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| 1 | Preparation, characterization and in vivo evaluation of alginate-coated chitosan and trimethylchitosan nanoparticles loaded with PR8 influenza virus for nasal immunization显示文摘For efficient mucosal vaccine delivery, nanoparticulate antigens are better taken by microfold cells in the nasal associated lymphoid tissue and also dendritic cells. Nanoparticles based on polymers such as chitosan(CHT) and its water soluble derivative, trimethylchitosan(TMC), could be successfully used as carrier/adjuvant for this purpose. Sodium alginate, a negatively charged biopolymer, could modify the immunostimulatory properties of CHT and TMC NPs and increase their stability. Sodium alginate(ALG)-coated chitosan(CHT)and trimethylchitosan(TMC) nanoparticles(NPs) loaded with inactivated PR8 influenza virus were successfully prepared by direct coating of the virus with CHT or TMC polymers to evaluate their immunoadjuvant potential after nasal immunization. After nasal immunizations in BALB/c mice, PR8-CHT formulation elicited higher IgG2 a and Ig G1 antibody titers compared with PR8-TMC. ALG coating of this formulation(PR8-CHT-ALG) significantly decreased the antibody titers and a less immune response was induced than PR8-TMC-ALG formulation. PR8-TMC-ALG formulation showed significantly higher Ig G2 a/Ig G1 ratio, as criteria for Th1-type immune response, compared with PR8-CHT-ALG and PR8 virus alone. Altogether, the PR8-TMC-ALG formulation could be considered as an efficient intranasal antigen delivery system for nasal vaccines. | Jafar Mosafer Amir-Hossein Sabbaghi Ali Badiee Solmaz Dehghan Mohsen Tafaghodi | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 2 |
| 2 | Human microbiome and prostate cancer development:current insights into the prevention and treatment显示文摘The huge communities of microorganisms that symbiotically colonize humans are recognized as significant players in health and disease.The human microbiome may influence prostate cancer development.To date,several studies have focused on the effect of prostate infections as well as the composition of the human microbiome in relation to prostate cancer risk.Current studies suggest that the microbiota of men with prostate cancer significantly differs from that of healthy men,demonstrating that certain bacteria could be associated with cancer development as well as altered responses to treatment.In healthy individuals,the microbiome plays a crucial role in the maintenance of homeostasis of body metabolism.Dysbiosis may contribute to the emergence of health problems,including malignancy through affecting systemic immune responses and creating systemic inflammation,and changing serum hormone levels.In this review,we discuss recent data about how the microbes colonizing different parts of the human body including urinary tract,gastrointestinal tract,oral cavity,and skin might affect the risk of developing prostate cancer.Furthermore,we discuss strategies to target the microbiome for risk assessment,prevention,and treatment of prostate cancer. | Solmaz Ohadian Moghadam Seyed Ali Momeni | 2021 | Frontiers of Medicine2021，15，1： | 2 |
| 3 | The phylogeny of Calligonum and Pteropyrum ( Polygonace- ae) based on nuclear ribosomal DNA ITS and chloroplast truL-F sequences 显示文摘 | Tavakkoli Solmaz Kazempour Osaloo Shahrokh Maassoumi Ali As- ghar | 2010 | Iran Journal of Biotechnology2010，8，1： | 1 |
| 4 | Chronic lithium treatment protects the rat kidney against ischemia/reperfusion injury: The role of nitric oxide and cyclooxygenase pathways显示文摘 | Saman Shafaat Talab Hamed Emami Azadeh Elmi Behtash Ghazi Nezami Solmaz Assa Armin Farajzadeh Deroee Ali Daneshmand Seyed Mohammad Tavangar Ahmad Reza Dehpour | 2010 | European Journal of Pharmacology2010，，1： | 1 |
| 5 | Coagulase gene polymorphism of Staphylococcus aureus isolates: A study on dairy food products and other foods in Tehran, Iran显示文摘Coagulase is considered as a major determinant factor for the identification of Staphylococcus aureus strains.The 3-end coding region of the coagulase(coa)gene contains a series of 81-bp tandem repeats,which differ in the number and location of enzymatic restriction sites among different isolates.coa PCR-RFLP has been used widely to type S.aureus isolates in epidemiological studies.The current study was conducted to investigate the coagulase gene polymorphisms in S.aureus isolated from various food samples using an in house PCR-RFLP method.A total of 100 strains of S.aureus were isolated from food samples.Isolates were typed by PCR-RFLP analysis using NdeI restriction digestion of the coagulase gene PCR products.Results showed that amplification of coagulase genes from S.aureus produced different PCR products.The isolates were grouped into 18 genotypes using RFLP analysis results of the genes.In this study,the S.aureus isolates have been shown to include more than one coagulase genotype,but only had a few coa genotypes predominated. | Mohammad Mehdi Soltan Dallal Mohammad Reza Khoramizadeh Solmaz Agha Amiri Ali Akbar Saboor Yaraghi Ramin Mazaheri Nezhad Fard | 2016 | Food Science and Human Wellness2016，5，4： | 0 |
| 6 | Frequency and safety of COVID-19 vaccination in children with multisystem inflammatory syndrome:a telephonic interview-based analysis显示文摘Coronavirus disease 2019(COVID-19)vaccines are currently approved or authorized to prevent serious outcomes,such as severe disease,hospitalization,and death.The Pfizer-BioNTech vaccine is recommended for everyone aged five and older in the United States(US)to prevent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection[1,2].However,it is unclear whether children with a history of multisystem,inflammatory syndrome in children(MIS-C)may be at risk for a MIS-like response following COVID-19 vaccination or SARS-CoV-2 reinfection[2].Therefore,physicians remain uncertain about vaccinating children with a history of MIS-C.This study investigates the occurrence of severe,systemic side effects of COVID-19 vaccines and the recurrence of the MIS-C symptoms in children with a history of MIS-C to overcome vaccine hesitancy. | Kubra Aykac Kubra Ozturk Osman Oguz Demir Dilan Demir Gumus Sevgi Aslan Ela Cem Miray Yilmaz Celebi Mustafa Dogan Karabacak Gulsum Alkan Fatma Dilsad Aksoy Burcu Ceylan Cura Yayla Eda Kepenekli Solmaz Celebi Melike Emiroglu Ilker Devrim Ali Bulent Cengiz Mehmet Ceyhan Yasemin Ozsurekci | 2022 | World Journal of Pediatrics2022，18，10： | 0 |
| 7 | Relation of binge eating disorder with impulsiveness in obese individuals显示文摘AIM To investigate the levels of impulsiveness, and the relationship between the binge eating disorder(BED) and the levels of impulsiveness in obese individuals.METHODS Two hundred and forty-one obese patients who were included in the study and candidate for bariatric surgery(weight loss surgery) were clinically interviewed to identify the BED group, and patients were divided into two groups: Those with BED and those without BED. The comorbidity rate of groups was determined by using structured clinical interview for DSM-Ⅳ(SCID-Ⅰ). A sociodemographic data form including the story of previous psychiatric treatment, structured clinical interview for DSM-Ⅳ(SCID-Ⅰ), Beck Anxiety Inventory, Beck Depression Inventory(BDI) and Barratt Impulsiveness Scale-11 were applied to both of the groups.RESULTS In regard to 241 obese individuals included in the study, total score and score of attention subscale for BED(+) group were significantly high(P < 0.05). In addition, suicide attempt, story of psychiatric consultation, and score for BDI were again significantly high in the BED(+) group(P < 0.05).CONCLUSION In assessment of obese individuals, assessment of associated psychopathology such as impulsive characteristics and suicide attempt in addition to disrupted eating behaviors will allow to have a more extensive view. | Cenk Ural Hasan Belli Mahir Akbudak Ali Solmaz Zuhal Dogan Bektas Fatih Celebi | 2017 | World Journal of Psychiatry2017，7，2： | 0 |
| 8 | Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment显示文摘Blood loss by hemorrhaging wounds accounts for over one-third of~5 million trauma fatalities worldwide every year.If not controlled in a timely manner,exsanguination can take lives within a few minutes.Developing new biomaterials that are easy to use by non-expert patients and promote rapid blood coagulation is an unmet medical need.Here,biocompatible,and biodegradable microneedle arrays(MNAs)based on gelatin methacryloyl(GelMA)biomaterial hybridized with silicate nanoplatelets(SNs)are developed for hemorrhage control.The SNs render the MNAs hemostatic,while the needle-shaped structure increases the contact area with blood,synergistically accelerating the clotting time from 11.5 min to 1.3 min in vitro.The engineered MNAs reduce bleeding by~92%compared with the untreated injury group in a rat liver bleeding model.SN-containing MNAs outperform the hemostatic effect of needle-free patches and a commercial hemostat in vivo via combining micro-and nanoengineered features.Furthermore,the tissue adhesive properties and mechanical interlocking support the suitability of MNAs for wound closure applications.These hemostatic MNAs may enable rapid hemorrhage control,particularly for patients in developing countries or remote areas with limited or no immediate access to hospitals. | Reihaneh Haghniaz Han-Jun Kim Hossein Montazerian Avijit Baidya Maryam Tavafoghi Yi Chen Yangzhi Zhu Solmaz Karamikamkar Amir Sheikhi Ali Khademhosseini | 2023 | Bioactive Materials2023，，5： | 0 |
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