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| 1 | 新版Bethesda指南、微卫星不稳定性检测和免疫组化检查诊断遗传性非息肉性结直肠癌的准确性显示文摘背景:挑选适当个体进行遗传性非息肉性结直肠癌(hereditary nonpolyposis colorectal cancer,HNPCC)基因检测有一定难度。最近,美国国立癌症研究所(National Cancer Institute)在新版Bethesda指南中给出了一套新的推荐方案,以明确哪些HNPCC个体应行微卫星不稳定性检测。 | Virginia Pinol, MD Antoni Castells, MD Montserrat Andreu, MD 许峰(译) 祝学光(校) | 2005 | 美国医学会杂志(中文版)2005，24，6： | 23 |
| 2 | Prognostic value of increased carbohydrate antigen in patients with heart failure显示文摘AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) patients.METHODS:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to 2011.Patients were included in the study if they had a previous documented episode of HF and received HF treatment.CA125 and NT-proBNP concentrations were measured.The independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) index.RESULTS:The mean age of the 156 patients was 72 ± 12 years.During follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for HF.Higher CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P < 0.05),and 94 ± 121 KU/L in those who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P < 0.01).After adjusting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P < 0.001) and intermediate when only NT-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P < 0.01).Moreover,when CA125 was added to the clinical model with NT-proBNP,a 4%(P < 0.05) improvement in the IDI was found.CONCLUSION:CA125 > 60 KU/L identified patients in stable HF with poor survival.Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes. | Ana B Méndez Jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig | 2014 | World Journal of Cardiology2014，6，4： | 13 |
| 3 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 4 | Detection of BRAF V600E Mutation in Colorectal Cancer显示文摘 | Susana Benlloch Artemio Payá Cristina Alenda Xavier Bessa Montserrat Andreu Rodrigo Jover Antoni Castells Xavier Llor F. Ignacio Aranda Bartomeu Massutí | 2006 | The Journal of Molecular Diagnostics2006，，5： | 1 |
| 5 | Shape and Cross-section Optimization of a Truss Structure显示文摘 | Lluís Gil Antoni Andreu | 2001 | Computers and Structures2001，79，： | 1 |
| 6 | Integration Methodology of Dif- ferent Software Tools for Constrainted Optimization of Struc- tures显示文摘 | GIL Llius ANDREU Antoni | 2004 | Computers and Structures2004，82，： | 1 |
| 7 | Shape and cross-section optimization of a truss structure 显示文摘 | Lluis Gil Antoni Andreu | 2001 | Computers and Structures2001，79，7： | 1 |
| 8 | Shape and cross-section optimisation of a truss structure 显示文摘 | GIL Llu_os ANDREU Antoni | 2001 | Computers Structures2001，79，： | 1 |
| 9 | Shape and cross-section optimization of a truss structure显示文摘 | Lluis Gil Antoni Andreu | 2001 | Computers and Structures2001，79，： | 1 |
| 10 | Energy use, CO 2 emissions and waste throughout the life cycle of a sample of hotels in the Balearic Islands显示文摘 | Beatriz Rosselló-Batle Andreu Moià Antoni Cladera Víctor Martínez | 2009 | Energy & Buildings2009，，4： | 1 |
| 11 | Shape and cross-section optimisation of a truss structure 显示文摘 | Lluis Gil Antoni Andreu | 2001 | Computers & Structures2001，79，7： | 1 |
| 12 | Liver transplantation in patients with Caroli’s disease and recurrent cholangitis显示文摘 | Miquel Sans A. Rimola Miquel Navasa Luis Grande Juan-Carlos García-Valdecasas Hernán Andreu Joan Manuel Salmerón Antoni Mas Juan Rodés | 1997 | Transplant International1997，，3： | 1 |
| 13 | Aberrant DNA Methylation in Hereditary Nonpolyposis Colorectal Cancer Without Mismatch Repair Deficiency显示文摘 | Ajay Goel Rosa M. Xicola Thuy–Phuong Nguyen Brian J. Doyle Vanessa R. Sohn Prathap Bandipalliam Laura S. Rozek Josep Reyes Carmen Cordero Francesc Balaguer Antoni Castells Rodrigo Jover Montserrat Andreu Sapna Syngal C. Richard Boland Xavier Llor | 2010 | Gastroenterology2010，，5： | 1 |
| 14 | Shape and cross-section optimisation of a truss structure 显示文摘 | Llufs Gil Antoni Andreu | 2001 | Computers & Structures2001，79，7： | 1 |
| 15 | Energy use, CO 2 emissions and waste throughout the life cycle of a sample of hotels in the Balearic Islands显示文摘 | Beatriz Rosselló-Batle Andreu Moià Antoni Cladera Víctor Martínez | 2009 | Energy & Buildings2009，，4： | 1 |
| 16 | The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status显示文摘 | Rodrigo Jover Pedro Zapater Antoni Castells Xavier Llor Montserrat Andreu Joaquín Cubiella Francesc Balaguer Laura Sempere Rosa M. Xicola Luis Bujanda Josep M. Re?é Juan Clofent Xavier Bessa Juan D. Morillas David Nicolás-Pérez Elisenda Pons Artemio Payá | 2008 | European Journal of Cancer2008，，3： | 1 |
| 17 | Colorectal cancer prognosis twenty years later显示文摘AIM:To evaluate changes in colorectal cancer(CRC) survival over the last 20 years.METHODS:We compared two groups of consecutive CRC patients that were prospectively recruited:Group Ⅰincluded 1990 patients diagnosed between 1980 and 1994.GroupⅡincluded 871 patients diagnosed in 2001.RESULTS:The average follow up time was 21 mo(1-229)for GroupⅠand 50 mo(1-73.4)for GroupⅡ.Overall median survival was significantly longer in Group Ⅱthan in GroupⅠ(73 mo vs 25 mo,P<0.001)and the difference was significant for all tumor stages.Post surgical mortality was 8% for GroupⅠand 2% for Group Ⅱ(P<0.001).Only 17% of GroupⅠpatients received chemotherapy compared with 50% of GroupⅡpatients(P<0.001).CONCLUSION:Survival in colorectal cancer patients has doubled over the past 20 years.This increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality. | Luis Bujanda Cristina Sarasqueta Elisabeth Hijona Lander Hijona Angel Cosme Ines Gil Jose Luis Elorza Jose I Asensio Santiago Larburu José M Enríquez-Navascués Rodrigo Jover Francesc Balaguer Xavier Llor Xavier Bessa Montserrat Andreu Artemio Paya Antoni Castells Gastrointestinal Oncology Group of the Spanish Gastroenterological Association | 2010 | World Journal of Gastroenterology2010，16，7： | 0 |
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