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| 1 | Cerebral aneurysm treatment: modern neurovascular techniques显示文摘Endovascular treatment of cerebral aneurysm continues to evolve with the development of new technologies.This review provides an overview of the recent major innovations in the neurointerventional space in recent years. | Bowen Jiang Michelle Paff Geoffrey P Colby Alexander L Coon Li-Mei Lin | 2016 | Stroke & Vascular Neurology2016，1，3： | 6 |
| 2 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 3 | Three-dimensional oste- ogenic and chondrogenic systems to model osteochondral physio- logy and degenerative joint diseases显示文摘 | Alexander P G Gottardi R Lin H | 2014 | Exp Biol Med2014，239，9： | 1 |
| 4 | Ap- plication of visible light-based projection stereolithog- raphy for live cell-scaffold fabrication with designed ar- chitecture 显示文摘 | LIN H ZHANG D ALEXANDER P G | 2013 | Biomaterials2013，34，2： | 1 |
| 5 | Lama Glama Mast Cell Tumors in a Llama (Lama Glama)显示文摘 | Tzu-Yin Lin Alexander H Rebecca P | 2010 | J VET Diagn In- vest2010，22，： | 1 |
| 6 | Richardson Skeletal muscle oxidative metabolism in sedentary humans:31P MRS assessment of O2 supply and demand limitations显示文摘 | Luke J Haseler Alexander P Lin Russell S | 2004 | J Appl Physiol2004，97，： | 1 |
| 7 | Utilization of the Navien distal intracranial catheter in 78 cases of anterior circulation aneurysm treatment with the Pipeline embolization device显示文摘 | Geoffrey P Colby Li-Mei Lin Judy Huang Rafael J Tamargo Alexander L Coon | 2013 | Journal of NeuroInterventional Surgery . 2013 (Supp)2013，，： | 1 |
| 8 | Advances in endovascular aneurysm management: flow modulation techniques with braided mesh devices显示文摘Flow diverters and flow disruption technology,alongside nuanced endovascular techniques,have ushered in a new era of treating cerebral aneurysms.Here,we provide an overview of the latest flow modulation devices and highlight their clinical applications and outcomes. | Jessica K Campos Barry Cheaney II Brian V Lien David A Zarrin Chau D Vo Geoffrey P Colby Li-Mei Lin Alexander L Coon | 2020 | Stroke & Vascular Neurology2020，5，1： | 1 |
| 9 | Multimodal management of giant cerebral aneurysms: review of literature and case presentation显示文摘The pathophysiology of giant cerebral aneurysms renders them difficult to treat.Advances in technology have attempted to address any shortcomings associated with open surgery or endovascular therapies.Since the introduction of the flow diversion technique,the endovascular approach with flow diversion has become the first-line modality chosen to treat giant aneurysms.A subset of these giant aneurysms may persistent despite any treatment modality.Perhaps the best option for these recurrent and/or persistent giant aneurysms is to employ a multimodal approach-both surgical and endovascular-rather than any single technique to provide a curative result with favourable patient outcomes.This paper provides a review of the histopathology and treatment options for giant cerebral aneurysms.Additionally,an illustrative case is presented to highlight the unique challenges of a curative solution for giant cerebral aneurysms that persist despite initial treatment. | Jessica K Campos Benjamin Z Ball Barry Cheaney II Alexander J Sweidan Bima J Hasjim Frank P K Hsu Alice S Wang Li-Mei Lin | 2020 | Stroke & Vascular Neurology2020，5，1： | 0 |
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