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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 3 | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response显示文摘 | Ivan Grskovic Anna Kutsch Christian Frie Gergely Groma Jacek Stermann Ursula Schl?tzer‐Schrehardt Anja Niehoff Stephen E Moss Sabrina Rosenbaum Ernst P?schl Markus Chmielewski Gunter Rappl Hinrich Abken John F Bateman Kathryn SE Cheah Mats Paulsson Bent B | 2012 | J Bone Miner Res2012，，11： | 1 |
| 4 | Recent advances in membrane bioreactors ( MBRs ) : Membrane fouling and membrane material 显示文摘 | Meng F G Chae S R Anja D | 2009 | Water Res2009，43，6： | 1 |
| 5 | Migration of plasticizers from PVC gaskets of lids for glass jars into oily foods: Amount of gasket material in food contact, proportion of plasticizer migrating into food and compliance testing by simulation显示文摘 | Anja F Ni Koni G | 2006 | Food Science and Technology2006，17，： | 1 |
| 6 | A CFD study of fuel evaporation and related thermo-fluid dynamics in the inlet manifold, port and cylinder of the CFR octane engine 显示文摘 | Anja T Garetha F Chris M | 2012 | SAE International Journal of Fuels and Lubricants2012，，3： | 1 |
| 7 | A globin gene of ancient evolutionary origin in lower vertebrates:evidence for two distinct globin families in animals显示文摘 | Anja R Christine F Thomas H | 2005 | Mol Biol Evol2005，22，1： | 1 |
| 8 | Aberrant hypomethylation of the cancer–testis antigen PRAME correlates with PRAME expression in acute myeloid leukemia显示文摘 | Christina A. Ortmann Lewin Eisele Holger Nückel Ludger Klein-Hitpass Anja Führer Ulrich Dührsen Michael Zeschnigk | 2008 | Annals of Hematology2008，，10： | 1 |
| 9 | Effect of microgrooved poly-l-lactic (PLA) surfaces on prolifera- tion, cytoskeletal organization, and min- eralized matrix formation of rat bone mar- row cells显示文摘 | MATSUZAKA K WALBOOMERS F ANJA D R | 2000 | Clin Oral Impl Res2000，11，4： | 1 |
| 10 | Physical activity and risk of colon cancer in a cohort of Danish middle-aged men and women显示文摘 | Nina F?ns Johnsen Jane Christensen Birthe Lykke Thomsen Anja Olsen Steffen Loft Kim Overvad Anne Tj?nneland | 2006 | European Journal of Epidemiology2006，，12： | 1 |
| 11 | Magnesium alloys for temporary implants in osteosynthesis: In vivo studies of their degradation and interaction with bone 显示文摘 | Kraus Tanja Fischerauer Stefan F Hanzi Anja C | 2012 | Acta Biomaterialia2012，8，3： | 1 |
| 12 | Antigen presentation function of brain - derived dendriform cells depends on astrocyte help 显示文摘 | Hans- Georg F Anja KB | 1999 | Int Immunol1999，11，8： | 1 |
| 13 | A CFD study of fuel evaporation and related thermo-fiuid dynamics in the inlet manifold, port and cylinder of the CFR octane engine 显示文摘 | Anja T Gareth F Chris M | 2012 | SAE International Jour- nal of Fuels and Lubricants2012，，3： | 1 |
| 14 | Self-efficacy instruments for patients with chronic diseases suffer from methodological limitations-a systematic review显示文摘 | Anja F Anna S Claudia SS | | 0，，01： | 1 |
| 15 | Mechanism of Cd2+ toxicity:Cd2+ inhibits photoactivation of Photosystem Ⅱ by competitive binding to the essential Ca2+ site显示文摘 | Peter F Katharina K Anja K L | 2005 | Biochimica et Biophysica Acta2005，1706，： | 1 |
| 16 | Antagonism of the complement component C4 by flavivirus nonstructural protein NS1显示文摘 | Panisadee A Anja F Richard EH | | 0，，04： | 1 |
| 17 | Boswellic acids activatep 42MAPK and p38 MAPK and stimulate Ca2+ mobilizationl显示文摘 | Anja A Lutz F Manfred S | 2002 | Biochem Biophys Res Commun2002，290，： | 1 |
| 18 | On theperformance, complexity, and fairness of suboptimal resource al- location for multi-user MIMO - OFDMA systems 显示文摘 | Tarcisio F Maciel Anja Klein | 2010 | IEEE Transactions on Vehicular Technology2010，59，1： | 1 |
| 19 | Migration of Plasticizers from PVC Gaskets of Lids for Glass Jars into Oily Foods:Amount of Gasket Material in Food Contact, Proportion of Plasticizer Migrating into Food and Compliance Testing by Simulation 显示文摘 | ANJA F N KONI G | 2006 | Trends in Food Science & Technology2006，17，3： | 1 |
| 20 | CD46-induced human Treg en- hance B-cell responses 显示文摘 | Anja F John P A Veronique FB | 2009 | Eur J Immunol2009，39，11： | 1 |
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