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| 1 | The Chinese Society of Clinical Oncology(CSCO):clinical guidelines for the diagnosis and treatment of gastric cancer显示文摘China is one of the countries with the highest incidence of gastric cancer.There are differences in epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selection between gastric cancer patients from the Eastern and Western countries.Non-Chinese guidelines cannot specifically reflect the diagnosis and treatment characteristics for the Chinese gastric cancer patients.The Chinese Society of Clinical Oncology(CSCO)arranged for a panel of senior experts specializing in all sub-specialties of gastric cancer to compile,discuss,and revise the guidelines on the diagnosis and treatment of gastric cancer based on the findings of evidence-based medicine in China and abroad.By referring to the opinions of industry experts,taking into account of regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted experts’consensus judgement on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes.This guideline uses tables and is complemented by explanatory and descriptive notes covering the diagnosis,comprehensive treatment,and follow-up visits for gastric cancer. | Feng-Hua Wang Lin Shen Jin Li Zhi-Wei Zhou Han Liang Xiao-Tian Zhang Lei Tang Yan Xin Jing Jin Yu-Jing Zhang Xiang-Lin Yuan Tian-Shu Liu Guo-Xin Li Qi Wu Hui-Mian Xu Jia-Fu Ji Yuan-Fang Li Xin Wang Shan Yu Hao Liu Wen-Long Guan Rui-Hua Xu | 2019 | Cancer Communications2019，39，1： | 127 |
| 2 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 3 | New generation of multi-scale NWP system (GRAPES):general scientific design显示文摘A new generation of numerical prediction system GRAPES (a short form of Global/Regional Assimilation and PrEdiction System) was set up in China Meteorological Administration (CMA). This paper focuses on the scientific design and preliminary results of the numerical prediction model in GRAPES, including basic idea and strategy of the general scientific design, multi-scale dynamic core, physical package configuration, architecture and parallelization of the codes. A series of numerical experiments using the real data with horizontal resolutions from 10 to 280 km and idealized experiments with very high resolution up to 100 m are conducted, giving encouraging results supporting the multi-scale application of GRAPES. The results of operational implementation of GRAPES model in some NWP centers are also presented with stress at evaluations of the capability to predict the main features of precipitation in China. Finally the issues to be dealt with for further development are discussed. | CHEN DeHui XUE JiShan YANG XueSheng ZHANG HongLiang SHEN XueShun HU JiangLin WANG Yu JI LiRen CHEN JiaBin | 2008 | Chinese Science Bulletin2008，53，22： | 70 |
| 4 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 5 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 6 | Southwest monsoon changes indicated by oxygen isotope of ostracode shells from sediments in Qinghai Lake since the late Glacial显示文摘The δ 18O records of ostracode shells in sediments of core QH-2000 from Qinghai Lake can be used as a better proxy to reflect monsoon changes. Low monsoon precipitation between 17.5 and 11 cal. ka BP is indicated by positive δ 18O values averaging 2.37‰. A fast shift in δ 18O from positive at 11 cal. ka BP to negative at 10 cal. ka BP indicates sharp increase of monsoon precipitation. An interval of generally high monsoon precipitation is observed between 10 and 6 cal. ka BP with δ 18O values averaging -2.15‰. Decrease of monsoon precipitation between 6 and 2.5 cal. ka BP is indicated by positive δ 18O values. δ 18O keeps positive values averaging 3.0‰ between 2.5 and 0 cal. ka BP suggesting low high monsoon precipitation. The climatic changes indicated by δ 18O records of ostracode shells in sedi- ments of core QH-2000 from Qinghai Lake and our broader regional comparison show that the climate in Qinghai Lake since the late Glacial is probably controlled by southwest monsoon other than southeast monsoon. | LIU XingQi SHEN Ji WANG SuMin WANG YongBo LIU WeiGuo | 2007 | Chinese Science Bulletin2007，52，4： | 39 |
| 7 | Research on trusted computing and its development显示文摘Trusted computing is a novel technology of information system security. It has become a new tide in worldwide information security area and achieved inspiring accomplishment. In China, the initiative research of trusted computing is not late, and the achievements are plentiful and substantial. Our country is in the front rank of the world in trusted computing. This paper comprehensively illustrates the recent development in theory and technology of trusted computing, introduces some improvements in trusted computing in our country, and proposes our opinions and viewpoints towards the existing problems in trusted computing and its future development. | SHEN ChangXiang ZHANG HuanGuo WANG HuaiMin WANG Ji ZHAO Bo YAN Fei YU FaJiang ZHANG LiQiang XU MingDi | 2010 | Science China(Information Sciences)2010，53，3： | 37 |
| 8 | Early Cretaceous extensional structures in the Liaodong Peninsula:Structural associations,geochronological constraints and regional tectonic implications显示文摘Various extensional structures,e.g.,half grabens,detachment faults,and metamorphic core complexes,were formed in the Liaodong Peninsula.There are two metamorphic core complexes (mcc's) in the western part of the Peninsula,i.e.the Liaonan mcc and the Wanfu mcc.They share the same lower plate and constitute a conjugate mcc pair.The Dayingzi detachment fault system and the three half grabens are exposed in the central and eastern parts,respectively.U-Pb dating of zircons from syntectonic plutons in the lower plates of the detachment faults and volcanic rocks from half graben basins indicates that their formation spans from 135 to 106 Ma,although the individual structure may be formed at a particular stage.Despite the differences in age of formation,in the regional attitudes,and in rooting depths,the extensional structures have great similarities in their kinematics,geometrical asymmetry,and coeval tectono-magmatic activities etc.Macroscopically,the extensional structures constitute conjugate associations,but a particular one generally has asymmetric patterns.Early Cretaceous extensional structures extend from the Liaodong Peninsula to North China,Northeast China,South China,and eastern Mongolia and Transbaikal area in Russia.The extensional structures from different areas share many common features.The Liaodong Peninsula is the miniature of the East Asia with respect to the formation of extensional structures in Early Cretaceous.It is suggested that the interaction of the Izanagi Plate with Eurasia Plate is responsible for the extension of crust.The structural mobility of the lithosphere,partly attributed to the fluid flow at the depth,and detachment faulting in both the crustal and mantle lithosphere provide important constraints on the development of Early Cretaceous extensional structures in the East Asia. | LIU JunLai JI Mo SHEN Liang GUAN HuiMei Gregory A DAVIS | 2011 | Science China Earth Sciences2011，54，6： | 38 |
| 9 | A 16000-year pollen record of Qinghai Lake and its paleoclimate and paleoenvironment显示文摘The paleoclimate and paleoenvironment of Qinghai Lake indicated by a 16000-year pollen record are as follows. It was very cold and dry before 15200 years. During the Late Glacial, the climate varied from colder and semiarid to cool and semi-humid and fluctuated frequently but with little amplitude. Three cold events in the periods of 13400-13000, 11600-12000, and 11000-10400 aBP respectively correspond to the Oldest Dryas, Older Dryas and Younger Dryas events, whereas the two warm periods between them, 12000-13000 and 11600-11000 aBP, respectively correspond to Boiling and Allerod periods. The temperature increased abruptly after the Younger Dryas event, and then the climate gradually turned to be warm and wet from warm and semiarid. In the Holocene, the largest amplitude of cold event that occurred at ca. 8200 aBP is quite prominent. The Holocene climatic optimum culminated at 6700 aBP. After 2100 aBP, the climate tended to be cold and dry, keeping on up to now. Palaeoclimatic evolution and events of | LIU Xingqi SHEN Ji WANG Sumin YANG Xiangdong TONG Guobang ZHANG Enlou | 2002 | Chinese Science Bulletin2002，47，22： | 33 |
| 10 | Holocene vegetational and climatic variation in westerly-dominated areas of Central Asia inferred from the Sayram Lake in northern Xinjiang,China显示文摘Changes in the vegetation and climate of the westerly-dominated areas in Central Asia during the Holocene were interpreted using pollen-assemblages and charcoal data from a 300-cm-long sediment core of the Sayram Lake,northern Xinjiang.Accele-rator Mass Spectrometry(AMS) radiocarbon dating methods were applied to bulk organic matter of the samples.Artemisia spp./Chenopodiaceae ratios and results from principal component analysis were used to infer that the lake basin was dominated by desert vegetation before ca.9.6 cal.ka BP,which suggests a warm and dry climate in the early Holocene.Desert steppe/steppe expanded during 9.6-5.5 cal.ka BP,indicating a remarkable increase both in the precipitation and temperature during the mid-Holocene.Desert vegetation dominated between 6.5 and 5.5 cal.ka BP,marking an extreme warmer and drier interval.The steppe/meadow steppe recovered,and temperatures decreased from 5.5 cal.ka BP in the late Holocene,as indicated by the increased abundance of Artemisia and the development of meadows.Holocene temperatures and moisture variations in the Sayram Lake areas were similar to those of adjacent areas.This consistency implies that solar radiation was the main driving factor for regional temperature changes,and that the effect of temperature variations was significant on regional changes in humidity.The evolution of climate and environment in the Sayram Lake areas,which were characterized as dry in the early Holocene and relatively humid in the middle-late Holocene,are clearly different from those in monsoonal areas.Dry conditions in the early Holocene in the Sayram Lake areas were closely related to decreased water vapor advection.These conditions were a result of reduced westerly wind speeds and less evaporation upstream,which in turn were caused by seasonal changes in solar radiation superimposed by strong evaporation following warming and drying local climate. | JIANG QingFeng JI JunFeng SHEN Ji Ryo MATSUMOTO TONG GuoBang QIAN Peng REN XueMei YAN DeZhi | 2013 | Science China Earth Sciences2013，56，3： | 32 |
| 11 | A high-resolution climatic change since Holocene inferred from multi-proxy of lake sediment in westerly area of China显示文摘Multi-proxy data are presented and a discuss is made of paleoclimatic and paleoenvironmental changes during Holocene from a 225-cm-long sediment core from Wulungu Lake, located in westerly area of China. The chronology is constructed from six AMS radiocarbon dates on the bulk organic matter. Analyses of pollen, TOC, TN, δ 13Corg, ostracod assemblages and the shell stable isotopes, suggest Holocene climate pattern as follows: temperate and dry (10.0―7.6 cal. ka BP)-warm and wet (7.6―5.3 cal. ka BP) -warm and moist (5.3―3.6 cal. ka BP) -temperate and dry (3.6―2.1 cal. ka BP)-temperate and moist (2.1―1.3 cal. ka BP) -cool and dry (1.3 cal. ka BP―present). With the climatic change, Wulungu Lake experienced two large-scale retreat (5.3―3.6 cal. ka BP and 1.3 cal. ka BP―present) and an obvious transgression (7.6―5.3 cal. ka BP). The records of climatic and environmental evolution of Wulungu Lake were in good accordance with those of adjacent areas. It responded to regional environmental change, global abrupt climate events and followed the westerly climate change mode. | JIANG QingFeng SHEN Ji LIU XingQi ZHANG EnLou XIAO XiaYun | 2007 | Chinese Science Bulletin2007，52，14： | 28 |
| 12 | Trends in particulate matter and its chemical compositions in China from 2013–2017显示文摘Accurate determination of the atmospheric particulate matter mass concentration and chemical composition is helpful in exploring the causes and sources of atmospheric enthalpy pollution and in evaluating the rationality of environmental air quality control strategies.Based on the sampling and chemical composition data of PM2.5 in different key regions of China in the CARE-China observation network,this research analyzes the environmental air quality data released by the China National Environmental Monitoring Centre during the studied period to determine the changes in the particulate matter mass concentration in key regions and the evolution of the corresponding chemical compositions during the implementation of the Action Plan for Prevention and Control of Air Pollution from 2013-2017.The results show the following.(1)The particulate matter mass concentration in China showed a significant downward trend;however,the PM2.5 annual mass concentration in 64%of cities exceeds the New Chinese Ambient Air Quality Standard(CAAQS)GradeⅡ(GB3095-2012).The region to the east of the Taihang Mountains,the Fenhe and Weihe River Plain and the Urumqi-Changji regions in Xinjiang,all have PM2.5 concentration loading that is still high,and heavy haze pollution occurred frequently in the autumn and winter.(2)During the heavy pollution in the autumn and winter,the concentrations of sulfate and organic components decreased significantly.The mean SO42-concentration in PM2.5 decreased by 76%,12%,81%and 38%in Beijing-Tianjin-Hebei(BTH),the Pearl River Delta(PRD),the Sichuan-Chongqing region(SC)and the Fenhe and Weihe River Plain,respectively.The mean organic matter(OM)concentration decreased by 70%,44%,48%and 31%,respectively,and the mean concentration of NH4+decreased by 68%,1.6%,38%and 25%,respectively.The mean elemental carbon(EC)concentration decreased by 84%and 20%in BTH and SC,respectively,and it increased by 61%and 11%in the PRD and Fenhe and Weihe River Plain,respectively.The mean concentration of mineral and unresolved chemical components(MI)dropped by 70%,24%and 13%in BTH,the PRD and the Fenhe and Weihe River Plain,respectively.The change in the PM2.5 chemical composition is consistent with the decrease of the PM2.5mass concentration.(3)In 2015,the mean OM concentration contributions to fine particles and coarse particles were 13-46%and 46-57%,respectively,and the mean MI concentration contributions to fine particles and coarse and particles were 31-60%and 39-73%,respectively;these values are lower than the 2013 values from the key regions,which is the most important factor behind the decrease of the particulate matter mass concentration.From 2013 to 2015,among the chemical components of different particle size fractions,the peak value of the coarse particle size fraction decreased significantly,and the fine particle size fractions of SO42-,NO3-,and NH4+decreased with the decrease of the particulate matter mass concentration in different particle size fractions.The fine-particle size peaks of SO42-,NO3-and NH4+shifted from 0.65-1.1μm to the finer size range of0.43-0.65μm during the same time frame. | Yuesi WANG Wenjie LI Wenkang GAO Zirui LIU Shili TIAN Rongrong SHEN Dongsheng JI Shuai WANG Lili WANG Guiqian TANG Tao SONG Mengtian CHENG Gehui WANG Zhengyu GONG Jiming HAO Yuanhang ZHANG | 2019 | Science China Earth Sciences2019，62，12： | 23 |
| 13 | Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and Hippocampal BDNF–TrkB Signaling显示文摘Depression is a debilitating psychiatric disorder with a huge socioeconomic burden, and its treatment relies on antidepressants including selective serotonin reuptake inhibitors(SSRIs). Recently, the melatonergic system that is closely associated with the serotonergic system has been implicated in the pathophysiology and treatment of depression. However, it remains unknown whether combined treatment with SSRI and melatonin has synergistic antidepressant effects. In this study, we applied a sub-chronic restraint stress paradigm, and evaluated the potential antidepressant effects of combined fluoxetine and melatonin in adult male mice. Sub-chronic restraint stress(6 h/day for 10 days) induced depression-like behavior as shown by deteriorated fur state, increased latency to groom in the splash test, and increased immobility time in the forced-swim test. Repeated administration of either fluoxetine or melatonin at 10 mg/kg during stress exposure failed to prevent depression-like phenotypes. However,combined treatment with fluoxetine and melatonin at theselected dose attenuated stress-induced behavioral abnormalities. Moreover, we found that the antidepressant effects of combined treatment were associated with the normalization of brain-derived neurotrophic factor(BDNF)–tropomyosin receptor kinase B(Trk B) signaling in the hippocampus, but not in the prefrontal cortex. Our findings suggest that combined fluoxetine and melatonin treatment exerts synergistic antidepressant effects possibly by restoring hippocampal BDNF–Trk B signaling. | Kun Li Si Shen Yu-Tian Ji Xu-Yun Li Li-San Zhang Xiao-Dong Wang | 2018 | Neuroscience Bulletin2018，34，2： | 20 |
| 14 | Infliximab monotherapy for Chinese patients with moderate to severe plaque psoriasis: a randomized, double-blind, placebo-controlled multicenter trial显示文摘 | YANG Hai-zhen WANG Ke JIN Hong-zhong GAO Tian-wen XIAO Sheng-xiang XU Jin-hua WANG Bao-xi ZHANG Fu-ren LI Chun-yang LIU Xiao-ming TU Cai-xia JI Su-zhen SHEN Yang ZHU Xue-jun | 2012 | Chinese Medical Journal2012，，11： | 20 |
| 15 | Spatiotemporal variations of Chinese lakes and their driving mechanisms since the Last Glacial Maximum:A review and synthesis of lacustrine sediment archives显示文摘In this article,the author provides the first synthesis and classification of available environment-indicating proxies for lacustrine sediment.A review of spatio-temporal variations in lakes from the Tibetan Plateau,the dry areas of Northwestern China,the Yunnan-Guizhou Plateau and the plains of Eastern China since the LGM is then provided.The driving mechanism for variations in lake processes and characteristics is also discussed based on various temporal scales.The author then proposes that future investigations be conducted to:(1) strengthen the study of theoretics and interpretation of environment-indicating proxies,(2) enhance the study of high-resolution time series and spatial variability of lake environment evolution,(3) provide more attention on the influence of human activities on lake environments,and(4) boost construction of the Quaternary lake database of China. | SHEN Ji | 2013 | Chinese Science Bulletin2013，58，1： | 20 |
| 16 | Effects of Tongxinluo-facilitated cellular cardiomyoplasty with autologous bone marrow-mesenchymal stem cells on postinfarct swine hearts显示文摘<正> Background Treatment of ischemic heart disease remains an important challenge,though there have been enormousprogresses in cardiovascular therapeutics.This study was conducted to evaluate whether Tongxinluo(TXL)treatmentaround the transplantation of mesenchymal stem cells(MSCs)can improve survival and subsequent activities ofimplanted cells in swine hearts with acute myocardial infarction(AMI)and reperfusion.Methods Twenty-eight Chinese mini-pigs were divided into four groups including a control group(n=7);group 2,administration of low-dose TXL alone from the 3rd day prior to AMI to the 4th day post transplantation(n=7);group 3,MSCs alone(n=7)and group 4,TXL+MSCs(n=7).AMI models were made by occlusion of the left anterior descendingcoronary artery for 90 minutes.Autologous bone marrow-MSCs(3×10~7 cells/animal)were then injected into thepost-infarct myocardium immediately after AMI and reperfusion.The survival and differentiation of implanted cells in vivowere detected by immunofluorescent analysis.The data of cardiac function were obtained at baseline(1 week aftertransplantation)and endpoint(6 weeks after transplantation)by single photon emission computed tomography(SPECT)and magnetic resonance imaging(MRI).Apoptosis was detected by TUNEL assay and the oxidative stress level wasinvestigated in the post-infarct myocardium at endpoint.Results At endpoint,there was less fibrosis and inflammatory cell infiltration with more surviving myocardium in group 4than in the control group.In group 4 the survival and differentiation of implanted MSCs were significantly improved morethan that seen in group 3 alone(P<0.0001);the capillary density was also significantly greater than in the control group,group 2 or 3 both in the infarcted zone(P<0.0001)and the peri-infarct zone(P<0.0001).MRI showed that parameters atbaseline were not significantly different between the 4 groups.At endpoint,regional wall thickening and the left ventricularejection fraction were increased while the left ventricular mass index,dyskinetic segments and infarcted size weredecreased only in group 4 compared with control group(P<0.0001).SPECT showed that the area of perfusion defectwas significantly decreased at endpoint only in group 4 compared with control group(P<0.0001).TUNEL assay indicatedthat TXL administration significantly decreased cell apoptosis in peri-infarct myocardium in groups 2 and 4.Furthermore,superoxide dismutase(SOD)significantly increased and malondialdehyde(MDA)decreased in groups 2 and 4 by theadministration of TXL.Conclusions Our study demonstrates the following:(1)immediate intramyocardial injection of MSCs after AMI andreperfusion resulted in limited survival and differentiation potential of implanted cells in vivo,thus being incapable ofbeneficially affecting post-hearts;(2)TXL-facilitation resulted in a significant survival and differentiation potential ofimplanted cells in vivo via inhibition of apoptosis and oxidative stress,accompanied by significant benefits in cardiacfunction.Chin Med J 2007;120(16) | QIAN Hai-yan YANG Yue-jin HUANG Ji GAO Run-lin DOU Ke-fei YANG Guo-sheng LI Jian-jun SHEN Rui HE Zuo-xiang LU Min-jie ZHAO Shi-hua | 2007 | Chinese Medical Journal2007，，16： | 19 |
| 17 | The Association between Lower Incisal Inclination and Morphology of the Supporting Alveolar Bone—A Cone-Beam CT Study显示文摘Aim To investigate the relationship between the positioning of the lower central incisor and physical morphology of the surrounding alveolar bone. Methodology Thirty-eight patients (18 males, 20 females), with mean age of 13.4 years, were included in this study. As part of orthodontic treatment planning the patients were required to take dental Cone-beam CT (CBCT) covering the region of lower incisors, the surrounding alveolar bone and the mandibular symphysis. The cephalometric parameters were designed and measured to indicate the inclination of lower central incisor and physical morphology of the adjacent alveolar bone. Computer-aided descriptive statistical analysis was performed using SPSS 15.0 software package for Windows. A correlation analysis and a linear regression analysis between the incisor inclination and the alveolar bone morphology were performed. Results Significant positive correlations were found between the lower central incisor inclination and the morphological contour of the alveolar bone (P<0.05). The lower central incisor root apex was closer to the lingual alveolar crest when it was buccally inclined. Conclusion The morphology of the alveolar bone may be affected by incisal inclination. | Quan Yu Xiao-gang Pan Guo-ping Ji Gang Shen | 2009 | International Journal of Oral Science2009，1，4： | 19 |
| 18 | The Dayingzi detachment fault system in Liaodong Peninsula and its regional tectonic significance显示文摘Large scale lithosphere thinning is an important characteristic of the destruction of the North China Craton (NCC) during the late Mesozoic. A series of extensional structures were developed under extensional setting, among which is the Dayingzi detachment fault system (DFS). The DFS is constituted by three parts, volcano-sedimentary basins at the hanging wall, the Dayingzi-Huanghuadian detachment fault zone, and Paleoproterozoic metamorphic rock series and Mesozoic plutons at the foot-wall. In the section across the detachment fault zone, there is a sequence of tectonites including fault gouge, microbreccia, cataclastic-mylonites, mylonites, and gneissic biotite monzonite granite. Microstructural characteristics of tectonites and electron backscatter diffraction (EBSD) patterns of quartz indicate that the rocks from the footwall experienced a process from upper greenschist facies to lower greenschist facies. SHRIMP and LA-ICP MS U-Pb dating of zircons from the volcanic rocks in the basins, the tectonic evolution of the DFS is summarized as follows: 1) regional extension started at 135.0±1.2 Ma ago, when the detachment fault cut through the middle crust. Faulting induced the upwelling of magma and eruption of volcanic rocks and deformed a series of medium-acid volcanic rocks; 2) after 135.0±1.2 Ma, a large scale detachment faulting was active cross-cutting the mid-upper crust. The western margin of Jurassic and Triassic granite was ductilly and brittly sheared; besides, the Cretaceous volcano-sedimentary rocks were tilted when the master fault approached the surface; 3) at around 127±1 Ma, the detachment fault stopped its activity and was intruded by the unsheared Cretaceous granite near Chaoyang. Comparison with the Liaonan metamorphic core complex (MCC) and other extensional structures in Liaodong Peninsula led to a general trend of including three zones in the Peninsula: MCC zone, detachment fault systems (DFS) zone, and half graben zone. MCC commonly cuts through the mid-lower crust, DFS through the mid-upper crust, and half graben through the upper crust. Therefore, development of the extensional structures in Liaodong Peninsula indicates that they are the results of crustal extension and thinning at different crustal levels. They may provide a deep insight into the dynamic mechanism, history of destruction and lithosphere thinning of the North China Craton (NCC). | SHEN Liang LIU JunLai HU Ling JI Mo GUAN HuiMei Gregory A DAVIS | 2011 | Science China Earth Sciences2011，54，10： | 17 |
| 19 | Carbon monoxide-induced adventitious rooting of hypo-cotyl cuttings from mung bean seedling显示文摘In this paper, the regulatory role of ex-ogenous carbon monoxide (CO) during the genera-tion and development of adventitious roots in mung bean (Phaseolus radiatus L. cv. Mingguang) hypo-cotyl cuttings was surveyed. The results indicated that, like nitric oxide (NO), CO donor Hematin in-duced adventitious rooting in dose- and time-de- pendent manners. These responses were also prov- en by the addition of gaseous CO aqueous solution with different concentrations. Additionally, the above CO-mediated effect was differently reversed when CO scavenger hemoglobin (Hb), CO specific syn-thetic inhibitor ZnPPIX, the auxin transport inhibitor NPA and nitric oxide synthase (NOS) inhibitor L-NAME were added with Hematin, respectively. Furthermore, after being treated with CO for 36 h, NO fluorescence was significantly enhanced and mainly distributed in the zone of vascular bundles whereas the specific NO scavenger cPTIO significantly inhib-ited NO fluorescence induced by CO, indicating that CO induces adventitious rooting of hypocotyl cuttings from mung bean seedling probably mediated by NO/NOS pathway. | XU Ji XUAN Wei HUANG Benkai ZHOU Yehua LING Tengfang XU Sheng SHEN Wenbiao | 2006 | Chinese Science Bulletin2006，51，6： | 16 |
| 20 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
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