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| 1 | Hidden risks associated with conventional short intermittent hemodialysis:A call for action to mitigate cardiovascular risk and morbidity显示文摘The development of maintenance hemodialysis(HD)for end stage kidney disease patients is a success story that continues to save many lives.Nevertheless,intermittent renal replacement therapy is also a source of recurrent stress for patients.Conventional thrice weekly short HD is an imperfect treatment that only partially corrects uremic abnormalities,increases cardiovascular risk,and exacerbates disease burden.Altering cycles of fluid loading associated with cardiac stretching(interdialytic phase)and then fluid unloading(intradialytic phase)likely contribute to cardiac and vascular damage.This unphysiologic treatment profile combined with cyclic disturbances including osmotic and electrolytic shifts may contribute to morbidity in dialysis patients and augment the health burdenof treatment. As such, HD patients are exposed to multiple stressors including cardiocirculatory,inflammatory, biologic, hypoxemic, and nutritional. This cascade of events can be termed thedialysis stress storm and sickness syndrome. Mitigating cardiovascular risk and morbidityassociated with conventional intermittent HD appears to be a priority for improving patientexperience and reducing disease burden. In this in-depth review, we summarize the hidden effectsof intermittent HD therapy, and call for action to improve delivered HD and develop treatmentschedules that are better tolerated and associated with fewer adverse effects. | Bernard Canaud Jeroen P Kooman Nicholas M Selby Maarten Taal Andreas Maierhofer Pascal Kopperschmidt Susan Francis Allan Collins Peter Kotanko | 2022 | World Journal of Nephrology2022，11，2： | 2 |
| 2 | Integration of community health workers into health systems in developing countries:Opportunities and challenges显示文摘Background:Developing countries have the potential to reach vulnerable and underserved populations marginalized by the country’s health care systems by way of community health work-ers(CHWs).It is imperative that health care systems focus on improving access to quality continu-ous primary care through the use of CHWs while paying attention to the factors that impact on CHWs and their effectiveness.Objective:To explore the possible opportunities and challenges of integrating CHWs into the health care systems of developing countries.Methods:Six databases were examined for quantitative,qualitative,and mixed-methods stud-ies that included the integration of CHWs,their motivation and supervision,and CHW policy making and implementation in developing countries.Thirty-three studies met the inclusion criteria and were double read to extract data relevant to the context of CHW programs.Thematic coding was conducted and evidence on the main categories of contextual factors influencing integration of CHWs into the health system was synthesized.Results:CHWs are an effective and appropriate element of a health care team and can assist in addressing health disparities and social determinants of health.Important facilitators of integration of CHWs into health care teams are support from other health workers and inclusion of CHWs in case management meetings.Sustainable integration of CHWs into the health care system requires the formulation and implementation of polices that support their work,as well as financial and nonfinancial incentives,motivation,collaborative and supportive supervision,and a manageable workload.Conclusions:For sustainable integration of CHWs into health care systems,high-performing health systems with sound governance,adequate financing,well-organized service delivery,and adequate supplies and equipment are essential.Similarly,competent communities could contrib-ute to better CHW performance through sound governance of community resources,promotion of inclusiveness and cohesion,engagement in participatory decision making,and mobilization of local resources for community welfare. | Collins Otieno Asweto Mohamed Ali Alzain Sebastian Andrea Rachel Alexander Wei Wang | 2016 | Family Medicine and Community Health2016，4，1： | 2 |
| 3 | R E Nanotube Nanodevice显示文摘 | PHILIP G COLLINS A ZETTL HIROSHI BANDO ANDREAS THESS SMALLEY | 1997 | Science1997，278，： | 1 |
| 4 | Blunted hypothalamic–pituitary–adrenocortical axis responsivity to stress in persons with a family history of alcoholism显示文摘 | Kristen H. Sorocco William R. Lovallo Andrea S. Vincent Frank L. Collins | 2006 | International Journal of Psychophysiology2006，，3： | 1 |
| 5 | P<sub>2x</sub>‐purinoceptors of myenteric neurones from the guinea‐pig ileum and their unusual pharmacological properties显示文摘 | Carlos Barajas‐López Jan D. Huizinga Stephen M. Collins Vladimir Gerzanich Rosa Espinosa‐Luna Andrea L. Peres | 2012 | British Journal of Pharmacology2012，，8： | 1 |
| 6 | Assessing the Environmental Impacts of Mega Sporting Events: Two Options ? 显示文摘 | Andrea Collins Calvin Jones Max Munday | 2009 | Tourism Management2009，，3： | 1 |
| 7 | Synthesis and evaluation of S- and C(1)-substituted analogues of lincomycin显示文摘 | Collin M P Hobbie S N B?ttger E C Andrea Vasella A | 2009 | Helv Chim Acta2009，92，： | 1 |
| 8 | Fatal and non-fatal injuries due to suspension trauma syndrome: A systematic review of definition, pathophysiology, and management controversies显示文摘BACKGROUND: Suspension trauma syndrome is a life-threatening event that occurs when a person is 'trapped' in a prolonged passive suspension. It is most commonly seen in people who engage in occupational or sport activities that require harness suspension. The aim of this study is to identify the predisposing factors, pathophysiology, and management of suspension trauma.METHODS: A review and analysis of the literature published in English and Spanish from 1972 to 2020 on suspension trauma were performed. Search sources were Pub Med, Medline, Cochrane Library, MeSH, Up To Date, and Google Scholar. Articles referring to suspension trauma associated with other injury mechanisms(traumatic impact injuries, drowning, asphyxiation, or bleeding), case reports, and pediatric population were excluded.RESULTS: Forty-one articles were identified. Of these, 29 articles related to mechanism, pathophysiology, and management of individuals who suffered prolonged suspension trauma without associated traumatic injuries were included in the study. We encountered several controversies describing the putative pathophysiology, ranging from blood sequestration in the lower extremities versus accumulation of metabolic waste and hyperkalemia to dorsal hook-type harness as a trigger cause of positional asphyxia;to vascular compression of femoral vessels exerted by the harness causing decreased venous return. Pstients suspended in a full-body harness with dorsal hook showed more hemodynamic alterations in response to the compressive effect on the rib cage, causing a reduction in perfusion by presenting a decrease in pulse pressure. Management strategies varied across studies.CONCLUSIONS: Progress has been made in individualizing the population at risk and in the management of suspension trauma. We recommend the formation of consensus definitions, larger cohort or registry studies to be conducted, and experimental animal models to better understand the mechanisms in order to develop management and life support guidelines from a trauma and emergency medicine perspective. | Patrizio Petrone Sofía Espinoza-Villalobos Gerard ABaltazar Kjetil Søreide Adam Stright Collin E.M.Brathwaite D’Andrea K.Joseph | 2021 | World Journal of Emergency Medicine2021，12，4： | 1 |
| 9 | The Malaysian health care system:Ecology,plans,and reforms显示文摘Malaysia is on its way to achieving developed nation status in the next 4 years.Currently,Malaysia is on track for three Millennium Development Goals(MDG1,MDG4,and MDG7).The maternal mortality rate,infant mortality rate,and mortality rate of children younger than 5 years improved from 25.6%(2012)to 6.6%(2013),and 7.7%(2012)per 100,000 live births,respectively whereas immunization coverage for infants increased to an average of 90%.As of 2013 the ratio of physicians to patients improved to 1:633 while the ratio of health facilities to the population was 1:10,272.The current government administration has proposed a reform in the form of the 10th Malaysian Plan coining the term“One Care for One Malaysia”as the newly improved and reorganized health care plan,where efficiency,effectiveness,and equity are the main focus.This review illustrates Malaysia’s transition from pre-independence to the current state,and its health and socioeconomic achievement as a country.It aims to contribute knowledge through identifying the plans and reforms by the Malaysian government while highlighting the challenges faced as a nation. | Andrea Sebastian Mohamed Ali Alzain Collins Otieno Asweto Gehendra Mahara Xiuhua Guo Manshu Song Youxin Wang Wei Wang | 2016 | Family Medicine and Community Health2016，4，3： | 0 |
| 10 | 佛罗里达国际大学(FIU)建筑学院显示文摘佛罗里达国际大学所在的迈阿密是美国东南地区最大也是发展最为迅速的城市。为该大学建筑学院设计一所新大楼,不仅是对这所年轻的学院的扩展,也是这座蓬勃发展的城市促进各个充满活力的文化群体间互动交流的良好契机。 | bernard tschumi anne save de beaurecueil johanne riegels oestergaard valentin bontjes van beek joel rutten robert holton william feuerman roderick villafranca kim starr peter cornell kevin collins tom kowalski andrea day | 2016 | 城市环境设计2016，0，1： | 0 |
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