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| 1 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 2 | Assessment of oocyte quality following repeated gonadotropin stimulation in the mouse 显示文摘 | Combelles C M Albertini D F | 2003 | Biology of Reproduction2003，68，3： | 1 |
| 3 | Testing individual risk of acute mountain sickness at greater altitudes 显示文摘 | TANNHEIMER M ALBERTINI N ULMER H V | 2009 | Mil Med2009，174，4： | 1 |
| 4 | Assessment of oocyte quality following repeated gonadotropin stimulation in the mouse显示文摘 | COMBELLES C M ALBERTINI D F | 2003 | Biol Reprod2003，68，3： | 1 |
| 5 | Anemia of chronic disease and defective erythropoietin production in patients with celiac disease显示文摘 | Bergamaschi G Markopoulos K Albertini M | 2008 | Hematologica2008，93，12： | 1 |
| 6 | Static magnetic fields affect cell size, shape, orientation, and membrane surface of human glioblastoma cells, as demonstrated by electron, optic, and atomic force microscopy 显示文摘 | Teodori L Albertini M C Uguccioni F | 2006 | Cytometry A2006，69，2： | 1 |
| 7 | Microtubule patterning during meiotic maturation in mouse oo- cytes is determined by cell cycle-specific sorting and redistribution of gamma-tubulin显示文摘 | COMBELLES M H ALBERTINI D F | 2001 | Dev Biol2001，239，2： | 1 |
| 8 | Origins and manifestations of oocyte maturation competencies显示文摘 | Albertini D F Sanfins A Combelles C M | 2003 | Reprod Biomed Online2003，6，4： | 1 |
| 9 | Sequence completion, identification and definition of the fengycin operon in Bacillus subtilis 168显示文摘 | Tosato V Albertini A M Zotti M | 1997 | Microbiology1997，143，11： | 1 |
| 10 | Testing individual risk of acute mountain sickness at greater altitudes 显示文摘 | Tannheimer M Albertini N Ulmer HV | 2009 | Mil Med2009，174，4： | 1 |
| 11 | Usefulness of changes inexercise tolerance induced by nitroglycerin in identifying patientswith syndrome X显示文摘 | Radice M Giudici Y Albertini A | 1994 | Am Heart J1994，127，3： | 1 |
| 12 | Distinct structural rearrangements of the VSV glycoprotein drive membrane fusion 显示文摘 | LIBERSOU S ALBERTINI A OULDALI M | 2010 | The Journal of Cell Biology2010，191，1： | 1 |
| 13 | AFLP fingerprinting in Pelargonium peltatum:its development and potential in cultivar identification显示文摘 | BARCACCIA G ALBERTINI E FALCINELLI M | 1999 | Hortic Sci Biotechnol1999，74，： | 1 |
| 14 | Aneuploidy: A report of an ECETOC task force 显示文摘 | Aardema M Albertini S Ami P | 1998 | Mutation Research: Reviews in Mutation Research1998，410，1： | 1 |
| 15 | DennieMorgan fold plus dark circles:suspect atopy at first sight显示文摘 | Blanc S Bourrier T Albertini M | 2015 | J Pediatr2015，166，6： | 1 |
| 16 | Biomarkers for assessing occupational exposure to 1,3- butadiene 显示文摘 | ALBERTINI R J SRAM R J VACEK P M | 2001 | Chem Biol Interact2001，，： | 1 |
| 17 | Secondhand smoke exposure in hospitality venues in Europe 显示文摘 | Lopez M J Nebot M Albertini M | 2008 | Environ Health Perspect2008，116，11： | 1 |
| 18 | Melatonin reduces en- doplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia-ischemia显示文摘 | Carloni S Albertini M C Galluzzi L et aI | 2014 | J Pineal Res2014，57，2： | 1 |
| 19 | Role of endothelin ETA receptors in sepsis-induced mortality, vascular leakage, and tissue injury in rats显示文摘 | Albertini M Clement MG Hussain SN | 2003 | Eur J Pharmacol2003，474，1： | 1 |
| 20 | Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins 显示文摘 | ABUJA P M ALBERTINI R | 2001 | Cliniea Chimiea Aeta2001，306，12： | 1 |
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