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| 1 | Nature:揭示干细胞惊人异质性显示文摘论文作者George Daley教授说:"这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。"研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们的发育景观。随后,他们分析了每个细胞的遗传组成,观察了每个细胞多能状态的微小波动。他们发现内部、化学和环境信号影响干细胞方式的许多细微差异,揭示出了复杂的发育调控因子"决策"回路。 | Roshan M.Kumar Patrick Cahan Alex K.Shalek Rahul Satija A.Jay Daley Keyser Hu Li Jin Zhang Keith Pardee David Gennert John J.Trombetta Thomas C.Ferrante Aviv Regev George Q.Daley James J. Collins | 2014 | 岭南现代临床外科2014，14，6： | 10 |
| 2 | Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage Ⅱ and Ⅲ rectal adenocarcinoma:The Freiburg experience(1989-2002)显示文摘AIM:To evaluate the long-term outcome of standard5-FU based adjuvant or neoadjuvant radiochemotherapyand to identify the predictive factors,especially anemiabefore and after radiotherapy as well as hemoglobinincrease or decrease during radiotherapy.METHODS:Two hundred and eighty-six patientswith Union International Contre Cancer(UICC)stageⅡ and Ⅲ rectal adenocarcinomas,who underwentresection by conventional surgical techniques(lowanterior or abdominoperineal resection),receivedeither postoperative(n=233)or preoperative(n=53)radiochemotherapy from January 1989 until July 2002.Overall survival(OAS),cancer-specific survival(CSS),disease-free survival(DFS),local-relapse-free(LRS)and distant-relapse-free survival(DRS)were evaluatedusing Kaplan-Meier,Log-rank test and Cox's proportionalhazards as statistical methods.Multivariate analysis wasused to identify prognostic factors.Median follow-uptime was 8 years.RESULTS:Anemia before radiochemotherapy was anindependent prognostic factor for improved DFS(riskratio 0.76,P=0.04)as well as stage,grading,R status(free radial margins),type of surgery,carcinoembryonicantigen(CEA)levels,and gender.The univariate analysisrevealed that anemia was associated with impaired LRS (better local control)but with improved DFS.In contrast,hemoglobin decrease during radiotherapy was anindependent risk factor for DFS(risk ratio 1.97,P=0.04).During radiotherapy,only 30.8% of RO-resected patientssuffered from hemoglobin decrease compared to 55.6%if R1/2 resection was performed(P=0.04).The 5-yearOAS,CSS,DFS,LRS and DRS were 47.0%,60.0%,41.4%,67.2%,and 84.3%,respectively.Significantdifferences between preoperative and postoperativeradiochemotherapy were not found.CONCLUSION:Anemia before radiochemotherapyand hemoglobin decrease during radiotherapy have nopredictive value for the outcome of rectal cancer.Stage,grading,R status(free radial margins),type of surgery,CEA levels,and gender have predictive value for theoutcome of rectal cancer. | Christian Weissenberger Geissler Michael Otto Florian Barke Annette Henne Karl von Plehn Georg Rein Alex Müller Christine Bartelt Susanne Henke Michael | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 3 | Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) supports adhesion and migration of mesenchymal stem cells and tenocytes显示文摘AIM: To establish the potential of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) as a material for tendon repair. METHODS: The biocompatibility of PHBHHx with both rat tenocytes (rT) and human mesenchymal stem cells (hMSC) was explored by monitoring adhesive characteristics on films of varying weight/volume ratios coupled to a culture atmosphere of either 21% O2 (air) or 2% O2 (physiological normoxia). The diameter and stiffness of PHBHHx films was established using optical coherence tomography and mechanical testing, respectively. RESULTS: Film thickness correlated directly with weight/volume PHBHHx (r2 = 0.9473) ranging from 0.1 mm (0.8% weight/volume) to 0.19 mm (2.4% weight/volume). Film stiffness on the other hand displayed a biphasic response which increased rapidly at values > 1.6% weight/volume. Optimal cell attachment of rT required films of ≥ 1.6% and ≥ 2.0% weight/volume PHBHHx in 2% O2 and 21% O2 respectively. A qualitative adhesion increase was noted for hMSC in films ≥ 1.2% weight/volume, becoming significant at 2% weight/volume in 2% O2. An increase in cell adhesion was also noted with ≥ 2% weight/volume PHBHHx in 21% O2. Cell migration into films was not observed. CONCLUSION: This evaluation demonstrates that PHBHHx is a suitable polymer for future cell/polymer replacement strategies in tendon repair. | Alex J Lomas George GQ Chen Alicia J El Haj Nicholas R Forsyth | 2012 | World Journal of Stem Cells2012，4，9： | 2 |
| 4 | Experimental Validation of a New Ultrasound Method for the Simultaneous Assessment of Radial and Longitudinal Myocardial Deformation Independent of Insonation Angle显示文摘 | Stian Langeland Jan D’hooge Patrick F. Wouters H Alex Leather Piet Claus Bart Bijnens George R. Sutherland | 2005 | Circulation2005，，14： | 2 |
| 5 | Mortality pattern in children:A hospital based study in Nigeria 显示文摘 | George IO Alex Hart BA Frank Briggs A/ | 2009 | Int J Biomed Sci2009，5，4： | 1 |
| 6 | A new algorithm for on- line structure and parameter adaptation of RBF networks显示文摘 | ALEX A HARALAMBOS S GEORGE B | 2003 | Neural Networks2003，16，7： | 1 |
| 7 | A new algorithm for online structure and parameter adaptation of RBF networks显示文摘 | ALEX A HARALAMBOS S GEORGE B | 2003 | Neural Networks2003，16，： | 1 |
| 8 | Positive solutions to a singular third - order three - point boundary value problem with an indefinitely signed Green' s function 显示文摘 | Alex P Palamides George Smyrlis | 2008 | Nonlinear Analysis2008，，68： | 1 |
| 9 | Gangdese retroarc thrust belt and foreland basin deposits in the Damxung area, southern Tibet显示文摘 | Alex Pullen Paul Kapp George E. Gehrels Peter G. DeCelles Edwin H. Brown J. Matthew Fabijanic Lin Ding | 2008 | Journal of Asian Earth Sciences2008，，5： | 1 |
| 10 | Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast显示文摘 | Dmitry K. Pokholok Christopher T. Harbison Stuart Levine Megan Cole Nancy M. Hannett Tong Ihn Lee George W. Bell Kimberly Walker P. Alex Rolfe Elizabeth Herbolsheimer Julia Zeitlinger Fran Lewitter David K. Gifford Richard A. Young | 2005 | Cell2005，，4： | 1 |
| 11 | Non-small cell lung carcinoma(NSCLC):Implications on molecular pathology and advances in early diagnostics and therapeutics显示文摘Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) provides the foundation for therapeutic advances by promoting molecular targeted and immunotherapies and ensuring accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention, diagnosis, and management, supporting health-care interventions. Global cancer mortality projections from 2016 to 2060 show that cancer will overtake ischemic heart diseases (IHD) as the leading cause of death (18.9 million) immediately after 2030, surpassing non-small cell lung cancer (NSCLC), which accounts for 85 percent of lung cancers. The clinical stage at the diagnosis is the main prognostic factor in NSCLC therapies. Advanced early diagnostic methods are essential as the initial stages of cancer show reduced mortality compared to the advanced stages. Sophisticated approaches to proper histological classification and NSCLC management have improved clinical efficiency. Although immune checkpoint inhibitors (ICIs) and targeted molecular therapies have refined the therapeutic management of late-stage NSCLC, the specificity and sensitivity of cancer biomarkers should be improved by focusing on prospective studies, followed by their use as therapeutic tools. The liquid biopsy candidates such as circulating tumor cells (CTCs), circulating cell-free tumor DNA (cfDNA), tumor educated platelets (TEP), and extracellular vesicles (EVs) possess cancer-derived biomolecules and aid in tracing: driver mutations leading to cancer, acquired resistance caused by various generations of therapeutic agents, refractory disease, prognosis, and surveillance. | Hafiza Padinharayil Jinsu Varghese Mithun Chacko John Golgodu Krishnamurthy Rajanikant Cornelia M.Wilson Minnatallah Al-Yozbaki Kaviyarasi Renu Saikat Dewanjee Rupa Sanyal Abhijit Dey Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Abilash Valsala Gopalakrishnan Alex George | 2023 | Genes & Diseases2023，10，3： | 1 |
| 12 | A new algorithm for online structure and parameter adaptation of RBF networks 显示文摘 | Alexandridis Alex Bafas George | 2003 | Neural Networks(S0893-6080)2003，16，7： | 1 |
| 13 | Short-Term Outcomes Following Open Versus Minimally Invasive Esophagectomy for Cancer in England: A Population-Based National Study显示文摘 | Ravikrishna Mamidanna Alex Bottle Paul Aylin Omar Faiz George B. Hanna | 2012 | Annals of Surgery2012，，2： | 1 |
| 14 | A new algorithm for developing dynamic radial basis function neural network models based on genetic algorithms显示文摘 | Haralambos Sarimveis Alex Alexandridis Stefanos Mazarakis George Bafas | 2004 | Computers and Chemical Engineering (S0098-1354)2004，28，2： | 1 |
| 15 | Force Generation by Actin Polymerization II: The Elastic Ratchet and Tethered Filaments显示文摘 | Alex Mogilner George Oster | 2003 | Biophysical Journal2003，，3： | 1 |
| 16 | A new algorithm for online structure and parameter adaptation of RBF networks显示文摘 | Alex A Haralambos S George B | 2003 | Neural Networks (0893 - 6080)2003，，16： | 1 |
| 17 | Mixed micelles of some anionic-anionic, cationic-cationic, and ionic-nonionic surfactants in aqueous media显示文摘 | Sambhav Vora Alex George Hemangi Desai Pratap Bahadur | 1999 | Journal of Surfactants and Detergents1999，，2： | 1 |
| 18 | Characterization of Enzyme-deproteinized Skim Rubber显示文摘 | Mariamma George K Rosamma Alex Susamma Joseph | 2009 | Journal of Applied Polymer Science2009，114，5： | 1 |
| 19 | Big Data Analytics for Earth Sciences:the EarthServer approach显示文摘Big Data Analytics is an emerging field since massive storage and computing capabilities have been made available by advanced e-infrastructures.Earth and Environmental sciences are likely to benefit from Big Data Analytics techniques supporting the processing of the large number of Earth Observation datasets currently acquired and generated through observations and simulations.However,Earth Science data and applications present specificities in terms of relevance of the geospatial information,wide heterogeneity of data models and formats,and complexity of processing.Therefore,Big Earth Data Analytics requires specifically tailored techniques and tools.The EarthServer Big Earth Data Analytics engine offers a solution for coverage-type datasets,built around a high performance array database technology,and the adoption and enhancement of standards for service interaction(OGC WCS and WCPS).The EarthServer solution,led by the collection of requirements from scientific communities and international initiatives,provides a holistic approach that ranges from query languages and scalability up to mobile access and visualization.The result is demonstrated and validated through the development of lighthouse applications in the Marine,Geology,Atmospheric,Planetary and Cryospheric science domains. | Peter Baumann Paolo Mazzetti Joachim Ungar Roberto Barbera Damiano Barboni Alan Beccati Lorenzo Bigagli Enrico Boldrini Riccardo Bruno Antonio Calanducci Piero Campalani Oliver Clements Alex Dumitrua,Mike Grant Pasquale Herzig George Kakaletris John Laxton Panagiota Koltsida Kinga Lipskoch Alireza Rezaei Mahdiraji Simone Mantovani Vlad Merticariu Antonio Messina Dimitar Misev Stefano Natali Stefano Nativi Jelmer Oosthoek Marco Pappalardo James Passmore Angelo Pio Rossi Francesco Rundo Marcus Sen Vittorio Sorbera Don Sullivan Mario Torrisi Leonardo Trovato Maria Grazia Veratelli Sebastian Wagner | 2016 | International Journal of Digital Earth2016，9，1： | 1 |
| 20 | Oral Chinese herbal medicine (CHM) as an adjuvant treatment during chemotherapy for non-small cell lung cancer: A systematic review显示文摘 | Sisi Chen Andrew Flower Andrew Ritchie Jianping Liu Alex Molassiotis He Yu George Lewith | 2009 | Lung Cancer2009，，2： | 1 |
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