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| 1 | 到用结构化的问询表的口头的抗病毒的肝炎 B 治疗的坚持的评估显示文摘 AIM:To assess adherence rates to nucleos(t)ide analogues(NUCs) therapy in patients with chronic hepatitis B virus infection and determine factors associated with adherence.METHODS:The questionnaire study was conducted in the liver clinics at Concord Repatriation General Hospital.All patients who were currently taking one or more NUCs were asked to complete a structured,selfadministered 32-item questionnaire.Adherence was measured using visual analogue scales.The patient’s treating clinician was also asked to assess their patient’s adherence via a structured questionnaire.RESULTS:A total of 80 patients completed the questionnaire.Sixty six percent of the patients(n = 49) reported optimal adherence whilst 25(33.8%) graded their adherence to NUCs as suboptimal.Thirty four(43%) patients reported to have omitted taking their NUCs sometime in the past.Recent non-adherence was uncommon.Amongst the patients who reported skipping medications,the most common reason cited was 'forgetfulness'(n = 27,56.25%).Other common reasons included:ran out of medications(n = 5,10.42%),being too busy(n = 4,8.33%) and due to a change in daily routine(n = 5,10.42%).Patients who reported low adherence to other prescription pills were also more likely to miss taking NUCs(P = 0.04).Patients who were under the care of a language-discordant clinician were also more likely to report suboptimal adherence to NUCs(P = 0.04).CONCLUSION:Adherence rates were much less than that expected by the physician and has potential adverse affect on long term outcome.Communication and education appear central and strategies need to be implemented to improve ongoing adherence. | Leesa Giang Christian P Selinger Alice Unah Lee | 2012 | World Journal of Hepatology2012，4，2： | 16 |
| 2 | Treatment responses in Asians and Caucasians with chronic hepatitis C infection显示文摘AIM:To conduct a multicentre retrospective review of virological response rates in Asians infected with genotype 1 chronic hepatitis C(CHC) treated with combination interferon and ribavirin and then to compare their responses to that among Caucasians.METHODS:Asian patients infected with genotype 1 CHC treated at 4 Australian centres between 2001 to 2005 were identified through hospital databases.Baseline demographic characteristics,biochemical,virological and histological data and details of treatment were collected.Sustained virological responses(SVR) in this cohort were then compared to that in Caucasian subjects,matched by genotype,age,gender and the stage of hepatic fibrosis.RESULTS:A total of 108 Asians with genotype 1 CHC were identified.The end of treatment response(ETR) for the cohort was 79% while the SVR was 67%.Due to the relatively advanced age of the Asian cohort,only sixty-four subjects could be matched with Caucasians.The ETR among matched Asians and Caucasians was 81% and 56% respectively(P=0.003),while the SVR rates were 73% and 36%(P <0.001) respectively.This difference remained significant after adjusting for other predictive variables. | Kenneth K Yan Marianne Guirgis Amany Zekry Thuy Dinh Anouk Dev Jacob George Alice Lee | 2008 | World Journal of Gastroenterology2008，14，21： | 12 |
| 3 | Epidemiology of inflammatory bowel disease in South America: A systematic review显示文摘BACKGROUND The worldwide epidemiology of inflammatory bowel disease(IBD)is rapidly changing.Increasing Crohn’s disease(CD)and ulcerative colitis(UC)incidence and prevalence have been recorded in developing regions such as Asia,Africa and Eastern Europe where it was previously thought to be uncommon.Whether this is also the case in South America is not well known.Demonstration that developing regions worldwide have increasing IBD incidence would indicate that environmental change plays a significant role in the development of IBD.AIM To report the incidence,prevalence and disease characteristics of CD and UC within the South American continent.METHODS A systematic review was conducted by searching published studies in major international and regional databases(MEDLINE,EMBASE and Scopus)between January 1990 and December 2018.Outcomes considered were incidence,prevalence,phenotype,environmental and genetic factors,ethnicity and gender.A pair of independent reviewers screened and reviewed all identified articles.RESULTS One hundred and sixty two citations were initially retrieved with 18 studies included in this systematic review.The majority of included studies were from Brazil(n=13,72%).The incidence of UC ranged from 4.3-5.3/100000 personyears whilst the incidence of CD ranged from 0.74-3.5/100000 person-years.Prevalence ranged from 15.0-24.1/100000 inhabitants for UC and from 2.4-14.1/100000 inhabitants for CD.The incidence and prevalence of both UC and CD has increased significantly in Brazil over the past 21 years.Pancolitis was the most common disease distribution in patients with UC whilst colonic involvement was the most common distribution in CD.People residing in urban areas were at higher risk of developing both CD and UC.CONCLUSION The IBD burden in South America is increasing at a rate possibly even greater than other developing regions around the world.There is a paucity of highquality epidemiological studies and further robust and representative data are required to further explore modifiable risk factors and disease phenotypes. | Sriharan Selvaratnam Santiago Gullino Lisa Shim Eric Lee Alice Lee Sudarshan Paramsothy Rupert W Leong | 2019 | World Journal of Gastroenterology2019，25，47： | 5 |
| 4 | 新冠病毒肺炎临床试验核心指标集显示文摘自2019年12月新型冠状病毒肺炎(Coronavirus Disease 2019, COVID-19)暴发以来,已有大量相关临床研究完成注册或已启动。然而,不同研究间临床结局指标存在显著的异质性,同时一些不关键的指标会造成研究资源的浪费。本研究旨在构建COVID-19临床试验核心结局指标集(core outcome set, COS),为相关临床研究方案设计、开展和证据转化提供参考。本研究的实施参照《有效性试验核心结局指标(COMET)手册》(1.0版),研究组成员包括呼吸系统和危重医学、中医学、循证医学、临床药理学、统计学专家以及医学杂志编辑等。通过检索临床试验注册网站(chictr.org.cn和clinicaltrials.gov)中COVID-19相关临床研究方案,提取方案中的结局指标,形成指标池。78个COVID-19临床试验方案纳入研究,收集结局指标259个,合并规范后确定132个结局指标,涉及7个指标域。经遴选,形成了包括58个结局指标在内的初始指标清单。经过两轮德尔菲调查和一轮共识会议,最终确立针对COVID-19不同临床分型的核心指标集(COS-COVID)。COS-COVID包括1个轻型指标(病毒核酸检测转阴时间)、4个普通型指标(住院时间、复合事件发生率、临床症状积分和病毒核酸检测转阴时间)、5个重型指标(复合事件发生率、住院时间、PaO2/FiO2、机械通气时间和病毒核酸检测转阴时间)、1个危重型指标(全因死亡率)及1个康复期指标(肺功能)。COS-COVID作为目前临床评价COVID-19干预效果最具临床价值及操作性的指标集合,对证据评估和决策具有重要意义。随着对疾病认知的不断深入和COS-COVID应用的反馈,课题组将对本核心指标集进行进一步完善并更新。 | 金鑫瑶 庞博 张俊华 刘清泉 杨忠奇 封继宏 刘学政 张磊 王保和 黄宇虹 Alice Josephine Fauci 马玉玲 Myeong Soo Lee 元唯安 谢雁鸣 唐健元 高蕊 杜亮 张硕 祁寒梅 孙宇 郑文科 杨丰文 蔡慧姿 王可仪 欧益 黄明 朱彦 喻佳洁 田金徽 赵敏 胡镜清 姚晨 李幼平 张伯礼 | 2020 | Engineering2020，6，10： | 5 |
| 5 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 6 | Seroprevalence of hepatitis B surface antigen in pregnant women attending antenatal clinic in Honiara Solomon Islands,2015显示文摘AIM To determine the seroprevalence of hepatitis B surface antigen(HBsAg) among pregnant women attending antenatal clinic in Honiara, Solomon Islands. METHODS This descriptive cross-sectional study was carried out in seven area health centers in Honiara. From March to June 2015, identification of eligible pregnant women in each site was conducted using systematic random sampling technique. A total of 243 pregnant women who gave written informed consent were enrolled. Standardized tool was used to record demographics, obstetric history and serology results. HBsAg and hepatitis B e antigen(HBeAg) were tested using point-of-care rapid diagnostic test. All HBsAg positive samples were verified using enzyme-linked immunosorbent assay. RESULTS The mean age of participants was 26 ± 6 years. The overall hepatitis HBsAg prevalence was 13.8% with higher rate(22%) reported in women between 30-34 years of age. Majority of HBsAg positive participants were Melanesians(29 out for 33). None of the pregnant women in the 15-19 years and ≥ 40 years tested positive for HBsAg. There was no statistically significant difference in HBsAg prevalence by age, ethnicity, education and residential location. The overall HBeAg seroprevalence was 36.7%. Women between 20-24 years of age had the highest rate of 54.5%. Low level of knowledge about hepatitis B vaccination was reputed. Overall, 54.6% of participants were not aware of their hepatitis B vaccination status and only 65.2% of mothers reported their child had been vaccinated. CONCLUSION Hepatitis B is a disease of public health importance in Solomon Islands and emphasize the need for integrated preventative interventions for its control. | Aneley Getahun Margaret Baekalia Nixon Panda Alice Lee Elliot Puiahi Sabiha Khan Donald Tahani Doris Manongi | 2016 | World Journal of Hepatology2016，8，34： | 2 |
| 7 | Persistent Subclinical Hypothyroidism and Cardiovascular Risk in the Elderly: The Cardiovascular Health Study显示文摘 | Kristen A. Hyland Alice M. Arnold Jennifer S. Lee Anne R. Cappola | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，2： | 2 |
| 8 | 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guid显示文摘 | Frederick G. Kushner Mary Hand Sidney C. Smith Spencer B. King Jeffrey L. Anderson Elliott M. Antman Steven R. Bailey Eric R. Bates James C. Blankenship Donald E. Casey Lee A. Green Judith S. Hochman Alice K. Jacobs Harlan M. Krumholz Douglass A. Morrison | 2009 | Circulation2009，，22： | 1 |
| 9 | Evaluating a web-based self-management program for employees with hypertension and prehypertension: A randomized clinical trial显示文摘 | Alice J. Watson Kanwaljit Singh Khinlei Myint-U Richard W. Grant Kamal Jethwani Ellen Murachver Kimberly Harris Thomas H. Lee Joseph C. Kvedar | 2012 | American Heart Journal2012，，4： | 1 |
| 10 | Major vascular resection as part of pancreaticoduodenectomy for cancer: Radiologic, intraoperative, and pathologic analysis显示文摘 | Richard J. Bold M.D. Chusilp Charnsangavej M.D. Karen R. Cleary M.D. Mary Jennings C.R.N.P. Alice Madary R.N. Steven D. Leach M.D. James L. Abbruzzese M.D. Peter W. T. Pisters M.D. Jeffrey E. Lee M.D. Douglas B. Evans M.D | 1999 | Journal of Gastrointestinal Surgery1999，，3： | 1 |
| 11 | Impact of Viral Hepatitis on Outcomes after Liver Resection for Hepatocellular Carcinoma: Results from a North American Center显示文摘 | Jonghun J. Lee Peter T. W. Kim Sandra Fischer Scott Fung Steven Gallinger Ian McGilvray Carol-anne Moulton Alice C. Wei Paul D. Greig Sean P. Cleary | 2014 | Annals of Surgical Oncology2014，，8： | 1 |
| 12 | 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guid显示文摘 | Frederick G. Kushner Mary Hand Sidney C. Smith Spencer B. King Jeffrey L. Anderson Elliott M. Antman Steven R. Bailey Eric R. Bates James C. Blankenship Donald E. Casey Lee A. Green Judith S. Hochman Alice K. Jacobs Harlan M. Krumholz Douglass A. Morrison | 2009 | Journal of the American College of Cardiology2009，，23： | 1 |
| 13 | A data envelopment analysis of the efficiency of China's thermal power gencration 显示文摘 | Pun -Lee Lain Alice Shiu | 2001 | Utilities Policy2001，10，： | 1 |
| 14 | Image-guided Tumor Ablation: Standardization of Terminology and Reporting Criteria显示文摘 | S. Nahum Goldberg Clement J. Grassi John F. Cardella J. William Charboneau Gerald D. Dodd Damian E. Dupuy Debra A. Gervais Alice R. Gillams Robert A. Kane Fred T. Lee Tito Livraghi John McGahan David A. Phillips Hyunchul Rhim Stuart G. Silverman Luigi Sol | 2009 | Journal of Vascular and Interventional Radiology2009，，7： | 1 |
| 15 | Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies显示文摘 | Celeste Leigh Pearce Claire Templeman Mary Anne Rossing Alice Lee Aimee M Near Penelope M Webb Christina M Nagle Jennifer A Doherty Kara L Cushing-Haugen Kristine G Wicklund Jenny Chang-Claude Rebecca Hein Galina Lurie Lynne R Wilkens Michael E Carney Mar | 2012 | Lancet Oncology2012，，： | 1 |
| 16 | Electricity Consumption and Economic Growth in China显示文摘 | Alice Shiu Pun- Lee Lam | 2004 | Energy Policy2004，，32： | 1 |
| 17 | Image-guided Tumor Ablation: Standardization of Terminology and Reporting Criteria显示文摘 | S. Nahum Goldberg Clement J. Grassi John F. Cardella J. William Charboneau Gerald D. Dodd Damian E. Dupuy Debra Gervais Alice R. Gillams Robert A. Kane Fred T. Lee Tito Livraghi John McGahan David A. Phillips Hyunchul Rhim Stuart G. Silverman | 2005 | Journal of Vascular and Interventional Radiology2005，，6： | 1 |
| 18 | Between Global and Local: The Glocalization of Online News Coverage on the Trans-regional Crisis of SARS显示文摘 | Alice Y. L. Lee | 2005 | Asian Journal of Communication2005，，3： | 1 |
| 19 | Clinical and Microbiological Characteristics of Fungal Keratitis in the United States, 2001–2007: A Multicenter Study显示文摘 | Lisa J. Keay Emily W. Gower Alfonso Iovieno Rafael A. Oechsler Eduardo C. Alfonso Alice Matoba Kathryn Colby Sonal S. Tuli Kristin Hammersmith Dwight Cavanagh Salena M. Lee John Irvine R. Doyle Stulting Thomas F. Mauger Oliver D. Schein | 2011 | Ophthalmology2011，，5： | 1 |
| 20 | Link weight assignment and loop-free routing table update for link state routing protocols in energy-aware internet显示文摘 | Steven S.W. Lee Po-Kai Tseng Alice Chen | 2011 | Future Generation Computer Systems2011，，2： | 1 |
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