|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic value of increased carbohydrate antigen in patients with heart failure显示文摘AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) patients.METHODS:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to 2011.Patients were included in the study if they had a previous documented episode of HF and received HF treatment.CA125 and NT-proBNP concentrations were measured.The independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) index.RESULTS:The mean age of the 156 patients was 72 ± 12 years.During follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for HF.Higher CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P < 0.05),and 94 ± 121 KU/L in those who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P < 0.01).After adjusting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P < 0.001) and intermediate when only NT-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P < 0.01).Moreover,when CA125 was added to the clinical model with NT-proBNP,a 4%(P < 0.05) improvement in the IDI was found.CONCLUSION:CA125 > 60 KU/L identified patients in stable HF with poor survival.Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes. | Ana B Méndez Jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig | 2014 | World Journal of Cardiology2014，6，4： | 13 |
| 2 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 3 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 4 | Accuracy of Magnetic Resonance Enterography in Assessing Response to Therapy and Mucosal Healing in Patients With Crohn’s Disease显示文摘 | Ingrid Ordás Jordi Rimola Sonia Rodríguez José M. Paredes María J. Martínez-Pérez Esther Blanc Juan A. Arévalo Marta Aduna Montserrat Andreu Alexander Radosevic Anna M. Ramírez-Morros Susana Pinó Marta Gallego Aranzazu Jauregui-Amezaga Elena Ricart Julián | 2013 | Gastroenterology2013，，： | 3 |
| 5 | Evaluation of 5 versus 10 granulocyteaphaeresis sessions in steroid-dependent ulcerative colitis: A pilot, prospective, multicenter, randomized study显示文摘瞄准:与活跃类固醇依赖者 ulcerative 在病人与 10 个 granulocyteaphaeresis 会议相比评估 5 的功效。方法:在这名飞行员,未来,多集中使随机化的试用,有中等活跃的类固醇的 20 个病人 -- 依赖 ulcerative 被使随机化到 5 或 10 个 granulocyteaphaeresis 会议。主要目的是在 wk 的临床的宽恕 17。第二等的措施包括了内视镜的宽恕和类固醇消费。结果:九个病人被使随机化到 5 个 granulocyteaphaeresis 会议(组 1 ) 和 11 个病人到 10 个 granulocyteaphaeresis 会议(组 2 ) 。在 wk 17,在在组 2 的组 1 病人和 45.45% 的 37.5% 病人在临床的宽恕。临床的宽恕被内视镜的宽恕在所有情况中伴随。完成宽恕的百分之 86 个病人在 wk 是没有类固醇的 17。每日的类固醇要求在组 2 是显著地更低的。病人的 89% 在一年后续期间留在宽恕。一个严肃的不利事件不与学习治疗有关,被报导。结论:Granulocyteaphaeresis 为类固醇依赖者 ulcerative 的治疗安全、有效。在这张人口,增加 aphaeresis 会议的数字没与更高的宽恕率被联系,但是负担得起重要类固醇圆材效果。 | Elena Ricart Maria Esteve Montserrat Andreu Francesc Casellas David Monfort Miquel Sans Natalia Oudovenko Raúl Lafuente Julián Panés | 2007 | World Journal of Gastroenterology2007，13，15： | 3 |
| 6 | Epidemiology of sepsis in the Valencian Community (Spain),1995-2004显示文摘 | Andreu Ballester J C Ballester F González Sánchez A | | 0，，7： | 1 |
| 7 | An analysis of e-business adoption and itsimpact on relational quality in travel agency-supplier relationships显示文摘 | Andreu L Aldás J Bigné J E Mattila A S (2010) | 2010 | Tourism Management2010，，： | 1 |
| 8 | Epidemiology of sepsis in the Valencian Community(Spain),1995-2004显示文摘 | Andreu Ballester JC Ballester F González Sánchez A | 2008 | Infect Control Hospital Epidemiol2008，29，7： | 1 |
| 9 | B2B services 1T adoption in travel agency supply chains显示文摘 | Bigné J E Ald(a)s J Andreu L(2008) | 2008 | Journal of Services Marketing2008，，： | 1 |
| 10 | Diseases of oxidative phosphorylation due to mtDNA mutations 显示文摘 | DiMauro S Andreu A L Musumeci O Bonilla E | 2001 | Semin Neurol2001，21，3： | 1 |
| 11 | Shape and Cross-section Optimization of a Truss Structure显示文摘 | Lluís Gil Antoni Andreu | 2001 | Computers and Structures2001，79，： | 1 |
| 12 | On Sequential Monte Carlo Sampling Methods for Bayesian Filtering显示文摘 | Doucet A Godsill S J Andreu C | 2000 | Sta- tiscs and Computing2000，10，3： | 1 |
| 13 | Blood transfusion after primary total knee arthroplasty can be significantly minimised through a muhimodal blood-loss prevention approach 显示文摘 | Mor6is S Ortega- Andreu M Rodrguez- Merch6n EC | 2014 | Int Orthop2014，38，2： | 1 |
| 14 | Disease severity in familial cases of IBD显示文摘 | M. Andreu L. Márquez E. Domènech J.P. Gisbert V. García I. Marín-Jiménez M. Pe?alva F. Gomollón X. Calvet O. Merino E. Garcia-Planella N. Vázquez-Romero M. Esteve P. Nos A. Gutiérrez I. Vera J.L. Cabriada M.D. Martín A. Ca?as-Ventura J. Panés | 2014 | Journal of Crohn’s and Colitis2014，，3： | 1 |
| 15 | Stress relaxation of five different soil samples whenuniaxially compacted at different water contents显示文摘 | SáNCHEZ-GIRóN V ANDREU E HERNANZ J L | 2001 | Soil&Tillage Research2001，62，： | 1 |
| 16 | Pigment epitheli- um-derived factor is A niche signal for neural stem cell renewal显示文摘 | Ramirez C Sanchez S Andreu A | 2006 | Nat Neurosci2006，9，3： | 1 |
| 17 | Successful Power Quality Monitoring 显示文摘 | SUMPERA ANDREU A S DURAN J R | 2005 | Electrical Power Quality and Utilization2005，1，1： | 1 |
| 18 | Identification of the IFITM fam- ily as a new molecular marker in human colorectal tumors 显示文摘 | Andreu P Colnot S Godard C | 2006 | Canc- er Res2006，66，4： | 1 |
| 19 | Determination of direct-bilirubin by a fluorimetric-enzymatic method based on bilirubin oxidase显示文摘 | Andreu Y Galban J de Marcos S | 2000 | Fresenius Journal of Analytical Chemistry2000，368，： | 1 |
| 20 | Identification of the IFITM family as a new molecular marker in human colorectal tumors 显示文摘 | Andreu P Colnot S Godard C | 2006 | Cancer Res2006，66，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员