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| 1 | Treatment responses in Asians and Caucasians with chronic hepatitis C infection显示文摘AIM:To conduct a multicentre retrospective review of virological response rates in Asians infected with genotype 1 chronic hepatitis C(CHC) treated with combination interferon and ribavirin and then to compare their responses to that among Caucasians.METHODS:Asian patients infected with genotype 1 CHC treated at 4 Australian centres between 2001 to 2005 were identified through hospital databases.Baseline demographic characteristics,biochemical,virological and histological data and details of treatment were collected.Sustained virological responses(SVR) in this cohort were then compared to that in Caucasian subjects,matched by genotype,age,gender and the stage of hepatic fibrosis.RESULTS:A total of 108 Asians with genotype 1 CHC were identified.The end of treatment response(ETR) for the cohort was 79% while the SVR was 67%.Due to the relatively advanced age of the Asian cohort,only sixty-four subjects could be matched with Caucasians.The ETR among matched Asians and Caucasians was 81% and 56% respectively(P=0.003),while the SVR rates were 73% and 36%(P <0.001) respectively.This difference remained significant after adjusting for other predictive variables. | Kenneth K Yan Marianne Guirgis Amany Zekry Thuy Dinh Anouk Dev Jacob George Alice Lee | 2008 | World Journal of Gastroenterology2008，14，21： | 12 |
| 2 | Virological course of hepatitis A virus as determined by real time RT-PCR: Correlation with biochemical, immunological and genotypic profiles显示文摘瞄准:承担肝炎 A 的分析,并且相关病毒的负担,丙氨酸 aminotransferase (中高音) ,和有病毒血的持续时间的病毒的遗传型有控制调停房间的免疫的 CD4 (+)/ CD8 (+) 淋巴细胞人口的这些参数。方法:房间计数用用荧光在乙二胺四乙酸小瓶收集的新鲜全血被执行激活的房间 sorter。肝炎 A 病毒(HAV ) RNA 从血浆液被提取,抄录进 cDNA 并且由实时聚合酶链反应确定了并且是 genotyped 的颠倒。结果:在 11 个病人之中, 10 能完全被分析。这些, 3 有严重尖锐肝炎(s -- 啊) 并且剩余物有自我限制尖锐肝炎 A (啊哈) ,在第 4 d 上与有暴发性的疾病(脑病等级 IV ) 的一个病人一起死。中高音水平在啊哈两个都是显著地更高的(1070.9 +/- 894.3;P = 0.0014 ) 并且 s -- 啊(1713.9 +/- 886.3;P = 0.001 ) 与正常控制相比(23.6 +/- 7.2 ) 。在 s 的前凝血酶时间 -- 啊病人(21.0 +/- 2.0;P = 0.02 ) 比在啊哈显著地高(14.3 +/- 1.1;P = 0.44 ) 。在啊哈病人的 CD4 (+)/CD8 (+) 比率(1.17 +/- 0.11;P = 0.22 ) 并且 s -- 啊(0.83 +/- 0.12;P = 0.0002 ) 比在正常健康控制(1.52 ) 看低。有的自我限制盒子达到顶点在分析的开始的病毒的负担当时在 s -- 啊病人这发生在第 15 或第 30 d。在敏锐、严格的组,一耐心的各个属于遗传型 IA,与仍然是 8 个盒子属于遗传型 IIIA。唯一的暴发性的肝的失败大小写属于遗传型 IA。在自我限制感染的全部功课期间收集的 HAV 病毒的负担和中高音价值直接为 s 被相关,但是这不是事实 -- 啊病人。结论:基于小规模的研究, s 的固执地更高的病毒的负担 -- 啊可能由于减少的细胞免疫和溶血。病毒血的持续时间依赖于主人,当病毒的遗传型没在 AVH 和 s 的临床的结果有明显的角色 -- 啊盒子。 | Zahid Hussain Bhudev C Das Syed A Husain Sunil K Polipalli Tanzeel Ahmed Nargis Begum Subhash Medhi Alice Verghese Mohammad Raish Apiradee Theamboonlers Yong Poovorawan Premashis Kar | 2006 | World Journal of Gastroenterology2006，12，29： | 10 |
| 3 | Advances in endovascular aneurysm management: coiling and adjunctive devices显示文摘Endovascular coil embolisation continues to evolve and remains a valid modality in managing ruptured and unruptured cerebral aneurysms.Technological advances in coil properties,adjunctive devices and interventional techniques continue to improve long-term aneurysm occlusion rates.This review elaborates on the latest advances in next-generation endovascular coils and adjunctive coiling techniques for treating cerebral aneurysms. | Jessica K Campos Brian V Lien Alice S Wang Li-Mei Lin | 2020 | Stroke & Vascular Neurology2020，5，1： | 5 |
| 4 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 5 | Future directions of clinical laboratory evaluation ol pregnancy显示文摘在最近的年里,我们免疫系统怎么与发展中的胎儿和胎盘交往的理解极大地膨胀了。有许多实验室,在有周期性的怀孕损失(RPL ) 或子间前的女人为怀孕结果的诊断提供测试。这些测试基于对胎儿的有免疫力的反应等价于的前提对的适应有免疫力的反应一 transplant。新理解导致激活的天生的反应为怀孕是重要的,这能导致以后阻止反常怀孕的更有效的测试和处理的概念。我们这里为未来测试描述仅仅三个如此的区域:一个区域包含精子和精液和为成功的授精必要的因素;另一个区域将在子宫为为培植必要的生长因素的生产决定条件;最后,最后区域将是由激活的生来的杀手(NK ) 决定为胎盘和成长胎儿的 vascularization 必要的条件房间(漂亮房间的联合有 HLA-C haplotypes 的像免疫球蛋白的受体(KIR ) 家庭基因) 导致 secreting angiogenic 生长因素的能力。这些区域是新奇的,但是理解他们在怀孕的角色能导致进怎么与复杂化因素维持并且对待怀孕的卓见。 | Kenneth D Beaman Mukesh K Jaiswal Svetlana Dambaeva Alice Gilman-Sachs | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 6 | Numerical study on a pool fire using large eddy simulation 显示文摘 | Alice L K C Richard K K Y | 2007 | A Treatise on the 4th Conference on the Development of Performance- Based Fire Code2007，，10： | 1 |
| 7 | Prediction of optimal height by anthropometric parameters显示文摘 | Pei-Te Huang Alice M K | | 0，，15： | 1 |
| 8 | Modeling of central domestic water heater for buildings 显示文摘 | Alice K Y Cihat A | 2004 | Applied Thermal Engineering2004，24，2： | 1 |
| 9 | An Investigation of Decision - Making Styles of Consumers in China 显示文摘 | Hiu Alice S Y Noel Y M Siu Charlie C L Wang Ludwig M K Chang | 2001 | The Journal of Consumer Affairs2001，35，2： | 1 |
| 10 | 5 - HT decreases contractile and electrical activities in lymphatic vessels of the guinea -pig mesentery:role of 5 - HT 7 - receptors 显示文摘 | Alice K C Pierre Y | 2003 | Br J Pharmacol2003，139，： | 1 |
| 11 | Therapeutic use of interleukin-2 in HIV- infected patients 显示文摘 | Alice K P Jorge A T | 2002 | Current Opinion In Pharmacology2002，2，： | 1 |
| 12 | Effect of protease-activated receptors on guineapig ileum contraction in vitro显示文摘 | Wan B Y Alic A Peh K H | 2003 | Inilamm Res2003，52，： | 1 |
| 13 | Prevention of Atrial Fibrillation: Report From a National Heart, Lung, and Blood Institute Workshop显示文摘 | Emelia J. Benjamin Peng-Sheng Chen Diane E. Bild Alice M. Mascette Christine M. Albert Alvaro Alonso Hugh Calkins Stuart J. Connolly Anne B. Curtis Dawood Darbar Patrick T. Ellinor Alan S. Go Nora F. Goldschlager Susan R. Heckbert José Jalife Charles R. K | 2009 | Circulation2009，，4： | 1 |
| 14 | Multi-objective optimization using genetic algorithms: a tutorial 显示文摘 | Abdullah K David W C Alice E S | 2006 | Reliability Engineering & System Safety2006，91，9： | 1 |
| 15 | In vivo platelet activation in ischemic stroke patients显示文摘 | Marina K Alice M Metallions CI | 2003 | Stroke2003，34，： | 1 |
| 16 | Evaluating and managing cardiovascular disease in women: understanding a woman' s heart 显示文摘 | Jacob S Alice K Eckel | 2005 | Circulation2005，111，4： | 1 |
| 17 | Impact of thrombolysis, intra-aortic balloon pump counterpulsation, and their combination in cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry显示文摘 | Timothy A Sanborn Lynn A Sleeper Eric R Bates Alice K Jacobs Jean Boland John K French Jo Dens Vladimir Dzavik Sebastian T Palmeri John G Webb Mark Goldberger Judith S Hochman | 2000 | Journal of the American College of Cardiology2000，，： | 1 |
| 18 | A chaotic attractor in timing noise from the vela pulsar显示文摘 | Alice K H Troy S | 1990 | The As-trophysical Journal1990，353，： | 1 |
| 19 | A phylogeny of Chloridoideae (Poaceae)based on matk sequences显示文摘 | Hilu K W Alice L A | 2001 | Syst Bot2001，26，2： | 1 |
| 20 | Resveratrol induces colon tumor cell apoptosis independently of p53 and preceded by epithelial differentiation, mitochondrial proliferation and membrane potential collapse显示文摘 | Mojgan M Alice K Pedro M | 2001 | Int J Cancer2001，94，： | 1 |
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