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| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | Effects of VE on cadmiuminduced locomotor dysfunctions in rats显示文摘 | Ali MM Shukla GS Srivastava RS | 1993 | Vet Hum Toxicol1993，35，： | 2 |
| 3 | Effects of VE on cadmium induced locomotor dysfunctions in rats显示文摘 | Ali MM Shukla GS Snivastva RS | 1993 | Vet Hum Toxicol1993，35，： | 1 |
| 4 | One-stage immediate breast reconstruction with implant following skin-sparing mastectomy in A- sian patients显示文摘 | Wang HY Ali RS Chen SC | 2008 | Ann Plast Surg2008，60，4： | 1 |
| 5 | Genotyping of HCV RNA re- veals that 3a Is the most prevalent genotype in mardan, Pakistan 显示文摘 | Ali S Abmad A Khan RS | 2014 | Adv Virol2014，，60： | 1 |
| 6 | Impact of iron overload in higher risk myelodysplastic syndromes 显示文摘 | KOMROKJI RS ALI NH YEPEZET MC | 2011 | Blood2011，118，： | 1 |
| 7 | Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation显示文摘 | Ali AA Weinstein RS Stewart SA | 2005 | Endocrinology2005，146，3： | 1 |
| 8 | The versatility of the anterolateral thigh flap显示文摘 | Ali RS Bluebond-Langner R Rodriguez ED | 2009 | Plast Reconstr Surg2009，124，： | 1 |
| 9 | Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation显示文摘 | Ali AA Weinstein RS Stewart SA | | 0，，03： | 1 |
| 10 | Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation显示文摘 | Ali AA Weinstein RS Stewart SA | | 0，，： | 1 |
| 11 | Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation 显示文摘 | Ali AA Weinsteiu RS Stewart SA | 2005 | Endocrinology2005，146，3： | 1 |
| 12 | Takieddin a simultaneous determination of metronidazole benzoate methylparaben, and propylparaben by high-Performance liquid chromatography显示文摘 | Ali MS Chaudhary RS Mahmoud A | 2009 | Drug Development and Induslrial Pharmacy2009，25，10： | 1 |
| 13 | One-stage immediate breast reconstruction with implant following skin-sparing mastectomy in Asian patients显示文摘 | Wang HY Ali RS Chen SC | 2008 | Ann Plast Surg2008，60，4： | 1 |
| 14 | Dental erosioncaused by silent gastroesophageal reflux disease显示文摘 | Ali DA Brown RS Rodriguez LO | 2002 | J AmDent Assoc2002，33，6： | 1 |
| 15 | One-stage immediate breast reconstruction with implant following skin-sparing mastectomy in Asian patients显示文摘 | Wang HY Ali RS Chen SC | 2008 | Ann Plast Surg2008，60，4： | 1 |
| 16 | Synthesis and effect of silver nanoparticles on the antibacterial activity of different antibiotics against Staphylococcus aureus and Escherichia coli 显示文摘 | Ahmad RS Ali F Hamid RS | 2007 | NanomedNanotechnol Biol Med2007，3，2： | 1 |
| 17 | Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation显示文摘 | Ali AA Weinstein RS Stewart SA | 2005 | Endocrinology2005，146，3： | 1 |
| 18 | Calcium phosphate microcrystal deposition in the human intervertebral disc 显示文摘 | Lee RS Kayser MV Ali SY | 2006 | J Anat2006，208，1： | 1 |
| 19 | The versatili- ty of the anterolateral thigh flap 显示文摘 | Ali RS Bluebond-Langner R Rodriguez ED | 2009 | Plast Reconstr Surg2009，124，6： | 1 |
| 20 | Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation 显示文摘 | Ali AA Weinstein RS Stewart SA | 2005 | Endocrinology2005，146，3： | 1 |
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