|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Correlation of Helicobacter pylori Genotypes with Gastric Histopathology in the Central Region of a South-European Country显示文摘 | Nuno Almeida Maria Manuel Donato José Manuel Rom?ozinho Cristina Luxo Olga Cardoso Maria Augusta Cipriano Carol Marinho Alexandra Fernandes Carlos Sofia | 2015 | Digestive Diseases and Sciences2015，，1： | 1 |
| 2 | Mechanical Characterisation of Porous Glass Reinforced Hydroxyapatite Ceramics Bonelike 显示文摘 | Marcelo Henrique Prado da Silvaa Alexandra Fernandes | 2003 | Materials Research2003，16，3： | 1 |
| 3 | Study of antimicrobial activity and atomic force microscopy imaging of the action mechanism of cashew tree gum显示文摘 | Débora A. Campos Alexandra C. Ribeiro Eduardo M. Costa Jo?o C. Fernandes Freni K. Tavaria Felipe Bastos Araruna Carla Eiras Peter Eaton José Roberto S.A. Leite M. Manuela Pintado | 2012 | Carbohydrate Polymers2012，，1： | 1 |
| 4 | 科技型中小企业专业培训对研发人员离职倾向的影响研究——以工作嵌入为中介变量显示文摘为寻求降低科技型中小企业研发人员离职倾向的路径,文章构建“专业培训—工作嵌入—离职倾向”的研究框架,并考虑员工性别、教育程度和职位层级的调节作用,采用大规模调查问卷的实证方法,通过数据分析发现:专业培训显著降低了研发人员离职倾向,工作嵌入发挥了中介作用,不同特征的员工接受专业培训的效果不同。文章的研究成果丰富了专业培训、工作嵌入等理论内涵并拓展其应用情境,系统地剖析了专业培训针对不同特征研发人员离职倾向的作用机制,具有深刻的理论与实践价值。 | 谷昊 Alexandra Fernandes 丁奕文 | 2024 | 西华大学学报(哲学社会科学版)2024，43，2： | 0 |
| 5 | Professional Knowledge and Professionalism Teaching in Nursing Education显示文摘 | Carla Alexandra Fernandes Nascimento | 2014 | US-China Education Review(A)2014，4，3： | 0 |
| 6 | Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity显示文摘T-cell development ensures the formation of diverse repertoires of T-cell receptors(TCRs)that recognize a variety of antigens.Glycosylation is a major posttranslational modification present in virtually all cells,including T-lymphocytes,that regulates activity/functions.Although these structures are known to be involved in TCR-selection in DP thymocytes,it is unclear how glycans regulate other thymic development processes and how they influence susceptibility to disease.Here,we discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes,as well as dynamic alterations.After restricting the N-glycosylation profile of thymocytes to high-mannose structures,using specific glycoengineered mice(Rag1CreMgat1fl/fl),we showed remarkable defects in key developmental checkpoints,includingß-selection,regulatory T-cell generation andγδT-cell development,associated with increased susceptibility to colon and kidney inflammation and infection.We further demonstrated that a single N-glycan antenna(modeled in Rag1CreMgat2fl/fl mice)is the sine-qua-non condition to ensure normal development.In conclusion,we revealed that mannosylated thymocytes lead to a dysregulation in T-cell development that is associated with inflammation susceptibility. | Manuel M.Vicente Inês Alves Ângela Fernandes Ana M.Dias Beatriz Santos-Pereira Elena Pérez-Anton Sofia Santos Tao Yang Alexandra Correia Anja Münster-Kühnel Afonso R.M.Almeida Sarina Ravens Gabriel A.Rabinovich Manuel Vilanova Ana E.Sousa SaloméS.Pinho | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员