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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | Lack of association between seroprevalence of Helicobacterpylori infection and primary biliary cirrhosis显示文摘AIM: To determine the association between seroprevalence of Helicobacter pylori(Hpylon) infection and primary biliary cirrhosis (PBC).METHODS: In this case-control study, 149 consecutive patients (10 males, 139 females, mean age 58.2+11 years, range 26-82 years) suffering from PBC and 619 consecutive healthy volunteer blood donors (523 males, 96 females, mean age 47±5.3 years, range 18-65 years) attending the Hospital Blood Bank and residing in the same area were recruited. A commercial enzyme linked immunosorbent assay was used to detect anti-Hpylori(IgG) antibodies in serum.RESULTS: Antibodies to Hpyloriwere present in 78 (52.3%) out of 149 PBC-patients and in 291 (47%) out of 619 volunteers (P= 0.24, OR 1.24, 95% CI 0.85-1.80). In the subjects less than 60 years old, the prevalence of Hpylori infection among PBC-patients (40/79) was slightly higher than in controls (50.6% vs46.2%) P= 0.46, OR = 1.19, 95% CI: 0.72-1.95). In those over 60 years, the prevalence of H pyloriinfection was similar between PBC-patients and controls (54.2% vs57.8%, P= 0.7, OR 0.86, 95% CI 0.36-2.07). CONCLUSION: There is no association between seroprevalence of Hpyloriinfection and primary biliary cirrhosis. | Marilena Durazzo Floriano Rosina Alberto Premoli Enrico Morello Sharmila Fagoonee Rosaria Innarella Enrico Solerio Rinaldo Pellicano Mario Rizzetto | 2004 | World Journal of Gastroenterology2004，10，21： | 4 |
| 3 | Optical molecular imaging for detection of Barrett's-associated neoplasia显示文摘Recent advancements in the endoscopic imaging of Barrett's esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression.This review summarizes relevant changes in optical properties as well as imaging approaches that measures those changes.Wide-field imaging approaches include narrow-band imaging that measures changes in light scattering and absorption,and autofluorescence imaging that measure changes in endogenous fluorophores.High-resolution imaging approaches include optical coherence tomography,endocytoscopy,confocal microendoscopy,and high-resolution microendoscopy.These technologies,some coupled with an appropriate contrast agent,can measure differences in glandular morphology,nuclear morphology,or vascular alterations associated with neoplasia.Advances in targeted contrast agents are further discussed.Studies that have explored these technologies are highlighted;as are the advantages and limitations of each. | Nadhi Thekkek Sharmila Anandasabapathy Rebecca Richards-Kortum | 2011 | World Journal of Gastroenterology2011，17，1： | 3 |
| 4 | Surface Plasmon Resonance Based Sensing of Different Chemical and Biological Samples Using Admittance Loci Method显示文摘 | Kaushik BRAHMACHARI Sharmila GHOSH Mina RAY | 2013 | Photonic Sensors2013，3，2： | 3 |
| 5 | Endoscopic imaging:How far are we from real-time histology?显示文摘Currently,in gastrointestinal endoscopy there is increasing interest in high resolution endoscopic technologies that can complement high-definition white light endoscopy by providing real-time subcellular imaging of the epithelial surface.These 'optical biopsy' technologies offer the potential to improve diagnostic accuracy and yield,while facilitating real-time decision-making.Although many endoscopic techniques have preliminarily shown high accuracy rates,these technologies are still evolving.This review will provide an overview of the most promising high-resolution imaging technologies,including high resolution microendoscopy,optical coherence tomography,endocytoscopy and confocal laser endoscopy.This review will also discuss the application and current limitations of these technologies for the early detection of neoplasia in Barrett's esophagus,ulcerative colitis and colorectal cancer. | Richa Shukla Wasif M Abidi Rebecca Richards-Kortum Sharmila Anandasabapathy | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 3 |
| 6 | Type 2 diabetes mellitus and chronic hepatitis C: Which is worse? Results of a long-term retrospective cohort study显示文摘 | Chiara Giordanino Simone Ceretto Simona Bo Antonina Smedile Alessia Ciancio Elisabetta Bugianesi Rinaldo Pellicano Sharmila Fagoonee Elisabetta Versino Giuseppe Costa Daniele Arese Marco Sacco Mario Rizzetto Giorgio Saracco | 2011 | Digestive and Liver Disease2011，，5： | 3 |
| 7 | Acetic acid chromoendoscopy: Improving neoplasia detection in Barrett's esophagus显示文摘Barrett's esophagus(BE) is an important condition given its significant premalignant potential and dismal five-year survival outcomes of advanced esophageal adenocarcinoma. It is therefore suggested that patients with a diagnosis of BE undergo regular surveillance in order to pick up dysplasia at an earlier stage to improve survival. Current 'gold-standard' surveillance protocols suggest targeted biopsy of visible lesions followed by four quadrant random biopsies every 2 cm. However, this method of Barrett's surveillance is fraught with poor endoscopist compliance as the procedures are time consuming and poorly tolerated by patients. There are also significant miss-rates with this technique for the detection of neoplasia as only 13% of early neoplastic lesions appear as visible nodules. Despite improvements in endoscope resolution these problems persist. Chromoendoscopy is an extremely useful adjunct to enhance mucosal visualization and characterization of Barrett's mucosa. Acetic acid chromoendoscopy(AAC) is a simple, non-proprietary technique that can significantly improve neoplasia detection rates. This topic highlight summarizes the current evidence base behind AAC for the detection of neoplasia in BE and provides an insight into the direction of travel for further research in this area. | Fergus JQ Chedgy Sharmila Subramaniam Kesavan Kandiah Sreedhari Thayalasekaran Pradeep Bhandari | 2016 | World Journal of Gastroenterology2016，22，25： | 2 |
| 8 | Etiology of chronic liver diseases in the Northwest of Italy, 1998 through 2014显示文摘AIM To assess the etiology of chronic liver diseases(CLD) from 1998 to 2014 at the outpatient clinic of Gastroenterology of the main hospital in Northwest of Italy among those dedicated to hepatology.METHODS A random sample of charts of patients referred to for increased liver enzymes between January 1998 and December 2006, and between January 2012 and December 2014 were reviewed. Etiology search included testing for hepatitis B virus(HBV), hepatitis C virus(HCV), autoimmune hepatitis, primary biliary cirrhosis, Wilson's disease and hereditary hemocromatosis. A risky alcohol consumption was also considered. Nonalcoholic fatty liver disease(NAFLD) was diagnosed in patients with histological and/or ultrasound evidence of steatosis/steatohepatitis, and without other causes of CLD.RESULTS The number of patients included was 1163. Of them, 528(45%) had positivity for HCV and 85(7%) for HBV. Among the virus-free patients, 417(36%) had metabolic disorders whereas the remaining had history of alcohol abuse, less prevalent causes of CLD or concomitant conditions. In comparison to 1998-2000(41%), a reduction of HCV alone-related cases was detected during the periods 2001-2003(35%, OR = 0.75, 95%CI: 0.53-1.06), 2004-2006(33%, OR = 0.70, 95%CI: 0.50-0.97) and 2012-2014(31%, OR = 0.64, 95%CI: 0.46-0.91). On the contrary, in comparison to 1998-2000(31%), metabolic-alone disorders increased in the period 2004-2006(39%, OR = 1.37, 95%CI: 0.99-1.91) and 2012-2014(41%, OR = 1.53, 95%CI: 1.09-2.16). The other etiologies remained stable. The increase of incidence of metabolic-alone etiology during the period 2004-2006 and 2012-2014 tended to be higher in older patients(≥ 50 years) compared to younger(P = 0.058).CONCLUSION In the Northwest of Italy, during this study period, the prevalence of HCV infection decreased notably whereas that of NAFLD increased. | Giorgio Maria Saracco Andrea Evangelista Sharmila Fagoonee Giovannino Ciccone Elisabetta Bugianesi Gian Paolo Caviglia Maria Lorena Abate Mario Rizzetto Rinaldo Pellicano Antonina Smedile | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 9 | Is Helicobacter pylori the Infectious Trigger for Headache?: A Review显示文摘 | Lidia Savi Davide G. Ribaldone Sharmila Fagoonee Rinaldo Pellicano | 2013 | Infectious Disorders - Drug Targets2013，，5： | 2 |
| 10 | Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog–GLI pathway显示文摘 | Shih-Hui Li Junsheng Fu Dara Nall Watkins Rakesh K. Srivastava Sharmila Shankar | 2013 | Molecular and Cellular Biochemistry2013，，1： | 2 |
| 11 | Effects of vitamin Cand E on PCB(Aroclor 1245)induced oxidative stress,andro-gen binding protein and lactate in rat Sertoli cells显示文摘 | Kumar J S Banudevi S Sharmila M | 2004 | ReprodToxicol2004，19，2： | 1 |
| 12 | A Suevey on Con- tent based Medical Image Retrieval for Mri Brain Images 显示文摘 | Sharmila G Saraswathi D Ramkumar R | 2014 | International Journal of Research in Engineering and Technology2014，3，19： | 1 |
| 13 | Characterizing flow distributionsin AVF for hemodialysis access 显示文摘 | Sharmila S Thien VH | 1998 | Nephrol DialTransplant1998，13，12： | 1 |
| 14 | Sequential statistical optimization of red pigment production by Monacta purpureus (MTCC 369 ) using potato powder显示文摘 | Sharmila G Nidhi B Muthukmaran C | 2013 | Industrial Crops and Products2013，44，： | 1 |
| 15 | Thermo mechani- cal behavior of unsaturated polyester toughed epoxy-clay hybrid nan composites显示文摘 | Chozhan C K Alagar M Sharmila R J | 2007 | Journal of Polymer Research2007，4，14： | 1 |
| 16 | High-resolution imaging in Barrett’s esophagus: a novel, low-cost endoscopic microscope显示文摘 | Timothy J. Muldoon Sharmila Anandasabapathy Dipen Maru Rebecca Richards-Kortum | 2008 | Gastrointestinal Endoscopy2008，，： | 1 |
| 17 | Tax Evasion and Equity Theory: An Investigative Approach显示文摘 | Sharmila King Steven M. Sheffrin | 2002 | International Tax and Public Finance2002，，4： | 1 |
| 18 | Improved Cardiac Risk Assessment With Noninvasive Measures of Coronary Flow Reserve显示文摘 | Venkatesh L. Murthy Masanao Naya Courtney R. Foster Jon Hainer Mariya Gaber Gilda Di Carli Ron Blankstein Sharmila Dorbala Arkadiusz Sitek Michael J. Pencina Marcelo F. Di Carli | 2011 | Circulation2011，，： | 1 |
| 19 | Foreign ownership technology adoption:evidence from Indian firms显示文摘 | SHARMILA VISHWASRAO WILLIAM BOSSHARDT | 2001 | Journal of Development Economics2001，65，36： | 1 |
| 20 | Right Ventricular Dysfunction Assessed by Cardiovascular Magnetic Resonance Imaging Predicts Poor Prognosis Late After Myocardial Infarction显示文摘 | Eric Larose Peter Ganz H. Glenn Reynolds Sharmila Dorbala Marcelo F. Di Carli Kenneth A. Brown Raymond Y. Kwong | 2007 | Journal of the American College of Cardiology2007，，8： | 1 |
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