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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Clinical and Genetic Investigation of a Multi-generational Chinese Family Afflicted with Von Hippel-Lindau Disease显示文摘 | Jingyao Zhang Jie Ma Xiaoyun Du Dapeng Wu Hong Ai Jigang Bai Shunbin Dong Qinling Yang Kai Qu Yi Lyu Robert K Valenzuela Chang Liu | 2015 | Chinese Medical Journal2015，，1： | 6 |
| 3 | Pharmacological studies of human urinary kallidinogenase ( SK-827 ) : effects on arterial and regional blood flow 显示文摘 | Suzuki T Hirooka K Nakamura S et aI | 1993 | App Pharmacol1993，45，： | 1 |
| 4 | An approach to knowledge in database system显示文摘 | Cheek K S Ai K S | 1992 | Application Intellect1992，5，3： | 1 |
| 5 | Detailed measurements of local heat transfer coefficient and adiabatic wall temperature beneath an array of impingement jets 显示文摘 | Van Treuren K Wang Z Ireland P et aI | 1995 | Journal of Turbomachinery1995，116，2： | 1 |
| 6 | Gelation behaviour of konjac glucomannan with different molecular weights显示文摘 | Zhang H Yoshimura M Nishinari K et ai | 2001 | Biopolymers2001，59，1： | 1 |
| 7 | Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with stem cell characteristics显示文摘 | Tai M H Olson L K Madhukar B V et ai | 2003 | Pancreas2003，26，： | 1 |
| 8 | Antimicrobial activity of murine lung cells against Staphylococcus aureus is increased in vitro and in vivo after elafin gene transfer显示文摘 | McMichael JW Maxwell AI Hayashi K | 2005 | Infect Immun2005，73，： | 1 |
| 9 | A highly soluble dimethoxybenzene derivative as a redox shuttle for overcharge protection of secondary lithium batteries显示文摘 | Feng J K Ai X P Cao L | 2006 | Electrochem Commun2006，9，： | 1 |
| 10 | In vitro fertilization and breast cancer risk:a review显示文摘 | SALHAB M ai SARAKBI W MOKBEL K | 2005 | Int J Fertil Womens Med2005，50，6： | 1 |
| 11 | Mixed mode fatigue crack growth criteria显示文摘 | Ai K S Li C B | 2001 | International Journal of Fatigue2001，23，5： | 1 |
| 12 | Development of ultra-precision machining system with unique wire EDM tool fabrica-tion system for micro/nano-machining 显示文摘 | Cheng X Nakamoto K Sugai M et ai | 2008 | CIRP Annals2008，57，1： | 1 |
| 13 | Effects of replacing fish meal with soy protein concentrate on feed intake and growth of juvenile Japanese flounder, Paralichthys olivaceus显示文摘 | Deng J M Mai K S Ai Q H | 2006 | Aquaculture2006，，： | 1 |
| 14 | Self-expanding metallic stent as a bridge to surgery versus emergency resection for obstructing left-sided colorectal cancer:a case-matched study 显示文摘 | Ng K C Law W L Lee Y M et aI | 2006 | J Gas- trointest Surg2006，10，： | 1 |
| 15 | The association of metabolic syndrome with adipose tissue hormones and insulin resistance in patients with COPD without co- morbidities显示文摘 | Minas M Kostikas K Papaioannou AI Mystridou P Karetsi E Georgoulias P Liakos N Pournaras S Gourgoulianis KI | 2011 | COPD2011，8，6： | 1 |
| 16 | Effects of Cr on the properties of Mo2NiB2 ternary boride 显示文摘 | KEN-ICHI T WATARU K AI M | 2012 | Solid State Science2012，14，1112： | 1 |
| 17 | Prevention of gesta- tional diabetes through lifestyle intervention:study design and methods of a finnish randomized controUed multicenter trial (RADIEL) 显示文摘 | RSnfi K Stach - Lempinen B Klemetti MM et aI | 2014 | BMC Pregnancy Childbirth2014，14，： | 1 |
| 18 | Theory of mind, humour processing and executive functioning in alcoholism 显示文摘 | Uekermann J Channon S Winkel K et aI | 2007 | Addiction2007，102，2： | 1 |
| 19 | Birth prevalence of homocystinuria显示文摘 | efsum H Fredriksen A Meyer K et aI | 2014 | J Pediatr2014，144，： | 1 |
| 20 | Molecular genetics of methiciUin -resistant Staphylococcus aureus显示文摘 | I- Katayarna Y Yuzawa H et ai | 2002 | International Journal of Medical Microbiology2002，292，2： | 1 |
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