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| 1 | Safety and effectiveness of propofol sedation during and after outpatient colonoscopy显示文摘AIM:To study the safety and effectiveness of propofol sedation for outpatient colonoscopy.METHODS:Propofol was given by bolus injection with an age-adjusted standard protocol consisting of 60 mg for patients < 70 years old,40 mg for patients age 70-89 years,and 20 mg for those ≥ 90 years,and additional injections of 20 mg propofol were given up to a maximum of 200 mg.The principal parameters were the occurrence of adverse events within 24 h after colonoscopy and overall satisfaction for this procedure.Secondary parameters included successful procedure,respiratory depression,and other complications.RESULTS:Consecutive patients were entered prospectively and all 2101 entered successfully completed outpatient colonoscopy.The mean dose of propofol used was 96.4 mg(range 40-200 mg).Younger patients required higher doses of propofol than older patients(20-40 years vs ≥ 61 years:115.3 ± 32 mg vs 89.7 ± 21 mg,P < 0.001).Transient supplemental oxygen supply was needed by five patients(0.2%);no other complications occurred.The questionnaires were completed by 1820(87%) of 2101 patients and most rated their overall satisfaction as excellent(80%) or good(17%).The majority(65%) of patients drove home or to their office after their colonoscopy.Most(99%) were willing to repeat the same procedure.No incidents occurred within 24 h after colonoscopy.CONCLUSION:Propofol sedation using a dose < 200 mg proved both safe and practical for outpatient colonoscopy. | Akira Horiuchi Yoshiko Nakayama Masashi Kajiyama Naoyuki Kato Tetsuya Kamijima Yasuyuki Ichise Naoki Tanaka | 2012 | World Journal of Gastroenterology2012，18，26： | 15 |
| 2 | Hepatocellular carcinoma in extremely elderly patients:An analysis of clinical characteristics,prognosis and patient survival显示文摘瞄准:80 年或更多与肝细胞癌(HCC ) 识别病人的临床、预示的特征。方法:有 HCC 的 1310 个病人的一个总数在这研究被包括。80 年或更多的 91 个病人在 HCC 的诊断的时候被定义为极其老的组。>
或 = 的 234 个病人 50 年但是不到 60 年被认为是非老的组。结果:两性比率(到女性的男性) 比在非老的组在极其老的组(0.90:1 ) 是显著地更低的(3.9:1, P <
0.001 ) 。为 HBsAg 的积极的率在极其老的组和为显然在极其老的组增加的 HBsAg 和 HCVAb 否定的病人的比例是显著地更低的(P <
0.001 ) 。在下列参数没有有效差量:肿瘤,分级的孩子呸,肿瘤阶段,门静脉血栓形成或腹水的存在,和为 HCVAb 的积极的率的直径和数字。极其老的病人经常没收到外科疗法(P <
0.001 ) 并且他们是更可能的收到保守疗法(P <
0.01 ) 。基于与在二个组之间的全面病人比较的 Kaplan-Meier 方法在幸存曲线没有有效差量。然而,幸存曲线在有阶段 I/II 的极其老的病人是显著地更坏的,上演 I/II,孩子呸分级与非老的组比较的肝硬化。死亡的原因没在病人之中不同,并且大多数盒子甚至在极其老的病人死于肝相关的疾病。结论:在有好肝功能和好表演地位的病人,为 HCC 的好攻击的治疗可能改进幸存率,甚至在极其老的病人。 | Gengo Tsukioka Satoru Kakizaki Naondo Sohara Ken Sato Hitoshi Takagi Hirotaka Arai Takehiko Abe Mitsuo Toyoda Kenji Katakai Akira Kojima Yuichi Yamazaki Toshiyuki Otsuka Yutaka Matsuzaki Fujio Makita Daisuke Kanda Katsuhiko Horiuchi Tetsuya Hamada Mieko Kaneko Hideyuki Suzuki Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 3 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 4 | Improving quality measures in colonoscopy and its therapeutic intervention显示文摘Colonoscopy with polypectomy has been shown to reduce the risk of colon cancer. The critical element in the quality of colonoscopy in terms of polyp detection and removal continues to be the performance of the endoscopist, independent of patient-related factors. Improved results in terms of polyp detection and complete removal have implications regarding the development of screening and surveillance intervals and the reduction of interval cancers after negative colonoscopy. Advances in colonoscopy techniques such as high-definition colonoscopy, hood-assisted colonoscopy and dye-based chromoendoscopy have improved the detection of small and flat-type colorectal polyps. Virtual chromoendoscopy has not proven to improve polyp detection but may be useful to predict polyp pathology. The majority of polyps can be removed endoscopically. Available polypectomy techniques include cold forceps polypectomy, cold snare polypectomy, conventional polypectomy, endoscopic mucosal resection and endoscopic submucosal dissection. The preferred choice depends on the polyp size and characteristics. Other useful techniques include colonoscopic hemostasis for acute colonic diverticular bleeding, endoscopic decompression using colonoscopic stenting, and transanal tube placement for colorectal obstruction. Here we review the current knowledge concerning the improvement of quality measures in colonoscopy and colonoscopy-related therapeutic interventions. | Akira Horiuchi Naoki Tanaka | 2014 | World Journal of Gastroenterology2014，20，36： | 3 |
| 5 | Non-alcoholic fatty liver disease later diagnosed as myotonic dystrophy显示文摘BACKGROUND Myotonic dystrophy(MD)is sometimes accompanied by metabolic/endocrine disorders,including dyslipidemia,central obesity,and hypogonadism.Due to considerable individual differences in the severity and progression of myopathy,MD patients with minimal-to-mild muscle symptoms might be followed as having other diseases,such as non-alcoholic fatty liver disease(NAFLD).CASE SUMMARY A 40-year-old non-obese man without a history of regular ethanol consumption was referred to our hospital due to persistent liver dysfunction and hyperlipidemia.His body mass index was 23.4 kg/m2.Liver histology demonstrated macrovesicular steatosis,ballooned hepatocytes with eosinophilic inclusion bodies,and perisinusoidal fibrosis,leading to the diagnosis of nonalcoholic steatohepatitis(NASH).Although he had no discernable muscle pain or weakness,persistently high serum creatine kinase(CK)and myoglobin levels as well as the presence of frontal baldness,a hatched face,history of cataract surgery,and grip myotonia indicated the possibility of MD.Southern blotting of the patient’s DNA revealed the presence of CTG repeats,confirming the diagnosis.CONCLUSION When gastroenterologists encounter NAFLD/NASH patients,serum CK should be verified.If hyperCKemia,frontal baldness,a hatched face,history of cataract surgery,and grip myotonia are noted,the possibility of MD may be considered. | Naoki Tanaka Takefumi Kimura Naoyuki Fujimori Yasuyuki Ichise Kenji Sano Akira Horiuchi | 2020 | World Journal of Hepatology2020，12，9： | 3 |
| 6 | Removal of small colorectal polyps in anticoagulated patients: a prospective randomized comparison of cold snare and conventional polypectomy显示文摘 | Akira Horiuchi Yoshiko Nakayama Masashi Kajiyama Naoki Tanaka Kenji Sano David Y. Graham | 2014 | Gastrointestinal Endoscopy2014，，3： | 3 |
| 7 | 门诊病人的有效性经皮的内视镜的 gastrostomy 代替使用 esophagogastroduodenoscopy 和 propofol 镇静显示文摘 AIM: To evaluate the effectiveness of outpatient percutaneous endoscopic gastrostomy (PEG) replacement using esophagogastroduodenoscopy (EGD) and propofol sedation. METHODS: We retrospectively assessed the outcome and complications of consecutive patients referred for PEG replacement which was performed using EGD under propofol sedation in the outpatient setting. The success rate, the mean dose of propofol, procedure time, EGD findings, discharge time from endoscopy unit, respiratory depression, and complications within 72 h of the procedure were evaluated. In a subset of these patients, the blood concentrations of propofol were measured.RESULTS: All 221 patients underwent successful PEG replacement. The mean dose of propofol was 34 mg (range, 20-60 mg) with a mean procedure time of 5.9 min (range, 3-8 min). Reflux esophagitis (12 patients), gastric ulcer (5), gastric neoplasm (2), and duodenal ulcer (1) were newly diagnosed at replacement. Discharge from endoscopy unit was possible in 100% of patients 45 min after the procedure. Only 3.6% (8) required transient supplemental oxygen. No complications occurred within 72 h of the procedure. During EGD the level of sedation and propofol blood concentrations after administration of propofol (30 mg) in these PEG patients corresponded to those of propofol (60 mg) in middle aged subjects (control). | Akira Horiuchi Yoshiko Nakayama Masashi Kajiyama Naoki Tanaka | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，2： | 2 |
| 8 | Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia显示文摘 | Akira Ito Yuko Kuga Hiroyuki Honda Hiroyuki Kikkawa Atsushi Horiuchi Yuji Watanabe Takeshi Kobayashi | 2004 | Cancer Letters2004，，2： | 1 |
| 9 | Highly Purified Eicosapentaenoic Acid Treatment Improves Nonalcoholic Steatohepatitis显示文摘 | Naoki Tanaka Kenji Sano Akira Horiuchi Eiji Tanaka Kendo Kiyosawa Toshifumi Aoyama | 2008 | Journal of Clinical Gastroenterology2008，，4： | 1 |
| 10 | HLA DRB1*0405-DQB1*0401 haplotype is associated with autoimmune pancreatitis in the japanese population显示文摘 | Shigeyuki Kawa Masao Ota Kaname Yoshizawa Akira Horiuchi Hideaki Hamano Yasuhide Ochi Kohzo Nakayama Yuriko Tokutake Yoshihiko Katsuyama Satoshi Saito Osamu Hasebe Kendo Kiyosawa | 2002 | Gastroenterology2002，，5： | 1 |
| 11 | Hood-Assisted Colonoscopy Is More Effective in Detection of Colorectal Adenomas Than Narrow-Band Imaging显示文摘 | Akira Horiuchi Yoshiko Nakayama Naoyuki Kato Yasuyuki Ichise Masashi Kajiyama Naoki Tanaka | 2010 | Clinical Gastroenterology and Hepatology2010，，4： | 1 |
| 12 | ERCP features in 27 patients with autoimmune pancreatitis显示文摘 | Akira Horiuchi Shigeyuki Kawa Hideaki Hamano Masayoshi Hayama Hiroyoshi Ota Kendo Kiyosawa | 2002 | Gastrointestinal Endoscopy2002，，4： | 1 |
| 13 | Magnetic Reso-nance Imaging Investigation of Secondary Degeneration of the Mesen-cephalic Substantia Nigra After Cerebral Infarction 显示文摘 | Yasuko Ohe Akira Uchino Yousuke Horiuchi | 2013 | Journal of Strokeand Cerebrovascular Diseases2013，22，1： | 1 |
| 14 | Correlation between cortical plate proximity and apical root resorption显示文摘 | Akira Horiuchi Hitoshi Hotokezaka Kazuhide Kobayashi | 1998 | American Journal of Orthodontics & Dentofacial Orthopedics1998，，3： | 1 |
| 15 | 载脂蛋白E-基因敲除鼠VLDL和IDL在动脉硬化中的作用显示文摘探讨载脂蛋白E(apoE)-基因敲除鼠极低密度脂蛋白(VLDL)和中间密度脂蛋白(IDL)组分(apoEko-VLDL/IDL)致动脉硬化作用.采用超离法从apoE-基因敲除鼠血浆中分离VLDL和IDL组分,与鼠腹腔巨噬细胞共育,观察apoEko-VLDL/IDL与巨噬细胞的相互作用.ApoEko-VLDL/IDL导致细胞胆固醇酯含量显著增加.其诱导的细胞[3H]胆固醇油酸脂量高达15.1nmol/mg细胞蛋白,是天然低密度脂蛋白的8.4倍.形态学观察显示,经apoEko-VLDL/IDL处理的巨噬细胞与苏丹黑B呈阳性染色.细胞结合实验表明,125I-apoEko-VLDL/IDL与巨噬细胞的总结合可被非标记配基取代80%以上,特异结合呈一饱和图形.同时细胞缔合和细胞内降解实验也显示相似结果. | 张春妮 Hakamata Hideki Sakaguchi Hisashi Suzuki Hirosh Miyazaki Akira 庄一义 Horiuchi Seikoh | 1999 | 南京大学学报(自然科学版)1999，35，2： | 1 |
| 16 | CD36, serves as a receptor for advanced glycation endproducts (AGE)显示文摘 | Nobutaka Ohgami Ryoji Nagai Mamoru Ikemoto Hiroyuki Arai Akira Miyazaki Hideki Hakamata Seikoh Horiuchi Hitoshi Nakayama | 2002 | Journal of Diabetes and Its Complications2002，，1： | 1 |
| 17 | Endoscopist-Directed Administration of Propofol: A Worldwide Safety Experience显示文摘 | Douglas K. Rex Viju P. Deenadayalu Emely Eid Thomas F. Imperiale John A. Walker Kuldip Sandhu Anthony C. Clarke Lybus C. Hillman Akira Horiuchi Lawrence B. Cohen Ludwig T. Heuss Shajan Peter Christoph Beglinger James A. Sinnott Thomas Welton Magdy Rofail | 2009 | Gastroenterology2009，，4： | 1 |
| 18 | HLA DRB1*0405-DQB1*0401 haplotype is associated with autoimmune pancreatitis in the japanese population显示文摘 | Shigeyuki Kawa Masao Ota Kaname Yoshizawa Akira Horiuchi Hideaki Hamano Yasuhide Ochi Kohzo Nakayama Yuriko Tokutake Yoshihiko Katsuyama Satoshi Saito Osamu Hasebe Kendo Kiyosawa | 2002 | Gastroenterology2002，，5： | 1 |
| 19 | Attenuation of Inflammatory Vascular Remodeling by Angiotensin II Type 1 Receptor–Associated Protein显示文摘 | Akira Oshita Masaru Iwai Rui Chen Ayumi Ide Midori Okumura Shiori Fukunaga Toyofumi Yoshii Masaki Mogi Jitsuo Higaki Masatsugu Horiuchi | 2006 | Hypertension2006，，4： | 1 |
| 20 | 587g: Prospective Randomized Comparison of Cold Snare Polypectomy and Conventional Polypectomy显示文摘 | Akira Horiuchi Yoshiko Nakayama | 2010 | Gastrointestinal Endoscopy2010，，5： | 1 |
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