoperative and postoperative prevention and control of infection serve as vital measures for effectively avoiding the incidence of incision infection in patients undergoing day cataract surgery. | Chunyan Yang Aihuan Chen Yinghuan Wang Xiaoqun Fang Ronghua Ye Jingyi Lin | 2014 | Eye Science2014，29，3： | 7 |
| 5 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 6 | Improvement of the Compressive Strength of Carbon Fiber/Epoxy Composites via Microwave Curing显示文摘Microwave processing was used to cure the carbon fiber/epoxy composites and designed for improving the compressive strength of the materials. By controlling the power of microwave heating, vacuum bagged laminates were fabricated under one atmosphere pressure without arcing. The physical and mechanical properties of composites produced through vacuum bagging using microwave and thermal curing were compared and the multistep(2-step or 3-step) microwave curing process for improved compressive properties was established. The results indicated that microwave cured samples had somewhat differentiated molecular structure and showed slightly higher glass transition temperature. The 2-step process was found to be more conducive to the enhancement of the compressive strength than the 3-step process. A 39% cure cycle time reduction and a 22% compressive strength increment were achieved for the composites manufactured with microwave radiation. The improvement in specific compressive strength was attributed to better interfacial bonding between resin matrix and the fibers, which was also demonstrated via scanning electron microscopy analysis. | Xuehong Xu Xiaoqun Wang Qun Cai Xu Wang Ran Wei Shanyi Du | 2016 | Journal of Materials Science & Technology2016，32，3： | 6 |
| 7 | Benthic macro red alga:A new possible bio-precursor of Jurassic mudstone source rocks in the northern Qaidam Basin,northwestern China显示文摘Whether benthic macroalga can be an important type of bio-precursor of source rocks is a contentious issue in source-rock studies,and has not been well understood.This paper represents a case study of Jurassic mudstone source rocks from the northern Qaidam Basin,northwestern China,in which the benthic macro red algae were recognized for the first time based on combined organic petrological and biomarker works.We found not only cystocarps in the algae,representative of rhodophyta,but also diahopanes,which are diagnostic biomarkers of such algae.Thus,as many reservoired oils in the northern Qaidam Basin contain abundant diahopanes,it may indicate that the red algae have contributed to hydrocarbon accumulation.This was confirmed by integrated geological and geochemical analyses.Hence,this study provides new evidence for macroalga-generated hydrocarbons. | CAO Jian BIAN LiZeng HU Kai LIU YunTian WANG LiQun YANG ShaoYong CHEN Yan PENG XiaoQun | 2009 | Science China Earth Sciences2009，52，5： | 5 |
| 8 | Questions about NgAgo显示文摘 | Shawn Burgess Linzhao Cheng Feng Gu Zhiwei Huang Shuo Lin Jinsong Li Wei Li Wei Qin Yujie Sun Zhou Songyang Wensheng Wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-Wei Xiong Jianzhong Xi Hui Yang Bin Zhou Bo Zhang Junjiu Huang | 2016 | Protein & Cell2016，7，12： | 5 |
| 9 | Lectin receptor kinase OsLecRK-S.7 is required for pollen development and male fertility显示文摘Pollen grains are covered by exine that protects the pollen from stress and facilitates pollination.Here we isolated a male sterile mutant s13283 in rice exhibiting aborted pollen with abnormal exine and defective aperture.The mutant gene encodes a novel plasma membrane-localized legume-lectin receptor kinase that we named OsLecRK-S.7.OsLecRK-S.7 was expressed at different levels in all tested tissues and throughout anther development.In vitro kinase assay showed OsLecRK-S.7 capable of autophosporylation.Mutation in s13283(E560K)and mutation of the conserved ATP binding site(K418E)both knocked out the kinase activity.Mass spectrometry showed Thr376,Ser378,Thr386,Thr403,and Thr657 to be the autophosphorylation sites.Mutation of individual autophosphorylation site affected the in vitro kinase activity to different degrees,but did not abolish the gene function in fertility complementation.oslecrk-s.7 mutant plant overexpressing OsLecRK-S.7 recovered male fertility but showed severe growth retardation with reduced number of tillers,and these phenotypes were abolished by E560K or K418E mutation.The results indicated that OsLecRK-S.7 was a key regulator of pollen development. | Xiaoqun Peng Menglong Wang Yiqi Li Wei Yan Zhenyi Chang Zhufeng Chen Chunjue Xu Chengwei Yang Xing Wang Deng Jianxin Wu Xiaoyan Tang | 2020 | Journal of Integrative Plant Biology2020，62，8： | 4 |
| 10 | Identification of late-stage pollen-specific promoters for construction of pollen-inactivation system in rice显示文摘Large-scale production of male sterile seeds can be achieved by introducing a fertility-restoration gene linked with a pollen-killer gene into a recessive male sterile mutant.We attempted to construct this system in rice by using a late-stage pollen-specific(LSP)promoter driving the expression of maizeα-amylase gene ZM-AA1.To obtain such promoters in rice,we conducted comparative RNA-seq analysis of mature pollen with meiosis anther,and compared this with the transcriptomic data of various tissues in the Rice Expression Database,resulting in 269 candidate LSP genes.Initial test of nine LSP genes showed that only the most active OsLSP3 promoter could drive ZM-AA1 to disrupt pollen.We then analyzed an additional 22 LSP genes and found 12 genes stronger than OsLSP3 in late-stage anthers.The promoters of OsLSP5 and OsLSP6 showing higher expression than OsLSP3 at stages 11 and 12 could drive ZM-AA1 to inactivate pollen,while the promoter of OsLSP4 showing higher expression at stage 12 only could not drive ZM-AA1 to disrupt pollen,suggesting that strong promoter activity at stage 11 was critical for pollen inactivation.The strong pollen-specific promoters identified in this study provided valuable tools for genetic engineering of rice male sterile system for hybrid rice production. | Menglong Wang Wei Yan Xiaoqun Peng Zhufeng Chen Chunjue Xu Jianxin Wu Xing Wang Deng Xiaoyan Tang | 2020 | Journal of Integrative Plant Biology2020，62，8： | 4 |
| 11 | Topology inference of uncertain complex dynamical networks and its applications in hidden nodes detection显示文摘一个复杂动态网络的拓扑的结构在决定网络起一个重要作用进化机制和功能的行为,因此认出并且推断网络结构具有理论、实际的意义。尽管各种各样的途径被建议了估计网络拓扑学,许多很好没在网络个人之中被建立到网络动力学和传播延期的普遍存在的吵闹的性质。这份报纸集中于不明确的复杂动态网络的拓扑学推理。一个辅助网络被构造,一个适应计划被建议追踪拓扑的参数。考虑网络模型应当包含实际随机的不安,是引人注目的,并且吵闹的观察作为构造辅助网络的控制输入被拿。特别地,控制技术能进一步被采用找到隐藏的消息提供者(或潜伏的变量) 在网络。数字例子被提供说明建议计划的有效性。另外,联合力量并且在鉴定性能上联合延期的影响被估计。建议计划向工程师提供一条方便途径推断一般复杂动态网络的拓扑学并且找到隐藏的消息提供者,和评估能进一步便于的详细表演实际电路设计。 | WANG YingFei WU XiaoQun FENG Hui LU JunAn LU JinHu | 2016 | Science China(Technological Sciences)2016，59，8： | 4 |
| 12 | Preparation and Characterization of Exfoliated Poly(ethyleneterephthalate)/Montmorillonite Nanocomposites Using Modified MMTs with Variable Content of Antimony Acetate显示文摘(乙烯 terephthalate )( 宠物) Poly, /montmorillonite (MMT ) nanocomposite 被直接聚合准备, MMT 与锑醋酸盐的可变内容修改了(Sb (OAc ) 3 ) ,它也被用作催化剂聚合。修改 MMT (AS-Sb-MMT ) 被两个都设置准备 Sb (OAc ) 3 并且两性的表面活化剂(作为) 进 MMT 层。九种 Sb-MMTs [与 Sb (OAc ) 对待的 MMT 3 ] 与不同 Sb,内容被获得,但是六种仅仅 PET/MMT nanocomposites 能被准备。ICPAES 被用来描绘修改 MMT 的 Sb 内容, XRD 被用来描绘夹层间距,红外光谱学被用来在修改 MMT 描绘 Sb 催化剂的作文变化, TEM 被用来调查 PET/MMT nanocomposites 的 micromorphology。几结果被获得,即, Sb-MMT 的(a) Sb 内容被两个都弄干温度和洗弄干顺序影响,(b)与 Na-MMT (未修改的 MMT )相比,在 Sb-MMT 的夹层间距的变化被归因于溶剂乙烯乙二醇(例如)而非设置或吸收的 Sb ( OAc ) 3 ,(c)基于这,一个模型被开发描述 Na-MMT 胀大并且修改了 MMT 由例如并且在夹层间距上弄干温度的效果, MMT 的(d) | Wang, xiaoqun Wang, Yaqing Zhao, Zhenlu Zhu, Xiaoguang Nie, Cong Du, Shanyi | 2011 | Chinese Journal of Chemistry2011，29，6： | 3 |
| 13 | Comparative study of carbonic anhydrase activity in waters among different geological eco-environments of Yangtze River basin and its ecological significance显示文摘This study provides the presence of carbonic anhydrase(CA) activity in waters of the Yangtze River basin, China, as well as the correlation of CA activity with HCO-3 concentration and CO_2 sink flux. Different degrees of CA activity could be detected in almost all of the water samples from different geological eco-environments in all four seasons. The CA activity of water samples from karst areas was significantly higher than from non-karst areas(PP3-concentration(r = 0.672, P2 sink flux(r = 0.602, P = 0.076) in karst areas. This suggests that CA in waters might have a promoting effect on carbon sinks for atmospheric CO_2 in karst river basins. In conditions of similar geological type, higher CA activity was generally detected in water samples taken from areas that exhibited better eco-environments, implying that the CA activity index of waters could be used as an indicator for monitoring ecological environments and protection of river basins. These findings suggest that the role of CA in waters in the karst carbon sink potential of river basins is worthy of further in-depth studies. | Sila Onesmus Nzung'a Weizhi Pan Taiming Shen Wei Li Xiaoqun Qin Chenwei Wang Liankai Zhang Longjiang Yu | 2018 | Journal of Environmental Sciences2018，30，4： | 3 |
| 14 | CRISPR/Cas9-mediated genome engineering of the ferret显示文摘 | Zhaohui Kou Qian Wu Xiaochen Kou Chonghai Yin Hong Wang Zhentao Zuo Yan Zhuo Antony Chen Shaorong Gao Xiaoqun Wang | 2015 | Cell Research2015，25，12： | 3 |
| 15 | Immune fluorescence test strips based on quantum dots for rapid and quantitative detection of carcino-embryonic antigen显示文摘At present,many researchers focused on the point-of-care testing(POCT),a method of disease markers detection without large-scale instruments and specialized persons.However,most POCT diagnostic methods were suffered from poor detection sensitivity or inefficiency in quantitative detection.Herein,we developed a newly QD-immune fluorescence test strips(QD-IFTS) based on quantum dots(QDs) as the fluorescence nanocarrier to prepare the immune fluorescence probes in the classical immunochromatography detection system for sensing carcino-embryonic antigen(CEA),a kind of glycoprotein produced by intestinal tissue and a broad spectrum of tumor marker for cancer diagnosis.And we designed a homemade strips fluorescence reader for detection of fluorescence intensity of QDs on the QD-IFTS.Under the optimized reaction conditions,chromatographic time of the newly QD-IFTS was only25 min,sample volume of the newly QD-IFTS was only 40 m L and the LOD of the newly QD-IFTS was 0.72 ng/m L.In addition,the efficiency and robustness of the newly QD-IFTS were confirmed by successfully application in 300 clinical serum samples,and the results revealed great potential in clinical POCT of other biomarkers. | Yudong Wu Weipan Peng Qian Zhao Jiafang Piao Bo Zhang Xiaoli Wu Hanjie Wang Zhihong Shi Xiaoqun Gong Jin Chang | 2017 | Chinese Chemical Letters2017，28，9： | 3 |
| 16 | Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease显示文摘在 vitro 的一种服的 organoid 文化的发展提供一个机会产生人的像大脑的器官调查对光线的 glial ( RG )和外部光线的 glial ( oRG )的神经发生特定的人的疾病的机制在室的地区( VZ )和 subventricular 地区( SVZ )的细胞发展中的 neocortex 。为在开发的早阶段期间生产成熟 subcortical 神经原子类型的 neuronal 祖先和组织建模为学习人的大脑是必要的发展疾病。几个以前的努力出现了成功地在文化盘子中种神经 organoid,然而,我们表明与 VZ, OSVZ 形成和外皮的层结构的迭合组织概括 neocortical 发展过程的一个新范例。用有从一个主要头小畸型病人的 Aspm 基因的机能障碍的病人特定的导致的 pluripotent 干细胞(iPSCs ) ,另外,我们证明神经发生缺点在耐心的 organoids 导致有缺点的 neuronal 活动,建议新策略学习在中央神经系统的人的发展疾病。 | Rui Li Le Sun Ai Fang Peng Li Qian Wu Xiaoqun Wang | 2017 | Protein & Cell2017，8，11： | 2 |
| 17 | Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans显示文摘Whether adult hippocampal neurogenesis(AHN)persists in adult and aged humans continues to be extensively debated.A major question is whether the markers identified in rodents are reliable enough to reveal new neurons and the neurogenic trajectory in primates.Here,to provide a better understanding of AHN in primates and to reveal more novel markers for distinct cell types,droplet-based single-nucleus RNA sequencing(snRNA-seq)is used to investigate the cellular heterogeneity and molecular characteristics of the hippocampi in macaques across the lifespan and in aged humans.All of the major cell types in the hippocampus and their expression profiles were identified.The dynamics of the neurogenic lineage was revealed and the diversity of astrocytes and microglia was delineated.In the neurogenic lineage,the regulatory continuum from adult neural stem cells(NSCs)to immature and mature granule cells was investigated.A group of primate-specific markers were identified.We validated ETNPPL as a primate-specific NSC marker and verified STMN1 and STMN2 as immature neuron markers in primates.Furthermore,we illustrate a cluster of active astrocytes and microglia exhibiting proinflammatory responses in aged samples.The interaction analysis and the comparative investigation on published datasets and ours imply that astrocytes provide signals inducing the proliferation,quiescence and inflammation of adult NSCs at different stages and that the proinflammatory status of astrocytes probably contributes to the decrease and variability of AHN in adults and elderly individuals. | Wei Wang Mengdi Wang Meng Yang Bo Zeng Wenying Qiu Qiang Ma Xiaoxi Jing Qianqian Zhang Bosong Wang Chonghai Yin Jiyao Zhang Yuxin Ge Yufeng Lu Weizhi Ji Qian Wu Chao Ma Xiaoqun Wang | 2022 | Cell Research2022，32，8： | 2 |
| 18 | Soybean glycinin subunits : characterization of physicochemical and adhesion properties 显示文摘 | Mo Xiaoqun Zhong Zhikai Wang Donghai | 2006 | Journal of Agricultural and Food Chemistry2006，54，20： | 1 |
| 19 | Manufacturing and Characteristics of Glass Reinforced PTFE显示文摘 | Xiaoqun Wang Jiecai Han Shanyi Du Dianfu Wang | 1998 | Journal of Reinforced Plastics and Composites1998，17，17： | 1 |
| 20 | Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice显示文摘Cenpj is a centrosomal protein located at the centrosomes and the base of cilia,it plays essential roles in regulating neurogenesis and cerebral cortex development.Although centrosomal and cilium dysfunction are one of the causes of obesity,insulin resistance,and type 2 diabetes,the role that Cenpj plays in the regulation of body weight remains unclear.Here,we deleted Cenpj by crossing Cenpjflox/flox mice with Nkx2.1-Cre mice.Loss of the centrosomal protein Cenpj in Nkx2.1-expressing cells causes morbid obesity in mice at approximately 4 months of age with expended brain ventricles but no change of brain size.We found that hypothalamic cells exhibited reduced proliferation and increased apoptosis upon Cenpj depletion at the embryonic stages,resulting in a dramatic decrease in the number of Proopiomelanocortin(POMC)neurons and electrophysiological dysfunction of NPY neurons in the arcuate nucleus(ARC)in adults.Furthermore,depletion of Cenpj also reduced the neuronal projection from the ARC to the paraventricular nucleus(PVN),with decreased melanocortin-4 receptors(MC4R)expression in PVN neurons.The study defines the roles that Cenpj plays in regulating hypothalamus development and body weight,providing a foundation for further understanding of the pathological mechanisms of related diseases. | Wenyu Ding Changjiang Zhang Baisong Wang Xin Zhou Le Sun Suijuan Zhong Jing Liu Junjing Zhang Xiaoqun Wang Qian Wu | 2021 | Science China(Life Sciences)2021，64，3： | 1 |
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