维普期刊资源整合服务平台（V6.5）

127篇 您的检索式：作者名="Borlak"

选中清除导出查看参考文献查看引证文献引用追踪共7页首页上一页第1页下一页末页 /7 跳转

	题名	作者	年代	出处	被引量
1	MicroRNAs in the Human Heart: A Clue to Fetal Gene Reprogramming in Heart Failure显示文摘	Thomas Thum Paolo Galuppo Christian Wolf Jan Fiedler Susanne Kneitz Linda W. van Laake Pieter A. Doevendans Christine L. Mummery Jürgen Borlak Axel Haverich Carina Gross Stefan Engelhardt Georg Ertl Johann Bauersachs	2007	Circulation2007，，3：	3
2	Mapping of liver-enriched transcription factors in the human intestine显示文摘AIM: To investigate the gene expression pattern of hepatocyte nuclear factor 6 (HNF6) and other liverenriched transcription factors in various segments of the human intestine to better understand the differentiation of the gut epithelium. METHODS: Samples of healthy duodenum and jejunum were obtained from patients with pancreatic cancer whereas ileum and colon was obtained from patients undergoing right or left hemicolectomy or (recto)sigmoid or rectal resection. All surgical specimens were subjected to histopathology. Excised tissue was shock-frozen and analyzed for gene expression of liver-enriched transcription factors by semiquantitative reverse transcription polymerase chain and compared to the human colon carcinoma cell line Caco-2. Protein expression of major liver-enriched transcription factors was determined by Western blotting while the DNA binding of HNF6 was investigated by electromobility shift assays. RESULTS: The gene expression patterning of liverenriched transcription factors differed in the various segments of the human intestine with HNF6 gene expression being most abundant in the duodenum (P < 0.05) whereas expression of the zinc finger protein GATA4 and of the HNF6 target gene ALDH3A1 was most abundant in the jejunum (P < 0.05). Likewise, expression of FOXA2 and the splice variants 2 and 4 of HNF4α were most abundantly expressed in the jejunum (P < 0.05). Essentially, expression of transcription factors declined from the duodenum towards the colon with the most abundant expression in the jejunum and less in the ileum. The expression of HNF6 and of genes targeted by this factor, i.e. neurogenin 3 (NGN3) was most abundant in the jejunum followed by the ileum and the colon while DNA binding activity of HNF4α and of NGN3 was conf irmed by electromobility shift assays to an optimized probe. Furthermore, Western blotting provided evidence of the expression of several liver-enriched transcription factors in cultures of colon epithelial cells, albeit at different levels. CONCLUSION: We describe significant local and segmental differences in the expression of liver-enriched transcription factors in the human intestine which impact epithelial cell biology of the gut.	Frank Lehner Ulf Kulik Juergen Klempnauer Juergen Borlak	2010	World Journal of Gastroenterology2010，16，31：	2
3	Hallmarks of ion channel gene expression in end-stage heart failure 显示文摘	BORLAK J THUM T	2003	FASEB J2003，17，12：	1
4	Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis显示文摘	Anderson N Borlak J	2008	Pharmacol Rev2008，60，3：	1
5	The environmental carcinogen 3 - nitro- bcnzanthrone and its main me/abolite 3 - aminobenzanthrone enhance formation of reactive oxygen intermediates in human A549 lung epi- thelial cells显示文摘	Hansen T Seidel A Borlak J	2007	Toxicol Appl Pharmaco12007，221，2：	1
6	Drug-induced liver injury: Interactions between drug properties and host factors显示文摘	Minjun Chen Ayako Suzuki Jürgen Borlak Raúl J. Andrade M Isabel Lucena	2015	Journal of Hepatology2015，，2：	1
7	An optimized method for isolation and identification of membrane protein显示文摘	LEHNER I NIEHOF M BORLAK J	2003	Electrophoresis2003，24，11：	1
8	Automated in-tube solid-phase microextraction in cell cultures 显示文摘	Mullett W M Levsen K Borlak J	2002	Anal Chem2002，74，：	1
9	Epidermal growth fOtor - in- ducedhepatocellular carcinoma: gene expression profiles in pre- cursor lesions, early stage and solitary tumours 显示文摘	Borlak J Meier T haher R	2005	Oncogene2005，24，11：	1
10	Identification of major CYP2C9 and CYP2C19 polymorphisms by fluorescence resonance energy transfer analysis显示文摘	Borlak J Thum T		0，，：	1
11	An optimized method for the isolation and identification of membrane proteins显示文摘	Lehner I Niehof M Borlak J	2003	Electro- phoresis2003，24，11：	1
12	GATA4 zinc finger mutations as a molecular rationale for septation defects of the human heart 显示文摘	Reamon-Buettner SM Borlak J	2005	J Med Genet2005，42，5：	1
13	Functional dissection of sequence-specific NKX2-5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system显示文摘	Inga A Reamon-Buettner SM Borlak J	2005	Hum Mol Genet2005，14，14：	1
14	Drug-induced phospholipidosis 显示文摘	Anderson N Borlak J	2006	FEBS Lett2006，580，：	1
15	LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltr-ansferases显示文摘	Boger R H Sydow K Borlak J	2000	Cir Res2000，2187，2：	1
16	Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein induced vascular injury:therapy through LOX- 1 receptor antagonism显示文摘	Thum T Borlak J	2004	Circ Res2004，94，1：	1
17	Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis显示文摘	Anderson N Borlak J	2008	Pharmacol Rev2008，60，：	1
18	LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells:involvement of S-adenosylmethionine-dependent methyltransferases显示文摘	Boger RH Sydow K Borlak J	2000	Circ Res2000，87，：	1
19	Physiological incompatibilities of porcine hepatocytes for clinical liver support显示文摘	SCHREM H KLEINE M BORLAK J	2006	Liver Transpl2006，12，：	1
20	TBX5mutations in non-Holt-Oram syndrome(HOS) malformed hearts显示文摘	Reamon-Buettner SM Borlak J	2004	Hum Mutat2004，24，：	1

返回顶部每页显示：

共7页首页上一页第1页下一页末页 /7 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示