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| 1 | Discovery of the Early Paleozoic post-collisional granites in northern margin ofthe Erguna massif and its geological significance显示文摘The Luoguhe intrusion, located in MoheCounty, Heilongjiang Province, is mainly composed of mon-zogranite, quartz diorite and granodiorite, with minor dio-rite, tonalite, quartz monzodiorite, quartz monzonite, syeno-granite and alkali-feldspar granite. The intrusion can bedivided into two lithological units, i.e. quartz diorite andmonzogranite units, with affinities to high-K calc-alkalineseries. The quartz diorite unit (SiO2: 54.79%―58.30%Na2O/CaO: 0.79―1.53 and Shand index: 0.77―0.82) belongsto metaluminous rocks. And the monzogranite unit (SiO2:65.29%―66.45%, Na2O/CaO: 1.73―3.43 and Shand index<1.05) can be considered as weakly peraluminous rocks. Theintrusion is characterized by high REE abundance (∑REE =180.2―344.3 μg/g), medium-strong negative Eu anomalies(δ Eu = 0.33―0.82), weak REE fractionation [(La/Yb)N =4.12―10.45], enrichments in Rb, Th, U, K, La, Ce, Nd, HfZr and Sm, but strong depletions of Ba, Nb, Ta, Sr, P and TiThese characteristics of major, REE and trace elements in-dicate that the intrusion was formed in a transitional tectonicsetting from compressional to extensional regime, which canbe classified as post-collisional granitoids. SHRIMP U-Pbzircon analyses yield ages of 517±9 and 504±8 Ma for thequartz diorite and monzogranite units, respectively. The dis-covery of Early Paleozoic post-collisional granites in thenorthern margin of the Erguna massif indicates that thenorthern branch of Paleo-Asian Ocean between Siberianplate and Erguna massif was closed in the Early Paleozoicand the Salair orogeny ended ca. 500 Ma ago. | WU Guang SUN Fengyue ZHAO Caisheng LI Zhitong ZHAO Ailin PANG Qingbang LI Guangyuan | 2005 | Chinese Science Bulletin2005，50，23： | 69 |
| 2 | An EcoCity model for regulating urban land cover structure and thermal environment: Taking Beijing as an example显示文摘Urban land-use/cover changes and their effects on the eco-environment have long been an active research topic in the urbanization field. However, the characteristics of urban inner spatial heterogeneity and its quantitative relationship with thermal environment are still poorly understood, resulting in ineffective application in urban ecological planning and management.Through the integration of 'spatial structure theory' in urban geography and 'surface energy balance' in urban climatology, we proposed a new concept of urban surface structure and thermal environment regulation to reveal the mechanism between urban spatial structure and surface thermal environment. We developed the EcoCity model for regulating urban land cover structure and thermal environment, and established the eco-regulation thresholds of urban surface thermal environments. Based on the comprehensive analysis of experimental observation, remotely sensed and meteorological data, we examined the spatial patterns of urban habitation, industrial, infrastructure service, and ecological spaces. We examined the impacts of internal land-cover components(e.g., urban impervious surfaces, greenness, and water) on surface radiation and heat flux. This research indicated that difference of thermal environments among urban functional areas is closely related to the proportions of the land-cover components.The highly dense impervious surface areas in commercial and residential zones significantly increased land surface temperature through increasing sensible heat flux, while greenness and water decrease land surface temperature through increasing latent heat flux. We also found that different functional zones due to various proportions of green spaces have various heat dissipation roles and ecological thresholds. Urban greening projects in highly dense impervious surfaces areas such as commercial, transportation, and residential zones are especially effective in promoting latent heat dissipation efficiency of vegetation, leading to strongly cooling effect of unit vegetation coverage. This research indicates that the EcoCity model provides the fundamentals to understand the coupled mechanism between urban land use structure and surface flux and the analysis of their spatiotemporal characteristics. This model provides a general computational model system for defining urban heat island mitigation, the greening ratio indexes, and their regulating thresholds for different functional zones. | KUANG WenHui YANG TianRong LIU AiLin ZHANG Chi LU DengSheng CHI WenFeng | 2017 | Science China Earth Sciences2017，60，6： | 16 |
| 3 | Remote sensing-based artificial surface cover classification in Asia and spatial pattern analysis显示文摘Artificial surfaces, characterized with intensive land-use changes and complex landscape structures, are important indicators of human impacts on terrestrial ecosystems. Without high-resolution land-cover data at continental scale, it is hard to evaluate the impacts of urbanization on regional climate, ecosystem processes and global environment. This study constructed a hierarchical classification system for artificial surfaces, promoted a remote sensing method to retrieve subpixel components of artificial surfaces from 30-m resolution satellite imageries(Globe Land30) and developed a series of data products of high-precision urban built-up areas including impervious surface and vegetation cover in Asia in 2010. Our assessment, based on multisource data and expert knowledge, showed that the overall accuracy of classification was 90.79%. The mean relative error for the impervious surface components of cities was 0.87. The local error of the extracted information was closely related to the heterogeneity of urban buildings and vegetation in different climate zones. According to our results, the urban built-up area was 18.18×104 km2, accounting for 0.59% of the total land surface areas in Asia; urban impervious surfaces were 11.65×104 km2, accounting for 64.09% of the total urban built-up area in Asia. Vegetation and bare soils accounted for 34.56% of the urban built-up areas. There were three gradients: a concentrated distribution, a scattered distribution and an indeterminate distribution from east to west in terms of spatial pattern of urban impervious surfaces. China, India and Japan ranked as the top three countries with the largest impervious surface areas, which respectively accounted for 32.77%, 16.10% and 11.93% of the urban impervious surface area of Asia. We found the proportions of impervious surface and vegetation cover within urban built-up areas were closely related to the economic development degree of the country and regional climate environment. Built-up areas in developed countries had relatively low impervious surface and high public green vegetation cover, with 50–60% urban impervious surfaces in Japan, South Korea and Singapore. In comparison, the proportion of urban impervious surfaces in developing countries is approaching or exceeding 80% in Asia. In general, the composition and spatial patterns of built-up areas reflected population aggregation and economic development level as well as their impacts on the health of the environment in the sub-watershed. | KUANG WenHui CHEN LiJun LIU JiYuan XIANG WeiNing CHI WenFeng LU DengSheng YANG TianRong PAN Tao LIU AiLin | 2016 | Science China Earth Sciences2016，59，9： | 12 |
| 4 | Bilayer dissolving microneedle array containing 5-fluorouracil and triamcinolone with biphasic release profile for hypertrophic scar therapy显示文摘Hypertrophic scar(HS)is an undesirable skin abnormality following deep burns or operations.Although intralesional multi-injection with the suspension of triamcinolone acetonide(TA)and 5-fluorouracil(5-Fu)has exhibited great promise to HS treatment in clinical,the difference of metabolic behavior between TA and 5-Fu remarkably compromised the treatment efficacy.Besides,the traditional injection with great pain is highly dependent on the skill of the experts,which results in poor compliance.Herein,a bilayer dissolving microneedle(BMN)containing TA and 5-Fu(TA-5-Fu-BMN)with biphasic release profile was designed for HS therapy.Equipped with several micro-scale needle tips,the BMN could be self-pressed into the HS with uniform drug distribution and less pain.Both in vitro permeation and in vivo HS retention tests revealed that TA and 5-Fu could coexist in the scar tissue for a sufficient time period due to the well-designed biphasic release property.Subsequently,the rabbit ear HS model was established to assess therapeutic efficacy.The histological analysis showed that TA-5-Fu-BMN could significantly reduce abnormal fibroblast proliferation and collagen fiber deposition.It was also found that the value of scar elevation index was ameliorated to a basal level,together with the downregulation of mRNA and protein expression of Collagen I(Col I)and transforming growth factor-β1(TGF-β1)after application of TA-5-Fu-BMN.In conclusion,the BMN with biphasic release profiles could serve as a potential strategy for HS treatment providing both convenient administrations as well as controlled drug release behavior. | Beibei Yang Yating Dong Yifeng Shen Ailin Hou Guilan Quan Xin Pan Chuanbin Wu | 2021 | Bioactive Materials2021，6，8： | 8 |
| 5 | Drug screening for influenza neuraminidase inhibitors显示文摘Neuraminidase (NA) is one of the most important targets to screen the drugs of anti-influenza virus A and B. After virtual screening approaches were applied to a compound database which possesses more than 10000 compound structures, 160 compounds were selected for bioactivity assay, then a High Throughput Screening (HTS) model established for influenza virus NA inhibitors was applied to detect these compounds. Finally, three compounds among them displayed higher inhibitory activities, the range of their IC50 was from 0.1 μmol/L to 3μmol/L. Their structural scaffolds are novel and different from those of NA inhibitors approved for influenza treatment, and will be useful for the design and research of new NA inhibitors. The resuit indicated that the combination of virtual screening with HTS was very significant to drug screening and drug discovery. | LIU Ailin, CAO Hongpeng & DU Guanhua Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China | 2005 | Science China(Life Sciences)2005，48，1： | 7 |
| 6 | Analysis and construction status of SG-Ⅱ 5PW laser facility显示文摘We present a recent progress of the SG-II 5 PW facility, which designed a multi-petawatt ultrashort pulse laser based on optical parametric chirped-pulse amplification(OPCPA). The prior two optical parametric amplifiers have been accomplished and chirped pulses with an energy of 49.7 J and a full-width-at-half-maximum(FWHM) spectrum bandwidth of 85 nm have been achieved. In the PW-scale optical parametric amplification(OPA), with the pump pulse that has an energy of 118 J from the second harmonic generation of the SG-II 7 th beam, the pump-to-signal conversion efficiency is up to 41.9%, which to the best of our knowledge is the highest among all of the reported values for OPCPA systems. The compressed pulse is higher than 37 J in 21 fs(1.76 PW), and the focal spot is ~10 μm after the closed-loop corrections by the adaptive optics. Limited by the repetition of the pump laser, the SG-II 5 PW facility operates one shot per hour. It has successfully been employed for high energy physics experiments. | Jianqiang Zhu Xinglong Xie Meizhi Sun Jun Kang Qingwei Yang Ailin Guo Haidong Zhu Ping Zhu Qi Gao Xiao Liang Ziruo Cui Shunhua Yang Cheng Zhang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，2： | 7 |
| 7 | A New Discovery on the Deformation Behavior of Shale Gas Reservoirs Affecting Pore Morphology in the Juhugeng Coal Mining Area of Qinghai Province, Northwest China显示文摘Objective The Juhugeng mining area in Qinghai Province of northwest China has attracted wide attention among geologists for it hosts typical coal measure gases.The shale gas reservoirs were reformed by intensive structural movements during geological periods,resulting in the deformation of shale pores.The different temperature- | WANG Anmin CAO Daiyong LI Jing JIANG Ailin YANG Chengwei | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 5 |
| 8 | Research Progress of the Antiviral Bioactivities of Natural Flavonoids显示文摘Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications.Most recent researches have focused on the health aspects of flavonoids for humans.Especially,different flavonoids have been investigated for their potential antiviral activities,and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo.This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids,highlights the cellular and molecular mechanisms of natural flavonoids on viruses,and presents the details of most reported flavonoids.Meanwhile,future perspectives on therapeutic applications of flavonoids against viral infections were discussed. | Lin Wang Junke Song Ailin Liu Bin Xiao Sha Li Zhang Wen Yang Lu Guanhua Du | 2020 | Natural Products and Bioprospecting2020，10，5： | 4 |
| 9 | Soil Microbial Community and Enzyme Activity Responses to Herbaceous Plant Expansion in the Changbai Mountains Tundra, China显示文摘As one of the most sensitive regions to global climate change, alpine tundra in many places around the world has been undergoing dramatic changes in vegetation communities over the past few decades.Herbaceous plant species in the Changbai Mountains area have significantly expanded into tundra shrub communities over the past 30 yr.Soil microbial communities, enzyme activities, and soil nutrients are intertwined with this expansion process.In order to understand the responses of the soil microbial communities to such an expansion, we analyzed soil microbial community structures and enzyme activities in shrub tundra as well as areas with three different levels of herbaceous plant expansion.Our investigation was based on phospholipid fatty acid(PLFA) analysis and 96-well microtiter plates.The results showed that herbs have expanded greatly in the tundra, and they have become the dominant species in herbaceous plant expansion areas.There were differences for community composition and appearance among the shrub tundra and the mild expansion, moderate expansion, and severe expansion areas.Except for soil organic matter, soil nutrients were increased in herbaceous plant expansion areas, and the total nitrogen(TN), total phosphorus(TP), available nitrogen(AN), and available phosphorus(AP) were greatest in moderate expansion areas(MOE), while soil organic matter levels were highest in the non-expanded areas(CK).The total soil PLFAs in the three levels of herbaceous plant expansion areas were significantly higher than those in the non-expanded areas, and total soil PLFAs were highest in the moderately expanded area and lowest in the severely expanded area(SEE).Bacteria increased significantly more than fungi and actinomycetes with herbaceous plant expansion.Soil hydrolase activities(β-1,4-glucosidase(βG) activity, β-1, 4-N-acetylglucosaminidase(NAG) activity, and acid phosphatase(aP) activity) were highest in MOE and lowest in the CK treatment.Soil oxidase activities(polyphenol oxidase(PPO) activities and peroxidase(PER) activities) were also highest in MOE, but they were lowest in the SEE treatment.The variations in total soil PLFAs with herbaceous plant expansion were mostly correlated with soil organic matter and available phosphorus concentrations, while soil enzyme activities were mostly correlated with the total soil nitrogen concentration.Our results suggest that herbaceous plant expansion increase the total soil PLFAs and soil enzyme activities and improved soil nutrients.However, soil microorganisms, enzyme activity, and nutrients responded differently to levels of herbaceous plant expansion.The soil conditions in mild and moderate expansion areas are more favorable than those in severe expansion areas. | JIN Yinghua ZHANG Yingjie XU Zhiwei GU Xiaonan XU Jiawei TAO Yan HE Hongshi WANG Ailin LIU Yuxia NIU Liping | 2019 | Chinese Geographical Science2019，29，6： | 4 |
| 10 | Theory, technology and prospects of conventional and unconventional natural gas显示文摘The development of natural gas in China has entered a golden and leap-forward stage, which is a necessary bridge to clean energy. This in-depth study on the status quo, theory, technology and prospect of natural gas development shows:(1) The global remaining proven recoverable reserves of natural gas are 186×1012 m3, and the reserves-production ratio is 52.4, indicating a solid resource base for long-term and rapid development.(2) Ten formation and distribution laws of conventional and unconventional natural gas reservoirs have been proposed. In terms of exploration geology, the theory of conventional 'monolithic' giant gas fields with different gas sources, and an unconventional gas accumulation theory with continuous distribution of 'sweet areas' in different lithologic reservoirs have been established; in terms of development geology, a development theory of conventional structural gas reservoirs is oriented to 'controlling water intrusion', while a development theory of unconventional gas is concentrated on man-made gas reservoirs.(3) With the geological resources(excluding hydrates) of 210×1012 m3 and the total proven rate of the resources less than 2% at present, the natural gas in China will see a constant increase in reserve and production; by 2030, the proven geological reserves of natural gas are expected to reach about(6 000-7 000)×108 m3, the production of conventional and unconventional natural gas each will reach about 1 000×108 m3, and the gas consumption will reach 5 500×108 m3. The dependence on imported natural gas may be 64% by 2030, and 70% by 2050.(4) Ten measures for future development of natural gas have been proposed, including strengthening exploration in large-scale resource areas, increasing the development benefits of unconventional gas, and enhancing the peak adjusting capacity of gas storage and scale construction of liquified natural gas. | ZOU Caineng YANG Zhi HE Dongbo WEI Yunsheng LI Jian JIA Ailin CHEN Jianjun ZHAO Qun LI Yilong LI Jun YANG Shen | 2018 | Petroleum Exploration and Development2018，45，4： | 4 |
| 11 | Pharmacokinetic study of gallocatechin-7-gallate from Pithecellobium clypearia Benth. in rats显示文摘The pharmacokinetic profile of gallocatechin-7-gallate(J10688)was studied in rats after intravenous administration.Male and female Sprague-Dawley(SD)rats received 1,3,and 10 mg/kg(i.v.)of J10688 and plasma drug concentrations were determined by a high performance liquid chromatography-mass spectrometry(LC–MS)method.The pharmacokinetic software Data Analysis System(Version 3.0)was used to calculate the pharmacokinetic parameters.For different i.v.doses of J10688,the mean peak plasma concentration(C_0)values ranged from 11.26 to 50.82 mg/L,and mean area under the concentration-time curve(AUC_(0–t))values ranged from 1.75 to 11.80(mg h/L).J10688 lacked dosedependent pharmacokinetic properties within doses between 1 and 10 mg/kg,based on the power model.The method developed in this study was sensitive,precise,and stable.The pharmacokinetic properties of J10688 in SD rats were shown to have rapid distribution and clearance values.These pharmacokinetic results may contribute to an improved understanding of the pharmacological actions of J10688. | Chao Li Xiaowei Song Junke Song Xiaocong Pang Zhe Wang Ying Zhao Wenwen Lian Ailin Liu Guanhua Du | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 4 |
| 12 | Damage of hippocampal neurons in rats with chronic alcoholism显示文摘Chronic alcoholism can damage the cytoskeleton and aggravate neurological deficits. However, the effect of chronic alcoholism on hippocampal neurons remains unclear. In this study, a model of chronic alcoholism was established in rats that were fed with 6% alcohol for 42 days. Endogenous hydrogen sulfide content and cystathionine-beta-synthase activity in the hippocampus of rats with chronic alcoholism were significantly increased, while F-actin expression was decreased. Hippocampal neurons in rats with chronic alcoholism appeared to have a fuzzy nuclear membrane, mitochondrial edema, and ruptured mitochondrial crista. These findings suggest that chronic alcoholism can cause learning and memory decline in rats, which may be associated with the hydrogen sulfide/cystathionine-beta-synthase system, mitochondrial damage and reduced expression of F-actin. | Ailin Du Hongbo Jiang Lei Xu Na An Hui Liu Yinsheng Li Ruiling Zhang | 2014 | Neural Regeneration Research2014，9，17： | 3 |
| 13 | Comparative Assessment of Tundra Vegetation Changes Between North and Southwest Slopes of Changbai Mountains, China, in Response to Global Warming显示文摘Vegetation in high altitude areas normally exhibits the strongest response to global warming. We investigated the tundra vegetation on the Changbai Mountains and revealed the similarities and differences between the north and the southwest slopes of the Changbai Mountains in response to global warming. Our results were as follows: 1) The average temperatures in the growing season have increased from 1981 to 2015, the climate tendency rate was 0.38℃/10 yr, and there was no obvious change in precipitation observed. 2) The tundra vegetation of the Changbai Mountains has changed significantly over the last 30 years. Specifically, herbaceous plants have invaded into the tundra zone, and the proportion of herbaceous plants was larger than that of shrubs. Shrub tundra was transforming into shrub-grass tundra. 3) The tundra vegetation in the north and southwest slopes of the Changbai Mountains responded differently to global warming. The southwest slope showed a significantly higher degree of invasion from herbaceous plants and exhibited greater vegetation change than the north slope. 4) The species diversity of plant communities on the tundra zone of the north slope changed unimodally with altitude, while that on the tundra zone of the southwest slope decreased monotonously with altitude. Differences in the degree of invasion from herbaceous plants resulted in differences in species diversity patterns between the north and southwest slopes. Differences in local microclimate, plant community successional stage and soil fertility resulted in differential responses of tundra vegetation to global warming. | JIN Yinghua ZHANG Yingjie XU Jiawei TAO Yan HE Hongshi GUO Meng WANG Ailin LIU Yuxia NIU Liping | 2018 | Chinese Geographical Science2018，28，4： | 3 |
| 14 | Determination of Cd-MT in Pteria penguin with Indirect Non-Competitive ELISA显示文摘Cadmium-metallothionein (Cd-MT) of Pteria penguin was used to immunize domestic rabbit in order to obtain polyclonal antibody against Cd-MT. Using the anti-Cd-MT antibody, a method of indirect non-competitive enzyme-linked immunosorbent assay (non-competitive ELISA) was established to detect shellfish Cd-MT. In this case, the minimum detectable concentration of P. penguin Cd-MT was (4.563±0.051) ng/mL. The linear range of detection was 9.75-2.0×104 ng/mL. Intra-assay relative standard deviation (RSD) was less than 11.6%, and inter-assay RSD less than 6.7%. The recovery rates ranged from 83.7% to 119.0%. The polyclonal antibody against Cd-MT of P. penguin can also be used to detect MT of other four types of shellfish. In the crude extracts from different organs of P. penguin, the MT concentrations determined by this method matched well with the concentrations of cadmium detected by the atomic absorption spectroscopy. | WU Xiaoping LIAO Ailin ZHANG Chaohua LIAO Yan LU Hongyu YANG Jie | 2011 | Wuhan University Journal of Natural Sciences2011，16，4： | 2 |
| 15 | Characterization of novel microsatellite markers of the Emei Shan Liocichla using restriction site-associated DNA sequencing显示文摘Background:The Emei Shan Liocichla(Liocichla omeiensis) is an endemic bird species to southwestern China with a small geographic range. However, little was known about the genetic status of this threatened species.Methods:We applied restriction-site-associated DNA sequencing(RAD-Seq) for rapid mass identification of microsatellite markers of the Emei Shan Liocichla.Results:A total of 11,564 microsatellite sequences were obtained, 600 random loci were designed for screening and 24 polymorphic microsatellite loci were selected for further validation. The average allele number, average observed heterozygosity and average expected heterozygosity were relatively low in our samples, which were 6.08, 0.6618 and 0.7048, respectively, indicating that the Emei Shan Liocichla might have lost some genetic diversity. Further analyses suggested that the populations distributed on two mountains(Daxiangling and Xiaoliangshan) showed a modest degree of genetic differentiation.Conclusions:These novel microsatellite markers provided valuable preliminary knowledge regarding the genetic status of the Emei Shan Liocichla and can be useful in further studies, as well as in the management and conservation of this species. | Ailin Yang De Chen Pengcheng Wang Yiqiang Fu Zhengwang Zhang | 2017 | Avian Research2017，8，2： | 2 |
| 16 | A quantitative study of the scale and distribution of tight gas reservoirs in the Sulige gas field, Ordos Basin, northwest China显示文摘Gas and water distribution is discontinuous in tight gas reservoirs,and a quantitative understanding of the factors controlling the scale and distribution of effective reservoirs is important for natural gas exploration.We used geological and geophysical explanation results,dynamic and static well test data,interference well test and static pressure test to calculate the distribution and characteristics of tight gas reservoirs in the H_(8) Member of the Shihezi Formation,Sulige gas field,Ordos Basin,northwest China.Our evaluation system examines the scale,physical properties,gas-bearing properties,and other reservoir features,and results in classification of effective reservoirs into types Ⅰ,Ⅱ,and Ⅲ that differ greatly in size,porosity,permeability,and saturation.The average thickness,length,and width of type Ⅰ effective reservoirs are 2.89,808,and 598 m,respectively,and the porosity is>10.0%,permeability is>1010^(–3)µm^(2),and average gas saturation is>60%.Compared with conventional gas reservoirs,tight gas effective reservoirs are small-scale and have low gas saturation.Our results show that the scale of the sedimentary system controls the size of the dominant microfacies in which tight gas effective reservoirs form.The presence of different types of interbeds hinders the connectivity of effective sand body reservoirs.The gas source conditions and pore characteristics of the reservoirs control sand body gas filling and reservoir formation.The physical properties and structural nature of the reservoirs control gas–water separation and the gas contents of effective reservoirs.The results are beneficial for the understanding of gas reservoir distribution in the whole Ordos Basin and other similar basins worldwide. | Chao LUO Ailin JIA Jianlin GUO Qing TIAN Junlei WANG Hun LIN Nanxin YIN Xuanbo GAO | 2021 | Frontiers of Earth Science2021，15，2： | 2 |
| 17 | Milliampere He^2+ beam generator using a compact GHz ECRIS显示文摘Multi-charged helium ion beam He2+ is useful for helium accelerator to obtain a higher energy with lower cost and for deuterium accelerator to avoid neutron activation during machine commissioning.An attempt to generate milliampere multi-charged helium He2+ion beam with a 2.45 GHz electron cyclotron resonance ion source(ECRIS) was tested recently.A design using a specfic permanent magnet 2.45 GHz ECRIS(PMECRIS) source(ERCIS) is reported and the He2+beam production ability is described.With this source,we produced a total helium beam of 40 mA at 40 kV with 180 W of net microwave power and a gas flow of less than 0.5 sccm.At steady state the He2+beam intensity is 4.4 mA,that being the fraction of multi-charged helium ion beam is at approximately 11%. | REN HaiTao PENG ShiXiang XU Yuan ZHAO Jie CHEN Jia ZHANG Tao ZHANG AiLin GUO ZhiYu CHEN JiaEr | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，10： | 2 |
| 18 | Sensitivity of on-line wavelength during retrieval of atmospheric CO2 vertical profile显示文摘Accurately measuring the differential molecular absorption cross section is the key to obtaining a high-precision concentration of atmospheric trace gases in a differential absorption lidar(DIAL) system. However, the CO2 absorption line is meticulous at 1.6 μm, easily translating and broadening because of the change of temperature and pressure. Hence, measuring the vertical profile of atmospheric temperature and pressure to calculate the vertical profile of the CO2 weight parameter is necessary. In general, measuring atmospheric temperature and pressure has a certain amount of uncertainty. Therefore, this study proposes the concept of a balanced on-line wavelength,where the differential molecular absorption cross section is larger and the CO2 weight parameter is insensitive to the uncertainty of atmospheric temperature and pressure. In this study, we analyzed the influence of uncertainty on the CO2 weight parameter at every preselected wavelength, as well as determined an appropriate wavelength near one of the absorption peaks. Our result shows that 1572.023 nm should be one of the appropriate balanced online wavelengths. The measurement errors of the mixing ratio of CO2 molecule in this wavelength are only 0.23%and 0.25% and are caused by 1 K temperature error and 1h Pa pressure error, respectively. This achievement of a balanced on-line wavelength will not only depress the requirement of the laser’s frequency stabilization but also the demand for measurement precision of the atmospheric temperature and pressure profile. Furthermore, this study can achieve the exact measurement of the vertical profile of atmospheric CO2 based on an independent differential absorption laser. | Wei Gong Ailin Liang Ge Han Xin Ma Chengzhi Xiang | 2015 | Photonics Research2015，3，4： | 2 |
| 19 | Persistence of tumor-infiltrating CD8 T cells is tumor-dependent but antigen-independent显示文摘How tumor-infiltrating lymphocytes(TILs)that are tumor-specific but functionally tolerant persist in the antigen-expressing tumor tissue is largely unknown.We have previously developed a modified TRansgenic Adenocarcinoma of the Mouse Prostate(TRAMP)model where prostate cancer cells express the T-cell epitope SIYRYYGL(SIY)recognized by CD8 T cells expressing the 2C T-cell receptor(TCR)(referred to as TRP-SIY mice).In TRP-SIY mice,activated 2C T cells rapidly become tolerant following infiltration into the prostate tumor.In this study,we show that tolerant 2C T cells persist in the prostate tumor of TRP-SIY mice by proliferating slowly in a tumor-dependent,but antigen-,interleukin(IL)-7-and IL-15-independent manner.We also show that disappearance of 2C T cells from the lymphoid organs of TRP-SIY mice are due to antigen-induced T-cell contraction rather than altered trafficking or generalized T-cell depletion in the mice.Finally,we show that clonal T cells unreactive to SIY are equally capable of persisting in the prostate tumor.These findings suggest that while functional tolerance of TILs is induced by antigen,persistence of tolerant TILs in the tumor tissue is mediated by a novel mechanism:slow proliferation independent of antigen and homeostatic cytokines.These results also allow CD8 T-cell survival in the tumor environment to be compared with T-cell survival in chronic infection. | Mobolaji O Olurinde Ching-Hung Shen Adam Drake Ailin Bai Jianzhu Chen | 2011 | Cellular & Molecular Immunology2011，8，5： | 1 |
| 20 | Temperature Distribution and Scuffing of Tapered Roller Bearing显示文摘In the field of aerospace, high-speed trains and automobile, etc, analysis of temperature filed and scuffing failure of tapered roller bearings are more important than ever, and the scuffing failure of elements of such rolling bearings under heavy load and high speed still cannot be effectively predicted yet. A simplified model of tapered roller bearings consisted of one inner raceway, one outer raceway and a tapered roller was established, in which the interaction of several heat sources is ignored. The contact mechanics model, temperature model and model of scuffing failure are synthesized, and the corresponding computer programs are developed to analyze the effects of bearings parameters, different material and operational conditions on thermal performance of bearings, and temperature distribution and the possibility of surface scuffing are obtained. The results show that load, speed, thermal conductivity and tapered roller materials influence temperature rise and scuffing failure of bearings. Ceramic material of tapered roller results in the decrease of scuffing possibility of bearings to a high extent than the conventional rolling bearing steel. Compared with bulk temperature, flash temperature on the surfaces of bearing elements has a little influence on maximum temperature rise of bearing elements. For the rolling bearings operated under high speed and heavy load, this paper proposes a method which can accurately calculate the possibility of scuffing failure of rolling bearings. | WANG Ailin WANG Jiugen | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 1 |
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