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| 1 | Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes显示文摘Background:To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus(DCP)metrics in patients with diabetes mellitus(DM).Methods:563 eligible eyes(221 with no diabetic retinopathy[DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography-angiography(OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Tokyo,Japan).Strict criteria were applied to exclude from analysis those DCP images with artifacts and of poor quality,including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality score.A customized MATLAB program was then used to quantify DCP morphology from the artifact-free DCP images by calculating three metrics:foveal avascular zone(FAZ),vessel density(VD),and fractal dimension(FD).Results:166(29.5%)eyes were excluded after quality control,leaving in the analysis 397 eyes(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 subjects.In the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity(VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;p<0.001)and with older age(β=−0.142;p=0.004).Conclusions:Quantitative artifact-free DCP metrics are associated with VA,DR severity,AL,subfoveal choroidal thickness,age,and BMI in diabetic patients.The effects of ocular and systemic factors should be considered for meaningful interpretations of DCP changes in DM patients. | Fang Yao Tang Erica O.Chan Zihan Sun Raymond Wong Jerry Lok Simon Szeto Jason C.Chan Alexander Lam Clement C.Tham Danny S.Ng Carol Y.Cheung | 2020 | Eye and Vision2020，7，1： | 7 |
| 2 | Pandemic of the aging society—sporadic cerebral small vessel disease显示文摘Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population.The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD.In this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD. | Alexander Yuk Lun Lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka Lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 3 | Liver transplantation for acute-on-chronic liver failure显示文摘 | Albert C. Chan Sheung Tat Fan Chung Mau Lo Chi Leung Liu See Ching Chan Kelvin K. Ng Boon Hun Yong Alexander Chiu Banny K. Lam | 2009 | Hepatology International2009，，4： | 2 |
| 4 | Dexmedetomidine use in critical care 显示文摘 | Lam SW Alexander E Suisa GM | 2008 | AACN Adv Crit Care2008，19，2： | 1 |
| 5 | Dexmedetomidine use in criticalcare显示文摘 | Lam SW Alexander E | 2008 | AACN Adv Crit Care2008，19，2： | 1 |
| 6 | Dexmedetomidine use in critical care显示文摘 | Lam SW Alexander E | 2008 | AACN Adv Crit Care2008，19，2： | 1 |
| 7 | Dexmedetomidine use in critical care显示文摘 | LAM SW ALEXANDER E | 2008 | AACN Adv Crit Care2008，19，2： | 1 |
| 8 | Dexmedetomidine use in critical care显示文摘 | Lam S W Alexander E | 2008 | AACN Adv Crit Care2008，19，1： | 1 |
| 9 | Dexmedetomidine use in critical care显示文摘 | Lam SW Alexander E | 2008 | AACN Adv Crit Care2008，19，2： | 1 |
| 10 | Dexmedetomidine use in criti-cal care显示文摘 | Lam SW Alexander E Sulsa GM | 2008 | AACN Advanced Crlt Care2008，19，2： | 1 |
| 11 | Dexmedetomidine use in critical care显示文摘 | Lam SW Alexander E | 2008 | AACN Adv Crit Care2008，19，2： | 1 |
| 12 | Dexmedetomidine use in critical care显示文摘 | Lam SW Alexander E | 2008 | AACN Adv Crit Care2008，19，2： | 1 |
| 13 | Dexmedetomidine use in critical care显示文摘 | Lam SW Alexander E Sulsa GM | 2008 | AACN Advanced Crit Care2008，19，2： | 1 |
| 14 | dexmedetomidine use in critical carc 显示文摘 | Lam SW Alexander E | 2008 | AACN Adv Critic Care2008，19，2： | 1 |
| 15 | Dexmedetomidine use in critical care显示文摘 | Lam S W Alexander E | 2008 | AACN Adv Crit Care2008，19，2： | 1 |
| 16 | Dexmedetomidine use in critical care显示文摘 | Lam SW Alexander E | 2008 | AACN Adv Crit Care2008，19，2： | 1 |
| 17 | Systematic review and meta - analysis of the clinical effectiveness of bipolar compared with monopolar transurethral resection of the prostate (TURP) 显示文摘 | Omar M1 Lam TB Alexander CE | 2014 | BJU Int2014，113，1： | 1 |
| 18 | Dexmedetomidine use in critical care显示文摘 | LAM S W ALEXANDER E | 2008 | AACN Adv Crit Care2008，19，2： | 1 |
| 19 | Dexmedetomidine use in critical care显示文摘 | LAM S W ALEXANDER E | 2008 | AACN Adv Crit Care2008，19，： | 1 |
| 20 | Liver transplantation for acute-on-chronic liver failure显示文摘 | Albert C. Chan Sheung Tat Fan Chung Mau Lo Chi Leung Liu See Ching Chan Kelvin K. Ng Boon Hun Yong Alexander Chiu Banny K. Lam | 2009 | Hepatology International2009，，4： | 1 |
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