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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches显示文摘 | Antonella De Luca Monica R Maiello Amelia D’Alessio Maria Pergameno Nicola Normanno | 2012 | Expert Opinion on Therapeutic Targets2012，，2： | 2 |
| 3 | ST14 (Suppression of Tu- morigenicity 14) Gene Is a Target for miR-27b, and the Inhibitory Effect of ST14 on Cell Growth Is Independent of miR-27b Regula- tion 显示文摘 | Wang YF Rajamani R Amelia W | 2009 | J Biol chem2009，284，23： | 1 |
| 4 | Metabolic response of juvenile gray snapper (Lutjanus griseus ) to temperature and salinity: Physiological cost of different environments 显示文摘 | MARK J W AMELIA R J JONATHAN A H | 2005 | Journal of Experimental Marine Biology and Ecology2005，321，2： | 1 |
| 5 | Characterization of atmospheric ammonia emissions from a commercial chicken house on the Delmarva Peninsula 显示文摘 | Siefert Ronald L Scudlark Joseph R Potter Amelia G | 2004 | Environmental Science and Technology2004，38，： | 1 |
| 6 | Bulk and interfacial viscoelasticity in concentrated emul-sions: the role of the surfactant显示文摘 | MIGUEL W P AMELIA T G ANTONIO M R | 2011 | Food Hydrocol-loids2011，25，： | 1 |
| 7 | Impacts of Infor- mation Technology on Personal Travel and Commercial Vehicle Operations: Research Challenges and Opportunities显示文摘 | Thomas F G Amelia C R | 2001 | Transporta- tion Research Part C2001，9，2： | 1 |
| 8 | The Relationship Between Information Technology Use and Buyer - Supplier Relationships: An Exploratory Analysis of the Buying Firm's Perspeetive显示文摘 | Carr Amelia S Smeltzer Larry R | 2002 | IEEE Transactions on Engineering Management2002，，49： | 1 |
| 9 | Long-term of severe SAPHO sydrome with adalimumab: case report and a review of the literature显示文摘 | Garcovich S Amelia R Magarelli N | 2012 | Am J Clin Dermatol2012，13，1： | 1 |
| 10 | The role of echocardiogra- phy and its comparison with NT-pro-BNP measurements in patients with acute myocardial infarction 显示文摘 | Naresh R Rosemary JP Amelia SK | 2007 | Med Sci Monit2007，3，12： | 1 |
| 11 | Recovery of CdS nanoerystal defects through conjugation with proteins 显示文摘 | AMELIA M FLAMINI R LATI'ERINI L | 2010 | Langmuir2010，26，10： | 1 |
| 12 | Long-term of se?vere SAPHO syndrome with adalirnumab , case report and a review of the literature显示文摘 | Garcovich S Amelia R Magarelli N | 2012 | AmJ Clin Dermatol2012，3，： | 1 |
| 13 | The growing prevalence of Nosema ceranae in honey bees in Spain, an emerging problem for the last decade显示文摘 | Cristina Botías Raquel Martín-Hernández Encarna Garrido-Bailón Amelia González-Porto Amparo Martínez-Salvador Pilar De La Rúa Aránzazu Meana Mariano Higes | 2011 | Research in Veterinary Science2011，，1： | 1 |
| 14 | The European registry on obstetric antiphospholipid syndrome (EUROA/X3): A survey of 247 consecutive cases 显示文摘 | Janme AR Raquel FO Amelia R | 2015 | Autoimmun Rev2015，14，： | 1 |
| 15 | Water saving technology and saving water in China 显示文摘 | Amelia B Scott R | 2007 | agricultural water management2007，87，： | 1 |
| 16 | The role of echocardiogra- phy and its comparison with NT-pro-BNP measurements in patients with acute myocardial infarction显示文摘 | Naresh R Rosemary JP Amelia SK | 2007 | Med Sci Monit2007，3，12： | 1 |
| 17 | An empirically- based operational definition of strategic purchasing 显示文摘 | CARR S AMELIA SMELTZER R LARRY | 1997 | European Journal of Purchasing &Supply Management1997，3，4： | 1 |
| 18 | The perceived usefulness of different sources of traffic information to trucking operations 显示文摘 | THOMAS F G AMELIA C R | 2002 | Transportation Research Part E2002，38，2： | 1 |
| 19 | Transient excitation of a straight thin-wire segment: A new look at an old problem显示文摘 | Anton G T Peng Z Q Amelia R B | 1992 | IEEE Transactions on Antennas and Propa- gations1992，40，10： | 1 |
| 20 | Two Contrasting Severe Seasonal Extremes in Tropical South America in 2012: Flood in Amazonia and Drought in Northeast Brazil显示文摘 | Marengo Jose A Alves Lincoln M Soares Wagner R Rodriguez Daniel A Camargo Helio Riveros Marco Paredes Pabl? Amelia Diaz | 2013 | Journal of Climate2013，，22： | 1 |
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