|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected. | Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena | 2007 | World Journal of Gastroenterology2007，13，3： | 18 |
| 2 | drug-induced autoimmune liver disease:a diagnostic dilemma of an increasingly reported disease显示文摘The aetiology of autoimmune hepatitis(AIH) is uncer-tain but the disease can be triggered in susceptible patients by external factors such as viruses or drugs.AIH usually develops in individuals with a genetic back-ground mainly consisting of some risk alleles of the major histocompatibility complex(HLA).Many drugs have been linked to AIH phenotypes,which sometimes persist after drug discontinuation,suggesting that they awaken latent autoimmunity.At least three clini-cal scenarios have been proposed that refers to drug- induced autoimmune liver disease(DIAILD):AIH with drug-induced liver injury(DILI); drug induced-AIH(DI-AIH); and immune mediated DILI(IM-DILI).In addi-tion,there are instances showing mixed features of DI-AIH and IM-DILI,as well as DILI cases with positive autoantibodies.Histologically distinguishing DILI from AIH remains a challenge.Even more challenging is the differentiation of AIH from DI-AIH mainly relying in histological features; however,a detailed standard-ised histologic evaluation of large cohorts of AIH and DI-AIH patients would probably render more subtle features that could be of help in the differential diag-nosis between both entities.Growing information on the relationship of drugs and AIH is being available,being drugs like statins and biologic agents more fre-quently involved in cases of DIAILD.In addition,there is some evidence on the fact that patients diagnosed with DIAILD may have had a previous episode of hepa-totoxicity.Further collaborative studies in DIAILD will strengthen the knowledge and understanding of this intriguing and complex disorder which might represent different phenotypes across the spectrum of | Agustin Castiella Eva Zapata M Isabel Lucena Raúl J Andrade | 2014 | World Journal of Hepatology2014，6，4： | 13 |
| 3 | Comparison of two clinical scales for causality assessment in hepatotoxicity显示文摘 | Ma Isabel Lucena Raquel Camargo Raúl J. Andrade Carlos J. Perez-Sanchez Felipe Sanchez De La Cuesta | 2001 | Hepatology2001，，1： | 2 |
| 4 | Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: Is there still a role for these drugs?显示文摘四乙秋兰姆化二硫和钙 carbimide 是二白酒威慑然而,广泛地在那里在酒精中毒治疗使用的狂言存在对他们的安全的大担心。hepatotoxicity 上的报告主要与四乙秋兰姆化二硫治疗有关,被出版了。钙 carbimide 的肝毒素的潜力是很好描绘的更少。这里,我们描述与被提交到 hepatotoxicity 的一张注册表并且当规定这些混合物时,指出我们面对的限制的这个治疗学的组有关的肝损坏的四个案例。对在白酒依赖的管理的这些混合物的角色的重估清楚地被需要。 | Carmen Verge M Isabel Lucena Enrique López-Torres M José Puche-García Enrique Fraga Manuel Romero-Gomez Raúl J Andrade | 2006 | World Journal of Gastroenterology2006，12，31： | 2 |
| 5 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 6 | 显示文摘 | Santos RA Campagnole-Santos M J Andrade SP | 2000 | Regul Peptide2000，91，13： | 1 |
| 7 | Drug-induced liver injury: Interactions between drug properties and host factors显示文摘 | Minjun Chen Ayako Suzuki Jürgen Borlak Raúl J. Andrade M Isabel Lucena | 2015 | Journal of Hepatology2015，，2： | 1 |
| 8 | P53 and Bcl-2 as prognostic predictors in epithelial ovarian cancer显示文摘 | Sagarra RA Andrade LA Martima EZ | 2002 | Int J Gynecol Cancer2002，12，： | 1 |
| 9 | Mechanisms of angiotensin-( 1- 7)-induced inhibition of anglogenesis 显示文摘 | Machado RD Santos RA Andrade SP | 2001 | Am J Physiol Regall Integr Comp Physiol2001，280，4： | 1 |
| 10 | Effect of sustained virological response to treatment on the incidence of abnormal glucose values in chronic hepatitis C显示文摘 | Manuel Romero-Gómez Conrado M. Fernández-Rodríguez Raúl J. Andrade Moisés Diago Sonia Alonso Ramón Planas Ricard Solá José A. Pons Javier Salmerón Rafael Barcena Ramón Perez Isabel Carmona Santiago Durán | 2008 | Journal of Hepatology2008，，5： | 1 |
| 11 | The effects of Roux-en-Y limb length on gastric emptying and enterogastric reflux in rats显示文摘 | Dutra RA Araújo WM Andrade JI | | 0，，02： | 1 |
| 12 | Mechanisms of angiotensin-(1-7)-induced inhibition of angiogenesis显示文摘 | Machado RD Santos RA Andrade SP | 2001 | Am J Physiol Regul Integr Comp Physiol2001，280，4： | 1 |
| 13 | The systematic distortion hypothesis 显示文摘 | Shweder RA D'Andrade RG | 1980 | New Directions for Methodology of Social and Behavior Science1980，4，： | 1 |
| 14 | Patient decision to initiate ther-apy for osteoporosis :the influence of knowledge and beliefs显示文摘 | Yood RA Mazor KM Andrade SE | 2008 | J GenIntern Med’2008，23，11： | 1 |
| 15 | Treatment for low-risk gestational trophoblastic disease:comparison of single-agent methotrexate,dactinomycin and combination regimens显示文摘 | Abrao RA de Andrade JM Tiezzi DG | | 0，，01： | 1 |
| 16 | Prevalence of dental trauma in Pan American games athletes显示文摘 | Andrade RA Evans PL Almeida AL | 2010 | Dent Traumatol2010，26，3： | 1 |
| 17 | Interleukin 10 protect mice against staphylococcal enterotoxin B-induced lethaI shock显示文摘 | Bean AG Freiberg RA Andrade S | | 0，，： | 1 |
| 18 | Treatment of low-risk gestational trophoblastic disease: comparison of single agent methotrexate, dactinomycin and combination regimens显示文摘 | Abrao RA de Andrade JM Tiezzi DG | 2008 | Gyneeol Oncol2008，108，： | 1 |
| 19 | Surface modification of maize starch films by low-pressure glow 1- butene plasma显示文摘 | Andrade CT Simao RA Thire RMSM | 2005 | Carbohydrate Polymers2005，61，4： | 1 |
| 20 | Treatment for low-risk gestational tmphoblastic disease:comparison of single-agent methotrexate,dactinomycin and combination regimens显示文摘 | Abrao RA de Andrade JM Tiezzi DG | 2008 | GynecolOncol2008，108，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员