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| 1 | PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation显示文摘AIM:To investigate the in vivo effect of atrial natriureticpeptide(ANP)and its signaling pathway during ortho-topic rat liver transplantation.METHODS:Rats were infused with NaCl,ANP(5 μg/kg),wortmannin(WM,16 μg/kg),or a combination ofboth for 20 min.Livers were stored in UW solution(4°C)for 24 h,transplanted and reperfused.Apoptosis wasexamined by caspase-3 activity and TUNEL staining.Phosphorylation of Akt and Bad was visualized by West-ern blotting and phospho-Akt-localization by confocalmicroscopy.RESULTS:ANP-pretreatment decreased caspase-3activity and TUNEL-positive cells after cold ischemia,indicating antiapoptotic effects of ANP in vivo.The an-tiapoptotic signaling of ANP was most likely caused byphosphorylation of Akt and Bad,since pretreatment withPI 3-kinase inhibitor WM abrogated the ANP-inducedreduction of caspase-3 activity.Interestingly,analysis ofliver tissue by confocal microscopy showed translocationof phosphorylated Akt to the plasma membrane of hepa-tocytes evoked by ANP.CONCLUSION:ANP activates the PI-3-kinase pathwayin the liver in vivo leading to phosphorylation of Bad, an event triggering antiapoptotic signaling cascade inischemic liver. | Uwe Grutzner Melanie Keller Michael Bach Alexandra K Kiemer Herbert Meissner Manfred Bilzer Stefan Zahler Alexander L Gerbes Angelika M Vollmar | 2006 | World Journal of Gastroenterology2006，12，7： | 3 |
| 2 | Detection and quantification of the iap gene of Listeria monocytogenes and Listeria innocua by a new real-time quantitative PCR assay显示文摘 | INGEBORG H DIETER K ANGELIKA L | 2001 | Research Microbiology2001，152，： | 1 |
| 3 | Chiral Phosphites and Phosphoramidites Based on the Tropane Skeleton and Their Application in Catalysis显示文摘 | Nicolai C Sabine L Angelika B | 2006 | Organometallics2006，25，： | 1 |
| 4 | A Randomized and Blinded Single-Center Trial Comparing the Effect of Intracranial Pressure and Intracranial Pressure Wave Amplitude-Guided Intensive Care Management on Early Clinical State and 12-Month Outcome in Patients With Aneurysmal Subarachnoid Hemo显示文摘 | Per Kristian Eide Gunnar Bentsen Angelika G. Sorteberg P?l Bache Marthinsen Audun Stubhaug Wilhelm Sorteberg | 2011 | Neurosurgery2011，，5： | 1 |
| 5 | Synthesis and characterization of azido plasticizer 显示文摘 | Detlef D Dieter L Angelika M | 1999 | Propellants Explosives Pyrotechnics1999，24，： | 1 |
| 6 | cDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein显示文摘 | Pari Malherbe J.Grayson Richards Hélène Gaillard Annick Thompson Catherine Diener Angelika Schuler Gerda Huber | 1999 | Molecular Brain Research1999，，2： | 1 |
| 7 | V-ATPase inhibition overcomes trastuzumab resistance in breast cancer显示文摘 | Karin von Schwarzenberg Tamás Lajtos Làszló Simon Rolf Müller Gy?rgy Vereb Angelika M. Vollmar | 2014 | Molecular Oncology2014，，1： | 1 |
| 8 | Assessment of focal liver reaction by multiphasic CT after stereotactic single-dose radiotherapy of liver tumors显示文摘 | Klaus K Herfarth Holger Hof Malte L Bahner Frank Lohr Angelika H?ss Gerhard van Kaick Michael Wannenmacher Jürgen Debus | 2003 | International Journal of Radiation Oncology Biology Physics2003，，2： | 1 |
| 9 | Signalling and reg- ulation of collagen I synthesis by ET-1 and TGF~I 显示文摘 | Angelika H Christoph L Gabriele S | 2011 | FEBS Journal2011，272，24： | 1 |
| 10 | Frequency and spectrum of congenital heart defects among live births in Germany: a study of the competence network for congenital heart defects显示文摘 | Gerda S Angelika L Peter E | 2011 | Clin Res Cardiol2011，100，12： | 1 |
| 11 | Natriuretic peptides as markers of mild forms of left ventricular dysfunction:effects of assays on diagnostic performance of markers显示文摘 | Angelika H Wilma L Gerda F | 2004 | Clin Chem2004，50，8： | 1 |
| 12 | Piracetam and levetiracetam, two pyrrolidone derivatives, exert antidystonic activityin a hamster model of paroxysmaldystonia 显示文摘 | Angelika R | 2000 | Eur J Pharmacol2000，391，3： | 1 |
| 13 | Natriuretic peptides as markers of mild forms of left ventricular dysfunction:effects of assays on diagnostic performance of markers显示文摘 | Angelika H Wilma L Gerda F | 2004 | Clinical Chemistry2004，50，8： | 1 |
| 14 | Natriuretic peptides as markers of mild forms of left ventricular dysfunction:effects of assays on diagnosis performance of markers显示文摘 | Angelika H Wilma L Gerde F | 2004 | Clin Chem2004，50，8： | 1 |
| 15 | The impact of cardiac natriuretic peptide determination on the diagnosis and management of heart failure显示文摘 | Johannes M Angelika H L Bernd P | 2001 | Clin Chem Lab Med2001，39，7： | 1 |
| 16 | Biological soil crusts and their microenvironment: Impact on emergence, survival and establish- ment of seedlings 显示文摘 | Tanja M L Christian S Angelika S | 2009 | Flora2009，204，： | 1 |
| 17 | Randomized, Double-Blind, Parallel-Group, 48-Week Study for Efficacy and Safety of a Higher-Dose Rivastigmine Patch (15 vs. 10 cm) in Alzheimer’s Disease显示文摘 | Cummings Jeffrey Froelich Lutz Black Sandra E Bakchine Serge Bellelli Giuseppe Molinuevo José L Kressig Reto W Downs Pamela Caputo Angelika Strohmaier Christine | 2012 | Dementia and Geriatric Cognitive Disorders2012，，5： | 1 |
| 18 | Flux analysis of glucose metabolism in Rlaizopus oryzae for the purpose of increasing lactic yield显示文摘 | ANGELIKA L JACQUELINE M R JAMES E G | 1997 | Fungal Genetics and Biology1997，21，7： | 1 |
| 19 | Models of metabolism in Rhizopus oryzae显示文摘 | BARBARA E W ANGELIKA L JACQUELINE R | 1996 | J Theor Biol1996，182，： | 1 |
| 20 | Diastereose-lective alkylation of a proline-derived bicyclic lactim ether显示文摘 | DANIELA H SABINE L ANGELIKA B | 2006 | Helvetica Chimica Acta2006，89，9： | 1 |
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