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| 1 | Expression of Cytokine Signaling Genes in Morbidly Obese Patients with Non-Alcoholic Steatohepatitis and Hepatic Fibrosis显示文摘 | J. Michael Estep Ancha Baranova Noreen Hossain Hazem Elariny Kathy Ankrah Arian Afendy Vikas Chandhoke Zobair M. Younossi | 2009 | Obesity Surgery2009，，5： | 1 |
| 2 | Obesity-related Differential Gene Expression in the Visceral Adipose Tissue显示文摘 | Ancha Baranova Rochelle Collantes Shobha J Gowder Hazem Elariny Karen Schlauch Abraham Younoszai Steve King Manpreet Randhawa Sitapati Pusulury Tariq Alsheddi Janus P Ong Lisa M Martin Vikas Chandhoke Zobair M Younossi | 2005 | Obesity Surgery2005，，6： | 1 |
| 3 | Hepatic Gene Expression of Caucasian and African-American Patients with Obesity-Related Non-Alcoholic Fatty Liver Disease显示文摘 | Maria Stepanova Noreen Hossain Arian Afendy Kellie Perry Zachary D. Goodman Ancha Baranova Zobair Younossi | 2010 | Obesity Surgery2010，，5： | 1 |
| 4 | A Novel Diagnostic Biomarker Panel for Obesity-related Nonalcoholic Steatohepatitis (NASH)显示文摘 | Zobair M. Younossi Mohammed Jarrar Clare Nugent Manpreet Randhawa Mariam Afendy Maria Stepanova Nila Rafiq Zachary Goodman Vikas Chandhoke Ancha Baranova | 2008 | Obesity Surgery2008，，11： | 1 |
| 5 | Gene Expression of Leptin, Resistin, and Adiponectin in the White Adipose Tissue of Obese Patients with Non-Alcoholic Fatty Liver Disease and Insulin Resistance显示文摘 | Ancha Baranova Shobha J Gowder Karen Schlauch Hazem Elariny Rochelle Collantes Arian Afendy Janus P Ong Zachary Goodman Vikas Chandhoke Zobair M Younossi | 2006 | Obesity Surgery2006，，： | 1 |
| 6 | Shared genetics and bidirectional causal relationships between type 2 diabetes and attention-deficit/hyperactivity disorder显示文摘Background Type 2 diabetes(T2D)is a chronic metabolic disorder with high comorbidity with mental disorders.The genetic links between attention-deficit/hyperactivity disorder(ADHD)and T2D have yet to be elucidated.Aims We aim to assess shared genetics and potential associations between ADHD and T2D.Methods We performed genetic correlation,two-sample Mendelian randomisation and polygenic overlap analyses between ADHD and T2D.The genome-wide association study(GWAS)summary results of T2D(80154 cases and 853816 controls),ADHD2019(20183 cases and 35191 controls from the 2019 GWAS ADHD dataset)and ADHD2022(38691 cases and 275986 controls from the 2022 GWAS ADHD dataset)were used for the analyses.The T2D dataset was obtained from the DIAGRAM Consortium.The ADHD datasets were obtained from the Psychiatric Genomics Consortium.We compared genome-wide association signals to reveal shared genetic variation between T2D and ADHD using the larger ADHD2022 dataset.Moreover,molecular pathways were constructed based on large-scale literature data to understand the connection between ADHD and T2D.Results T2D has positive genetic correlations with ADHD2019(rg=0.33)and ADHD2022(rg=0.31).Genetic liability to ADHD2019 was associated with an increased risk for T2D(odds ratio(OR):1.30,p<0.001),while genetic liability to ADHD2022 had a suggestive causal effect on T2D(OR:1.30,p=0.086).Genetic liability to T2D was associated with a higher risk for ADHD2019(OR:1.05,p=0.001)and ADHD2022(OR:1.03,p<0.001).The polygenic overlap analysis showed that most causal variants of T2D are shared with ADHD2022.T2D and ADHD2022 have three overlapping loci.Molecular pathway analysis suggests that ADHD and T2D could promote the risk of each other through inflammatory pathways.Conclusions Our study demonstrates substantial shared genetics and bidirectional causal associations between ADHD and T2D. | Ancha Baranova Vikas Chandhoke Hongbao Cao Fuquan Zhang | 2023 | General Psychiatry2023，36，2： | 0 |
| 7 | Causal associations between major depressive disorder and COVID-19显示文摘Background We aimed to evaluate whether major depressive disorder(MDD)could aggravate the outcomes of coronavirus disease 2019(COVID-19)or whether the genetic liability to COVID-19 could trigger MDD.Aims We aimed to assess bidirectional causal associations between MDD and COVID-19.Methods We performed genetic correlation and Mendelian randomisation(MR)analyses to assess potential associations between MDD and three COVID-19 outcomes.Literature-based network analysis was conducted to construct molecular pathways connecting MDD and COVID-19.Results We found that MDD has positive genetic correlations with COVID-19 outcomes(rg:0.10–0.15).Our MR analysis indicated that genetic liability to MDD is associated with increased risks of COVID-19 infection(odds ratio(OR)=1.05,95%confidence interval(CI):1.00 to 1.10,p=0.039).However,genetic liability to the three COVID-19 outcomes did not confer any causal effects on MDD.Pathway analysis identified a panel of immunity-related genes that may mediate the links between MDD and COVID-19.Conclusions Our study suggests that MDD may increase the susceptibility to COVID-19.Our findings emphasise the need to increase social support and improve mental health intervention networks for people with mood disorders during the pandemic. | Ancha Baranova Yi Zhao Hongbao Cao Fuquan Zhang | 2023 | General Psychiatry2023，36，2： | 0 |
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