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| 1 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 2 | Prognosis of ulcerative colitis differs between patients with complete and partial mucosal healing, which can be predicted from the platelet count显示文摘AIM:To determine the difference in clinical outcome between ulcerative colitis(UC)patients with Mayo endoscopic subscore(MES)0 and those with MES 1.METHODS:UC patients with sustained clinical remission of 6 mo or more at the time of colonoscopy were examined for clinical outcomes and the hazard ratios of clinical relapse according to MES.Parameters,including blood tests,to identify predictive factors for MES 0and slight endoscopic recurrence in clinically stablepatients were assessed.Moreover,a receiver operating characteristic curve was generated,and the area under the curve was calculated to indicate the utility of the parameters for the division between complete and partial mucosal healing.All P values were two-sided and considered significant when less than 0.05.RESULTS:A total of 183 patients with clinical remission were examined.Patients with MES 0(complete mucosal healing:n=80,44%)were much less likely to relapse than those with MES 1(partial mucosal healing:n=89,48%)(P<0.0001,log-rank test),and the hazard ratio of risk of relapse in patients with MES 1 vs MES0 was 8.17(95%CI:4.19-17.96,P<0.0001).The platelet count(PLT)<26×104/μL was an independent predictive factor for complete mucosal healing(OR=4.1,95%CI:2.15-7.99).Among patients with MES 0 at the initial colonoscopy,patients of whom colonoscopy findings shifted to MES 1 showed significant increases in PLT compared to those who maintained MES 0(3.8×104/μL vs-0.6×104/μL,P<0.0001).CONCLUSION:The relapse rate differed greatly between patients with complete and partial mucosal healing.A shift from complete to partial healing in clinically stable UC patients can be predicted by monitoring PLT. | Asuka Nakarai Jun Kato Sakiko Hiraoka Toshihiro Inokuchi Daisuke Takei Yuki Moritou Mitsuhiro Akita Sakuma Takahashi Keisuke Hori Keita Harada Hiroyuki Okada Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，48： | 11 |
| 3 | One-Step Synthesis of Magnetically Recyclable Au/Co/Fe Triple- Layered Core-Shell Nanoparticles as Highly Efficient Catalysts for the Hydrolytic Dehydrogenation of Ammonia Borane显示文摘有磁力地, recyclable Au/Co/Fe 核心壳 nanoparticles (NP ) 成功地在 situ 过程经由一出一步舞被综合了。传播电子显微镜(TEM ) ,精力散 X 光检查分光镜(版本) ,并且电子精力损失分光镜(鳗) 大小表明 trimetallic Au/Co/Fe NP 有三元组分层的核心壳结构一个 Au 核心,合作富人夹层,和 Fe 富有的壳镇静。Au/Co/Fe 核心壳 NP 为氨 borane 的 hydrolytic 除氢作用展出高得多的催化活动(NH3BH3, AB ) 比一金属(Au,公司, Fe ) 或二金属(AuCo, AuFe, CoFe ) 对应物。 | Kengo Aranishi Hai-Long Jiang Tomoki Akita Masatake Haruta Qiang Xu | 2011 | Nano Research2011，4，12： | 8 |
| 4 | Cloud Point Extraction of Polycyclic Aromatic Hydrocarbons in Aqueous Solution with Silicone Surfactants显示文摘有二硅酮表面活化剂, Dow Corning DC-190 和 DC-193 的浊点抽取(用户终端设备) 过程,作为 preconcentration 被学习,为水的处理由三踪迹多环芳香烃弄脏(哼) :蒽,菲和分核。为所有情况,二硅酮表面活化剂获得的充满表面活化剂的阶段的体积是很小的,即在充满表面活化剂的阶段的更低的含水率被获得。例如,不到 3% 起始的答案被获得在一 1%( 由质量) 表面活化剂答案,它是比在一样的表面活化剂集中的 TX-114 的小得多的。并且 TX-114 非在大多数之中作为一个高紧缩的充满表面活化剂的阶段被知道离子型表面活性剂,因此,比较证明优秀丰富被用户终端设备进程与硅酮表面活化剂在分析应用程序保证,并且在充满表面活化剂的阶段获得的更低的含水率在大规模水处理也是重要的。恢复上的添加剂和析相作用方法论的影响哼被讨论。与 DC-193 作比较。DC-190 有一个下浊点和所有的更高的恢复(近的 100%) 三在一样的表面活化剂集中哼,它在 HPLC 以前作为 preconcentration 进程为申请被要求系统。然而, DC-190 答案是难的是而 DC-193 有一个相对更高的阶段由加热,而是一个高浊点分开速度,仅仅由加热分开的阶段(在 360K 附近) 限制它的申请。由于由加热的析相作用是对大规模水处理合适的用户终端设备的唯一的方法,二个硅酮表面活化剂答案的混合物在这研究被调查。包含 1% 混合 DC-190 和 DC-193 的一个答案(在 90:10 的比率) 有分开的一个相对低浊点和快阶段的 100% 附近的移开的蒽,菲和分核加速。 | 姚炳佳 杨立 胡琼 Shigendo Akita | 2007 | Chinese Journal of Chemical Engineering2007，15，4： | 7 |
| 5 | 优化下肢慢性创面愈合中的技术应用:共识文件(译文)显示文摘目的:慢性创面处理中技术创新随处可见。尽管多种技术得到了广泛的应用,但并不总是能够确保创面愈合的结局。这份共识文件为创面标准化处理的相关诊疗技术应用提供了循证研究依据。 | Raj Mani Divid J.Margolis Vijay Shukla Sadanori Akita Miltos Lazarides Alberto Piaggesi Vincent Falanga Luc Teot 谢挺 付小兵 Marco Romanelli Chris Attinger 韩春茂 陆树良 Sylvie Meaume 许樟荣 Vijay Viswanathan 孙晓芳 肖娴 | 2017 | 感染.炎症.修复2017，18，2： | 7 |
| 6 | CD13 is a therapeutic target in human liver cancer stem cells显示文摘 | Haraguchi Naotsugu Ishii Hideshi Mimori Koshi Tanaka Fumiaki Ohkuma Masahisa Kim Ho Min Akita Hirofumi Takiuchi Daisuke Hatano Hisanori Nagano Hiroaki Barnard Graham F Doki Yuichiro Mori Masaki | 2010 | Journal of Clinical Investigation2010，，9： | 7 |
| 7 | Long-term follow-up of ulcerative colitis patients treated on the basis of their cytomegalovirus antigen status显示文摘AIM:To clarify the impact of cytomegalovirus(CMV)activation and antiviral therapy based on CMV antigen status on the long-term clinical course of ulcerative colitis(UC)patients.METHODS:UC patients with flare-up were divided into CMV-positive and-negative groups according to the CMV antigenemia assay.The main treatment strategy provided for the patients in the CMV-positive group comprised a dose reduction of corticosteroids and administration of ganciclovir.RESULTS:The median number of days to initial remission was significantly greater for the patients in the CMV-positive group(21 d vs 16 d,P=0.009).However,the relapse rate after remission and colectomy rate during more than 30 mo of observation did not differ between the two groups.Multivariate analysis revealed that administration of ganciclovir was the only independent factor for avoiding colectomy in patients of the CMV-positive group.CONCLUSION:CMV antigen status did not significantly affect the long-term prognosis in UC patients under treatment with appropriate antiviral therapy. | Toshihiro Inokuchi Jun Kato Sakiko Hiraoka Hideyuki Suzuki Asuka Nakarai Tomoko Hirakawa Mitsuhiro Akita Sakuma Takahashi Keita Harada Hiroyuki Okada Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，2： | 6 |
| 8 | Study on steel plate reinforced concrete panels subjected to cyclic in-plane shear显示文摘 | Masahiko Ozaki Shodo Akita Hiroshi Osuga Tatsuo Nakayama Naoyuki Adachi | 2003 | Nuclear Engineering and Design2003，，1： | 3 |
| 9 | Descending Branch of the Perforating Branch of the Peroneal Artery Perforator–Based Island Flap for Reconstruction of the Lateral Malleolus with Minimal Invasion显示文摘 | Shinsuke Akita Nobuyuki Mitsukawa Naoaki Rikihisa Juni Himeta Yoshitaka Kubota Natsuko Shimada Hideki Tokumoto Takane Suzuki Kaneshige Satoh | 2013 | Plastic and Reconstructive Surgery2013，，2： | 2 |
| 10 | L-精氨酸能改善MELAS卒中样发作症状 | Koga Y. Akita Y. Nishioka J. 李一明 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，7： | 2 |
| 11 | Cranial bone defect healingisaccelerated by mesenchymal stem cells induced by coadministration ofbone morphogenetic protein-2 and basic fibroblast growth factor显示文摘 | AKITA S FUKUI M NAKAGAWA H | 2004 | Wound Repair Regen2004，12，2： | 1 |
| 12 | Induction of tumor necrosis factoy-αin the mouse hippocampus following transient forebrain is chemia显示文摘 | Uno H Matsuyama T Akita H | 1997 | J Cereb Blood Flow Metab1997，7，5： | 1 |
| 13 | Prediction of collapse with magnetic resonance imaging of avascular necrosis of the femoral head显示文摘 | Shimizu ME Moriya H Akita T | 1994 | J Bone Jiont Surg Am1994，76，2： | 1 |
| 14 | Ectopic expression of c-myc fails to overcome downregulation of telomerase activity induced by hetbimyclin A, but ectopic hTERT expression overcomes it 显示文摘 | Akiyama M Yamada O Akita S | 2000 | Leukemia2000，14，7： | 1 |
| 15 | Vapor-phase epoxidation of propene using H2 and O2 over Au/Ti-MCM-48 显示文摘 | Uphade B S Akita T Nakamura T | 2002 | Journal of Catalysis2002，209，： | 1 |
| 16 | Prevalence of extendedspectrum beta-lactamases produced by isolates of enterobacteriaceae In traka University Hospital显示文摘 | Akita F Tatemono-0zkunm 0zkan e | 2003 | Turkey new microbiol2003，26，3： | 1 |
| 17 | A practical procedure for the analysis of moisture transfer within concrete due to drying显示文摘 | Akita H Fujiwara T Ozaka Y | 1997 | Mag azine of Concrete Research1997，49，179： | 1 |
| 18 | Pig cloning by microinjection of fetal fibroblast nuclei显示文摘 | Onishi A Iwamoto M Akita T | 2000 | Science2000，289，5482： | 1 |
| 19 | Preclinical studies with erlotinib (Tarreva) 显示文摘 | Akita RW Sliwkowski MX | 2003 | Semin Oncol2003，30，37： | 1 |
| 20 | CA 125/MUC 16 interacts with Src family kinases,and over-expression of its C-terminal fragment in human epithelial cancer ceils reduces cell-cell adhesion显示文摘 | Akita K Tanaka M Tanida S | 2013 | Eur J Cell Biol2013，92，89： | 1 |
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