维普中文期刊产品整合服务
134篇 您的检索式:作者名="Aiyer"
    题名 作者 年代 出处 被引量
1Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids显示文摘AIM:To investigate the ability of curcumin to counteract the impact of bile acids on gene expression of esophageal epithelial cells.METHODS:An esophageal epithelial cell line(HET1A)was treated with curcumin in the presence of deoxycholic acid.Cell proliferation and viability assays were used to establish an appropriate dose range for curcumin.The combined and individual effects of curcumin and bile acid on cyclooxygenase-2(COX-2)and superoxide dismutase(SOD-1 and SOD-2)gene expression were also assessed.RESULTS:Curcumin in a dose range of 10-100μmol/L displayed minimal inhibition of HET-1A cell viability.Deoxycholic acid at a concentration of 200μmol/L caused a 2.4-fold increase in COX-2 gene expression compared to vehicle control.The increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin,and curcumin reduced COX-2 expression 3.3-to 1.3-fold.HET-1A cells exposed to bile acid yielded reduced expression of SOD-1 and SOD-2 genes with the exception that high dose deoxycholic acid at 200μmol/L led to a 3-fold increase in SOD-2 expression.The addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin tested.CONCLUSION:Curcumin reverses bile acid suppression of gene expression of SOD-1.Curcumin is also able to inhibit bile acid induction of COX-2 gene expression.Matthew R Bower Harini S Aiyer Robert CG Martin Yan Li 2010World Journal of Gastroenterology2010,16,33:10
2Uric acid: role in cardiovascular disease and effects of losartan显示文摘Michael Alderman Kala J. V. Aiyer 2004Current Medical Research and Opinion?2004,,3:2
3Uric acid:role in cardiovascular disease and effects of losartan显示文摘Alderman M Aiyer KJ 2004Curr Med Res Opin2004,20,3:1
4Uric acid: role in cardiovascular disease and effects of losartan 显示文摘Alderman M Aiyer KJ 2004Curr Med Res Opin2004,20,3:1
5Initial growth behaviour of LiNbO3 films on α-Al2O3 substrates with atomic scale step structure显示文摘 AIYER H N 2001Solid State Communications2001,118,:1
6Tumor necrosis factor-α as a proliferative signal for an IL-2-dependent T cell Line:strict species specificity of action显示文摘 Bombara M Aiyer R 1989J Immunol1989,142,:1
7Traditional and nontraditional cardiovascular risk factors in comorbid insomnia and sleep apnea 显示文摘Luyster FS Kip KE Buysse DJ Aiyer AN Reis SE Strollo PJ Jr 2014Sleep2014,37,3:1
8Effect of solvents on the synthesis of nano-size zinc oxide and its properties显示文摘Kanade K G Kale B B Aiyer R C 2006Materials Research Bulletin2006,41,:1
9Uricacid:Role in cardiovascular diseaseand elect of losartan显示文摘Alderman MH Aiyer KJ 2004Curt Med Res Opin2004,20,3:1
10Prediction of posterior ligamentous complex injury in thoracolumbar frac- tures using non-MRI imaging techniques 显示文摘Rajasekaran S Maheswaran A Aiyer SN 2016Int Orthop2016,40,6:1
11Uric acid:Role in cardiovascular disease and efect of losartan显示文摘ALDERMAN M H AIYER K J 2004Curt Med Res Opin2004,20,:1
12Uric acid:role in cardiovascular disease andeffect of losartan显示文摘Alderman MH Aiyer KJ 2004Curr Med Res Opin2004,20,3:1
13Supernumeary nostril in association with incomplete naso-ocular cleft显示文摘Tambwekar SR Aiyer PM Vij VK 1997Plast Reconstr Surg1997,100,3:1
14A Theoretical Investigation Into the Performance of the Hopfield Model显示文摘S U B Aiyer 1990IEEE Trans NN1990,,:1
15Primary extracranial meningioma of paranasal sinuses显示文摘AIYER RN G PRASHANTH V AMBANI K 2013Indian J Otolaryngol Head Neck Surg2013,65,2:1
16Impact of all evidence-based medi-cine cur- riculum on medical students' attitude and skills 显示文摘Dorsch Aiyer MK Meyer LE 2004J Med Libr Assoc2004,92,4:1
17Uric acid:role in cardiovascular disease and effects of losartan显示文摘Alademan M Aiyer KJ 2004Curr Med Res Opin2004,20,3:1
18Uric acid : Role in cardiovascular disease and effect of Iosartan显示文摘Alderman MH - Aiyer K J 2004Cart Med Res Opin2004,20,3:1
19Efficiency of the APTIMA HPV assay for detection of HPV RNA and DNA targets显示文摘Getman D Aiyer A Dockter J 2009J Clin Virol2009,45,1:1
20A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature显示文摘Jin H Aiyer A Su J et aI 2006J Clin Invest2006,116,3:1
返回顶部 每页显示:
共7页 首页 上一页 第1页 下一页 末页 /7 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费