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7篇 您的检索式：作者名="Alice Guo"

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		题名	作者	年代	出处	被引量
	1	A Novel Oncogenic Role of Inositol Phosphatase SHIP2 in ER‐Negative Breast Cancer Stem Cells: Involvement of JNK/Vimentin Activation显示文摘	Chiung‐Hui Fu Ruey‐Jen Lin John Yu Wen‐Wei Chang Guo‐Shiou Liao Wen‐Ying Chang Ling‐Ming Tseng Yi‐Fang Tsai Jyh‐Cherng Yu Alice L. Yu	2014	Stem Cells2014，，8：	1
	2	Ambulatory Arterial Stiffness Index Derived From 24-Hour Ambulatory Blood Pressure Monitoring显示文摘	Yan Li Ji-Guang Wang Eamon Dolan Ping-Jin Gao Hui-Feng Guo Tim Nawrot Alice V. Stanton Ding-Liang Zhu Eoin O’Brien Jan A. Staessen	2006	Hypertension2006，，3：	1
	3	Temporary migration in Shanghai and Beijing显示文摘	Alice Goldstein Shenyang Guo	1993	Studies In Comparative International Development1993，，2：	1
	4	On the origin of SARS-CoV-2——The blind watchmaker argument显示文摘In the comparison with SARS-CoVof 2003,SARS-CoV-2 is extremely well adapted to the human populations and its adaptive shift from the animal host to humans must have been even more extensive.By the blind watchmaker argument,such an adaptive shift can only happen prior to the onset of the current pandemic and with the aid of step-by-step selection.	Chung-I Wu Haijun Wen Jian Lu Xiao-dong Su Alice CHughes Weiwei Zhai Chen Chen Hua Chen Mingkun Li Shuhui Song Zhaohui Qian Qihui Wang Bingjie Chen Zixiao Guo Yongsen Ruan Xuemei Lu Fuwen Wei Li Jin Le Kang Yongbiao Xue Guoping Zhao Ya-Ping Zhang	2021	Science China(Life Sciences)2021，64，9：	1
	5	Pooled analysis of the performance of liquid‐based cytology in population‐based cervical cancer screening studies in China显示文摘	Qin‐Jing Pan Shang‐ying Hu Xun Zhang Pu‐wa Ci Wen‐hua Zhang Hui‐qin Guo Jian Cao Fang‐hui Zhao Alice Lytwyn You‐lin Qiao	2013	Cancer Cytopathology2013，，9：	1
	6	Ambulatory Arterial Stiffness Index Derived From 24-Hour Ambulatory Blood Pressure Monitoring显示文摘	Yan Li Ji-Guang Wang Eamon Dolan Ping-Jin Gao Hui-Feng Guo Tim Nawrot Alice V. Stanton Ding-Liang Zhu Eoin O’Brien Jan A. Staessen	2006	Hypertension2006，，3：	1
	7	Activation of PXR causes drug interactions with Paxlovid in transgenic mice显示文摘Paxlovid is a nirmatrelvir(NMV)and ritonavir(RTV)co-packaged medication used for the treatment of coronavirus disease 2019(COVID-19).The active component of Paxlovid is NMV and RTV is a pharmacokinetic booster.Our work aimed to investigate the drug/herb-drug interactions associated with Paxlovid and provide mechanism-based guidance for the clinical use of Paxlovid.By using recombinant human cytochrome P450s(CYPs),we confirmed that CYP3A4 and 3A5 are the major enzymes responsible for NMV metabolism.The role of CYP3A in Paxlovid metabolism were further verified in Cyp3a-null mice,which showed that the deficiency of CYP3A significantly suppressed the metabolism of NMV and RTV.Pregnane X receptor(PXR)is a ligand-dependent transcription factor that upregulates CYP3A4/5 expression.We next explored the impact of drug-and herb-mediated PXR activation on Paxlovid metabolism in a transgenic mouse model expressing human PXR and CYP3A4/5.We found that PXR activation increased CYP3A4/5 expression,accelerated NMV metabolism,and reduced the systemic exposure of NMV.In summary,our work demonstrated that PXR activation can cause drug interactions with Paxlovid,suggesting that PXR-activating drugs and herbs should be used cautiously in COVID-19 patients receiving Paxlovid.	Saifei Lei Alice Guo Jie Lu Qian Qi Aaron S.Devanathan Junjie Zhu Xiaochao Ma	2023	Acta Pharmaceutica Sinica B2023，13，11：	0

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