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| 1 | Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling:role of the ubiquitin proteasome system显示文摘Monosodium urate(MSU)crystals activate inflammatory pathways that overlap with interleukin-1β(IL-1β)signaling.However,the post-translational mechanisms involved and the role of signaling proteins in this activation are unknown.In the present study,we investigated the intracellular signaling mechanisms involved in MSU-induced activation of THP-1 macrophages and human nondiseased synovial fibroblasts(NLSFs)and the in vivo efficacy of an inhibitor of tumor grovArth factor-β(TGF-β)-activated kinase 1(TAK1),5Z-7-oxozeaenoI,in MSU-induced paw inflammation in C57BL76 mice.THP-1 macrophage activation with MSU crystals(25-200 ng/ml)resulted in the rapid and sustained phosphorylation of interleukin-1 receptor-activated kinase 1(IRAK1 Thr^(209))and TAK1(Thr^(184/187))and their association with the E3 ubiquitin ligase TRAF6.At the cellular level,MSU inhibited the deubiquitinases A20 and UCHL2 and increased 20s proteasomal activity,leading to a global decrease in K^(63)-linked ubiquitination and increase in K^(48)-linked ubiquitination in THP-1 macrophages.While MSU did not stimulate cytokine produaion in NLSFs,it significantly amplified IL-1β-induced IL-6,IL-8,and ENA-78/CXCL5 production.Docking studies and MD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation,resulting in sustained TAK1 kinase activation.Importantly,MSU-induced proinflammatory cytokine production was completely inhibited by 5Z-7-oxozeaenol but not IRAK1/4 or TRAF6 inhibitors.Administration of 5Z-7-oxozeaenol(5 or 15 mg/kg;orally)significantly inhibited MSU-induced paw inflammation in C57BL/6 mice.Our study identifies a novel post-translational mechanism of TAK1 activation by MSU and suggests the therapeutic potential of TAK1 in regulating MSU-induced Inflammation. | Anil K.Singh Mahamudul Haque Kayla O'Sullivan Mukesh Chourasia Madhu M.Ouseph Salahuddin Ahmed | 2021 | Cellular & Molecular Immunology2021，18，1： | 2 |
| 2 | Strengthening of RC T-section beams with low strength concrete using CFRP composites subjected to cyclic load 显示文摘 | Anil O | 2008 | Construction and Building Materials2008，22，： | 1 |
| 3 | Evalu-ation of genetic diversity in lemons and some of their relatives based on SRAP and SSR markers显示文摘 | UZUN A YESILOGLU T POLAT L AKA-KACAR Y GULSEN O YILDIRIM B TUZCU O TEPE S CANAN L ANIL S | 2011 | Plant Molecular Biology Reporter2011，29，3： | 1 |
| 4 | Development of phase change technology for heating and cooling of residential buildings and other applications显示文摘 | Ival O Anil Sircar K | 1993 | Proceedings of the 28th intersociety energy conversion engineering conference Atlanta:American Chemical Society1993，，2： | 1 |
| 5 | Hysteretic behavior of RC shear walls strengthened with CFRP strips显示文摘 | ALTIN S ANIL O KOPRAMAN Y | 2013 | Composites Part B:Engineering2013，44，1： | 1 |
| 6 | 显示文摘 | Anil I O Shear K | 1993 | American Chemical Society1993，，2： | 1 |
| 7 | Thyroid volume in patients with glucose metabolism disorders 显示文摘 | Duran A O Anil C Gursoy A | 2014 | Arq Bras Endocrinol Metabol2014，58，8： | 1 |
| 8 | An experimental study on rein- forced concrete partially infilled frames显示文摘 | ANIL O ALTIN S | 2007 | Engineer- ing Structures2007，29，： | 1 |
| 9 | The relationship between glucose metabolism disorders and malignantthy- roid disease显示文摘 | Duran A O Anil C Gursoy A | 2013 | Int J Clin Oncol2013，18，4： | 1 |
| 10 | Improving shear capacity of existing RC beams using external bonding of steel plates显示文摘 | Altin S Anil O Kam M E | 2005 | Engineering Structures2005，27，5： | 1 |
| 11 | An experimental study on strengthening of masonry infilled RC frames using diagonal CFRP strips显示文摘 | Sinan Altin O zgur Anil M Emin Kara | 2008 | Composites:Part B2008，39，： | 1 |
| 12 | Long-range potential source contributions of episodic aerosol events to PM10 profile of a megacity显示文摘 | KARACA F ANIL I ALAGHA O | 2009 | Atmos Environ2009，43，： | 1 |
| 13 | Severe hemodynamie impairment and border zone-region infarction显示文摘 | Colin P Anil K Tom O | 2001 | Radiology2001，220，7： | 1 |
| 14 | Effect of different tillage systems on thequality and crop productivity of a clay-loam soil in semi-arid north western Turkey显示文摘 | Sakine O Anil C | 2006 | Soil & Tillage Research2006，88，： | 1 |
| 15 | Multi-Channel Scheduling and Spanning Trees : Throughput-Delay Trade-off for Fast Data Collection in Sensor Networks 显示文摘 | GHOSH A INCEL O ANIL K | 2011 | IEEE/ACM Transactions on Networking2011，19，6： | 1 |
| 16 | Effect of angiotensin receptor blockade and antihypertensive drugs on diastolic function in patients with hypertension and diastolic dysfunction: a randomised trial显示文摘 | Scott D Solomon Rajesh Janardhanan Anil Verma Mikhail Bourgoun William L Daley Das Purkayastha Yves Lacourcière Stephen E Hippler Harold Fields Tasneem Z Naqvi Sharon L Mulvagh J Malcolm O Arnold James D Thomas Michael R Zile Gerard P Aurigemma | 2007 | The Lancet . 2007 (9579)2007，，： | 1 |
| 17 | Influence of temperature and salinity on larval development of Balanus amphitrite: implications in fouling ecology 显示文摘 | ANIL A C CHIBA K KAMOTO K O | 1995 | Mar Ecol Prog Ser1995，118，： | 1 |
| 18 | Diastolic Heart Failure: Evidence of Increased Myocardial Collagen Turnover Linked to Diastolic Dysfunction显示文摘 | Ramón Martos John Baugh Mark Ledwidge Christina O’Loughlin Carmel Conlon Anil Patle Seamas C. Donnelly Kenneth McDonald | 2007 | Circulation2007，，7： | 1 |
| 19 | Molecular phylogenetics and biogeography of the Neocellia Series of Anopheles mosquitoes in the Oriental Region显示文摘 | Katy Morgan Samantha M. O’Loughlin Fong Mun-Yik Yvonne-Marie Linton Pradya Somboon Sein Min Pe Than Htun Simone Nambanya Indira Weerasinghe Tho Sochantha Anil Prakash Catherine Walton | 2009 | Molecular Phylogenetics and Evolution2009，，3： | 1 |
| 20 | Hysteretic behavior of RC shear walls strengthened with CFRP strips显示文摘 | Altin S Anil O Kopraman Y | 2013 | Composites(Part B)2013，44，1： | 1 |
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