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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Long and fast Up/Down counters 显示文摘 | Mircea R Stan Alexandre F Tenca Milos D Ercegovac | 1998 | IEEE Trans on Computers1998，47，7： | 1 |
| 3 | Early coagulopathy in trauma patients: An on-scene and hospital admission study 显示文摘 | Bernard F Lucia R Alexandre F | 2012 | Injury2012，43，1： | 1 |
| 4 | The cortical column : a new processing unit for muhilayered networks 显示文摘 | Alexandre F Guyot R Haton J | 1991 | Neural Networks1991，4，： | 1 |
| 5 | Extraction of ribosomal RNA and genornic DNA from soil for studying the diversity of the indigenous bacterial community 显示文摘 | Gabriela F D Alexandre S R Lucy S A C | 1998 | J Microbiol Meth1998，32，： | 1 |
| 6 | Efficient synthesis of thiazoloquinazolinone derivatives显示文摘 | ALEXANDRE F R BERECIBAR A WRIGGLESWORTH R | 2003 | Trtra Lett2003，44，： | 1 |
| 7 | Assessment of Lipid Compounds and Phosphorus in Mangrove Sedi- ments of Santa Catarina Island, SC, Brazil 显示文摘 | Mater L Alexandre M R Hansel F A | 2004 | Journal of the Brazilian Chemical Society2004，15，5： | 1 |
| 8 | The element-free galerkin method in three-dimensional electromagnetic problems显示文摘 | Guilherme F Parreira Elson J Silva Alexandre R Fonseca | 2006 | IEEE Transactions on Magnetics2006，42，4： | 1 |
| 9 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HCI solution 显示文摘 | VANESSA V T ROBERTO S A CAMILA F TATIANA L F CARLOS R ALEXANDRE G T ELIANE D | 2011 | Corrosion Science2011，53，： | 1 |
| 10 | Stereoinversion of β-and γ-substituted-α-amino acids using a chemoenzymatic oxidation-reduction procedure显示文摘 | Enright A Alexandre F R Roff G | 2003 | Chem Commun2003，，20： | 1 |
| 11 | Ni - containing mixed oxides as catalysts for the one - step synthesis of methyl - isobutyl - ketone ( MIBK ) from acetone 显示文摘 | Jose L F M Cristiane A H Alexandre C C R | 2009 | Comptes Rendus Chimie2009，12，12： | 1 |
| 12 | Direct synthesis of MIBK from ace- tone over Pd /NaX catalysts 显示文摘 | Alexandre C C R Jose L F M | 2009 | Applied Catalysis A : General2009，362，12： | 1 |
| 13 | Production and charaeterization of bioactive peptides from soy hydrolysate and soy-fermented food显示文摘 | Gibbs B F Alexandre Z Masse R | | 0，，： | 1 |
| 14 | Kinetics of Nanocrystalline MgO Growth by the Sol-gel Combustion Method显示文摘 | Alexandre R B Renata F M O Paula M J | 2014 | Microporous and Mesoporous Materials2014，185，： | 1 |
| 15 | Incremental data-driven learningof a novelty detection model for one-class classification with application to high-dimensional noisy data 显示文摘 | Kassab R Alexandre F | 2009 | (74)2: 191-2342009，，74： | 1 |
| 16 | Genetic diversity of nifH gene sequences in paenibacillus azotofixans strain and soil samples analyzed by denaturing gradient gel electriphoresis of PCR-amplified gene fragments显示文摘 | Alexandre S R Duarte G F Seldin L | 1998 | App Environmental Microbiology1998，64，79： | 1 |
| 17 | Melatonin prevents oxidative stress,inflammatory activity,and DNA damage in cirrhotic rats显示文摘BACKGROUND Cirrhosis is an important health problem characterized by a significant change in liver parenchyma.In animals,this can be reproduced by an experimental model of bile duct ligation(BDL).Melatonin(MLT)is a physiological hormone synthesized from serotonin that has been studied for its beneficial properties,including its antioxidant potential.AIM To evaluate MLT’s effects on oxidative stress,the inflammatory process,and DNA damage in an experimental model of secondary biliary cirrhosis.METHODS Male Wistar rats were divided into 4 groups:Control(CO),CO+MLT,BDL,and BDL+MLT.MLT was administered(20 mg/kg)daily beginning on day 15 after biliary obstruction.On day 29 the animals were killed.Blood samples,liver tissue,and bone marrow were collected for further analysis.RESULTS BDL caused changes in biochemical and histological parameters and markers of inflammatory process.Thiobarbituric acid(0.46±0.01)reactive substance levels,superoxide dismutase activity(2.30±0.07)and nitric oxide levels(2.48±0.36)were significantly lower(P<0.001)n the groups that received MLT.DNA damage was also lower(P<0.001)in MLT-treated groups(171.6±32.9)than the BDL-only group(295.5±34.8).Tissue damage and the expression of nuclear factor kappa B,interleukin-1β,Nrf2,NQO1 and Hsp70 were significantly lower in animals treated with MLT(P<0.001).CONCLUSION When administered to rats with BDL-induced secondary biliary cirrhosis,MLT effectively restored the evaluated parameters. | Josieli R Colares Renata M Hartmann Elizângela G Schemitt Sandielly R B Fonseca Marilda S Brasil Jaqueline N Picada Alexandre S Dias Aline F Bueno Cláudio A Marroni Norma P Marroni | 2022 | World Journal of Gastroenterology2022，28，3： | 1 |
| 18 | Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma显示文摘 | ALEXANDRE P R CAROLINE F ERICA B | 2008 | European Journal of Pharmacology2008，580，： | 1 |
| 19 | Increasing the wear resistance of molds for injection of glass fiber reinforced plastics显示文摘 | Silva F J G Martinho R P Alexandre R J D | | 0，，： | 1 |
| 20 | Novel series of 8H- quinazolino quinazolin-8-ones via two niementowski condensations显示文摘 | Alexandre F R Berecibar A Wrigglesworth R | 2003 | Tetrahedron2003，59，9： | 1 |
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