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| 1 | Enhanced recovery program is safe and improves postoperative insulin resistance in gastrectomy显示文摘AIM: To assess the safety of enhanced recovery after surgery(ERAS) program in gastrectomy and influences on nutrition state and insulin-resistance. METHODS: Our ERAS program involved shortening the fasting periods and preoperative carbohydrate loading. Eighty gastrectomy patients were randomly assigned to either the conventional group(CG) or ERAS group(EG). We assessed the clinical characteristics and postoperative outcomes prospectively. The primary endpoint was noninferiority in timely discharge from the hospital within 12 d. Secondary endpoints were the incidence of aspiration at anesthesia induction, incidence of postoperative complications, health related quality of life(HRQOL) using the SF8 Health Survey questionnaire, nutrition state [e.g., albumin, transthyretin(TTR), retinal-binding protein(RBP), and transferrin(Tf)], the homeostasis model assessment-insulin resistance(HOMA-R) index, postoperative urine volume,postoperative weight change, and postoperative oral intake.RESULTS: The ERAS program was noninferior to the conventional program in achieving discharge from the hospital within 12 d(95.0% vs 92.5% respectively; 95%CI:-10.0%-16.0%). There was no significant difference in postoperative morbidity between the two groups. Adverse events such as vomiting and aspiration associated with the induction of general anesthesia were not observed. There were no significant differences with respect to postoperative urine volume, weight change, and oral intake between the two groups. EG patients with preoperative HOMA-R scores above 2.5 experienced significant attenuation of their HOMA-R scores on postoperative day 1 compared to CG patients(P = 0.014). There were no significant differences with respect to rapid turnover proteins(TTR, RBP and Tf) or HRQOL scores using the SF8 method.CONCLUSION: Applying the ERAS program to patients who undergo gastrectomy is safe, and improves insulin resistance with no deterioration in QOL. | Nobuaki Fujikuni Kazuaki Tanabe Noriaki Tokumoto Takahisa Suzuki Minoru Hattori Toshihiro Misumi Hideki Ohdan | 2016 | World Journal of Gastrointestinal Surgery2016，8，5： | 23 |
| 2 | Recurrence of autoimmune hepatitis after liver transplantation without elevation of alanine aminotransferase显示文摘It is controversial whether steroid therapy should be continued to prevent the recurrence of autoimmune hepatitis(AIH)in patients who have undergone liver transplantation(LTx)due to AIH.We report a case of recurrent autoimmune hepatitis after LTx despite a persistently normal range of alanine aminotransferase(ALT).A 50-year-old woman was admitted to our hospital because of jaundice and severe liver dysfunction,where she was diagnosed with liver failure due to AIH.Steroid therapy was not effective enough and the patient received living-donor LTx in 1999.Following the operation,the level of ALT was maintained within a normal range and anti-nuclear antibody(ANA)became negative,however,the serum level of IgG gradually elevated and ANA became positive,while platelets decreased.A liver biopsy performed 6 years after LTx showed histological findings of AIH and she was diagnosed with recurrent AIH.A recurrence of AIH may occur after LTx even if the level of ALT remains within a normal range.We consider that a protocol liver biopsy should be performed in patients who undergo LTx due to AIH to decide the indication for steroid therapy. | Huaiqi Yao Kojiro Michitaka Yoshio Tokumoto Yosuke Murata Toshie Mashiba Masanori Abe Yoichi Hiasa Norio Horiike Morikazu Onji | 2007 | World Journal of Gastroenterology2007，13，10： | 3 |
| 3 | Overexpression of cyclin dependent kinase inhibitor P27/Kip1 increases oligodendrocyte differentiation from induced pluripotent stem cells显示文摘 | Shinpei Tamaki Yasuhito Tokumoto | 2014 | In Vitro Cellular & Developmental Biology - Animal2014，，8： | 2 |
| 4 | Descending Branch of the Perforating Branch of the Peroneal Artery Perforator–Based Island Flap for Reconstruction of the Lateral Malleolus with Minimal Invasion显示文摘 | Shinsuke Akita Nobuyuki Mitsukawa Naoaki Rikihisa Juni Himeta Yoshitaka Kubota Natsuko Shimada Hideki Tokumoto Takane Suzuki Kaneshige Satoh | 2013 | Plastic and Reconstructive Surgery2013，，2： | 2 |
| 5 | Properties of ultra fine grain binderless cemented carbide 'RCCFN' 显示文摘 | Imasato S Tokumoto K Kitada T | 1995 | Intentional Journal of Refractory Metals and Hard Materials1995，13，5： | 1 |
| 6 | Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis 显示文摘 | Tanabe K Suzuki T Tokumoto N | 2010 | World J Surg Oncol2010，8，： | 1 |
| 7 | Aerobic exercise im- proves insulin resistance and decreases body fat and serum lev els of leptin in patients with hepatitis C virus显示文摘 | Konishi I Hiasa Y Tokumoto Y | 2011 | Hepatol Res2011，41，92： | 1 |
| 8 | Hydrogen production by co-cultures of Lactobacillus and a photosynthetic bacterium Rhodobacter sphaeroides RV 显示文摘 | Asada Y Tokumoto M Aihara Y | 2006 | International Journal of Hydrogen Energy2006，31，11： | 1 |
| 9 | Selective growth of single -walled carbon nanotubes by chemical vapor deposition显示文摘 | Matsumoto S Pan L Tokumoto H | 2002 | Phys B2002，323，： | 1 |
| 10 | Japanese single-center experience of kidney transplantation under tacrolimus immunosuppression显示文摘 | Taname K Tokumoto T Ishikawa T | 2000 | Transplant proc2000，32，5： | 1 |
| 11 | Simple thermal chemical vapor deposition synthesis and electrial property of multi-walled carbon nanotubes显示文摘 | ZOU X P ABE H SHIMIZU T ANDO A NAKAYAMA Y TOKUMOTO H ZHU S M ZHOU H S | 2004 | Physica E2004，24，： | 1 |
| 12 | 显示文摘 | Tokumoto M S Puleinelli S H Santilli C V | 2003 | J Phys Chem B2003，107，： | 1 |
| 13 | Direct involvement of the receptor- mediated apoptotic pathways in cisplatin-induced renal tubular cell death显示文摘 | TSURUYA K NINOMIYA T TOKUMOTO M et d | 2003 | Kidney lnt2003，63，1： | 1 |
| 14 | Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or\srecurrent gastric cancer:a retrospective analysis显示文摘 | Tanabe K Suzuki T Tokumoto N | 2010 | World J Surg Oncol2010，8，5： | 1 |
| 15 | Posttranscrigenesis regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentian 显示文摘 | TOKUMOTO Y M APPERLY J A GAO F B | 2002 | Dev Biol2002，245，1： | 1 |
| 16 | Efficient, high-speed methane fermentation for sewage sludge using sub- critical water hydrolysis as pretreatment显示文摘 | Hiroyuki Yoshida Hayato Tokumoto Kyoko Ishii | 2009 | Bioresource Technolo- gy2009，100，12： | 1 |
| 17 | Effect of electroporation and pH on the iontophoretic transdermai delivery of human insulin 显示文摘 | Tokumoto S Higo N Sugibayashi K | 2006 | Int JPharm2006，326，12： | 1 |
| 18 | Properties of ultra-fine grain binderless cemented carbide 'RCCFN' 显示文摘 | IMASATO S TOKUMOTO K KITADA T | 1995 | International Journal of Refractory Metals and Hard Materials1995，13，5： | 1 |
| 19 | Hydro- gen production by co-cultures of Laetobacillus and a photosynthetic bacterium, Rhodo&wter sphaeroides RV 显示文摘 | ASADA Y TOKUMOTO M AIHARA Y | 2006 | International Journal of Hydrogen Energy2006，31，11： | 1 |
| 20 | Combination ther- apy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric caneer-a ret- rospective analysis显示文摘 | Tanabe K Suzuki T Tokumoto N | 2010 | World J Surg Oncol2010，8，5： | 1 |
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