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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 3 | Heavy metal pollution of soils and vegetables in the midstream and downstream of the Xiangjiang River, Hunan Province显示文摘219 农业土壤和 48 件蔬菜样品的一个总数在湖南省 Xiangjiang 河(Hengyang 长沙节) 从中流并且下游地被收集。累积特征。 | WANG Lixia GUO Zhaohui XIAO Xiyuan CHEN Tongbin LIAO Xiaoyong SONG Jie WU Bin | 2008 | Journal of Geographical Sciences2008，18，3： | 56 |
| 4 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 5 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 6 | Wenchuan earthquake:Brightness temperature changes from satellite infrared information显示文摘By using an alternative processing method for satellite infrared remote sensing data and adopting the China Geostationary Meteorological Satellite(FY-2C) infrared remote sensing brightness temperature data,we studied the great 2008 Wenchuan Ms8.0 earthquake.Results indicate the obvious characteristic period and amplitude,and distribution of thermal infrared anomalies before the Wenchuan earthquake.And we discussed the mechanism of the observed pre-earthquake thermal anomalies.The characteristics of observed thermal infrared anomalies are easy to be recognized and applied,and could provide a criterion for thermal anomalies of earthquakes. | ZHANG YuanSheng GUO Xiao ZHONG MeiJiao SHEN WenRong LI Wen HE Bin | 2010 | Chinese Science Bulletin2010，55，18： | 47 |
| 7 | Semi-Fredholm Spectrum and Weyl's Theorem for Operator Matrices显示文摘当鈭? B (H)和 B 鈭? B (K)被给时,我们由 M C 表示在这份报纸对形式的 Hilbert 空间 H 鈯? K 起作用的一个操作员,首先,我们为是上面的 semi-Fredholm (更低的半 鈥揊r edholm ,或 Fredholm )的 M C 给必要、足够的条件为一些 C 鈭? B 的操作员( K , H )。另外,让(A)={ 位鈭吗?? :A?位 I 不是一个上面的 semi-Fredholm 操作员 } 鈭 ? B 的上面的半鈥揊r edholm 光谱是(H) 并且让(A)={ 位鈭吗?? :A?位 I 不是一个更低的半鈥揊r edholm 操作员 } 是 A 的更低的半鈥揊r edholm 光谱。我们证明经过从被移开某些开的子集完成从前者,也就是说。 | Xiao Hong CAO Mao Zheng GUO Bin MENG | 2006 | Acta Mathematica Sinica,English Series2006，22，1： | 34 |
| 8 | Differentiation profile of brain tumor stem cells:a comparative study with neural stem cells显示文摘大脑肿瘤干细胞(BTSC ) 的区别侧面的理解,在肿瘤房间人口之中的关键的,将通过有神经干细胞(NSC ) 的比较借卓见进 glioma 的起源并且最终产出新途径与这难处理的疾病作斗争。这里,我们从外科的 glioma 标本的有教养、净化的 BTSC 和 NSCsfrom 人的胎儿的大脑织物,并且进一步分析了他们的细胞的生物行为,他们的特别区别性质。是期望,区分进成熟神经显型的 NSC。然而, BTSC 展出了的 Inthe 一样的区别状况区分了差别。词法上,房间变得变平并且属于第一个星期,但是逐渐地此后聚集了并且改过漂浮的肿瘤范围。在相应时期期间,无差别的房间标记 CD133 和巢在的表示率在 BTSC 不停地减少,但是 1 个星期以后,他们重获上升趋势。有趣地,区分的房间标记 GFAP 和 beta-tubulinIIIshowed 表示变化逆到无差别的房间标记的。总起来说, BTSCswere 揭示了拥有一个能力抵抗区别,它实际上代表 glioma 的恶意的行为。 | Quan Bin Zhang Xiao Yan Ji Qiang Huang Jun Dong Yu De Zhu Qing Lan | 2006 | Cell Research2006，16，12： | 34 |
| 9 | Tumor gene mutations and messenger RNA expression: correlation with clinical response to icotinib hydrochloride in non-small cell lung cancer显示文摘背景分子的指向的药现在广泛地在临床的 treatment.lcotinib hydrochloride 是的非小的房间肺癌症(NSCLC ) 被使用口头的表皮的生长的一种新类型因素受体(EGFR ) tyresine kinase 禁止者(EGFR-TKIs ) 。在这研究,我们作为我们分析了的 icotinib hydrochlodde.Methods 的功效的 predicators 从先进 NSCLC 病人在肿瘤标本检验了 EGFR ,K地岬,B皇家空军体的变化和 EGFR mRNAexpression 的角色肿瘤嵌入石蜡的标本,它与先进 NSCLC 从 40 个病人中的 14 个被获得在阶段注册了 icotinib hydrochloride 的临床的试用。体的变化被充实异种的 liquidchip (MEL ) 评估技术,和 EGFR mRNA 表示被分叉的 DNA liquidchip (MBL ) 测量在 14 个标本的 technology.Results,七个病人显示出 EGFR 变化, exon 19 删除(3/7 ) 和 exon 21 点变化(4/7 ) ;并且二个病人显示出 K 地岬变化。在 EGFR exon 的没有变化 20。或 B 皇家空军被检测。在有 EGFR 变化的病人,一个病人得了进步疾病(PD ) ,三个病人有稳定的疾病(SD ) ,二个病人有部分回答(PR ) ,一个病人有完全的回答(CR ) 。在有野类型的 EGFR 的病人,四个病人有 PD,三个病人获得了 SD,并且任何一个都没有 PR/CR (P=0.0407 ) 。EGFR 变化与更好没有进步的幸存(PFS )(141 天对 61 天) ,但是没有统计上重要的差别(P=0.8597 ) 被联系,并且中部的全面幸存(OS )(449 天对 140 天) 。 EGFR mRNA 表示层次被评估(三高度,八中等,一个低,并且二那不能由于不够的肿瘤织物被测量)并且没有统计上重要的关系与 EGFR 变化率是的反应, PFS 或 OS.Conclusions 被观察与在亚洲人口报导了那一致, MEL 技术因此为与高产量和快测量 EGFR 变化是可靠的。EGFR exon 19 删除和 exon 21 点变化作为第二线治疗以上是为对 icotinib hydrochloride 的反应的预兆的 biomarkers。 | REN Guan-jun ZHAO Yuan-yua ZHU Yu-jia XIAO Yi XU Jia-sen SHAN Bin ZHANG Li | 2011 | Chinese Medical Journal2011，，1： | 30 |
| 10 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 11 | A chlorinated copolymer donor demonstrates a 18.13% power conversion efficiency显示文摘The rapid development of low-bandgap(LBG)nonfullerene acceptors and wide-bandgap(WBG)copolymer donors in recent years has boosted the power conversion efficiency(PCE)of organic solar cells(OSCs)to the 18%level[1−21].The commercialization of OSCs is highly expected.However,critical issues like the cost and the stability also determine whether OSCs can enter the market or not[22]. | Jianqiang Qin Lixiu Zhang Chuantian Zuo Zuo Xiao Yongbo Yuan Shangfeng Yang Feng Hao Ming Cheng Kuan Sun Qinye Bao Zhengyang Bin Zhiwen Jin and Liming Ding | 2021 | Journal of Semiconductors2021，42，1： | 19 |
| 12 | Safety and efficacy of ciprofol vs.propofol for sedation in intensive care unit patients with mechanical ventilation:a multi-center,open label,randomized,phase 2 trial显示文摘Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous intravenous infusion for 12 h maintenance sedation in a previous phase 1 trial.The phase 2 trial was designed to investigate the safety,efficacy,and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation.Methods:In this multicenter,open label,randomized,propofol positive-controlled,phase 2 trial,39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio.The ciprofol infusion was started with a loading infusion of 0.1-0.2 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 0.30 mg·kg^(-1)·h^(-1),which could be adjusted to an infusion rate of 0.06 to 0.80 mg·kg^(-1)·h^(-1),whereas for propofol the loading infusion dose was 0.5-1.0 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 1.50 mg·kg^(-1)·h^(-1),which could be adjusted to 0.30-4.00 mg·kg^(-1)·h^(-1)to achieve-2 to+1 Richmond Agitation-Sedation Scale sedation within 6-24 h of drug administration.Results:Of the 39 enrolled patients,36 completed the trial.The median(min,max)of the average time to sedation compliance values for ciprofol and propofol were 60.0(52.6,60.0)min and 60.0(55.2,60.0)min,with median difference of 0.00(95%confidence interval:0.00,0.00).In total,29(74.4%)patients comprising 18(69.2%)in the ciprofol and 11(84.6%)in the propofol group experienced 86 treatment emergent adverse events(TEAEs),the majority being of severity grade 1 or 2.Drug-and sedation-related TEAEs were hypotension(7.7%vs.23.1%,P=0.310)and sinus bradycardia(3.8%vs.7.7%,P=1.000)in the ciprofol and propofol groups,respectively.The plasma concentration-time curves for ciprofol and propofol were similar.Conclusions:ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting.Trial registration:ClinicalTrials.gov,NCT04147416. | Yongjun Liu Xiangyou Yu Duming Zhu Jun Zeng Qinhan Lin Bin Zang Chuanxi Chen Ning Liu Xiao Liu Wei Gao Xiangdong Guan | 2022 | Chinese Medical Journal2022，，9： | 19 |
| 13 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 14 | Generation of a monkey with MECP2 mutations by TALEN-based gene targeting显示文摘Gene editing in model organisms has provided critical insights into brain development and diseases. Here, we report the generation of a cynomolgus monkey(Macaca fascicularis) carrying MECP2 mutations using transcription activator-like effector nucleases(TALENs)-mediated gene targeting. After injecting TALENs mRNA into monkey zygotes achieved by in vitro fertilization and embryo transplantation into surrogate monkeys, we obtained one male newborn monkey with an MECP2 deletion caused by frameshifting mutation in various tissues. The monkey carrying the MECP2 mutation failed to survive after birth, due to either the toxicity of TALENs or the critical requirement of MECP2 for neural development. The level of MeCP2 protein was essentially depleted in the monkey's brain. This study demonstrates the feasibility of introducing genetic mutations in non-human primates by site-specific gene-editing methods. | Zhen Liu Xue Zhou Ying Zhu Zhi-Fang Chen Bin Yu Yan Wang Chen-Chen Zhang Yan-Hong Nie Xiao Sang Yi-Jun Cai Yue-Fang Zhang Chen Zhang Wen-Hao Zhou Qiang Sun Zilong Qiu | 2014 | Neuroscience Bulletin2014，30，3： | 17 |
| 15 | Preliminary design and parametric study of 1400 m partially earth-anchored cable-stayed bridge显示文摘The preliminary design and parametric study of 1400 m partially earth-anchored cable-stayed bridge are described. Static per-formance of this new type of bridge is discussed. Compared with fully self-anchored cable-stayed bridge, its advantages in fin-ished state are summarized. Based on numerical calculation, effects of several structural parameters on static performance are presented. | SUN Bin, CHENG Jin & XIAO RuCheng Department of Bridge Engineering, Tongji University, Shanghai 200092, China | 2010 | Science China(Technological Sciences)2010，53，2： | 17 |
| 16 | Changes of wetland landscape patterns in Dadu River catchment from 1985 to 2000, China显示文摘基于在 1985 和 2000 遥感图象处理的解释和向量,在在最后二十年的 Dadu 河集水的沼泽地风景模式的空间变化用空间分析被学习方法。由 Apack 软件支持了,沼泽地的索引美化模式被计算,并且信息熵(IE ) 是也介绍了证明沼泽地的变化美化信息。结果证明在这个区域的那处沼泽地风景 patch-corridor-matrix 配置是特征的并且主导地由自然沼泽地组成了。风景模式随着低碎片有点变化了并且从 1985 ~ 2000 在时期期间与部分散布分发显示出集中的分发。使稳定的补丁密度和集中索引的值,和差异,平均索引和 IE 的值显示出细微减少,当优势和分数维的尺寸索引被增加时。沼泽地风景的所有类型在 1985 和 2000 与草地风景有更高的毗邻可能性,并且由于低毗邻矩阵价值在河,冰河,水库和池溏沼泽地之中有极其弱的水文学连接和大空间差距。因为他们的累积贡献通过 PCA 分析超过了 81% ,农业活动将在过去的 15 年期间是到风景变化的主要驱动力[出版摘要] | Laibin HUANG Junhong BAI Denghua YAN Bin CHEN Rong XIAO Haifeng GAO | 2012 | Frontiers of Earth Science2012，6，3： | 17 |
| 17 | Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration显示文摘 | Hu Wang Hongna Zuo Jin Liu Fei Wen Yawei Gao Xudong Zhu Bo Liu Feng Xiao Wengong Wang Gang Huang Bin Shen Zhenyu JU | 2018 | Cell Research2018，28，10： | 16 |
| 18 | Percutaneous transhepatic extraction and balloon dilation for simultaneous gallbladder stones and common bile duct stones:A novel technique显示文摘AIM To evaluate the clinical efficacy and safety of an innovative percutaneous transhepatic extraction and balloon dilation(PTEBD) technique for clearance of gallbladder stones in patients with concomitant stones in the common bile duct(CBD).METHODS The data from 17 consecutive patients who underwent PTEBD for clearance of gallbladder stones were retrospectively analyzed. After removal of the CBD stones by percutaneous transhepatic balloon dilation(PTBD), the gallbladder stones were extracted to the CBD and pushed into the duodenum with a balloon after dilation of the sphincter of Oddi. Large stones were fragmented using a metallic basket. The patients were monitored for immediate adverse events including hemorrhage, perforation, pancreatitis, and cholangitis. During the two-year follow-up, they were monitored for stone recurrence, reflux cholangitis, and other longterm adverse events.RESULTS Gallbladder stones were successfully removed in 16(94.1%) patients. PTEBD was repeated in one patient. The mean hospitalization duration was 15.9 ± 2.2 d. Biliary duct infection and hemorrhage occurred in one(5.9%) patient. No severe adverse events, including pancreatitis or perforation of the gastrointestinal or biliary tract occurred. Neither gallbladder stone recurrence nor refluxing cholangitis had occurred two years after the procedure.CONCLUSION Sequential PTBD and PTEBD are safe and effective for patients with simultaneous gallbladder and CBD stones. These techniques provide a new therapeutic approach for certain subgroups of patients in whom endoscopic retrograde cholangiopancreatography/endoscopic sphincterotomy or surgery is not appropriate. | Bin Liu De-Shun Wu Pi-Kun Cao Yong-Zheng Wang Wu-Jie Wang Wei Wang Hai-Yang Chang Dong Li Xiao Li Yancu Hertzanu Yu-Liang Li | 2018 | World Journal of Gastroenterology2018，24，33： | 15 |
| 19 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 20 | Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine显示文摘Traumatic spinal cord injury(SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold(LOCS) and human placenta-derived mesenchymal stem cells(hPMSCs) when transplanted into completely transected beagle dogs. After 36 weeks observation, we found that LOCS+hPMSCs implants promoted better hindlimb locomotor recovery than was observed in the non-treatment(control) group and LOCS group. Histological analysis showed that the regenerated tissue after treatment was well integrated with the host tissue, and dramatically reduced the volume of cystic and chondroitin sulfate proteoglycans(CSPGs) expression. Furthermore, the LOCS+hPMSCs group also showed more neuron-specific βIII-tubulin(Tuj-1)-and NeuN-positive neurons in the lesion area, as well as axonal regeneration, remyelination and synapse formation in the lesion site. Additionally, dogs in the LOCS+hPMSCs group experienced enhanced sprouting of both ascending(CGRP-positive) sensory fibers and descending(5-HT-and TH-positive) motor fibers at the lesion area. All these data together suggested that the combined treatment had beneficial effects on neuronal regeneration and functional improvement in a canine complete transection model. Therefore, LOCS+hPMSCs implantation holds a great promise for bridging the nerve defect and may be clinically useful in the near future. | Sufang Han Zhifeng Xiao Xing Li Huan Zhao Bin Wang Zhixue Qiu Zhi Li Xin Mei Bai Xu Caixia Fan Bing Chen Jin Han Yanzheng Gu Huilin Yang Qin Shi Jianwu Dai | 2018 | Science China(Life Sciences)2018，61，1： | 15 |
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