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| 1 | 胸苷酸合成酶和拓扑异构酶-1及Ki-67对伊立替康联合5-氟脲嘧啶治疗晚期大肠癌的预测价值显示文摘目的探讨胸苷酸合成酶(TS)、拓扑异构酶1(Topo1)和肿瘤增殖指标Ki67对伊立替康(CPT11)联合5氟脲嘧啶(5Fu)治疗晚期大肠癌患者的临床疗效和预后的预测价值。方法采用免疫组化方法检测了CPT11+5Fu一线治疗78例大肠癌患者的TS、Topo1和Ki67的表达,并与化疗疗效和患者的临床预后进行了分析。结果各检测指标的表达水平与临床疗效之间无关,但是临床预后不同。其中,TS低表达患者表现明显长的肿瘤进展时间(TTP,P<0.05)和存活期(OS,P<0.05);Ki67低表达也预示长的OS(P<0.05)。与单个指标相比较,两个指标的联合也不能预测临床疗效,但是对预后的判断作用明显提高。TS低表达、Ki67低表达以及TS和Ki67均低表达患者的中位TTP分别为9,8和17个月(P=0.02);TS低表达、Topo1低表达以及TS和Topo1均低表达患者的中位TTP分别为9,9和13个月(P=0.03);而Topo1低表达、Ki67低表达、Ki67和Topo1均低表达患者的中位TTP分别为8,9和11个月(P=0.05)。其中任何两个指标均低表达肿瘤的TTP和OS均明显长于高表达者(P<0.05)。结论TS、Topo1和Ki67不能预测大肠癌患者CPT11+5Fu的疗效,但对其临床预后有一定的预测作用。其中任何两个指标的联合,比单一指标对患者预后的预测价值明显提高。 | 徐建明 朱步东 Mangia Anita Simone Gianni Montemurro Severino Giuliani Francesco Maiello Evaristo Colucci Giuseppe Paradiso Angelo | 2005 | 中华肿瘤杂志2005，27，5： | 9 |
| 2 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 3 | Total and not bevacizumab-bound vascular endothelial growth factor as potential predictive factors to bevacizumab-based chemotherapy in colorectal cancer显示文摘AIM: To identify suitable biomarkers of response to bevacizumab(BV)- it remains an open question. The measurement of serum vascular endothelial growth factor(VEGF) has been proposed as a predictive factor for this drug, even if literature data are contradictory. METHODS: We prospectively evaluated the role of BV, total and not BV-bound VEGF and angiopoietin-2(Ang-2) serum levels as potential predictive factors of response for BV in combination with an oxaliplatinbased chemotherapy. BV, Ang-2, total and not BVbound VEGF levels were measured at baseline, before 2^(nd) and 5^(th) cycle of oxaliplatin-based chemotherapy in 20 consecutive metastatic colorectal cancer patients. RESULTS: Results were correlated to response to treatment. Variability in BV levels have been found, with decreased level in less responding patients. In particular, the concentration of BV increased of 3.96 ± 0.69 folds in serum of responsive patients after 3 more cycles of therapy compared to those with stable or progressive disease with a 0.72 ± 0.25 and 2.10 ± 0.13 fold increase, respectively. The determination of free and total VEGF demonstrated that the ratio between the two values, evaluated immediately before the 2^(nd) and the 5^(th) cycle of therapy, decreased from 26.65% ± 1.33% to 15.50% ± 3.47% in responsive patients and from 53.41% ± 4.75 to 34.95% ± 2.88% in those with stable disease. Conversely, in those with progression of disease, the ratio showed the opposite behavior coming up from 25.99% ± 5.23% to 51.71% ± 5.28%. The Ang-2 levels did not show any relationship. CONCLUSION: Our data show that the ratio of not BV-bound VEGF to total VEGF serum and BV plasma concentrations for predicting the response to BV plus oxaliplatin-based chemotherapy could be a promising biomarker of response to BV. | Amalia Azzariti Letizia Porcelli Oronzo Brunetti Marzia Del Re Vito Longo Patrizia Nardulli Michele Signorile Jian-Ming Xu Angela Calabrese Anna Elisa Quatrale Evaristo Maiello Vito Lorusso Nicola Silvestris | 2016 | World Journal of Gastroenterology2016，22，27： | 4 |
| 4 | The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches显示文摘 | Antonella De Luca Monica R Maiello Amelia D’Alessio Maria Pergameno Nicola Normanno | 2012 | Expert Opinion on Therapeutic Targets2012，，2： | 2 |
| 5 | Target Therapies in Pancreatic Carcinoma显示文摘 | Nicola Silvestris Antonio Gnoni Anna Elisabetta Brunetti Leonardo Vincenti Daniele Santini Giuseppe Tonini Francesca Merchionne Evaristo Maiello Vito Lorusso Patrizia Nardulli Amalia Azzariti Michele Reni | 2014 | Current Medicinal Chemistry2014，，8： | 2 |
| 6 | EGFR and MEK blockade in tri- ple negative breast cancer ceils 显示文摘 | MAIELLO M R D'ALESSIO A | 2015 | J Cell Biochem2015，116，12： | 1 |
| 7 | Defense mechanisms as outcome measure in short-term psychotherapy related to symptoms, severity and overall functioning: a preliminary study显示文摘 | Coccanari de' Fornari MA Piccione M Maiello L | 2011 | Res Psychiatry2011，46，1： | 1 |
| 8 | Coronary angioplasty of chronic occlusions:factors predictive of procedural success显示文摘 | Maiello L Colombo A Gianrossi R | 1992 | Am Heart J1992，124，3： | 1 |
| 9 | Resources for nuclear and radia-tion disaster response显示文摘 | Maiello ML 'Ken'Groves KL | | 0，，9： | 1 |
| 10 | Evaluation of cytotoxic concentration-time response in A549 cells exposed to respirable α-quartz显示文摘 | FANIZZA C FRESEGNA A M MAIELLO R | 2009 | J Appl Toxicol2009，29，： | 1 |
| 11 | Coronary angioplasty of chronic occlusions:factors predictive of procedural success显示文摘 | Maiello L Colombo A Gianrossi R | 1992 | Am Heart J1992，124，3： | 1 |
| 12 | Evaluation of the pharmacokinetics of ixabepilone for the treatment of breast cancer显示文摘 | De Luca A D’Alessio A Maiello MR | 2015 | Expert Opin Drug Metab Toxicol2015，11，7： | 1 |
| 13 | EGFR and MEK blockade in triple negative breast cancer cells 显示文摘 | Maiello MR D'Alessio A Bevilaequa S | 2015 | J Cell Biochem2015，116，： | 1 |
| 14 | Percutaneous translumi- nal coronary revascularization in women: Higher risk of dissection and need for stenting显示文摘 | Carcagni A Carnellini M Maiello L | 2000 | ItaI Heart J2000，1，： | 1 |
| 15 | Coronary angioplasty of chronic occlusions:factors predictive of procedural success显示文摘 | Maiello L Coclmbo A Gianrossi R | 1992 | Am Heart J1992，124，： | 1 |
| 16 | Fetal lung lesions diagnosis:the crucial role of ultrasonography显示文摘 | Pedata R Palermo M Maiello M | 2009 | J Prenat Med2009，3，4： | 1 |
| 17 | Second21ine chemotherapy in advanced pancreatic carcinoma:a multicenter survey of the Gruppo Oncologico Italia Meridionale on the activity and safety of the F0L2 F0X4 regimen in clinical practice显示文摘 | Gebbia V Maiello E Giuliani F | 2007 | Ann Oncol2007，18，16： | 1 |
| 18 | Adjuvant colon cancer chemotherapy: where we are and where we’ll go显示文摘 | L. Lombardi F. Morelli S. Cinieri D. Santini N. Silvestris N. Fazio L. Orlando G. Tonini G. Colucci E. Maiello | 2010 | Cancer Treatment Reviews2010，，： | 1 |
| 19 | Treatment of inoperable and/or metastatic biliary tree carcinomas with single-agent gemcitabine or in combination with levofolinic acid and infusional fluorouracil: resuhs of a muhicenter phase Ⅱ study 显示文摘 | Gebbia V Giuliani F Maiello E | 2001 | J Clin Oncol2001，19，： | 1 |
| 20 | Fate of octamethylcyclotetrasiloxane (OMCTS) in the atmosphere and in sewage treatment plants as an estimation of aquatic exposure显示文摘 | Mueller J A Di Tom D M Maiello J A | 1995 | Environmental Toxicology and Chemistry1995，14，10： | 1 |
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