|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | The molecular pathogenesis of small cell lung cancer显示文摘 | D' Angelo S P Pietanza M C | 2010 | Zhongguo Fei Ai Za Zhi2010，13，11： | 1 |
| 3 | Delayed ischemic preconditioning is mediated by opening of ATPsensitive potassium channels in rabbit heart显示文摘 | Bernado N D' angelo M Okubo S | 1999 | Am J Physiol Heart Circ Physiol1999，276，： | 1 |
| 4 | Lipid oxi-dation in foods显示文摘 | Vercellotti J R Angelo A J S Spanier A M | 1996 | Critical Reviews in Food Scienceand Nutrition1996，36，3： | 1 |
| 5 | Application of fuzzy logic for the simulation of Plasmopara viticola using agrometeorological variables 显示文摘 | Orlandini S Dalla M A D'Angelo I | 2003 | EPPO/OEPP Bulletin2003，33，3： | 1 |
| 6 | The effects of Fe on the oxygen storage and release properties of model Pd-Rh/CeO2-Al2O3 three-way catalyst显示文摘 | Panayiota S Lambrou Angelos M Efstathiou | 2006 | Journal of Catalysis2006，240，210： | 1 |
| 7 | Exergetic analysis of the refrigeration system in ethylene and propylene production process显示文摘 | Fabrega F M Rossi J S d'Angelo J V H | 2010 | Energy2010，35，3： | 1 |
| 8 | A classification of time and/or probability dependent security properties显示文摘 | RUGGERO L ANDREA M S ANGELO T | 2006 | Electronic Notes in Theoretical Computer Science2006，153，： | 1 |
| 9 | Spatial patterns of nitrogen mineralization, fertilizer distribution and roots explain nitrate leaching from mature Amazonian oil palm plantation显示文摘 | Schroth G Rodrigues M R L D'Angelo S A | 2000 | Soil Use and Management2000，16，3： | 1 |
| 10 | Monte Carlo procedure for investigating light propagation and imaging of highly scattering media 显示文摘 | Angelo S Costantino B Fabrizio M | 1998 | Applied Optics1998，37，31： | 1 |
| 11 | Integrated seismic texture seg- mentation and clustering analysis to delineate reservoir heterogenei- ty 显示文摘 | Angelo M S Matos M C Marfurt K J | 2009 | SEG Technical Program Expanded Abstracts2009，，28： | 1 |
| 12 | The effects of Fe on the oxygen storage and release properties of model Pd-Rh/CeO2-Al2O3 three-way catalyst 显示文摘 | Panayiota S Lambrou Angelos M Efstathiou | 2006 | Journal of Catalysis2006，240，： | 1 |
| 13 | Plant L-ascorbic acid:chemistry,function,metabolism,bioavailability and effects of processing显示文摘 | DAVEY M W MONTAGU M V INZéD S MAITE K ANGELOS S NICHOLAS B IRIS J J S JOHN J F DEREK F JOHN | 2000 | Journal of the Science of Food and Agriculture2000，80，7： | 1 |
| 14 | Reference values of tissue Doppler imaging and pulsed Doppler echocardio- graphy for analysis of left ventricular diastolic function in healthy a- dults 显示文摘 | ANGELO L C VIEIRA M L RODRIGUES S L | 2010 | Echocardiography2010，27，7： | 1 |
| 15 | Management of midclavicularfractures: comparison between nonoperative treatment and open intramedullary fixation in 80 patients显示文摘 | Grassi FA Tajana M S D' Angelo F | 2001 | J Trauma2001，1096，50： | 1 |
| 16 | Salivary chro- mogranin A, but not a-amylase, correlates with cardiovascular param- eters during high-intensity exercise 显示文摘 | Gallina S Di Manre M D'Amico MA D'Angelo E Sablone A Di Fonso A Bascelli A Izzicupo P Di Baldassarre A | 2011 | Clin Endocrinol ( Oxf)2011，75，： | 1 |
| 17 | Mesoporous silicate materials as substrates for molecular machines and drug delivery 显示文摘 | Angelos S Liong M Choi E | 2008 | Chemical Engineering Journal2008，137，： | 1 |
| 18 | Incipient fault detection in induction machine stator-winding using a fuzzy-Bayesian change point detection approach显示文摘 | D'ANGELO M F S V PALHARES R M TAKAHASHI R H C | | 0，，01： | 1 |
| 19 | Integrated seismic texture segmentation and cluster analysis applied to channel delineation and chert reservoir characterization 显示文摘 | MATOS M C YENUGU M ANGELO S M MARFURT K J | 2011 | Geophysics2011，76，5： | 1 |
| 20 | Correlation receivers using Laguerre filter banks for modelling narrowband ultrasonic echoes and estimating their time-of-flights显示文摘 | ANGELO M S | 1997 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control1997，44，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员