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| 1 | Discovery of the Early Paleozoic post-collisional granites in northern margin ofthe Erguna massif and its geological significance显示文摘The Luoguhe intrusion, located in MoheCounty, Heilongjiang Province, is mainly composed of mon-zogranite, quartz diorite and granodiorite, with minor dio-rite, tonalite, quartz monzodiorite, quartz monzonite, syeno-granite and alkali-feldspar granite. The intrusion can bedivided into two lithological units, i.e. quartz diorite andmonzogranite units, with affinities to high-K calc-alkalineseries. The quartz diorite unit (SiO2: 54.79%―58.30%Na2O/CaO: 0.79―1.53 and Shand index: 0.77―0.82) belongsto metaluminous rocks. And the monzogranite unit (SiO2:65.29%―66.45%, Na2O/CaO: 1.73―3.43 and Shand index<1.05) can be considered as weakly peraluminous rocks. Theintrusion is characterized by high REE abundance (∑REE =180.2―344.3 μg/g), medium-strong negative Eu anomalies(δ Eu = 0.33―0.82), weak REE fractionation [(La/Yb)N =4.12―10.45], enrichments in Rb, Th, U, K, La, Ce, Nd, HfZr and Sm, but strong depletions of Ba, Nb, Ta, Sr, P and TiThese characteristics of major, REE and trace elements in-dicate that the intrusion was formed in a transitional tectonicsetting from compressional to extensional regime, which canbe classified as post-collisional granitoids. SHRIMP U-Pbzircon analyses yield ages of 517±9 and 504±8 Ma for thequartz diorite and monzogranite units, respectively. The dis-covery of Early Paleozoic post-collisional granites in thenorthern margin of the Erguna massif indicates that thenorthern branch of Paleo-Asian Ocean between Siberianplate and Erguna massif was closed in the Early Paleozoicand the Salair orogeny ended ca. 500 Ma ago. | WU Guang SUN Fengyue ZHAO Caisheng LI Zhitong ZHAO Ailin PANG Qingbang LI Guangyuan | 2005 | Chinese Science Bulletin2005，50，23： | 69 |
| 2 | Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin显示文摘LRP16 以前在乳癌房间作为导致雌激素的基因被识别。到在子宫内膜的癌症(EC ) 的雌激素和它的功能的效果的 LRP16 的应答的海角房间仍然是不清楚的。这里,我们证明 LRP16 基因的信使 rna 水平和倡导者活动被 17beta-estradiol (E2 ) 显著地在雌激素受体高山增加哈(嗯高山哈)-positiveIshikawa 人 EC 房间。尽管 Ishikawa 细胞的生长率没被 LRP16 的宫外的表示显然影响, Transwell 试金的结果显示出 LRP16-overexpressing 细胞的侵略能力的近似 one-thirdincrease。由于分子的屏蔽,我们观察到 E-cadherin 的表示,与肿瘤转移联系的一个必要粘附分子,被 LRP16 镇压。进一步的倡导者分析以一种剂量依赖者方式表明了那 LRP16 inhibitedE-cadherin transactivation。然而,抑制被雌激素剥夺废除,显示由 LRP16requires 的 E-cadherin 抄写的 down 规定嗯高山哈调停。染色质免疫降水分析表明到 E-cadherin 倡导者的 ERalpha 的绑定被 LRP16 反对,建议那 LRP16 能防碍嗯调停 alpha 的抄写。这些结果建议起来由雌激素的 LRP16 的规定能被在人的 EC 调整 E-cadherin 的 down 涉及侵略生长。 | Yuan Guang Meng Wei Dong Han Ya Li Zhao Ke Huang Yi Ling Si Zhi Qiang Wu Yi Ming Mu | 2007 | Cell Research2007，17，10： | 27 |
| 3 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 4 | Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis显示文摘AIM To evaluate the differences in acute kidney injury(AKI) between acute-on-chronic liver failure(ACLF) and decompensated cirrhosis(DC) patients. METHODS During the period from December 2015 to July 2017, 280 patients with hepatitis B virus(HBV)-related ACLF(HBV-ACLF) and 132 patients with HBV-related DC(HBV-DC) who were admitted to our center were recruited consecutively into an observational study. Urine specimens were collected from all subjects and the levels of five urinary tubular injury biomarkers were detected,including neutrophil gelatinase-associated lipocalin(NGAL), interleukin-18(IL-18), liver-type fatty acid binding protein(L-FABP), cystatin C(CysC), and kidney injury molecule-1(KIM-1). Simultaneously, the patient demographics, occurrence and progression of AKI, and response to terlipressin therapy were recorded. All patients were followed up for 3 mo or until death after enrollment. RESULTS AKI occurred in 71 and 28 of HBV-ACLF and HBV-DC patients, respectively(25.4% vs 21.2%, P = 0.358). Among all patients, the levels of four urinary biomarkers(NGAL, CysC, L-FABP, IL-18) were significantly elevated in patients with HBV-ACLF and AKI(ACLF-AKI), compared with that in patients with HBV-DC and AKI(DC-AKI) or those without AKI. There was a higher proportion of patients with AKI progression in ACLF-AKI patients than in DC-AKI patients(49.3% vs 17.9%, P = 0.013). Fortythree patients with ACLF-AKI and 19 patients with DC-AKI were treated with terlipressin. The response rate of ACLFAKI patients was significantly lower than that of patients with DC-AKI(32.6% vs 57.9%, P = 0.018). Furthermore, patients with ACLF-AKI had the lowest 90 d survival rates among all groups(P < 0.001).CONCLUSION AKI in ACLF patients is more likely associated with structural kidney injury, and is more progressive, with a poorer response to terlipressin treatment and a worse prognosis than that in DC patients. | Qun-Qun Jiang Mei-Fang Han Ke Ma Guang Chen Xiao-Yang Wan Semvua Bukheti Kilonzo Wen-Yu Wu Yong-Li Wang Jie You Qin Ning | 2018 | World Journal of Gastroenterology2018，24，21： | 25 |
| 5 | Application of retrievable Solitaire AB stents in the endovascular treatment of acute ischemic stroke显示文摘Purpose: Retrievable stents are widely used in acute ischemic stroke(AIS); however, the results remain unclear in Chinese patients. This study aimed to explore the usefulness of Solitaire AB stents in AIS. Materials and Methods: Seventy-three AIS patients treated with Solitaire AB stents for thrombectomy of large artery occlusion of anterior circulation in January 2014-June 2015 were retrospectively evaluated. Recanalization was assessed with the Thrombolysis In Cerebral Ischemia(TICI) scale. Clinical outcomes were assessed according to the National Institute of Health Stroke Scale(NIHSS) and the modified Rankin Scale(mRS). Operation-related complications were recorded. The main factors affecting successful recanalization with Solitaire AB were analyzed. Results: The 73 patients enrolled included 39 males and 34 females(median age of 59 [31-78] years); 77 Solitaire AB stents were used. The initial recanalization rate with Solitaire AB as the first thrombectomy method was 53.42%(39/73; recanalization group). Among the 34 patients with failed stent retrieval, 32 underwent other treatments; the final arterial recanalization rate was 89.04%(65/73). Perioperative embolization events and symptomatic intracranial hemorrhage(sICH) occurred in 5 and 8 patients, respectively. The mean NIHSS score was 9.12±3.86 one week after thrombectomy, significantly lower compared with admission values. In 31 patients(42.47%), NIHSS score decreased by >8. Good functional independence(mRS score≤2) was achieved in 39 patients(53.42%) at 90 days; 12 patients(16.44%) died. Compared with the recanalization group, the remaining patients showed lower AF and higher LAA percentages. Conclusion: Solitaire AB stents are useful in the endovascular treatment of AIS. | Teng-Fei Zhou Liang-Fu Zhu Tian-Xiao Li Zi-Liang Wang Wei-Xing Bai Jiang-Yu Xue Guang Feng Li Li Ying-Kun He Li-Heng Wu Bu-Lang Gao | 2018 | Journal of Interventional Medicine2018，1，2： | 21 |
| 6 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 7 | Mutation trend of hemagglutinin of influenza A virus: a review from a computational mutation viewpoint显示文摘自从 1999,我们开发了二条计算变化途径分析蛋白质其方法论和含意在 2002 被考察的主要结构。我们的第一条途径是在蛋白质的氨基酸的对的可预言、无法预言的部分的计算,并且第二是在蛋白质的氨基酸的分发等级的计算。两条途径提供量的措施介绍蛋白质,我们使用了它与象 p53 蛋白质那样的众多的变化学习很多蛋白质。更最近,我们在分析随着时间的过去经常变异例如甲型流感病毒的红血球凝聚素的蛋白质上集中了我们的努力。在这评论,我们与一些最新可得到的数据在联合为红血球凝聚素变化总结我们的调查结果和他们的含意。我们的途径使流行性感冒病毒红血球凝聚素的基因异质的真性质清楚些;也就是说,蛋白质可变性与它的氨基酸的构造高度相关。用这些途径,我们能从流行性感冒病毒红血球凝聚素监视新变化并且以后可以预言他们的变化。 | Guang WU Shao-min YAN | 2006 | Acta Pharmacologica Sinica2006，27，5： | 17 |
| 8 | The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation显示文摘最近的研究在 PHF8 识别了变化,编码 JmjC 的 X 连接基因包含域的蛋白质,为 X 连接智力迟钝(XLMR ) 的一个原因的因素并且劈开 lip/cleft 腭。然而,内在的机制是未知的。这里,我们证明 PHF8 为 retinoic 酸受体(RAR ) 是 histone demethylase 和激活剂。尽管为 H3K4me3/2/1 和 H3K9me2/1 demethylation 的活动在细胞底的试金被检测, recombinant PHF8 在 vitro 展出了仅仅 H3K9me2/1 demethylase 活动,建议 PHF8 是其特性可以在 vivo 被调制的 H3K9me2/1 demethylase。重要地,在 XLMR 病人识别的变异的 PHF8 (在到丝氨酸的位置 279 点的本氨基丙酸) 在酶的活动是有缺点的,显示 histone demethylase 活动的损失有原因地与疾病的发作被连接。另外,我们证明 PHF8 经由一个 N 终端哲学博士手指领域明确地绑在 H3K4me3/2 肽。与为在 neuronal 区别的 PHF8 的一个角色一致,在鼠标的 PHF8 击倒胚胎的癌 P19 房间损害导致 RA 的 neuronal 区别,而 overexpression 野类型然而并非向 neuronal 区别的 F279S 变异的 PHF8 驱动器 P19 房间。而且,我们证明 PHF8 为 RAR 伪作为激活剂与 RAR 伪和功能交往。一起拿,我们的结果建议 PHF8 调制的 histone methylation 在 neuronal 区别起一个关键作用。 | Jihui Qiu Guang Shi Yuanhui Jia Jing Li Meng Wu Jiwen Li Shuo Dong Jiemin Wong | 2010 | Cell Research2010，20，8： | 16 |
| 9 | Evaluating the Nutritional Status of Oncology Patients and Its Association with Quality of Life显示文摘Objective The primary aim of the study was to compare two nutritional status evaluation tools: the Patient-Generated Subjective Global Assessment(PG-SGA) and Nutritional Risk Screening(NRS-2002). Using the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30(EORTC QLQ-C30), the second aim was to provide constructive advice regarding the quality of life of patients with malignancy. Methods This study enrolled 312 oncology patients and assessed their nutritional status and quality of life using the PG-SGA, NRS-2002, and EORTC QLQ-C30. Results The data indicate that 6% of the cancer patients were well nourished. The SGA-A had a higher sensitivity(93.73%) but a poorer specificity(2.30%) than the NRS-2002(69.30% and 25.00%, respectively) after comparison with albumin. There was a low negative correlation and a high similarity between the PG-SGA and NRS-2002 for evaluating nutritional status, and there was a significant difference in the median PG-SGA scores for each of the SGA classifications(P < 0.001). The SGA-C group showed the highest PG-SGA scores and lowest body mass index. The majority of the target population received 2 points for each item in our 11-item questionnaire from the EORTC QLQ-C30. Conclusion The data indicate that the PG-SGA is more useful and suitable for evaluating nutritional status than the NRS-2002. Additionally, early nutrition monitoring can prevent malnutrition and improve the quality of life of cancer patients. | ZHANG Ya Hui XIE Fang Yi CHEN Ya Wen WANG Hai Xia TIAN Wen Xia SUN Wen Guang WU Jing | 2018 | Biomedical and Environmental Sciences2018，31，9： | 14 |
| 10 | Lie Bialgebras of Generalized Virasoro-like Type显示文摘In this paper,Lie bialgebra structures on generalized Virasoro-like algebras are studied.Itis proved that all such Lie bialgebras are triangular coboundary. | Yue Zhu WU Guang Ai SONG Yu Cai SU | 2006 | Acta Mathematica Sinica,English Series2006，22，6： | 13 |
| 11 | Low molecular weight heparin suppresses lymphatic endothelial cell proliferation induced by vascular endothelial growth factor C in vitro显示文摘背景胰腺的癌症是最好攻击的人的恶意之一。Lymphangiogenesis 在许多稳固的肿瘤的淋巴节点转移起一个重要作用。低分子的重量肝磷脂(LMWH ) 能禁止房间生长,房间侵略和 angiogenesis,是众所周知的,它是在肿瘤前进的关键过程。我们用反向的抄写聚合酶在胰腺的癌症细胞(PANC-1 ) 测量了脉管的 endothelial 生长因素 C (VEGF-C ) 的表示的方法锁住反应(RT-PCR ) 并且西方的弄污。我们使用了一在里面评估 LMWH 的 anti-lymphangiogenic 效果的 vitroassay, Fragmin,在人的淋巴的 endothelial 上房间(HLEC ) 增长。在一个低集中罐头的结果 Fragmin 有效地禁止 VEGF-C 导致的 HLEC 增长。PANC-1 房间分泌的 VEGF-C 刺激了 HLEC 增长。低集中 LMWH 压制了 VEGF-C 导致的 HLEC 增长但是没影响增长或 PANC-1 房间的 VEGF-C 表示,而 LMWH 的高集中禁止了 PANC-1 房间增长。这些结果建议那 VEGF-C 的结论在支持 HLEC 增长由癌症房间戏释放了一个重要角色。LMWH Fragmin 有 anti-lymphangiogenic 效果并且可以在胰腺的癌症禁止淋巴的转移。 | CAO Guang WU Ji-xiang WU Qing-hua | 2009 | Chinese Medical Journal2009，，13： | 13 |
| 12 | Chinese Medicine Sequential Therapy Improves Pregnancy Outcomes after Surgery for Endometriosis-Associated Infertility: A Multicenter Randomized Double-blind Placebo Parallel Controlled Clinical Trial显示文摘Objective:To evaluate the efficacy and safety of Chinese medicine(CM)improving pregnancy outcomes after surgery for endometriosis-associated infertility.Methods:A multicenter,randomized,doubleblind placebo parallel controlled clinical trial was designed.A total of 202 patients who had laparoscopy for endometriosis-associated infertility with qi stagnation and blood stasis syndrome were included and randomly divided into the CM treatment group and placebo control group at a ratio of 1:1 using a central block randomization from May 2014 to September 2017,101 patients in each group.The two groups received continuous intervention at 1–5 days after surgery,for 6 menstrual cycles.Before ovulation,the CM group was treated Huoxue Xiaoyi Granule(活血消异颗粒);after ovulation,Bushen Zhuyun Granule(补肾助孕颗粒)was involved.The control group was treated with placebo.Transvaginal ultrasonography was performed every menstrual cycle during the treatment,and female hormone levels in the follicular and luteal phases were measured during the 1 st,3 rd and 6 th menstrual cycles.The analysis was continued until pregnancy.The primary outcomes were clinical pregnancy rate and pregnancy outcome,and the secondary outcomes were follicular development and endometrial receptivity.Safety evaluations were performed before and after treatment.Results:(1)Clinical pregnancy and live birth rates:the clinical pregnancy and live birth rates of the CM group were significantly higher than those of the placebo group[44.6%(45/101)vs.29.7%(30/101),34.7%(35/101)vs.20.8%(21/101),both P<0.05].(2)Follicle development:the incidence of dominant follicles,rate of cumulative cycle ovulation,and rate of cumulative cycle mature follicle ovulation were significantly higher in the CM group than those in the placebo group[93.8%(350/373)vs.89.5%(341/381),80.4%(275/342)vs.69.1%(253/366),65.8%(181/275)vs 56.1%(142/253),P<0.05 or P<0.01]).The incidence of cumulative cycle luteinized unruptured follicle syndrome was significantly lower in the CM group than in the placebo group[11.7%(40/342)vs.17.8%(65/366),P<0.05).(3)Endometrial receptivity:after treatment,both endometrial types and endometrial blood flow types in the CM group were mainly types A and B,while those in the placebo group were mainly types B and C,with a significant difference between the two groups(both P<0.05).(4)Adverse events:the incidence of adverse events between the two groups was not significantly different(P>0.05).Conclusion:Strategies for activating blood circulation-regulating Gan(Liver)-tonifying Shen(Kidney)sequential therapy can effectively improve the clinical pregnancy rate and live birth rate of endometriosis-associated infertility with qi stagnation and blood stasis after laparoscopy,improve follicular development,promote ovulation,improve endometrial receptivity,while being a safe treatment option.(Trial registration No.NCT02676713). | ZHAO Rui-hua LIU Yong LU Dan WU Ying WANG Xiao-yun LI Wei-li ZENG Cheng MENG Qing-wei LIAN Feng-mei ZHOU Jun SHI Yun SUN Wei-wei HAN Qian TANG Yi SHI Guang | 2020 | Chinese Journal of Integrative Medicine2020，26，2： | 13 |
| 13 | Land Surface Displacement Geohazards Monitoring Using Multi-temporal InSAR Techniques显示文摘China has been affected by some of the world’s most serious geological disasters and experiences high economic damage every year.Geohazards occur not only in remote areas but also in highly populated cities.In the framework of the Dragon-432365 Project,this paper presents the main results and the major conclusions derived from an extensive exploitation of Sentinel-1,ALOS-2(Advanced Land Observing Satellite 2),GF-3(Gao Fen Satellite 3),and latest launched SAR(Synthetic Aperture Radar),together with methods that allow the evaluation of their importance for various geohazards.Therefore,in the scope of this project,the great benefits of recent remote sensing data(wide spatial and temporal coverage)that allow a detailed reconstruction of past displacement events and to monitor currently occurring phenomena are exploited to study different areas and geohazards problems,including:surface deformation of mountain slopes;identification and monitoring of ground movements and subsidence;landslides;ground fissure;and building inclination studies.Suspicious movements detected in the different study areas were cross validated with different SAR sensors and truth data. | Guang LIU Perski ZBIGNIEW Salvi STEFANO Thiebes BENNI Lixin WU Jinghui FAN Shibiao BAI Lianhuan WEI Shiyong YAN Rui SONG Bignami CHRISTIAN Tolomei CRISTIANO Stefan SCHNEIDERBAUER Joao Sousa JOAQUIM 无 | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 13 |
| 14 | Predicting the onset temperature(Tg) of GexSe1-x glass transition: a feature selection based two-stage support vector regression method显示文摘Despite the usage of both experimental and topological methods, realizing a rapid and accurate measurement of the onset temperature(Tg ) of GexSe1-xglass transition remains an open challenge. In this paper, a predictive model for the Tg in GexSe1-xglass system is presented by a machine learning method named feature selection based two-stage support vector regression(FSTS-SVR). Firstly, Pearson correlation coefficient(PCC) is used to select features highly correlated with Tg from the candidate features of GexSe1-x glass system. Secondly, in order to simulate the two-stage characteristic of Tg which is caused by structural variation with a turning point at x = 0.33 via the structural analysis, SVR is utilized to build predictive models for two stages separately and then the two achieved models are synthesized using a minimum error based model for Tg prediction. Compared with the topological and other methods based on SVR, the FSTS-SVR gives the highest predictive accuracy with the root mean square error(RMSE) and mean absolute percentage error(MAPE) of 10.64 K and 2.38%, respectively. This method is also expected to be more efficient for the prediction of Tg of other glass systems with the multi-stage characteristic. | Yue Liu Junming Wu Guang Yang Tianlu Zhao Siqi Shi | 2019 | Science Bulletin2019，64，16： | 12 |
| 15 | Bolt-grouting combined support technology in deep soft rock roadway显示文摘Analyzing the mineral composition, mechanical properties and ground stress testing in surrounding rock,the study investigated the failure mechanism of deep soft rock roadway with high stress. The boltgrouting combined support system was proposed to prevent such failures. By means of FLAC3D numerical simulation and similar material simulation, the feasibility of the support design and the effectiveness of support parameters were discussed. According to the monitoring the surface and deep displacement in surrounding rock as well as bolt axial load, this paper analyzed the deformation of surrounding rock and the stress condition of the support structure. The monitor results were used to optimize the proposed support scheme. The results of field monitors demonstrate that the bolt-grouting combined support technology could improve the surround rock strength and bearing capacity of support structure, which controlled the great deformation failure and rheological property effectively in deep soft rock roadway with high stress. As a result, the long term stability and safety are guaranteed. | Chen Yanlong Meng Qingbin Xu Guang Wu Haoshuai Zhang Guimin | 2016 | International Journal of Mining Science and Technology2016，26，5： | 10 |
| 16 | Geochemistry and Genesis of the Late Jurassic Granitoids at Northern Great Hinggan Range:Implications for Exploration显示文摘迟了的侏罗记的 Longgouhe 和 Ershiyizhan 侵入,在北大 Hinggan 范围的上面的 Heilongjiang 盆定位了,仔细与斑岩 Cu-Au 矿化作用有关。在岩性学,侵入是石英闪长岩,石英 monzodiorite 和 high-K 的 granodiorite 计算碱的系列,与 shoshonite 的次要的方面系列。他们的 SiO2 和 Al2O3 内容分别地从 61.37% ~ 66.59% 和 15.35% ~ 17.06%。MgO 内容从 2.02% ~ 3.47%,与 4459 的 Mg# 索引。(La/Yb ) N 和 Eu/Eu * 价值从 16.85 ~ 81.73 和 0.68 ~ 0.93 分别地,出现的强壮的区别稀土元素元素(REE ) adakites 的类似于那些的模式。岩石在 Ba, Sr 和轻 REE (LREE ) 被充实,显然在 Nb 和 Ta 弄空,稍微弄空在 Rb 和 Ti,和在 Yb 和 Y 的穷人与 0.311.32 ppm 和 4.3212.07 ppm 的 Yb 和 Y 内容,分别地。是由 67.74220.60 的 Sr/Y 比率显示了,岩石被 low-Y 和 high-Sr 内容描绘,它在世界上描绘 adakites。整体地, geochemical tracers 建议感兴趣的侵入是 adakitic 岩石。给 Paleo 亚洲的海洋和蒙古人鄂霍次克海海洋在晚古生代、二叠中间的侏罗记被关上分别地,感兴趣的侵入应该被 delaminated 外壳的部分融化形成,它在 collisional 造山运动在之间期间被变厚西伯利亚并且 Mongolian-Sinokorean 大陆。 | WU Guang CHEN Yanjing SUN Fengyue ZHANG Zhe LIU Ankun LI Zhitong | 2010 | Acta Geologica Sinica(English Edition)2010，84，2： | 10 |
| 17 | Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo显示文摘Fucoidan 是从棕色的海草孤立的主要 sulfated 多糖之一。在这研究,我们在弥漫的大 B 房间淋巴瘤(DLBCL ) 上决定了 fucoidan 的反癌症活动在 vitro 并且在 vivo 的房间。Fucoidan 在一个剂量依赖者和时间依赖者举止禁止了 DLBCL 细胞的生长,并且 fucoidan 治疗挑起了 G 0/G1 细胞周期拘捕,它被 p21 伴随起来规定和 cyclin D1, Cdk4,和 Cdk6 下面规定。Fucoidan 也在 DLBCL 房间线和主要 DLBCL 房间导致了 caspase 依赖的房间 apoptosis。另外, fucoidan 治疗从线粒体引起了 mitochondrial 膜潜力的损失和细胞色素 c 和导致 apoptosis 因素的版本进 cytosol。Fucoidan 也加强了在杀死 DLBCL 房间的 carfilzomib 的活动。fucoidan 的口头的管理有效地在异种皮移植老鼠模型禁止了肿瘤生长。我们的调查结果作为一个 anti-DLBCL 代理人揭示 fucoidan 的新奇功能,它能在 DLBCL 的临床的治疗被使用。 | Guang Yang Qianqiao Zhang Yuanyuan Kong Bingqian Xie Minjie Gao Yi Tao Hongwei Xu Fenghuang Zhan Bojie Dai Jumei Shi Xiaosong Wu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 9 |
| 18 | Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke显示文摘Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke.However,whether both factors exert a synergistic effect in the onset of stroke remains unclear.The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple intervertebral disk protrusion using a paired multivariate logistic regression method.Adjusting for known confounding variables including the patients’age,gender,smoking status,alcohol consumption status,patient and family medical history,and clinical biochemical indices,elevated homocysteine level was related to the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal homocysteine levels and blood lipids(odds ratio 1.409;95%confidence interval1.127–1.761).These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids are predisposed to stroke. | Lu Hao Liming Chen Xiaoyong Sai Zhefeng Liu Guang Yang Rongzeng Yan Lili Wang Caiyun Fu Xuan Xu Zhenzhen Cheng Qiang Wu Shuzhang Li | 2013 | Neural Regeneration Research2013，8，31： | 9 |
| 19 | Effect of arsenic trioxide on human hepatoma cell line BEL-7402 cultured in vitro显示文摘AIM To study the effect of a varyingconcentrations of arsenic trioxide on humanhepatoma cell line BEL-?402 cultured in vitro andits mechanism of action.METHODS The BEL-7402 cells were treatedwith arsenic trioxide(at the concentrations of0.5,1,2 μmol/L,respectively)for 4 successivedays.The cell growth and proliferation wereobserved by cell counting and cell-growth curve.Morphologic changes were studied withelectronmicroscopy.Flow cytometry was usedto assay celI-DNA distribution and the proteinexpression of Bcl-2 and Bax detected byimmunocytochemical method.RESULTS The cell growth was significantlyinhibited by varying concentrations of arsenictrioxide as revealed by cell counting and cell-growth curve,which was dose- and time-dependent.Arsenic trioxide treatment at 0.5,1and 2 μmol/L resulted in a sub-G1 cell peak,theapoptosis rate of the control group was 9.31%and that of 0.5 μmol/L arsenic trioxide 15.53%,no significant difference was seen between thetwo.The apoptosis rates of 1,2 μmol/L arsenictrioxide were 19.10% and 21.87% respectively,which were much higher(both P<0.05).Decrease of G0/G1 phase cells and increase of Sphase cells were observed by flow cytometry,suggesting the inhibition effect of 0.5,1,2 μmol/L arsenic trioxide on BEL-7402 cell lay in the G0/G1 phase.Morphologic changes such asintact cell membrane,nucleic condensation,apoptotic body formation were seen undertransmission electronmicrescopy,whereas the0.5 mol/L arsenic trioxide-treated BEL-7402cells showed decrease of nucleocytoplasmicratio,round nucleus,well-differentiatedorganelles in the cytoplasm.The processes andmicrovilli on the cell surface of the experimentalgroups under scanning electron microscopy weresignificantly decreased.High expressions ofBcl-2 and Bax were detected in 1 and 2 μmol/Larsenic trioxide-treated cells,these were 46%,87.33% and 83.08%,95.83% respectively,among which that of Bax was more significant.Arsenic trioxide treatment at 0.5 μmol/Lresulted in a higher expression level of Bcl-2 andlower expression level of Bax,which were8.81% and 3.83% respectively,as comparedwith that of the control group(15.33%)(P1<0.01,P2<0.01).CONCLUSION Arsenic trioxide not onlyinhibited proliferation but also induced apoptosisof human hepatoma cell line BEL-7402.Theinduced-apoptosis effect of 1,2 μmol/L arsenictrioxide was related to the expression level ofBcl-2 and Bax. | Hong Yu Xu You Lin Yang Yuan Yuan Gao Qiao Li Wu Guang Qiang Gao | 2000 | World Journal of Gastroenterology2000，6，5： | 8 |
| 20 | Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance显示文摘IRTKS 编码 IRSp53/MIM 相同领域家庭的一个成员,它被显示了在血浆膜伸出的形成起一个重要作用。尽管 IRTKS 的 phosphorylation 响应胰岛素刺激发生,在胰岛素发信号的这蛋白质的角色仍然保持未知。这里,我们证明 IRTKS 缺乏的老鼠展出胰岛素抵抗,包括多糖症, hyperinsulinemia,葡萄糖不耐,减少的胰岛素敏感,和增加的肝的葡萄糖生产。宫外的 IRTKS 的管理能改善 IRTKS 缺乏、糖尿病的老鼠的胰岛素抵抗。在平行, IRTKS 的表示水平显著地在糖尿病的老鼠模型被减少。而且, IRTKS 倡导者的 DNA hypermethylation 也在这些题目被观察。我们也证明作为胰岛素受体(红外) 的一个适配器, IRTKS 调制经由调整红外的 phosphorylation 发信号的 IR-IRS1-PI3K-AKT。这些调查结果增加新卓见进我们胰岛素发信号和抵抗的理解。 | Li-Yu Huang u-Ping Wang Bao-Feng Wei Jian Yang Ji-Qiu Wang Bing-Hao Wu Zhuang-Zhuang Zhang Ying-Yong Hou Wei-Ming Sun Ren-Ming Hu Guang Ning Ze-Guang Han | 2013 | Cell Research2013，23，11： | 8 |
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