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| 1 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 2 | Testing individual risk of acute mountain sickness at greater altitudes 显示文摘 | TANNHEIMER M ALBERTINI N ULMER H V | 2009 | Mil Med2009，174，4： | 1 |
| 3 | Characterization and taste-masking evaluation of acetaminophen granules:comparison between different preparation methods in a high-shear mixer显示文摘 | Albertini B Cavallari C Passerini N | 2004 | Eur J Pharm Science2004，21，23： | 1 |
| 4 | Testing individual risk of acute mountain sickness at greater altitudes 显示文摘 | Tannheimer M Albertini N Ulmer HV | 2009 | Mil Med2009，174，4： | 1 |
| 5 | Preparation and characterisation of ibuprofen-poloxamer 188 granules obtained by melt granulation显示文摘 | Passerini N Albertini B Marisa L | 2002 | Eur J Pharm Sci2002，15，2： | 1 |
| 6 | Retiform hemangioendothelioma developed on the site of an earlier cystic lymphangioma in a six-year-old girl 显示文摘 | Albertini AF Brousse N Bodemer C | 2011 | Am J Dermatopathol2011，33，7： | 1 |
| 7 | Characterization and taste-masking evaluation of acetaminophen granules: comparison between different preparation methods in a high- shear mixer 显示文摘 | Albertini B Cavallari C Passerini N | 2004 | EurJPharm Sci2004，21，23： | 1 |
| 8 | Oxidative stress in patients with acute heart failure显示文摘 | Charniot JC Vignat N Albertini JP | 2008 | Rejuvenation Res2008，11，2： | 1 |
| 9 | Characterization and taste-masking evaluation of acetaminophen granules:comparison between different preparation methods in a high-shear mixer显示文摘 | Albertini B Cavallari C Passerini N | 2004 | European Journal of Pharmaceutical Sciences2004，21，23： | 1 |
| 10 | Preparation and characterisation of ibuprofen-poloxamer 188 granules obtained by melt granulation显示文摘 | Passerini N Albertini B Gonzalez-Rodriguez ML | 2002 | Eur J Pharm Sci2002，15，1： | 1 |
| 11 | Preparation and characterisation of ibuprofen-poloxamer 188granules obtained by melt granulation显示文摘 | PASSERINI N ALBERTINI B GONZALEZ RODRIGUEZ ML etal | 2002 | Eur J Pharm Sci2002，15，1： | 1 |
| 12 | Melt ga'anulation of phar- maceutical powders: A comparison of high-shear mixer and flu- idized bed processes 显示文摘 | Passerini N Calogera G Albertini B | 2010 | Int J Pharm2010，391，12： | 1 |
| 13 | Evaluation of melt granulation and ultrasonic spray congealing as techniques to enhance the dissolution of praziquantel 显示文摘 | Passerini N Albertini B Perissutti B | 2006 | Int J Pharm2006，318，12： | 1 |
| 14 | Development of microparticulate systems for intestinal delivery of Lactobacillus acidophilus and Bifidobacterium lactis显示文摘 | Albertini B Vitali B Passerini N | 2010 | Eur J Pharm Sci2010，40，4： | 1 |
| 15 | Arterial hypoxia induced by fiberoptic bronchoscopy显示文摘 | Harrell JH Kurihara N | 1974 | JAMA1974，230，： | 1 |
| 16 | Evaluation of melt gran- ulation and ultrasonic spray congealing as techniques to enhance the dissolution of praziquantel显示文摘 | Passerini N Albertini B Perissutti B | 2006 | Int J Pharm2006，318，3： | 1 |
| 17 | Poloxamer 407 microspheres for orotransmucosal drug delivery,part Ⅰ:Formulation,manufacturing and characterization显示文摘 | Albertini B Passerini N Sabatino MD | 2010 | Int J Pharm2010，399，12： | 1 |
| 18 | Evaluation of melt granulation and ultrasonic spray congealing as techniques to enhance the dissolution of praziquantel 显示文摘 | Passerini N Albertini B Perissutti B | 2006 | Int J Pharm2006，318，3： | 1 |
| 19 | Testing individual risk of acute mountain sickness at greater altitudes 显示文摘 | Tannheimer M Albertini N Ulmer HV | | 0，，04： | 1 |
| 20 | Evaluation of beta-lactose, PVP K12 and PVP K90 as excipients to prepare piroxicam granules using two wet granulation techniques 显示文摘 | Albertini B Cavallari C Passerini N | 2003 | Eur J Pharm Biopharm2003，56，3： | 1 |
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