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| 1 | Peripheral T-lymphocyte subpopulations in different clinical stages of chronic HBV infection correlate with HBV load显示文摘AIM: To characterize the peripheral T-cell subpopulation profiles and their correlation with hepatitis B virus (HBV) replication in different clinical stages of chronic HBV infection.METHODS: A total of 422 patients with chronic HBV infection were enrolled in this study. The patients were divided into three stages: immune-tolerant stage, immune active stage, and immune-inactive carrier stage. Composition of peripheral T-cell subpopulations was determined by flow cytometry. HBV markers were detected by enzyme-linked immunosorbent assay. SerumHBV DNA load was assessed by quantitative real-time polymerase chain reaction.RESULTS: CD8+ T-cells were significantly higher in patients at the immune-tolerant stage than in patients at the immune-active and -inactive carrier stages (36.87 ± 7.58 vs 34.37 ± 9.07, 36.87 ± 7.58 vs 28.09 ± 5.64, P < 0.001). The peripheral blood in patients at the immune-tolerant and immune active stages contained more CD8+ T-cells than CD4+ T-cells (36.87 ± 7.58 vs 30.23 ± 6.35, 34.37 ± 9.07 vs 30.92 ± 7.40, P < 0.01), whereas the peripheral blood in patients at the immune-inactive carrier stage and in normal controls contained less CD8+ T-cells than CD4+ T-cells (28.09 ± 5.64 vs 36.85 ± 6.06, 24.02 ± 4.35 vs 38.94 ± 3.39, P < 0.01). ANOVA linear trend test showed that CD8+ T-cells were signif icantly increased in patients with a high viral load (39.41 ± 7.36, 33.83 ± 7.50, 31.81 ± 5.95 and 26.89 ± 5.71, P < 0.001), while CD4+ T-cells were signif icantly increased in patients with a low HBV DNA load (37.45 ± 6.14, 33.33 ± 5.61, 31.58 ± 6.99 and 27.56 ± 5.49, P < 0.001). Multiple regression analysis displayed that log copies of HBV DNA still maintained its highly signif icant coefficients for T-cell subpopulations, and was the strongest predictors for variations in CD3+, CD4+ and CD8+ cells and CD4+/CD8+ ratio after adjustment for age at HBV-infection, maternal HBV-infection status, presence of hepatitis B e antigen and HBV mutation.CONCLUSION: Differences in peripheral T-cell subpopulation profi les can be found in different clinical stages of chronic HBV infection. T-cell impairment is signifi cantly associated with HBV load. | Jing You Lin Zhuang Yi-Feng Zhang Hong-Ying Chen Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Teerha Piratvisuth Edward McNeil Lan Yu Bao-Zhang Tang .lun-Hua Huang | 2009 | World Journal of Gastroenterology2009，15，27： | 39 |
| 2 | Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B显示文摘AIM: To investigate peripheral T-lymphocyte sub-population profile and its correlation with hepatitis B virus (HBV) replication in patients with chronic hepatitis B (CHB).METHODS: Distribution of T-lymphocyte subpopulations in peripheral blood was measured by flow cytometry in 206 CHB patients. HBV markers were detected with ELISA. Serum HBV DNA load was assessed with quantitative real-time polymerase chain reaction (PCR). The relationship between HBV replication and variation in peripheral T-cell subsets was analyzed.RESULTS: CHB patients had significantly decreased CD3+ and CD4+ cells and CD4+/CD8+ ratio, and increased CD8+ cells compared with uninfected controls (55.44 ± 12.39 vs 71.07 ± 4.76, 30.92 ± 7.48 vs 38.94 ± 3.39, 1.01 ± 0.49 vs 1.67 ± 0.33, and 34.39 ± 9.22 vs 24.02 ± 4.35; P < 0.001, respectively). Univariate analysis showed a similar pattern of these parameters was significantly associated with high viral load, presence of serum hepatitis B e antigen (HBeAg) expression, liver disease severity, history of maternal HBV infection, and young age at HBV infection, all with P < 0.01. There was a significant linear relationship between viral load and these parameters of T-lymphocyte subpopulations (linear trend test P < 0.001). There was a negative correlation between the levels of CD3+ and CD4+ cells and CD4+/CD8+ ratio and serum level of viral load in CHB patients (r = -0.68, -0.65 and -0.75, all P < 0.0001), and a positive correlation between CD8+ cells and viral load (r = 0.70, P < 0.0001). There was a significant decreasing trend in CD3+ and CD4+ cells and CD4+/CD8+ ratio with increasing severity of hepatocyte damage and decreasing age at HBV infection (linear trend test P < 0.01). In multiple regression (after adjustment for age at HBV infection, maternal HBV infection status and hepatocyte damage severity) log copies of HBV DNA maintained a highly significant predictive coefficient on T-lymphocyte subpopulations, and was the strongest predictor of variation in CD3+, CD4+, CD8+ cells and CD4+/CD8+ ratio. However, the effect of HBeAg was not significant.CONCLUSION: T-lymphocyte failure was signifi-cantly associated with viral replication level. The substantial linear dose-response relationship and strong independent predictive effect of viral load on T-lymphocyte subpopulations suggests the possibility of a causal relationship between them, and indicates the importance of viral load in the pathogenesis of T cell hyporesponsiveness in these patients. | Jing You Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Lin Zhuang Hong-Ying Chen Lan Yu Bao-Zhang Tang Jun-Hua Huang | 2008 | World Journal of Gastroenterology2008，14，7： | 30 |
| 3 | The non-canonical Hippo/Mst pathway in lymphocyte development and functions显示文摘正规 Hippo/Mst 小径,原来在果蝇发现了,以它在支持 apoptosis,禁止房间增长和 tumorigenesis,并且调整织物的功能著名新生。然而,新兴的证据证明多重不在经典中的河马发信号小径也在许多其他的生物过程的规定被含有。最近的研究揭示了那 Mst1/2, Hippo/Mst 小径的核心 kinases 为 T 房间开发,功能,幸存, trafficking,和 homing 被要求,并且也在 autoimmunity 的规定包含了。在这评论,我们讨论在淋巴细胞开发和功能表明小径的不在经典中的 Hippo/Mst 的角色。 | Xingrong Du Alan Yu Wufan Tao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，1： | 8 |
| 4 | Efficacy of thymosin alpha-1 and interferon alpha in treatment of chronic viral hepatitis B:A randomized controlled study显示文摘AIM: To observe the efficiency and safety of thymosin-α1 treatment in patients with hepatitis B e antigen (HBeAg) and HBV DNA positive chronic hepatitis. METHODS: Sixty-two patients were randomly divided into groups A and B. The patients in group A received subcutaneous injection of 1.6 mg thymosin-α1, twice a week (T-α1 group) for six months, and the patients in group B received 5 MU interferon alpha (IFN-α) each day for fifteen days, then three times weekly (IFN-α group) for six months. The results between two groups treated with and the group untreated with IFN-α which was followed up for 12 mo (historical control group consisting of 30 patients) were compared, and three groups were comparable between each other (P > 0.05) at baseline (age, sex, clinical history, biochemical, and serological parameters). RESULTS: At the end of treatment, complete response, which was defined as alanine aminotransferase (ALT) normalization and HBV DNA and HBeAg loss, occurred in 9 of 29 (31.0%) patients in the T-α1 group and in 15 of 33 (45.5%) patients in the IFN-α group (c2 = 1.36, P >0.05). After a follow-up period of six months, a complete response was observed in 14 of 29 (48.3%) patients in the T-α1 group and in 9 of 33 (27.3%) patients in the IFN-α group (c2 = 2.93, P > 0.05). Compared with the results observed in the historical control (HC) group untreated with IFN-α which was followed up for 12 mo, the rate of complete response was significantly higher in IFN-α group at the end of therapy (1 of 30 vs 15 of 33, c2 = 14.72, P < 0.001) and in the T-α1 group at the end of follow-up (1 of 30 vs 14 of 29, c2 = 15.71, P < 0.001). In T-α1 and IFN-α treatment groups, the area under (the plasma concentration time) curve (AUC) of negative HBV DNA and HBeAg was 34%, 17%, 31% and 19% smaller than that in the HC group. By the end of the follow- up period, the proportions of ALT normalization and negative HBV DNA in the T-α1 group were significantly higher than those in the IFN-α and HC groups. The odds of ALT normalization and negative HBV DNA at the end of the follow-up was three-fold higher in the T-α1 group than in the IFN-α group. Unlike IFN-α, T-α1 was well tolerated by all patients, and no side effects appeared in T-α1 group.CONCLUSION: The results suggest that a 6-mo course of T-α1 therapy is effective and safe in patients with chronic hepatitis B. T-α1 is able to reduce HBV replication in patients with chronic hepatitis B. Furthermore, T-α1 is better tolerated than IFN-α and can gradually induce more sustained ALT normalization and HBV DNA and HBeAg loss. However, a response rate of 48.3% is still less ideal. A more effective therapeutic approach warrants further study. | Jing You Lin Zhuang Hong-Ying Cheng Shou-Ming Yan Lan Yu Jun-Hua Huang Bao-Zhang Tang Meng-Ling Huang Yong-Liang Ma Virasakdi Chongsuvivatwong Hutcha Sriplung Alan Geater Yan-Wei Qiao Rong-Xue Wu | 2006 | World Journal of Gastroenterology2006，12，41： | 8 |
| 5 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet . 2013 (9882)2013，，9882： | 4 |
| 6 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet2013，，9882： | 3 |
| 7 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | 2013 (9882)2013，，9882： | 3 |
| 8 | Hydrolysis of filter-paper cellulose to glucose by two recombinant endogenous glycosyl hydrolases of Coptotermes formosanus显示文摘 | Dunhua Zhang Alan R. Lax John M. Bland Jiujiang Yu Natalie Fedorova William C. Nierman | 2010 | Insect Science2010，17，3： | 3 |
| 9 | Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer显示文摘 | Li Chaoyang Yu Shuiliang Nakamura Fumihiko Yin Shaoman Xu Jinghua Petrolla Amber A Singh Neena Tartakoff Alan Abbott Derek W Xin Wei Sy Man-Sun | 2009 | Journal of Clinical Investigation2009，，9： | 1 |
| 10 | Endothelial progenitor cells in infantile hemangioma显示文摘 | Ying Yu Alan F John B | 2004 | Blood2004，103，4： | 1 |
| 11 | Dose Dependent Effects of Intraoperative Low Volume Red Blood Cell Transfusions on Postoperative Outcomes in Cardiac Surgery Patients显示文摘 | Pey-Jen Yu Hugh A. Cassiere Sophia L. Dellis Rick A. Esposito Nina Kohn Donna LaConti Alan R. Hartman | 2014 | Journal of Cardiothoracic and Vascular Anesthesia2014，，： | 1 |
| 12 | Environmental-adaptive RSSI-based Indoor Locatization显示文摘 | Alan H S Yu W | 2009 | IEEE Transactions on Automation Science and Engineering2009，6，4： | 1 |
| 13 | Blind MPEG -2 video watermarking robust against geometric attacks: a set of approaches in DCT domain 显示文摘 | WANG Yu -lin Alan Pearmain | 2006 | Image Processing2006，，： | 1 |
| 14 | Studies on the structure–activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents显示文摘 | Ben Li Eric Dale Jones Enkun Zhou Li Chen Dean Cameron Baylis Shanghai Yu Miao Wang Xing He Jonathan Alan Victor Coates David Ian Rhodes Gang Pei John Joseph Deadman Xin Xie Dawei Ma | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，17： | 1 |
| 15 | Elite endurance athletes and the ACE I allele – the role of genes in athletic performance显示文摘 | George Gayagay Bing Yu Brett Hambly Tanya Boston Alan Hahn David S. Celermajer R. J. Trent | 1998 | Human Genetics1998，，1： | 1 |
| 16 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet2013，，9882： | 1 |
| 17 | Electrochemical properties of luminescent polymers and polymer light-emitting electrochemical cells显示文摘 | Yongfang Li Yong Cao Jun Gao Deli Wang Gang Yu Alan J Heeger | 1999 | Synthetic Metals1999，，3： | 1 |
| 18 | Theoretical analysis of PAM-N and M-QAM BER computation with single-sideband signal显示文摘In this paper,the theoretical bit error rate(BER)of N-level pulse amplitude modulation(PAMN)and M-ary quadrature amplitude modulation(M-QAM)have been studied and compared under different scenarios,including(i)PAM with intensity modulation with direct detection(IM/DD)and field modulation with detection(FMD)(including coherent detection and single-sideband modulation with direct detection(SSB-DD)),and(ii)QAM with coherent detection and SSB-DD.Considering the relationship between the symbol spacing and signal-to-noise ratio(SNR),we provide the mathematical BER equations,including the optical signal-to-noise ratio(OSNR)and carrier-to-signal power ratio(CSPR),especially for PAM signals.To verify the validity of our theoretical expressions for SSB systems,transmissions with 224-Gb/s SSBPAM4/16QAM signals using the Kramers-Kronig(KK)receiver were implemented on a unified optical system platform.The simulation results agreed well with theoretical calculations both in back-to-back(BtB)and 120-km transmission scenarios,which showed that the BER evaluation methods can serve as a theoretical guidance and system assessment criteria for SSB scenarios. | Dongxu LU Xian ZHOU Yuqiang YANG Jiahao HUO Jinhui YUAN Keping LONG Changyuan YU Alan Pak Tao LAU Chao LU | 2021 | Science China(Information Sciences)2021，64，8： | 1 |
| 19 | Quantitative comparison of plantar foot shapes under different weight-bearing conditions显示文摘 | Ming Zhang Yu Bo Fan David Alan Boone | 2003 | Journal of Rehabilitation Research and Development2003，40，6： | 1 |
| 20 | Extensive Miocene speciation in and out of Indochina:The biogeographic history of Typhonium sensu stricto(Araceae)and its implication for the assembly of Indochina flora显示文摘The Asian paleotropical flora is characterized by abundance of endemic species,high biodiversity,and complex geological and climatic histories.However,the main driving mechanism underlying such high tropical biodiversity remains unclear.Hence,the present study aimed to investigate the biogeographic origin of the Asian paleotropical flora by tracking the speciation and diversification history of a typical tropical perennial,Typhonium sensu stricto(s.s.)(Araceae),using a time-calibrated whole-plastome phylogeny.In particular,we tested whether the Asian paleotropic region is a macroevolutionary source or sink.We observed that Typhonium s.s.originated in Indochina during the early–middle Miocene epoch,ca.17.24 Ma(95%highest posterior density[HPD]:12.83̶21.99 Ma).Most of the in situ diversification within the genus Typhonium s.s.has been underway since 14.73 Ma,with an accelerated lineage diversification at ca.15−17 Ma,which may have been triggered by the intensification of the Asian monsoon system around the middle Miocene.Furthermore,the underground tuberous stem of Typhonium s.s.might have played an essential role in the adaptation to the seasonality caused by the monsoon in Indochina.Our results also suggested that peripatric speciation may be important in the diversification of T.trilobatum and T.roxburghii.This study provides a framework for studies in biogeography and evolution of the Asian paleotropical flora. | Shook Ling Low Chih-Chieh Yu Im Hin Ooi Wichan Eiadthong Alan Galloway Zhe-Kun Zhou Yao-Wu Xing | 2021 | Journal of Systematics and Evolution2021，59，3： | 1 |
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