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| 1 | Carbon nanomaterials for cardiovascular theranostics:Promises and challenges显示文摘Cardiovascular diseases(CVDs)are the leading cause of death worldwide.Heart attack and stroke cause irreversible tissue damage.The currently available treatment options are limited to“damage-control”rather than tissue repair.The recent advances in nanomaterials have offered novel approaches to restore tissue function after injury.In particular,carbon nanomaterials(CNMs)have shown significant promise to bridge the gap in clinical translation of biomaterial based therapies.This family of carbon allotropes(including graphenes,carbon nanotubes and fullerenes)have unique physiochemical properties,including exceptional mechanical strength,electrical conductivity,chemical behaviour,thermal stability and optical properties.These intrinsic properties make CNMs ideal materials for use in cardiovascular theranostics.This review is focused on recent efforts in the diagnosis and treatment of heart diseases using graphenes and carbon nanotubes.The first section introduces currently available derivatives of graphenes and carbon nanotubes and discusses some of the key characteristics of these materials.The second section covers their application in drug delivery,biosensors,tissue engineering and immunomodulation with a focus on cardiovascular applications.The final section discusses current shortcomings and limitations of CNMs in cardiovascular applications and reviews ongoing efforts to address these concerns and to bring CNMs from bench to bedside. | Keshav Narayan Alagarsamy Sajitha Mathan Weiang Yan Alireza Rafieerad Saravanan Sekaran Hanna Manego Sanjiv Dhingra | 2021 | Bioactive Materials2021，6，8： | 2 |
| 2 | Synthesis and pharmacological investigation of novel 1-substituted-4-phenyl-1,2,4-lriazolo quinazolin-5(4H)-ones as a new class of H1-antihistaminic agents 显示文摘 | Alagarsamy V Giridhar R Yadav M R | 2005 | Bioorg Med Chem Lett2005，15，7： | 1 |
| 3 | Comparison of clinical criteria with echocardiographic findings in diagnosing PDA in preterm infants显示文摘 | Alagarsamy S Chhabra M Gudavalli M | 2005 | J Perinat Med2005，33，2： | 1 |
| 4 | Synthe- sis,analgesic,anti-inflammatory, ulcerogenic index and antibacte- rial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetra hydrobenzo (b) t hieno显示文摘 | ALAGARSAMY V MEENA S RAMSESHU K V | 2006 | Europe- an Journal of Medicinal Chemistry2006，，： | 1 |
| 5 | Pro-angiogenic effects of MDM2 through HIF-1α and NF-κB mediated mechanisms in LNCaP prostate cancer cells显示文摘 | Muthumani P Alagarsamy K Dhandayuthapani S | 2014 | Mol Biol Rep2014，41，8： | 1 |
| 6 | Microbiology and industrial biotechnology of food-grade proteases: a perspective显示文摘 | ALAGARSAMY S LARROCHE C PANDEY A | 2006 | Food Technology and Biotechnology2006，44，2： | 1 |
| 7 | Comparative evaluation of neutral protease production by aspergillus oryzae in submerged and solidstate fermentation显示文摘 | Sandhya Chandran Sumantha Alagarsamy Szakacs George | 2005 | Process Biochemistry2005，40，： | 1 |
| 8 | Synthesis,analgesic,anti-inflammatory,ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo(b)thienopyrimidin-4(3 H)-ones显示文摘 | ALAGARSAMY V MEENA S RAMSESHU K V | 2006 | Eur J Med Chem2006，41，11： | 1 |
| 9 | Design and synthesis of novel 2-( 3-sub-stitutedpropyl )-3-( 2-methyl-phenyl ) quinazolin-4-(3H)-ones as a new class of Hl-antihis- ta-minie agents 显示文摘 | Alagarsamy V Parthiban P | 2013 | J Enzym Inhib & Med Chem2013，28，： | 1 |
| 10 | Synthesisa,nalgesica,nti-in-flammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H)ones显示文摘 | Alagarsamy V Salomon V R | 2002 | Biologi-cal and Pharmaceutical Bulletin2002，，11： | 1 |
| 11 | Angiotensin Ⅱ stimulates Fibronectin pro-tein synthesis via a Gβγ/arachidonic acid-dependent pathway显示文摘 | Alexander LD Ding Y Alagarsamy S | 2014 | Am J Physiol Renal Physiol2014，307，3： | 1 |
| 12 | Microbiology and industrial biotechnology of food-grade proteases:a perspective 显示文摘 | Sumantha Alagarsamy Larroche Christian Pandey Ashok | 2006 | Food Technology and Bio- technology2006，44，2： | 1 |
| 13 | Comparison of clinical criteria with echocardiographic findings in diagnosing PDA in preterm infants显示文摘 | Sukirtha Alagarsamy Manoj Chhabra Madhu Gudavalli Ali M. Nadroo Vesna G. Sutija Dorina Yugrakh | 2005 | Journal of Perinatal Medicine2005，，2： | 1 |
| 14 | Effect ofcobalt doping on the structural microstructure and microwavedielectric properties of MgTiO3 ceramics prepared by semi alkoxideprecursor method显示文摘 | THATIKONDA S K PALLABI G ALAGARSAMY P | 2014 | J Am Ceram Soc2014，97，10： | 1 |
| 15 | Intraperitoneal chemotherapy: standard of care for patients with minimal residual stage Ⅲ ovarian cancer? 显示文摘 | Tummala MK Alagarsamy S McGuire WP | 2008 | Expert Rev Antieancer Ther2008，8，7： | 1 |
| 16 | Synthesis,analgesic,anti-inflammatory,ulcerogenic index andantibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo(b)thienopyrimidin-4(3H)-ones显示文摘 | Alagarsamy V Meena S Ramseshu K V | 2006 | Eur J Med Chem2006，41，11： | 1 |
| 17 | Propylphosphonic anhydride (T3P ? ): an efficient reagent for the one-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles显示文摘 | John Kallikat Augustine Veeramani Vairaperumal Sharmila Narasimhan Padma Alagarsamy Anbarasi Radhakrishnan | 2009 | Tetrahedron2009，，48： | 1 |
| 18 | Functionalized silicate sol-gel supported TiO2-au core-shell nanomaterials and their photoelectrocatalytic activity显示文摘 | Alagarsamy Pandikumar Sepperumal Murugesan Ramasamy Ramaraj | | 0，，07： | 1 |
| 19 | Coordinate regulation of metabotropic glutamate receptors 显示文摘 | Alagarsamy S Sorensen SD Conn PJ | 2001 | Curt Opin Neurobiol2001，11，3： | 1 |
| 20 | Comparison of clinical criteria with echocardiographic findings in diagnosing PDA in preterm infants显示文摘 | Alagarsamy S Chhabra M Gudavalli M | | 0，，02： | 1 |
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