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| 1 | Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress显示文摘BACKGROUND:Liver ischemia reperfusion(IR)injury triggers a systemic inflammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver surgery.Pentoxifylline(PTX)and hypertonic saline solution(HTS)have been identified to have beneficial effects against IR injury.This study aimed to investigate if the addition of PTX to HTS is superior to HTS alone for the prevention of liver IR injury. | Vinicius Rocha-Santos Estela RR Figueira Joel A Rocha-Filho Ana MM Coelho Rafael Soraes Pinheiro Telesforo Bacchella Marcel CC Machado Luiz AC D'Albuquerque | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 3 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 4 | Beneficial effects of adenosine triphosphate-sensitive K^+ channel opener on liver ischemia/reperfusion injury显示文摘AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury.METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation.They were divided into 3 groups:Control Group,rats submitted to liver manipulation,Saline Group,rats received saline,and Diazoxide Group,rats received intravenous injection diazoxide(3.5 mg/kg) 15 min before liver reperfusion.4 h and 24 h after reperfusion,blood was collected for determination of aspartate transaminase(AST),alanine transaminase(ALT),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitrite/nitrate,creatinine and tumor growth factor-β1(TGF-β1).Liver tissues were assembled for mitochondrial oxidation and phosphorylation,malondialdehyde(MDA) content,and histologic analysis.Pulmonary vascular permeability and myeloperoxidase(MPO) were also determined.RESULTS:Four hours after reperfusion the diazoxide group presented with significant reduction of AST(2009 ± 257 U/L vs 3523 ± 424 U/L,P = 0.005); ALT(1794 ± 295 U/L vs 3316 ± 413 U/L,P = 0.005); TNF-α(17 ± 9 pg/mL vs 152 ± 43 pg/mL,P = 0.013; IL-6(62 ± 18 pg/mL vs 281 ± 92 pg/mL); IL-10(40 ± 9 pg/mL vs 78 ± 10 pg/mL P = 0.03),and nitrite/nitrate(3.8 ± 0.9 μmol/L vs 10.2 ± 2.4 μmol/L,P = 0.025) when compared to the saline group.A significant reduction in liver mitochondrial dysfunction was observed in the diazoxide group compared to the saline group(P < 0.05).No differences in liver MDA content,serum creatinine,pulmonary vascular permeability and MPO activity were observed between groups.Twenty four hours after reperfusion the diazoxide group showed a reduction of AST(495 ± 78 U/L vs 978 ± 192 U/L,P = 0.032); ALT(335 ± 59 U/L vs 742 ± 182 U/L,P = 0.048),and TGF-β1(11 ± 1 ng/mL vs 17 ± 0.5 ng/mL,P = 0.004) serum levels when compared to the saline group.The control group did not present alterations when compared to the diazoxide and saline groups.CONCLUSION:Diazoxide maintains liver mitochondrial function,increases liver tolerance to ischemia/reperfusion injury,and reduces the systemic inflammatory response.These effects require further evaluation for using in a clinical setting. | Mateus Antunes Nogueira Ana Maria Mendona Coelho Sandra Nassa Sampietre Rosely Antunes Patzina Fabiano Pinheiro da Silva Luiz Augusto Carneiro D'Albuquerque Marcel Cerqueira Cesar Machado | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 5 | Diagnosis and Objective Pain Assessment of Traditional Chinese Medicine May Be Useful to Demonstrate Specific Effects of Acupuncture in Low Back Pain: A Prospective, Randomized, Controlled and Single Blinded Pre-study显示文摘Objective: To prove specific effects of acupuncture on chronic pain. It was speculated that the potential specific effectiveness of acupuncture could be better shown in more properly designed studies. Therefore, diagnoses of both Western medicine and traditional Chinese medicine (TCM) were used as inclusion criteria to allocate acupoints more precisely to the complaints of the patients. Secondly, objectively measurable parameters of pain relief in addition to usual Visual Analogue Scale (VAS) were chosen to quantify the effects of acupuncture. Methods: The study was prospective, randomized, controlled and single-blinded. Eighteen patients with chronic back pain and TCM diagnosis of a Taiyang/Yangming syndrome received one single session of acupuncture chosen according to TCM diagnosis or acupuncture on points outside the meridian system (controls). We evaluated pain via VAS and increased mobility via inclinometry of the back. Results: Although the sample size was small, there was a statistically significant improvement in pain and mobility in the intervention group (n=13), but not in the control group (n=5). The calculated sample size adequate power was lower for inclinometry than for VAS, indicating that VAS is less probable to discriminate acupuncture effects. Conclusion: Objectively measurable physical parameters such as the angle of flexion before and after acupuncture (inclinometry) may be more suitable to measure pain relief than subjective assessment by VAS in acupuncture studies. TCM diagnosis may be a helpful inclusion criterion in studies on acupuncture, so as to potentially allocate interventions better to the complaints of patients. | Susana Seca Paula Capelo Thomas Efferth Christoph Alexander Doenitz Sven Schroeder Ana Anjos Jorge Machado Henry Johannes Greten | 2013 | Journal of Acupuncture and Tuina Science2013，11，3： | 2 |
| 6 | Sleep deprivation induced by the modified multiple platform technique: quantification of sleep loss and recovery显示文摘 | Ricardo Borges Machado Débora C Hipólide Ana Amélia Benedito-Silva Sergio Tufik | 2004 | Brain Research2004，，1： | 1 |
| 7 | Rheological behavior of compatibilized and non-compatibilized PA6/EPM blends显示文摘 | Jorge Silva Ana Vera Machado Jo?o Maia | 2007 | Rheologica Acta2007，，8： | 1 |
| 8 | Timing-dependent protection of hypertonic saline solution administration in experimental liver ischemia/reperfusion injury显示文摘 | Estela Regina Ramos Figueira Telesforo Bacchella Ana Maria Mendon?a Coelho Sandra Nassa Sampietre Nilza Aparecida Trindade Molan Regina Maria Cubero Leit?o Marcel Cerqueira Cesar Machado | 2010 | Surgery2010，，3： | 1 |
| 9 | Helicobacter pylori infection generates genetic instability in gastric cells显示文摘 | Ana Manuel Dantas Machado Céu Figueiredo Raquel Seruca Lene Juel Rasmussen | 2010 | BBA - Reviews on Cancer2010，，1： | 1 |
| 10 | Positive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant显示文摘 | Nibia Mariana Eleuterio Ana C.T. Palei Jackeline S. Rangel Machado Jose E. Tanus-Santos Ricardo C. Cavalli Valeria C. Sandrim | 2015 | Pregnancy Hypertension: An International Journal2015，，： | 1 |
| 11 | Rheologi-cal behavior of compatibilized and non-compatibilizedPA6/EPM blends显示文摘 | Jorge Silva Ana Vera Machado Joao Maia | 2007 | Rheol Acta2007，46，8： | 1 |
| 12 | Timing-dependent protection of hypertonic saline solution administration in experimental liver ischemia/reperfusion injury显示文摘 | Estela Regina Ramos Figueira Telesforo Bacchella Ana Maria Mendon?a Coelho Sandra Nassa Sampietre Nilza Aparecida Trindade Molan Regina Maria Cubero Leit?o Marcel Cerqueira Cesar Machado | 2010 | Surgery2010，，3： | 1 |
| 13 | Sleep deprivation induced by the modified multiple platform technique: quantification of sleep loss and recovery显示文摘 | Ricardo Borges Machado Débora C Hipólide Ana Amélia Benedito-Silva Sergio Tufik | 2004 | Brain Research2004，，1： | 1 |
| 14 | Enhancement of the thermo oxidative degradability of polystyrene by chemical modification显示文摘 | Gabriela Botelhoa Arlete Queiro sa Ana Machado | 2004 | Polymer degradation and stability2004，86，3： | 1 |
| 15 | Colour stability of relined dentures after chemical disinfection. A randomised clinical trial显示文摘 | Eduardo Buozi Moffa Eunice Teresinha Giampaolo Fernanda Emiko Izumida Ana Cláudia Pavarina Ana Lúcia Machado Carlos Eduardo Vergani | 2011 | Journal of Dentistry2011，，： | 1 |
| 16 | Extraction of copper from acidic leach solution with A- corga M5640 using a pulsed sieve plate column显示文摘 | Ana E Ferreira Shiva Agarwal Remfgio M Machado et ft | 2010 | Hy- :lrometallurgy2010，104，1： | 1 |
| 17 | Electro-Acupuncture Efficacyon Pain Control after Mandibular Third Molar Surgery显示文摘 | MARCONI GONZAGA TAVARES ANA PAULA MACHADO BRENO GUTIERREZ MOTTA | 2007 | BRAZ Dent2007，18，2： | 1 |
| 18 | The experience of the family care- giver of stroke victim显示文摘 | Ana Larissa Gomes Machado | 2009 | Rev Bras Enferm2009，62，2： | 1 |
| 19 | Nitric oxide plays a key role in the suppressive activity of tolerogenic dendritic cells显示文摘 | Liana Verinaud Luidy Kazuo Issayama Fabio Zanucoli Ana Carolina de Carvalho Thiago Alves da Costa Rosaria Di Gangi Amanda Pires Bonfanti Isadora Tassinari Ferreira Alexandre Leite Rodrigues de Oliveira Dagmar Ruth Stach Machado Rodolfo Thome | 2015 | Cellular & Molecular Immunology2015，12，3： | 1 |
| 20 | Prime and boost immunization with influenza and adenovirus encoding the Toxoplasma gondii surface antigen 2 (SAG2) induces strong protective immunity显示文摘 | Alexandre V. Machado Bráulia C. Caetano Rafael P. Barbosa Ana Paula C. Salgado Renata H. Rabelo Cristiana C. Garcia Oscar Bruna-Romero Nicolas Escriou Ricardo T. Gazzinelli | 2010 | Vaccine2010，，： | 1 |
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