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| 1 | Peripheral T-lymphocyte subpopulations in different clinical stages of chronic HBV infection correlate with HBV load显示文摘AIM: To characterize the peripheral T-cell subpopulation profiles and their correlation with hepatitis B virus (HBV) replication in different clinical stages of chronic HBV infection.METHODS: A total of 422 patients with chronic HBV infection were enrolled in this study. The patients were divided into three stages: immune-tolerant stage, immune active stage, and immune-inactive carrier stage. Composition of peripheral T-cell subpopulations was determined by flow cytometry. HBV markers were detected by enzyme-linked immunosorbent assay. SerumHBV DNA load was assessed by quantitative real-time polymerase chain reaction.RESULTS: CD8+ T-cells were significantly higher in patients at the immune-tolerant stage than in patients at the immune-active and -inactive carrier stages (36.87 ± 7.58 vs 34.37 ± 9.07, 36.87 ± 7.58 vs 28.09 ± 5.64, P < 0.001). The peripheral blood in patients at the immune-tolerant and immune active stages contained more CD8+ T-cells than CD4+ T-cells (36.87 ± 7.58 vs 30.23 ± 6.35, 34.37 ± 9.07 vs 30.92 ± 7.40, P < 0.01), whereas the peripheral blood in patients at the immune-inactive carrier stage and in normal controls contained less CD8+ T-cells than CD4+ T-cells (28.09 ± 5.64 vs 36.85 ± 6.06, 24.02 ± 4.35 vs 38.94 ± 3.39, P < 0.01). ANOVA linear trend test showed that CD8+ T-cells were signif icantly increased in patients with a high viral load (39.41 ± 7.36, 33.83 ± 7.50, 31.81 ± 5.95 and 26.89 ± 5.71, P < 0.001), while CD4+ T-cells were signif icantly increased in patients with a low HBV DNA load (37.45 ± 6.14, 33.33 ± 5.61, 31.58 ± 6.99 and 27.56 ± 5.49, P < 0.001). Multiple regression analysis displayed that log copies of HBV DNA still maintained its highly signif icant coefficients for T-cell subpopulations, and was the strongest predictors for variations in CD3+, CD4+ and CD8+ cells and CD4+/CD8+ ratio after adjustment for age at HBV-infection, maternal HBV-infection status, presence of hepatitis B e antigen and HBV mutation.CONCLUSION: Differences in peripheral T-cell subpopulation profi les can be found in different clinical stages of chronic HBV infection. T-cell impairment is signifi cantly associated with HBV load. | Jing You Lin Zhuang Yi-Feng Zhang Hong-Ying Chen Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Teerha Piratvisuth Edward McNeil Lan Yu Bao-Zhang Tang .lun-Hua Huang | 2009 | World Journal of Gastroenterology2009，15，27： | 39 |
| 2 | Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B显示文摘AIM: To investigate peripheral T-lymphocyte sub-population profile and its correlation with hepatitis B virus (HBV) replication in patients with chronic hepatitis B (CHB).METHODS: Distribution of T-lymphocyte subpopulations in peripheral blood was measured by flow cytometry in 206 CHB patients. HBV markers were detected with ELISA. Serum HBV DNA load was assessed with quantitative real-time polymerase chain reaction (PCR). The relationship between HBV replication and variation in peripheral T-cell subsets was analyzed.RESULTS: CHB patients had significantly decreased CD3+ and CD4+ cells and CD4+/CD8+ ratio, and increased CD8+ cells compared with uninfected controls (55.44 ± 12.39 vs 71.07 ± 4.76, 30.92 ± 7.48 vs 38.94 ± 3.39, 1.01 ± 0.49 vs 1.67 ± 0.33, and 34.39 ± 9.22 vs 24.02 ± 4.35; P < 0.001, respectively). Univariate analysis showed a similar pattern of these parameters was significantly associated with high viral load, presence of serum hepatitis B e antigen (HBeAg) expression, liver disease severity, history of maternal HBV infection, and young age at HBV infection, all with P < 0.01. There was a significant linear relationship between viral load and these parameters of T-lymphocyte subpopulations (linear trend test P < 0.001). There was a negative correlation between the levels of CD3+ and CD4+ cells and CD4+/CD8+ ratio and serum level of viral load in CHB patients (r = -0.68, -0.65 and -0.75, all P < 0.0001), and a positive correlation between CD8+ cells and viral load (r = 0.70, P < 0.0001). There was a significant decreasing trend in CD3+ and CD4+ cells and CD4+/CD8+ ratio with increasing severity of hepatocyte damage and decreasing age at HBV infection (linear trend test P < 0.01). In multiple regression (after adjustment for age at HBV infection, maternal HBV infection status and hepatocyte damage severity) log copies of HBV DNA maintained a highly significant predictive coefficient on T-lymphocyte subpopulations, and was the strongest predictor of variation in CD3+, CD4+, CD8+ cells and CD4+/CD8+ ratio. However, the effect of HBeAg was not significant.CONCLUSION: T-lymphocyte failure was signifi-cantly associated with viral replication level. The substantial linear dose-response relationship and strong independent predictive effect of viral load on T-lymphocyte subpopulations suggests the possibility of a causal relationship between them, and indicates the importance of viral load in the pathogenesis of T cell hyporesponsiveness in these patients. | Jing You Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Lin Zhuang Hong-Ying Chen Lan Yu Bao-Zhang Tang Jun-Hua Huang | 2008 | World Journal of Gastroenterology2008，14，7： | 30 |
| 3 | Hepatitis B virus DNA is more powerful than HBeAg in predicting peripheral T-lymphocyte subpopulations in chronic HBV-infected individuals with normal liver function tests显示文摘AIM:To investigate the peripheral T-lymphocyte subpopulation profile,and its correlations with hepatitis B virus(HBV) replication level in chronic HBV-infected(CHI) individuals with normal liver function tests(LFTs) . METHODS:Frequencies of T-lymphocyte subpopu-lations in peripheral blood were measured by flow cytometry in 216 CHI individuals. HBV markers were detected with ELISA. Serum HBV DNA load was assessed with quantitative real-time PCR. Information of age at HBV infection,and maternal HBV infection status was collected. ANOVA linear trend test and linear regression were used in statistical analysis. RESULTS:CHI individuals had significantly decreased relative frequencies of CD3+,CD4+ subpopulationsand CD4+/CD8+ ratio,and increased CD8+ subset percentage compared with uninfected individuals(all P < 0.001) . There was a significant linear relationship between the load of HBV DNA and the parameters of T-lymphocyte subpopulations(ANOVA linear trend test P < 0.01) . The parameters were also significantly worse among individuals whose mothers were known to be HBV carriers,and those having gained infection before the age of 8 years. In multiple regressions,after adjustment for age at HBV infection and status of maternal HBV infection,log copies of HBV DNA maintained its highly significant predictive coefficient on T-lymphocyte subpopulations,whereas the effect of HBeAg was not significant. CONCLUSION:HBV DNA correlates with modification in the relative T-lymphocyte subpopulation frequencies. High viral load is more powerful than HBeAg in predicting the impaired balance of T-cell subsets. | Jing You Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Lin Zhuang Hong-Ying Chen Jun-Hua Huang Bao-Zhang Tang | 2008 | World Journal of Gastroenterology2008，14，23： | 11 |
| 4 | A subfossil chironomid-total phosphorus inference model for lakes in the middle and lower reaches of the Yangtze River显示文摘The results of an investigation into the relationship between surface sediment subfossil chi- ronomid distribution and water quality are presented. Data from 30 lakes in the middle and lower reaches of the Yangtze River indicate that the nutrient gradi- ent was the major factor affecting the distribution of chironomids across these sites. Canonical corre- spondence analysis (CCA) revealed that of 12 sum- mer water environmental variables, total Phosphorus was most important, accounting for 20.1% of the variance in the chironomid data. This was significant enough to allow the development of quantitative in- ference models. A TP inference model was devel- oped using weighted averaging (WA), partial least squares (PLS) and weighted averaging partial least squares (WA-PLS). An optimal two-component WA-PLS model provided a high jack-knifed coeffi- cient of prediction for conductivity r 2jack = 0.76, with a low root mean squared error of prediction (RMSEPjack = 0.13). Using this model it is possible to produce long-term quantitative records of past water quality for lacustrine sites across the middle and lower reaches of the Yangtze River, which has important implications for future lake management and eco- logical restoration. | ZHANG Enlou Alan Bedford Richard Jones SHEN Ji WANG Sumin TANG Hongqu | 2006 | Chinese Science Bulletin2006，51，17： | 10 |
| 5 | Efficacy of thymosin alpha-1 and interferon alpha in treatment of chronic viral hepatitis B:A randomized controlled study显示文摘AIM: To observe the efficiency and safety of thymosin-α1 treatment in patients with hepatitis B e antigen (HBeAg) and HBV DNA positive chronic hepatitis. METHODS: Sixty-two patients were randomly divided into groups A and B. The patients in group A received subcutaneous injection of 1.6 mg thymosin-α1, twice a week (T-α1 group) for six months, and the patients in group B received 5 MU interferon alpha (IFN-α) each day for fifteen days, then three times weekly (IFN-α group) for six months. The results between two groups treated with and the group untreated with IFN-α which was followed up for 12 mo (historical control group consisting of 30 patients) were compared, and three groups were comparable between each other (P > 0.05) at baseline (age, sex, clinical history, biochemical, and serological parameters). RESULTS: At the end of treatment, complete response, which was defined as alanine aminotransferase (ALT) normalization and HBV DNA and HBeAg loss, occurred in 9 of 29 (31.0%) patients in the T-α1 group and in 15 of 33 (45.5%) patients in the IFN-α group (c2 = 1.36, P >0.05). After a follow-up period of six months, a complete response was observed in 14 of 29 (48.3%) patients in the T-α1 group and in 9 of 33 (27.3%) patients in the IFN-α group (c2 = 2.93, P > 0.05). Compared with the results observed in the historical control (HC) group untreated with IFN-α which was followed up for 12 mo, the rate of complete response was significantly higher in IFN-α group at the end of therapy (1 of 30 vs 15 of 33, c2 = 14.72, P < 0.001) and in the T-α1 group at the end of follow-up (1 of 30 vs 14 of 29, c2 = 15.71, P < 0.001). In T-α1 and IFN-α treatment groups, the area under (the plasma concentration time) curve (AUC) of negative HBV DNA and HBeAg was 34%, 17%, 31% and 19% smaller than that in the HC group. By the end of the follow- up period, the proportions of ALT normalization and negative HBV DNA in the T-α1 group were significantly higher than those in the IFN-α and HC groups. The odds of ALT normalization and negative HBV DNA at the end of the follow-up was three-fold higher in the T-α1 group than in the IFN-α group. Unlike IFN-α, T-α1 was well tolerated by all patients, and no side effects appeared in T-α1 group.CONCLUSION: The results suggest that a 6-mo course of T-α1 therapy is effective and safe in patients with chronic hepatitis B. T-α1 is able to reduce HBV replication in patients with chronic hepatitis B. Furthermore, T-α1 is better tolerated than IFN-α and can gradually induce more sustained ALT normalization and HBV DNA and HBeAg loss. However, a response rate of 48.3% is still less ideal. A more effective therapeutic approach warrants further study. | Jing You Lin Zhuang Hong-Ying Cheng Shou-Ming Yan Lan Yu Jun-Hua Huang Bao-Zhang Tang Meng-Ling Huang Yong-Liang Ma Virasakdi Chongsuvivatwong Hutcha Sriplung Alan Geater Yan-Wei Qiao Rong-Xue Wu | 2006 | World Journal of Gastroenterology2006，12，41： | 8 |
| 6 | Continuous wound infusion of local anaesthetic agents following colorectal surgery:Systematic review and meta-analysis显示文摘AIM:To provide a specifi c review and meta-analysis of the available evidence for continuous wound infusion of local anaesthetic agents following midline laparoto-my for major colorectal surgery. METHODS: Medline, Embase, trial registries, conference proceedings and article reference lists were searched to identify randomised, controlled trials of continuous wound infusion of local anaesthetic agents following colorectal surgery. The primary outcomes were opioid consumption, pain visual analogue scores (VASs), return to bowel function and length of hospital stay. Weighted mean difference were calculated for continuous outcomes. RESULTS: Five trials containing 542 laparotomy wounds were eligible for inclusion. There was a sig- nificant decrease in post-operative pain VAS at rest on day 3 (weighted mean difference: -0.43; 95% CI: -0.81 to -0.04; P = 0.03) but not on post-operative day 1 and 2. Local anaesthetic infusion was associated with a signifi cant reduction in pain VAS on movement on all three post-operative days (day 1 weighted mean difference: -1.14; 95% CI: -2.24 to -0.041; P = 0.04, day 2 weighted mean difference: -0.97, 95% CI: -1.91to -0.029; P = 0.04, day 3 weighted mean difference: -0.61; 95% CI: 1.01 to -0.20; P = 0.0038). Local an- aesthetic wound infusion was associated with a signifi - cant decrease in total opioid consumption (weighted mean difference: -40.13; 95% CI: -76.74 to -3.53; P = 0.03). There was no signifi cant decrease in length of stay (weighted mean difference: -20.87; 95% CI: -46.96 to 5.21; P = 0.12) or return of bowel function (weighted mean difference: -9.40; 95% CI: -33.98 to 15.17; P = 0.45). CONCLUSION: The results of this systematic re- view and meta-analysis suggest that local anaesthetic wound infusion following laparotomy for major color- ectal surgery is a promising technique but do not pro- vide conclusive evidence of benefi t. Further research is required including cost-effectiveness analysis. | Alan Karthikesalingam Stewart R Walsh Sheraz R Markar Umar Sadat Tjun Y Tang Charles M Malata | 2008 | World Journal of Gastroenterology2008，14，34： | 4 |
| 7 | Automated generation and ensemble-learned matching of X-ray absorption spectra显示文摘X-ray absorption spectroscopy(XAS)is a widely used materials characterization technique to determine oxidation states,coordination environment,and other local atomic structure information.Analysis of XAS relies on comparison of measured spectra to reliable reference spectra.However,existing databases of XAS spectra are highly limited both in terms of the number of reference spectra available as well as the breadth of chemistry coverage.In this work,we report the development of XASdb,a large database of computed reference XAS,and an Ensemble-Learned Spectra IdEntification(ELSIE)algorithm for the matching of spectra.XASdb currently hosts more than 800,000 K-edge X-ray absorption near-edge spectra(XANES)for over 40,000 materials from the open-science Materials Project database.We discuss a high-throughput automation framework for FEFF calculations,built on robust,rigorously benchmarked parameters.FEFF is a computer program uses a real-space Green’s function approach to calculate X-ray absorption spectra.We will demonstrate that the ELSIE algorithm,which combines 33 weak“learners”comprising a set of preprocessing steps and a similarity metric,can achieve up to 84.2% accuracy in identifying the correct oxidation state and coordination environment of a test set of 19 K-edge XANES spectra encompassing a diverse range of chemistries and crystal structures.The XASdb with the ELSIE algorithm has been integrated into a web application in the Materials Project,providing an important new public resource for the analysis of XAS to all materials researchers.Finally,the ELSIE algorithm itself has been made available as part of veidt,an open source machine-learning library for materials science. | Chen Zheng Kiran Mathew Chi Chen Yiming Chen Hanmei Tang Alan Dozier Joshua J.Kas Fernando D.Vila John J.Rehr Louis F.J.Piper Kristin A.Persson Shyue Ping Ong | 2018 | npj Computational Materials2018，，1： | 3 |
| 8 | Detection of mycobacterial and viral DNA in Kikuchi-Fujimoto disease: an analysis of 153 Chinese pediatric cases显示文摘Dear Editor,Kikuchi-Fujimoto disease(KFD),or histiocytic necrotizing lymphadenitis,was initially described in 1972 by Drs.Kikuchi and Fujimoto(Shirakusa et al.,1988).The main clinical manifestations are fever and cervical lymphadenopathy with or without pain,sometimes accompanied by tachycardia,nausea and symptomatic infiltrative erythematous lesions.The diagnosis of KFD is usually based on characteristic lymph node histologic findings of coagulative necrosis,histiocytic infiltrate,loss of nodal architecture, | Zhe Xu Ying Liu Haijing Li Shufang Meng Alan S.Boyd Charles W.Stratton Lin Ma Yi-Wei Tang | 2017 | Science China(Life Sciences)2017，60，7： | 2 |
| 9 | Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis显示文摘 | Benjamin MP Tang Guy D Eslick Caryl Nowson Caroline Smith Alan Bensoussan | 2007 | The Lancet2007，，9588： | 2 |
| 10 | Genome-wide Association and Follow-Up Replication Studies Identified ADAMTS18 and TGFBR3 as Bone Mass Candidate Genes in Different Ethnic Groups显示文摘 | Dong-Hai Xiong Xiao-Gang Liu Yan-Fang Guo Li-Jun Tan Liang Wang Bao-Yong Sha Zi-Hui Tang Feng Pan Tie-Lin Yang Xiang-Ding Chen Shu-Feng Lei Laura M. Yerges Xue-Zen Zhu Victor W. Wheeler Alan L. Patrick ClareAnn H. Bunker Yan Guo Han Yan Yu-Fang Pei Yin-Pi | 2009 | The American Journal of Human Genetics2009，，3： | 1 |
| 11 | 地氟烷与七氟烷在门诊手术全身麻醉维持中的对比研究:对苏醒早晚期及围手术期咳嗽的影响显示文摘背景目前地氧垸已经用于门诊全身麻醉手术的维持阶段,其相对于七氖烷在围手术期的优略性尚存争议。尽管各研究一致指出,地氟烷比七氟烷苏醒更快,但这种差异对苏醒晚期的影响却未有明确报道。并且,地氟烷与七氟烷相比,对咳嗽发生率的影响也存在争议。方法本研究中纳入了130例在全身麻醉下行浅表门诊手术的患者,随机分为2组。所有患者都静脉注射丙泊酚2mg/kg诱导,置入喉罩,采用1%-3%的七氟烷或3%-8%的地氟炕维持麻醉,吸入混合空气或氧气。调节吸入麻醉药的浓度,维持血流动力学稳定,并维持脑电双频谱指数(BIS)于50—60。并用局部浸润和静脉注射酮洛酸30mg镇痛。在手术结束时给予预防性止吐药物,包括昂丹司琼4mg、地塞米松4mg及甲氧氨普胺10mg。评估标准包括睁眼恢复时间,对指令做出反应的时间,定向力恢复的时间,14分快通道评分,首次进食时间,能坐立,可站立,独立行走及出院时间。手术后早期及离院后24小时内,记录患者对于麻醉的满意度,手术后第1天恢复正常活动的能力,不良反应的发生(如咳嗽、意向性运动、氧饱和度〈90%、咽痛及手术后恶心、呕吐),手术后镇痛药及止吐药的使用情况。结果2组患者的流行病学资料相近。尽管围手术期地氯烷组咳嗽的总体发生率高于七氟烷组(分别为60%和32%,P〈0.05),然而在真正应用吸入麻醉药期间(即麻醉维持中),咳嗽发生率的组间差异无显著性。地氧烷组患者苏醒较快,但两组所有患者在离开手术室之前都达到了快通道恢复标准(快通道评分≥12)。此外,离院时间(七氟炕组90±31分钟,地氟炕组98±5分钟)及手术后第1天能恢复正常活动的患者比率(七氟烷48%,地氟炕60%),在两组间的差异无显著性。结论用地氧烷进行维持全身麻醉具有苏醒迅速、咳嗽发生率高的特点。尽管与七氟烷相比,地氟炕在麻醉早期恢复较快,但两组晚期恢复的差异无显著性。两种吸入麻醉药都适用于门诊手术的麻醉。 | Paul F. White Jun Tang Ronald H. Wender Roya Yumul O. lameson Stokes Alexander Sloninsky Robert Naruse Robert Kariger Evelyn Norel Steven Mandel Tom Webb Alan Zaentz 王琦(译) 李文志(校) | 2011 | 麻醉与镇痛2011，7，1： | 1 |
| 12 | Transcriptional regulation af hepatitis B vinls by nuclear hormone receptors is a critical determinant of viral tropism显示文摘 | Hang Tang Alan McLachlan | 2001 | Proc Natl Acad Sci USA2001，98，4： | 1 |
| 13 | National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Utilization of Cardiac Biomarker Testing in Heart Failure显示文摘 | W H. Wilson Tang Gary S. Francis David A. Morrow L Kristin Newby Christopher P. Cannon Robert L. Jesse Alan B. Storrow Robert H. Christenson Robert H. Christenson Fred S. Apple Christopher P. Cannon Gary S. Francis Robert L. Jesse David A. Morrow L Kristi | 2007 | Circulation2007，，5： | 1 |
| 14 | Rare earth element patterns in a Chinese stalagmite controlled by sources and scavenging from karst groundwater显示文摘 | Houyun Zhou Alan Greig Jing Tang Chen-Feng You Daoxian Yuan Xiaoning Tong Ying Huang | 2011 | Geochimica et Cosmochimica Acta2011，，： | 1 |
| 15 | A phase 3, randomized, double-blind, placebo-controlled study of the safety and efficacy of the live, oral adenovirus type 4 and type 7 vaccine, in U.S. military recruits显示文摘 | Robert A. Kuschner Kevin L. Russell Mary Abuja Kristen M. Bauer Dennis J. Faix Howard Hait Jennifer Henrick Michael Jacobs Alan Liss Julia A. Lynch Qi Liu Arthur G. Lyons Mohammad Malik James E. Moon Jeremiah Stubbs Wellington Sun Doug Tang Andrew C. Towl | 2013 | Vaccine2013，，28： | 1 |
| 16 | High-speed transmission of adaptively modulated optical OFDM signals over multimode fibers using directly modulated DFBs显示文摘 | Tang J M Lane P M Alan K | 2006 | IEEE Lightwave Technology2006，24，1： | 1 |
| 17 | Results of the PROspective MInnesota Study of ECHO/TDI in Cardiac Resynchronization Therapy (PROMISE-CRT) Study显示文摘 | Alan J. Bank Christopher L. Kaufman Aaron S. Kelly Kevin V. Burns Stuart W. Adler Tom S. Rector Steven R. Goldsmith Maria-Teresa P. Olivari Chuen Tang Linda Nelson Andrea Metzig | 2009 | Journal of Cardiac Failure2009，，： | 1 |
| 18 | Maximizing the Transmission Performance of Adaptively Modulated Optical OFDM Signals in Multimode-Fiber Links by Optimizing Analog-to-Digital Converters 显示文摘 | Tang J M Alan Shore K | 2007 | Lightwave Technol2007，25，： | 1 |
| 19 | Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis显示文摘 | Benjamin MP Tang Guy D Eslick Caryl Nowson Caroline Smith Alan Bensoussan | 2007 | 2007 (9588)2007，，9588： | 1 |
| 20 | High-speedtransmission of adaptively modulated optical OFDM signalsover multimode fibers using directly modulated DFBs 显示文摘 | Tang J M Alan Shore K Lane P M | 2006 | JLightwave Technol2006，24，1： | 1 |
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