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| 1 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 2 | Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature显示文摘Primary hepatic neuroendocrine carcinoma(NEC) with concurrent occurrence of hepatocellular carcinoma(HCC) of the liver is very rare. Only 8 cases have been reported in the literature. Concurrent occurrence of HCC and NEC in the liver is classified as combined type or collision type by histological distributional patterns; only 2 cases have been reported. Herein, we report a case of collision type concurrent occurrence of HCC and NEC, in which primary hepatic NEC was in only a small portion of the nodule, which is different from the 2 previously reported cases. A 72-year-old male with chronic hepatitis C was admitted to our hospital for a hepatic mass detected by liver computed tomography(CT) at another clinic. Because the nodule was in hepatic segment 3 and had proper radiologic findings for diagnosis of HCC, including enhancement in the arterial phase and wash-out in the portal and delay phases, the patient was treated with laparoscopic left lateral sectionectomy. The pathology demonstrated that the nodule was 2.5 cm and was moderately differentiated HCC. However, a 3 mm-sized focal neuroendocrine carcinoma was also detected on the capsule of the nodule. The tumor was concluded to be a collision type with HCC and primary hepatic NEC. After the surgery, for follow-up, the patient underwent a liver CT every 3 mo. Five multiple nodules were found in the right hepatic lobe on the follow-up liver CT 6 mo post-operatively. As the features of the nodules in the liver CT and MRI were different from that of HCC, a liver biopsy was performed. Intrahepatic recurrent NEC was proven after the liver biopsy, which showed the same pathologic features with the specimen obtained 6 mo ago. Palliative chemotherapy with a combination of etoposide and cisplatin has been administered for 4 months, showing partial response. | Gyu Ho Choi Sun Young Ann Soon Il Lee Suk BaeKim Il Han Song | 2016 | World Journal of Gastroenterology2016，22，41： | 8 |
| 3 | Complementation and Expression Analysis of SoRablA and SoRab2A in Sugarcane Demonstrates Their Functional Diversification显示文摘 | Jia-Ming Zhang Anne W Sylvester Ding-Qin Li Xue-Piao Sun | 2006 | Journal of Integrative Plant Biology2006，48，12： | 6 |
| 4 | The genetics of tiger pelage color variations显示文摘 | Xiao XU Gui-Xin Dong Anne Schmidt-Kuntzel Xue-Li Zhang Yan Zhuang Run Fang Xin Sun Xue-Song Hu Tian-You Zhang Han-Dong Yang De-Lu Zhang Laurie Marker Zheng-Fan Jiang Ruiqiang Li Shu-Jin Luo | 2017 | Cell Research2017，27，7： | 5 |
| 5 | A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding显示文摘 | John R. Saltzman Ying P. Tabak Brian H. Hyett Xiaowu Sun Anne C. Travis Richard S. Johannes | 2011 | Gastrointestinal Endoscopy2011，，6： | 3 |
| 6 | Proteome-based biomarkers in pancreatic cancer显示文摘Pancreatic cancer,as a highly malignant cancer and the fourth cause of cancer-related death in world,is characterized by dismal prognosis,due to rapid disease progression,highly invasive tumour phenotype,and resistance to chemotherapy.Despite significant advances in treatment of the disease during the past decade,the survival rate is little improved.A contributory factor to the poor outcome is the lack of appropriate sensitive and specific biomarkers for early diagnosis.Furthermore,biomarkers for targeting,directing and assessing therapeutic intervention,as well as for detection of residual or recurrent cancer are also needed.Thus,the identification of adequate biomarkers in pancreatic cancer is of extreme importance.Recently,accompanying the development of proteomic technology and devices,more and more potential biomarkers have appeared and are being reported.In this review,we provide an overview of the role of proteome-based biomarkers in pancreatic cancer,including tissue,serum,juice,urine and cell lines.We also discuss the possible mechanism and prospects in the future.That information hopefully might be helpful for further research in the field. | Chen Sun Ann H Rosendahl Roland Andersson Daniel Ansari | 2011 | World Journal of Gastroenterology2011，17，44： | 3 |
| 7 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 8 | Molecular modeling for the interaction between proteasome beta 5 subunit and organotin compounds显示文摘It has been reported that organotins can inhibit the proteasomal chymotrypsin-like activity and induce cell death,but the interaction mode of organotins with proteasome has not been well defined.In this study,the IC50 of butyltins and phenyltins against the proteasomal activity and the nature of their inhibition were investigated.It was found that both mono-and di-organotins were weak,reversible inhibitors against the proteasome,while tributyltin and triphenyltin were potent,irreversible proteasome inhibitors.In silico studies using the reversible organotin proteasome inhibitors demonstrated a tight correlation of the estimated proteasomal inhibition constants(Ki) with the experimental IC50 values for proteasome inhibition.Furthermore,the Sn atom in TBT and TPT was found susceptible to form a coordinate bond with Thr 1 OY of the β5 subunit,which may account for the irreversible proteasome inhibition.The computational docking approach well predicted the inhibition nature of organotins toward the proteasomal chymotrypsin-like activity.This predictive model might aid in understanding the cytotoxic behavior of similar organometallic compounds. | SHI GuoQing1*,SUN Qing1,YANG HuanJie2,DOU QingPing2,DENG QianMin1,WANG HaiOu1 & ZHONG GuangRong1 1Department of Biological Science and Technology,School of Applied Science,University of Science and Technology Beijing,Beijing 100083,China 2The Prevention Program,Barbara Ann Karmanos Cancer Institute,and Departments of Oncology,Pathology and Pharmacology,School of Medicine,Wayne State University,Detroit,Michigan,MI 48201,USA | 2010 | Science China Chemistry2010，53，11： | 2 |
| 9 | A doublethreshold image Segmentation binarization method based on edge detector 显示文摘 | Chen Qiang Sun Quansen Heng Pheng Ann | 2008 | Pattern Recognition2008，41，4： | 1 |
| 10 | Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic - induced neuro- apoptosis in the rat developing brain 显示文摘 | Ann Med Health Sci Res Dexmedetomidine sedation Pediatr Crit Care Med Sanders RD Sun P Patel S | 2010 | Acta Anaesthesiol Scand2010，54，6： | 1 |
| 11 | Survival of patients with BRCAl-assoeiated breast cancer diagnosed in an MRI-based surveillance program显示文摘 | Stormorken Christoffer Jonsrud Marit Muri Holmen Anne Irene Hagen Neal Clark Anita Sun Steven A Narod Lovise | 2013 | Breast cancer research and treatment2013，139，1： | 1 |
| 12 | A Comparative Assessment of Gold Plating Thickness Required for Stationary Electrical Contacts显示文摘 | Sun Ming Michael Peeht Marjorie Ann E | 1999 | Micro-electronics Journal1999，，30： | 1 |
| 13 | A Double-Threshold Image Binarization Method Based on Edge Detector显示文摘 | Qiang Chen Quan sen Sun Pheng Ann Heng | 2008 | Pattern Recognition2008，41，4： | 1 |
| 14 | Cyclability study of silicon–carbon composite anodes for lithium-ion batteries using electrochemical impedance spectroscopy显示文摘 | Juchen Guo Ann Sun Xilin Chen Chunsheng Wang Ayyakkannu Manivannan | 2011 | Electrochimica Acta2011，，11： | 1 |
| 15 | EBV encoded miR-BHRF1-1 potentiates viral lytic replication by downregulating host p53 in nasopharyngeal carcinoma显示文摘 | Zijian Li Xue Chen Lili Li Sufang Liu Lifang Yang Xiaoqian Ma Min Tang Ann M. Bode Zigang Dong Lunquan Sun Ya Cao | 2011 | International Journal of Biochemistry and Cell Biology2011，，2： | 1 |
| 16 | A double-threshold image binarization method based on edge detector显示文摘 | Chert Qiang Sun Quansen Heng Pheng Ann | 2008 | Pattern Recognition2008，41，4： | 1 |
| 17 | Characterization and environmental applications of clay–biochar composites显示文摘 | Ying Yao Bin Gao June Fang Ming Zhang Hao Chen Yanmei Zhou Anne Elise Creamer Yining Sun Liuyan Yang | 2014 | Chemical Engineering Journal2014，，： | 1 |
| 18 | Rela- tionship of serum fibroblast growth factor 23 with car- diovascular disease in older community-dwelling women显示文摘 | MANSI DALAL KAI SUN ANNE R | 2011 | Eur J Endocrinol2011，165，： | 1 |
| 19 | p-Nitrophenol degradation by a heterogeneous Fenton-like reaction on nano-magnetite: Process optimization, kinetics, and degradation pathways显示文摘 | Sheng-Peng Sun Ann T. Lemley | 2011 | Journal of Molecular Catalysis. A, Chemical2011，，1： | 1 |
| 20 | Microstructural stability of Cu-Nb microcomposite wires fabricated by the bundling and drawing process显示文摘 | Hong Sun Ig Hill Mary Ann | 2000 | Materials Science and Engineering A2000，28，12： | 1 |
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