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| 1 | 表观遗传学如何诠释人肿瘤转移microRNA的新作用显示文摘转移过程的特征是肿瘤细胞可通过血液系统播散到远端组织,然后这些变异的细胞在那里增殖,并形成继发性肿瘤,这也是肿瘤患者死亡最主要的原因。近年来,一系列重要的肿瘤相关基因陆续被报道,如钙粘素、层粘连蛋白、乙酰肝素硫酸盐、蛋白水解酶、血管生成抑制剂等。但是,这些基因在肿瘤转移中发生改变的机制尚不明了,因为尽管它们的表达普遍下调, | Amaia Lujambio Manel Esteller 南娟(翻译) 丁燕(翻译) 孙丹(校对) | 2009 | 中国肺癌杂志2009，12，8： | 11 |
| 2 | NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling显示文摘The NLRP3-IL-1β pathway plays an important role in adipose tissue(AT)-induced inflammation and the development of obesityassociated comorbidities.We aimed to determine the impact of NLRP3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix(ECM)remodeling.Samples obtained from 98 subjects were used in a case-control study.The expression of different components of the inflammasome as well as their main effectors and inflammation-and ECM remodeling-related genes were analyzed.The impact of blocking NLRP3 using siRNA in lipopolysaccharide(LPS)-mediated inflammation and ECM remodeling signaling pathways was evaluated.We demonstrated that obesity(P<0.01),obesity-associated T2D(P<0.01)and NAFLD(P<0.05)increased the expression of different com ponents of the inflammasome as well as the expression and release of IL-1β and IL-18 in AT.We also found that obese patients with T2D exhibited increased(P<0.05)hepatic gene expression levels of NLRP3,IL1B and IL18.We showed that NLRP3,but not NLRP1,is regulated by inflammation and hypoxia in visceral adipocytes.We revealed that the inhibition of NLRP3 in human visceral adipocytes significantly blocked(P<0.01)LPS-induced inflammation by downregulating the mRNA levels of CCL2,IL1B,IL6,IL8,S100A8,S100A9,TLR4 and TNF as well as inhibiting(P<0.01)the secretion of IL1-β into the culture medium.Furthermore,blocking NLRP3 attenuated(P<0.01)the LPS-induced expression of important molecules involved in AT fibrosis(COL1A1,COL4A3,COL6A3 and MMP2).These novel findings provide evidence that blocking the expression of NLRP3 reduces AT inflammation with significant fibrosis attenuation. | Xabier Unamuno Javier Gomez-Ambrosi Beatriz Ramirez Amaia Rodriguez Sara Becerril Victor Valenti Rafael Moncada Camilo Silva Javier Salvador Gema Fruhbeck Victoria Catalan | 2021 | Cellular & Molecular Immunology2021，18，4： | 9 |
| 3 | Habitat specialization and phylogenetic structure of tree species in a coastal Brazilian white-sand forest显示文摘Aims The coastal Brazilian rainforest on white-sand(restinga)ranks among the most fragmented forest types in the tropics,owing to both the patchy distribution of sandy soils and widespread coastal development activities.Here we study the environmental and evolutionary determinants of a forest tree assemblage at a single restinga forest in Southeastern Brazil.We also explore the ability of competing hypotheses to explain the maintenance of species diversity in this forest type,which includes contrasting extremes of edaphic conditions associated with flooding stress.Methods The study was conducted in a white-sand forest permanent plot of 10.24 ha on the coastal plain of Southeastern Brazil.This plot was divided into 256 quadrats of 20×20 m,which were classified into two main edaphic habitats(flooded and drained).Trees with a diameter≥1 cm at breast height were identified.We assembled DNA sequence data for each of the 116 morphospecies recognized using two chloroplast markers(rbcL and matK).A phylogenetic tree was obtained using the maximum likelihood method,and a phylogenetic distance matrix was produced from an ultrametric tree.We analyzed similarity in floristic composition and structure between habitats and related them to cross-plot distances using permutation procedures.Null model torus shift simulations were performed to obtain a statistical significance level for habitat association for each species.The phylogenetic structure for the two habitats and for each 20×20 m quadrat was calculated using the mean phylogenetic distance weighted by species abundance and checked for significance using the standardized effect size generated by 5000 randomizations of phylogenetic tip labels.Important Findings Our results indicate that partitioning among edaphic habitats is important for explaining species distributions and coexistence in restinga forests.Species distributions within the plot were found to be non-random:there was greater floristic similarity within than between habitats,and>40%of the more abundant species were positively or negatively associated with at least one habitat.Patterns of habitat association were not independent of phylogenetic relatedness:the community was overdispersed with respect to space and habitat type.Closely related species tended to occur in different habitats,while neighboring trees tended to belong to more distantly related species.We conclude that habitat specialization is important for the coexistence of species in restinga forests and that habitat heterogeneity is therefore an essential factor in explaining the maintenance of diversity of this unique but fragile and threatened type of forest. | Alexandre A.de Oliveira Alberto Vicentini Jerome Chave Camila de T.Castanho Stuart J.Davies Adriana M.Z.Martini Renato A.F.Lima Ricardo R.Ribeiro Amaia Iribar Vinicius C.Souza | 2014 | Journal of Plant Ecology2014，7，2： | 4 |
| 4 | Study of community-ac- quired pneumonia: incidence, patterns of care, and outcomes in primary and hospital care 显示文摘 | Alberto C Pedro PE Amaia B | 2010 | J Infect2010，61，5： | 1 |
| 5 | Effect of different thermal treatments on the self-assembled nanostructures of a styrene-butadiene-styrene star block copolymer显示文摘 | Elena Serrano Amaia Zubeldia Maider Larranaga | 2004 | Polym Degr Stab2004，83，3： | 1 |
| 6 | MHC class Ⅱ DRB1 gene polymorphism in the pathogenesis of Maedi-Visna and pulmonary adenocarcinoma viral diseasesin sheep显示文摘 | Amaia Larrus Kain Esmeralda Minguijon Koldo Garc-ia Etxebarri | 2010 | Immunogenetics2010，62，： | 1 |
| 7 | Responsiveness and Clinically Important Differences for the VF-14 Index,SF-36,and Visual Acuity in Patients Undergoing Cataract Surgery显示文摘 | Amaia Bilbao | 2009 | Ophthalmology2009，116，： | 1 |
| 8 | Impact of informal care giving on caregivers' health and quality of life: Analysis of gender inequali- ties显示文摘 | Isabel L Unai M Amaia B | 2008 | Gac Sanit2008，22，5： | 1 |
| 9 | Capillary hydrodynamic fractionation of hydrophobic colloids:Errors in the estimated particle size distribution显示文摘Capillary hydrodynamic fractionation(CHDF) with turbidity detection at a single wavelength is an analytical technique that is often used for sizing the sub-micrometric particles of hydrophobic colloids.This article investigates three sources of errors that affect the particle size distribution(PSD) estimated by CHDF:diameter calibration errors,uncertainties in the particle refractive index(PRI),and instrumental broadening(IB).The study is based on simulated and experimental examples that involve unimodal and bimodal PSDs.Small errors in the diameter calibration curve can produce important deviations in the number average diameter due to systematic shifts suffered by the PSD modes.Moderate uncertainties in the PRI are unimportant in the analysis of unimodal PSDs,but in the specific case of bimodal PSDs,errors in the PRI can strongly affect the estimated number concentration of each mode.The typical IB correction(based on the IB function estimated from narrow standards) produces slightly erroneous average diameters but can lead to PSDs with underestimated widths and distorted shapes.In practice,the three investigated sources of errors can be present simultaneously,and uncertainties in the average diameters,the shape and width of the PSD,and the number concentration of the PSD modes are unavoidable. | Luis A.Clementi Zohartze Artetxe Ziortza Aguirreurreta Amaia Agirre Jose R.Leiza Luis M.Gugliotta Jorge R.Vega | 2014 | Particuology2014，12，6： | 1 |
| 10 | Personalized E-Health Management System for Monitoring and Empowering Patients显示文摘 | Nuria Aresti Bartolome Amaia Mendez Zorrilla Begona Garcia Zapirain | 2011 | Computer Technology and Application2011，2，9： | 1 |
| 11 | Convergence in the innovative performance ofthe European Union countries显示文摘 | Amaia A | 2010 | Transition Studies Re_view2010，，17： | 1 |
| 12 | Effects of conjugated linoleie acid on skeletal muscle triacylglycerol metabolism in hamsters显示文摘 | AMAIA Z ALFREDO F Q MACARUuA M T | 2006 | Nutrition2006，22，5： | 1 |
| 13 | Study of community acquired pneumonia:Incidence,patterns of care,and outcomes in primary and hospital care显示文摘 | Alberto C Pedro PE Amaia B | 2010 | J Infect2010，61，5： | 1 |
| 14 | Cloning and characterization of the rainbow trout(Oncorhynchus mykiss)type Ⅱinterleukin-1 receptor Cdna显示文摘 | Amaia Sangrador-Vegas Samuel Martin A M Terry Smith J | 2000 | Eur J Biochem2000，267，： | 1 |
| 15 | Transdermal glyceryl trinitrate for prevention of post-ERCP pancreatitis: A randomized double-blind trial显示文摘 | Manuel Moretó Manuel Zaballa Ignacio Casado Olga Merino Miguel Rueda Kléber Ramírez Raquel Urcelay Amaia Baranda | 2003 | Gastrointestinal Endoscopy2003，，1： | 1 |
| 16 | Ownership structure and firm performance in non-listed firms: Evidence from Spain显示文摘 | Blanca Arosa Txomin Iturralde Amaia Maseda | 2010 | Journal of Family Business Strategy2010，，2： | 1 |
| 17 | Development and validation of an in-patient satisfaction questionnaire显示文摘 | Nerea G Jose MQ Amaia B | 2005 | Int J Qual Health Care2005，17，6： | 1 |
| 18 | Synthesis and characterization of a novel addition-fragmentation reactive surfactant(transurf) for use free-radical emulsion polymerizations显示文摘 | TERENCE S WILKINSON ARMIN BOONSTARA AMAIA MONTOYA-GONI | 2001 | Journal of Colloid and Interface Science2001，，237： | 1 |
| 19 | Life Expectancy, Human Capital, Social Security and Growth显示文摘 | CRUZ A ECHEVARRfA Amaia Iza | 2006 | Journal of Public Economics2006，12，： | 1 |
| 20 | Predictors of patient satisfaction with hospital health care显示文摘 | Jose M Quintana Nerea Gonzalezl Amaia Bilbao | 2006 | BMC Health Services Research2006，6，： | 1 |
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