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| 1 | A Simple Approach to Bioconjugation at Diverse Levels: Metal-Free Click Reactions of Activated Alkynes with Native Groups of Biotargets without Prefunctionalization显示文摘Te efcient bioconjugation of functional groups/molecules to targeted matrix and bio-related species drives the great development of material science and biomedicine,while the dilemma of metal catalysis,uneasy premodifcation,and limited reaction efciency in traditional bioconjugation has restricted the booming development to some extent.Here,we provide a strategy for metal-free click bioconjugation at diverse levels based on activated alkynes.As a proof-of-concept,the abundant native groups including amine,thiol,and hydroxyl groups can directly react with activated alkynes without any modifcation in the absence of metal catalysis.Trough this strategy,high-efcient modifcation and potential functionalization can be achieved for natural polysaccharide,biocompatible polyethylene glycol(PEG),synthetic polymers,cell penetrating peptide,protein,fast whole-cell mapping,and even quick diferentiation and staining of Gram-positive bacteria,etc.Terefore,current metal-free click bioconjugation strategy based on activated alkynes is promising for the development of quick fuorescence labeling and functional modifcation of many targets and can be widely applied towards the fabrication of complex biomaterials and future in vivo labeling and detection. | Xianglong Hu Xueqian Zhao Benzhao He Zheng Zhao Zheng Zheng Pengfei Zhang Xiujuan Shi Ryan T.K.Kwok Jacky W.Y.Lam Anjun Qin Ben Zhong Tang | 2018 | Research2018，，1： | 7 |
| 2 | Regularity of sediment transport and sedimentation during floods in the lower Yellow River,China显示文摘The flood season is the main period of flow,sediment transport,and sedimentation in the lower Yellow River(LYR).Within the flood season,most of the flow,sediment transport,and sedimentation occurs during flood events.Because of the importance of floods in forming riverbeds in the LYR,the regularity of sediment transport and sedimentation during floods in the LYR was studied.Measured daily discharge and sediment transport rate data for the LYR from 1960 to 2006 were used.A total of 299 floods were selected;these floods had a complete evolution of the flood process from the Xiaolangdi to the Lijin hydrological stations.For five hydrological stations(Xiaolangdi,Huayuankou,Gaocun,Aishan,and Lijin),a correlation was first established for floods of different magnitudes between the average sediment transport rate at a given station and the average sediment concentration at the closest upstream station.The results showed that the sediment transport rate at the downstream station was strongly correlated with the inflow(upstream station)sediment concentration during a flood event.A relation then was established between sedimentation in the LYR and the average sediment concentration at the Xiaolangdi station during a flood event.From this relation,the critical sediment concentrations were obtained for absolute erosion,sedimentation equilibrium,and absolute deposition during floods of different magnitudes in the LYR.The results of the current study contribute to a better understanding of the mechanisms of sediment transport and the regularity of sedimentation in the LYR during floods,and provide technical support to guide the joint operation of reservoirs and the regulation of the LYR. | Qingchao Guo Zhao Zheng Liemin Huang Anjun Deng | 2020 | International Journal of Sediment Research2020，35，1： | 6 |
| 3 | A specific aggregation-induced emission-conjugated polymer enables visual monitoring of osteogenic differentiation显示文摘Osteogenic differentiation is the basis of bone growth and repair related to many diseases,in which evaluating the degree and ability of osteogenic transformation is quite important and highly desirable.However,fixing or stopping the growth of cells is required for conventional methods to monitor osteogenic differentiation,which cannot realize the full investigation of the dynamic process.Herein,a new anion conjugated polymer featuring aggregation-induced emission(AIE)characteristics is developed with excellent solubility for in-situ monitoring the process of osteogenic differentiation.This novel polymer can bind with osteogenic differentiated cells,and the intracellular fluorescence increases gradually with the enhancement of osteogenic differentiation.Moreover,it possesses good biosafety with negligible effect on cell activity and osteogenic differentiation,which cannot be realized by the typical method of Alizarin Red S staining.Further study shows that the polymer crosses the cell membrane through endocytosis and enriches in lysosomes,whereas no obvious fluorescence is detected with other cells,including non-differentiated osteoblast cells,under the same conditions,demonstrating the high selectivity.This is the first fluorescent probe with excellent specificity to realize real-time observation of the process of osteogenic differentiation.Therefore,PTB-EDTA shows great promise in the study of osteogenic differentiation and related applications. | Zhenyu Zheng Taotao Zhou Rong Hu Minjun Huang Xiang Ao Jun Chu Tao Jiang Anjun Qin Zhongmin Zhang | 2020 | Bioactive Materials2020，5，4： | 3 |
| 4 | Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses显示文摘The surface glycoproteins of coronaviruses play an important role in receptor binding and cell entry. Different coronaviruses interact with their specific receptors to enter host cells. Lentiviruses pseudotyped with their spike proteins(S) were compared to analyze the entry efficiency of various coronaviruses. Our results indicated that S proteins from different coronaviruses displayed varied abilities to mediate pseudotyped virus infection. Furthermore, the cell tropisms of porcine epidemic diarrhea virus(PEDV) and transmissible gastroenteritis virus(TGEV) have been characterized by live and pseudotyped viruses. Both live and pseudoviruses could infected VeroCCL-81(monkey kidney), Huh-7(human liver), and PK-15(pig kidney) cells efficiently. CCL94(cat kidney) cells could be infected efficiently by TGEV but not PEDV. Overall, our study provides new insights into the mechanisms of viral entry and forms a basis for antiviral drug screening. | Jingjing Wang Feng Deng Gang Ye Wanyu Dong Anjun Zheng Qigai He Guiqing Peng | 2016 | Virologica Sinica2016，31，1： | 2 |
| 5 | Modulating Sand’s time by ion-transport-enhancement toward dendrite-free lithium metal anode显示文摘Metallic lithium is deemed as the“Holy Grail”anode in high-energy-density secondary batteries.Uncontrollable lithium dendrite growth and related issues originated from uneven concentration distribution of Li+in the vicinity of the anode,however,induce severe safety concerns and poor cycling efficiency,dragging lithium metal anode out of practical application.Herein we address these issues by using cross-linked lithiophilic amino phosphonic acid resin as the effective host with the ion-transportenhancement feature.Based on theoretical calculations and multiphysics simulation,it is found that this ion-transportenhancement feature is capable of facilitating the self-concentration kinetics of Li+and accelerating Li^(+)transfer at the electrolyte/electrode interface,leading to uniform bulk lithium deposition.Experimental results show that the proposed lithiumhosting resin decreases the irreversible lithium capacity and improves lithium utilization(with the Coulombic efficiency(CE)of 98.8%over 130 cycles).Our work demonstrates that inducing the self-concentrating distribution of Li+at the interface can be an effective strategy for improving the interfacial ion concentration gradient and optimizing lithium deposition,which opens a new avenue for the practical development of next-generation lithium metal batteries. | Yu Yan Chaozhu Shu Ruixin Zheng Minglu Li Zhiqun Ran Miao He Anjun Hu Ting Zeng Haoyang Xu Ying Zeng | 2022 | Nano Research2022，15，4： | 2 |
| 6 | Synthesis, thermal stability, and linear and nonlinear optical proper- ties of hyperbranched polyarylenes containing carbazole and/or fluorene moieties显示文摘 | Matthias Hal ussler Jianzhao Liu Ronghua Zheng Jacky Wing Yip Lam Anjun Qin Ben Zhong Tang | 2007 | Macromolecules2007，40，6： | 1 |
| 7 | High-pressure effects on cooking loss and histological structure of beef muscle显示文摘 | LIU Anjun ZHAN Hu ZHENG Jie | 2010 | High Pressure Research2010，30，4： | 1 |
| 8 | Ultralong organic room-temperature phosphorescence of electrondonating and commercially available host and guest molecules through efficient Förster resonance energy transfer显示文摘Ultralong organic room-temperature phosphorescence(RTP)materials have attracted tremendous attention recently due to their diverse applications.Several ultralong organic RTP materials mimicking the host-guest architecture of inorganic systems have been exploited successfully.However,complicated synthesis and high expenditure are still inevitable in these studies.Herein,we develop a series of novel host-guest organic phosphorescence systems,in which all luminophores are electron-rich,commercially available and halogen-atom-free.The maximum phosphorescence efficiency and the longest lifetime could reach 23.6%and 362 ms,respectively.Experimental results and theoretical calculation indicate that the host molecules not only play a vital role in providing a rigid environment to suppress non-radiative decay of the guest,but also show a synergistic effect to the guest through Förster resonance energy transfer(FRET).The commercial availability,facile preparation and unique properties also make these new host-guest materials an excellent candidate for the anti-counterfeiting application.This work will inspire researchers to develop new RTP systems with different wavelengths from commercially available luminophores. | Yeling Ning Junfang Yang Han Si Haozhong Wu Xiaoyan Zheng Anjun Qin Ben Zhong Tang | 2021 | Science China Chemistry2021，64，5： | 1 |
| 9 | Manipulating the ion-transference and deposition kinetics by regulating the surface chemistry of zinc metal anodes for rechargeable zinc-air batteries显示文摘Aqueous zinc-air battery(ZAB)has attractive features as the potential energy storage system such as high safety,low cost and good environmental compatibility.However,the issue of dendrite growth on zinc metal anodes has seriously hindered the development of ZAB.Herein,the N-doped carbon cloth(NC)prepared via magnetron sputtering is explored as the substrate to induce the uniform nucleation of zinc metal and suppress dendrite growth.Results show that the introduction of heteroatoms accelerates the migration and deposition kinetics of Zn^(2+)by boosting the desolvation process of Zn^(2+),eventually reducing the nucleation overpotential.Besides,theoretical calculation results confirm the zincophilicity of N-containing functional group(such as pyridine N and pyrrole N),which can guide the nucleation and growth of zinc uniformly on the electrode surface by both promoting the redistribution of Zn^(2+) in the vicinity of the surface and enhancing its interaction with zinc atoms.As a result,the half-cell assembled with magnetron sputtered carbon cloth achieves a high zinc stripping/plating coulombic efficiency of 98.8%and long-term stability of over 500 cycles at 0.2 mA cm^(-2).And the Coulombic efficiency reached about 99.5%at the 10th cycle and maintained for more than 210 cycles at a high current density of 5.0 mA cm^(-2).The assembled symmetrical battery can deliver 220 plating/stripping cycles with ultra-low voltage hysteresis of only 11 mV.In addition,the assembled zinc-air full battery with NC-Zn anode delivers a high special capacity of about 429 mAh g_(Zn)^(-1) and a long life of over 430 cycles.The effectiveness of surface functionalization in promoting the transfer and deposition kinetics of Zn^(2+) presented in this work shows enlightening significance in the development of metal anodes in aqueous electrolytes. | Miao He Chaozhu Shu Ruixing Zheng Wei Xiang Anjun Hu Yu Yan Zhiqun Ran Minglu Li Xiaojuan Wen Ting Zeng Jianping Long | 2023 | Green Energy & Environment2023，8，1： | 0 |
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