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| 1 | Acute complications of spinal cord injuries显示文摘The aim of this paper is to give an overview of acute complications of spinal cord injury(SCI). Along with motor and sensory deficits, instabilities of the cardiovascular, thermoregulatory and broncho-pulmonary system are common after a SCI. Disturbances of the urinary and gastrointestinal systems are typical as well as sexual dysfunction. Frequent complications of cervical and high thoracic SCI are neurogenic shock, bradyarrhythmias, hypotension, ectopic beats, abnormal temperaturecontrol and disturbance of sweating, vasodilatation and autonomic dysreflexia. Autonomic dysreflexia is an abrupt, uncontrolled sympathetic response, elicited by stimuli below the level of injury. The symptoms may be mild like skin rash or slight headache, but can cause severe hypertension, cerebral haemorrhage and death. All personnel caring for the patient should be able to recognize the symptoms and be able to intervene promptly. Disturbance of respiratory function are frequent in tetraplegia and a primary cause of both short and long-term morbidity and mortality is pulmonary complications. Due to physical inactivity and altered haemostasis, patients with SCI have a higher risk of venous thromboembolism and pressure ulcers. Spasticity and pain are frequent complications which need to be addressed. The psychological stress associated with SCI may lead to anxiety and depression. Knowledge of possible complications during the acute phase is important because they may be life threatening and/ or may lead to prolonged rehabilitation. | Ellen Merete Hagen | 2015 | World Journal of Orthopedics2015，6，1： | 19 |
| 2 | Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro显示文摘AIM: Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD).METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model.RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinA1,we found abundantly co-expressed EphB2 and ephrin-B1/2.Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrinB1/2 expressing rat IEC-6-cells with recombinant EphB1Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge.CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD. | Christian Hafner Stefanie Meyer Thomas Langmann Gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 3 | Associations between the physical environment and park-based physical activity:A systematic review显示文摘Background:With an increase in the evidence for the associations between park-based physical activity(PA)and physical environments(especially park and neighborhood environments),researchers face an important challenge in interpreting and summarizing the evidence to develop environ?mental change interventions.An updated review is needed to better inform policymaking and environmental interventions.The current study aimed to systematically review the research on the associations of park-based PA with park and neighborhood environmental characteristics.Methods:We targeted English peer-reviewed articles from 5 electronic databases using keywords related to park-based PA,park environments,and neighborhood environments.Of the 4071 identified papers,25 studies published between 2008 and 2016 met all the eligibility criteria and were included in this review.Results:The characteristics of physical environment that received consistent support included paths/trails,lighting,and incivilities(e.g.,broken glasses and litter).Mixed findings were revealed for 6 park environmental factors(unspecified active facilities,playgrounds and skating areas,fit?ness stations,picnic areas,greenness,and park size)and 2 neighborhood environmental factors(park density and park proximity).Conclusion:It can be concluded that paths/trails,lighting,and incivilities are 3 key physical environmental attributes of park-based PA.Given the inconsistent findings on park and neighborhood environmental factors,more robust designs such as prospective investigation are required. | Ru Zhang Hagen Wulff Yanping Duan Petra Wagner | 2019 | Journal of Sport and Health Science2019，8，5： | 7 |
| 4 | Wound-Induced Shoot-to-Root Relocation of JA-Ile Precursors Coordinates Arabidopsis Growth显示文摘Multicellular organisms rely on the movement of signaling molecules across cells,tissues,and organs to communicate among distal sites.In plants,localized leaf damage activates jasmonic acid(JA)-dependent transcriptional reprogramming in both harmed and unharmed tissues.Although it has been indicated that JA species can translocate from damaged into distal sites,the identity of the mobile compound(s),the tissues through which they translocate,and the effect of their relocation remain unknown.Here,we found that following shoot wounding,the relocation of endogenous jasmonates through the phloem is essential to initiate JA signaling and stunt growth in unharmed roots of Arabidopsis thaliana.By employing grafting experiments and hormone profiling,we uncovered that the hormone precursor cis-12-oxo-phytodienoic acid(OPDA)and its derivatives,but not the bioactive JA-Ile conjugate,translocate from wounded shoots into undamaged roots.Upon root relocation,the mobile precursors cooperatively regulated JA responses through their conversion into JA-Ile and JA signaling activation.Collectively,our findings demonstrate the existence of long-distance translocation of endogenous OPDA and its derivatives,which serve as mobile molecules to coordinate shoot-to-root responses,and highlight the importance of a controlled redistribution of hormone precursors among organs during plant stress acclimation. | Adina Schulze Marlene Zimmer Stefan Mielke Hagen Stellmach Charles WMelnyk Bettina Hause Debora Gasperini | 2019 | Molecular Plant2019，12，10： | 7 |
| 5 | Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier显示文摘Long-term chronic infection with Helicobacter pylori(H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer,tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach,or dysfunction in the infected stomach,however,are largely unknown. Although conventional tight junction components are expressed in gastric epithelial cells,claudins regulate paracellular permeability and are likely the target of inflammation or H. pylori itself. There are 27 different claudin molecules,each with unique properties that render the mucosa an intact barrier that is permselective in a way that is consistent with cell physiology. Understanding the architecture of tight junctions in the normal stomach and then changes that occur during infection is important but challenging,because most of the reports that catalog claudin expression in gastric cancer pathogenesis are contradictory. Furthermore,the role of H. pylori virulence factors,such as cytotoxin-associated gene A and vacoulating cytotoxin,in regulating tight junction dysfunction during infection is inconsistent in different gastric cell lines and in vivo,likely because non-gastric epithelial cell cultures were initially used to unravel the details of their effects on the stomach. Hampering further study,as well,is the relative lack of cultured cell models that have tight junction claudins that are consistent with native tissues. This summary will review the current state of knowledge about gastric tight junctions,normally and in H. pylori infection,and make predictions about the consequences of claudin reorganization during H. pylori infection. | Tyler J Caron Kathleen E Scott James G Fox Susan J Hagen | 2015 | World Journal of Gastroenterology2015，21，40： | 7 |
| 6 | Effects of insulin and pathway inhibitors on the PI3K-Akt- mTOR phosphorylation profile in acute myeloid leukemia cells显示文摘The phosphatidylinositol 3-kinase(PI3K)-Akt-mechanistic target of rapamycin(mTOR)pathway is constitutively activated in human acute myeloid leukemia(AML)cells and is regarded as a possible therapeutic target.Insulin is an agonist of this pathway and a growth factor for AML cells.We characterized the effect of insulin on the phosphorylation of 10 mediators in the main track of the PI3K-Akt-mTOR pathway in AML cells from 76 consecutive patients.The overall results showed that insulin significantly increased the phosphorylation of all investigated mediators.However,insulin effects on the pathway activation profile varied among patients,and increased phosphorylation in all mediators was observed only in a minority of patients;in other patients,insulin had divergent effects.Global gene expression profiling and proteomic/phosphoproteomic comparisons suggested that AML cells from these two patient subsets differed with regard to AML cell differentiation,transcriptional regulation,RNA metabolism,and cellular metabolism.Strong insulin-induced phosphorylation was associated with weakened antiproliferative effects of metabolic inhibitors.PI3K,Akt,and mTOR inhibitors also caused divergent effects on the overall pathway phosphorylation profile in the presence of insulin,although PI3K and Akt inhibition caused a general reduction in Akt pT308 and 4EBP1 pT36/pT45 phosphorylation.For Akt inhibition,the phosphorylation of upstream mediators was generally increased or unaltered.In contrast,mTOR inhibition reduced mTOR pS2448 and S6 pS244 phosphorylation but increased Akt pT308 phosphorylation.In conclusion,the effects of both insulin and PI3K-Akt-mTOR inhibitors differ between AML patient subsets,and differences in insulin responsiveness are associated with differential susceptibility to metabolic targeting. | Ina Nepstad Kimberley Joanne Hatfield Ida Sofie Grønningsæter Elise Aasebø Maria Hernandez-Valladares Karen Marie Hagen Kristin Paulsen Rye Frode SBerven Frode Selheim Håkon Reikvam Øystein Bruserud | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 7 | Identification of Early Nuclear Target Genes of Plastidial Redox Signals that Trigger the Long- Term Response of Arabidopsis to Light Quality Sh∽ts显示文摘自然照明条件是高度可变的并且因为他们的无柄的生活方式,植物在细胞、分子的水平被强迫到 acclimate 到他们。在轻紧张或质量的变化在减小 / 氧化(氧化还原作用) 导致变化为包括光合作用和新陈代谢的功能、结构的调整的补偿环境适应回答充当一个扳机的光合的电子链的状态。如此的回答在原子核和细胞器在植物基因表示包括控制氧化还原作用的变化。这里,我们在模型有机体 Arabidopsis thaliana 的原子核为早调整氧化还原作用的基因(尔格) 的鉴定描述策略显著地回答 30 或在在光合的电子运输链的一个减小信号的产生以后的 60min。由把野类型的植物的反应与环境适应异种 stn7 的作比较,我们能明确地识别尔格。结果为 mitochondrial 电子运输链, tetrapyrrole 生合成,糖类新陈代谢,和发信号的类脂化合物合成包括基因在不同原子基因组上揭示叶绿体氧化还原作用信号的重要影响。这些表示侧面与响应光合的电子 transportby 的减小观察的那些清楚地不同高轻的处理。因此,识别的尔格对在光合的电子运输的氧化还原作用不平衡唯一并且然后被使用分析潜在的氧化还原作用应答的 cis 元素, trans 因素,和 chromosomal 规章的热点。数据识别一个新奇氧化还原作用应答的元素并且在在 epigenetic 进程上指向氧化还原作用信号的崭新的影响的 transcriptional 和 chromosomal 层次显示广泛的氧化还原作用控制。 | Lars Dietzel Christine Glaeer Monique Liebers Stefan Hiekel Florence Courtois Olaf Czarneckit Hagen Schlicke Yan Zubo Thomas Borner Klaus Mayer Bernhard Grimm Thomas Pfannschmidt | 2015 | Molecular Plant2015，8，8： | 4 |
| 8 | Agent-oriented Aid-modeling for the Distributed Activity Network | DENG Gui\|shi\+1,\ LI Wen\|lei\+1,\ O. Moeschlin\+2 1.Institute of Systems Engineering, Dalian University of Technology Dalian 116024, China 2.Department of Mathematics, Fern University in Hagen, D 58084 Germany | 2000 | Systems Science and Systems Engineering2000，10，1： | 4 |
| 9 | The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression显示文摘 | Thomas Derrien Rory Johnson Giovanni Bussotti Andrea Tanzer Sarah Djebali Hagen Tilgner Gregory Guernec David Martin Angelika Merkel David G. Knowles Julien Lagarde Lavanya Veeravalli Xiaoan Ruan Yijun Ruan Timo Lassmann Piero Carninci James B. Brown Leon | 2012 | Genome Research2012，，9： | 3 |
| 10 | Epiphytic orchids and their ecological niche under anthropogenic influence in central Himalayas,Nepal显示文摘The survival chance of epiphytic orchids today not only depends on the natural site conditions required by the orchids but also on anthropogenic changes in site conditions.This study answers two questions:(1) What is the ecological niche of the different epiphytic orchid species?(2) What are the ecological factors that threaten epiphytic orchid's population under anthropogenic disturbances? Our study area was the Kathmandu valley,Nepal,with its subtropical forest.We established 156 systematically selected sampling points in the Kathmandu area covering different types of ecosystems under human impacts such as densely populated area,agricultural land,mixed agricultural and settled area,old tree patches,and a natural forest in a national park.The ecological niche of the orchid species was analyzed with a principal component analysis(PCA).The correlations between the different site factors were statistically significant.Spearman's rank correlation matrices showed that the variables land-use intensities with altitude,and height with diameter in breast height(dbh) of host had the highest significant positive correlation coefficient(0.67 and 0.64 respectively).On the other hand,host bark p H and altitude as well as land use had a significantly strong negative correlation coefficient(-0.80 and-0.61,respectively).Different epiphytic orchid species interact differently with the given set ofenvironmental factors:for occurrence of Vanda cristata there is no single environmental factor of special influence,while for Rhynchostylis retusa high bark p H and high light availability are important.First two axis of the PCA explained more than 50% of the total variance.Most orchid species occupy a specific,narrow niche in this ecological space.The main causes of anthropogenic influence of orchid population in the Kathmandu Valley are loss of adequate host trees(species and size) and increasing air pollution,resulting in increasing host bark p H. | ADHIKARI Yagya Prasad FISCHER Anton FISCHER Hagen Siegfried | 2016 | Journal of Mountain Science2016，13，5： | 3 |
| 11 | Techno-economic comparison of three technologies for precombustion CO2 capture from a lignite-fired IGCC显示文摘This paper compares the techno-economic performances of three technologies for CO2 capture from a lignite-based IGCC power plant located in the Czech Republic:(1)Physical absorption with a Rectisol-based process;(2)Polymeric CO2-selective membrane-based capture;(3)Low-temperature capture.The evaluations show that the IGCC plant with CO2 capture leads to costs of electricity between 91 and 120€·MWh−1,depending on the capture technology employed,compared to 65€·MWh−1 for the power plant without capture.This results in CO2 avoidance costs ranging from 42 to 84€·tCO2,avoided−1,mainly linked to the losses in net power output.From both energy and cost points of view,the low-temperature and Rectisol based CO2 capture processes are the most efficient capture technologies.Furthermore,partial CO2 capture appears as a good mean to ensure early implementation due to the limited increase in CO2 avoidance cost when considering partial capture.To go beyond the two specific CO2-selective membranes considered,a cost/membrane property map for CO2-selective membranes was developed.This map emphasise the need to develop high performance membrane to compete with solvent technology.Finally,the cost of the whole CCS chain was estimated at 54€·tCO2,avoided−1 once pipeline transport and storage are taken into consideration. | Simon Roussanaly Monika Vitvarova Rahul Anantharaman David Berstad Brede Hagen Jana Jakobsen Vaclav Novotny Geir Skaugen | 2020 | Frontiers of Chemical Science and Engineering2020，14，3： | 3 |
| 12 | Induced Deactivation of Genes Encoding Chlorophyll Biosynthesis Enzymes Disentangles Tetrapyrrole- Mediated Retrograde Signaling显示文摘在光合的有机体,调停 tetrapyrrole 后退信号被建议在叶绿体响应新陈代谢的活动贡献平衡原子 geneexpression (NGE ) 。我们跟随了一条试验性的短期的途径对修改 NGE 的那个 allowedthe 评价 tetrapyrrolebiosynthesis 在 Mg 的明确地修改的酶的步骤的第一个小时期间分叉,当另外的信号的多种的效果能被避免时。响应编码 Mg chelatase, Mg protoporphyrin methyltransferase 和 Mg protoporphyrin monomethylestercyclase 的 CHLH 子单元的 CHLH, CHLM,和 CHL27 的 24-h-induced silencing,分别地,撤销的基因表示很快导致了相应的酶和 alteredMg 卟啉层次的减少的活动。但是 NGE 实质地没被改变。这三基因什么时候连续地在 to4 d 上面被使失去活性为,原子基因的抄本层次的变化被决定。为在坏死的叶损害和调制抄本的超过 24h 结果的 CHL27 silencing 氧化 stress-responsiveand 铺平联系光合作用的原子基因(PhANGs ) 。CHLH 和 CHLM 的延长释放导致 PhANGs 和联系 tetrapyrrole 的基因的稍微提高的抄本层次。为 NGE 上的 tetrapyrrole 生合成的贡献的这些解决时间的研究 indicatea 建筑群情形由 1 O 2-induced 发信号和调整反馈的翼 synthesis.Key 词: | Hagen Schlicke Annabel Salinas Hartwig Vivien Firtzlaff Andreas S. Richter , Christine Glasser Klaus Maier Iris Finkemeier Bernhard Grimm | 2014 | Molecular Plant2014，7，7： | 3 |
| 13 | Mixed Reflux of Gastric and Duodenal Juices Is More Harmful to the Esophagus than Gastric Juice Alone: The Need for Surgical Therapy Re-Emphasized显示文摘 | Werner K. H. Kauer Jeffrey H. Peters Tom R. DeMeester Adrian P. Ireland Cedric G. Bremner Jeffrey A. Hagen | 1995 | Annals of Surgery1995，，4： | 2 |
| 14 | 能源投资的回报:探索一个统一的框架显示文摘对于矿物能源储备的减少,我们已提出了很多种技术作为部分解决该问题的方案。现在非常需要有一个统一的标准来对不同技术的可取性(desirability)进行比较。一种能源生产技术的能源产出对能源消耗的比率,即能源投资回报(EROI),是其对社会潜在贡献的第一重要指标。然而,EROI分析因为缺乏一个统一的框架而导致出现显然互相矛盾的结果。在这篇文章中,我们为EROI分析建立了一个包含了文献中现存的多种方法的理论框架。根据它们所包含的成本和对非能源资源的管理,我们在两个不同的维数上建立了一系列的EROI分析方法。最后我们通过估计一种技术的可取性及其终极净能源容量来说明EROI不同计算方法的意义。 | Kenneth Mulder Nathan John Hagens 陶书田(译) 丁莉(校) | 2008 | AMBIO-人类环境杂志2008，37，2： | 2 |
| 15 | Comparison of the 6th and 7th Editions of the UICC-AJCC TNM Classification for Esophageal Cancer显示文摘 | Koen Talsma Pieter Hagen Brechtje Grotenhuis Ewout Steyerberg Hugo Tilanus Jan Lanschot Bas Wijnhoven | 2012 | Annals of Surgical Oncology2012，，7： | 2 |
| 16 | A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation显示文摘 | Van GELDER I HAGENS V BOSKER H | 2002 | N Engl J Med2002，347，23： | 2 |
| 17 | Effect of Station Improvement Measures on Customer Satisfaction显示文摘 | Mark van Hagen | 2015 | Journal of Traffic and Transportation Engineering2015，3，1： | 2 |
| 18 | Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells显示文摘AIM: Eph receptors and ephrin ligands play a pivotal role in development and tissue maintenance. Since previous data have indicated an involvement of ephrin-B2 in epithelial healing, we investigated the gene expression and downstream signaling pathways induced by ephrin-B mediated cell-cell signaling in intestinal epithelial cells.METHODS: Upon stimulation of ephrin-B pathways in IFC-6 cells with recombinant rat EphB1-Fc, gene expression was analyzed by Affymetrix(R) rat genome 230 high density arrays at different time points. Differentially expressed genes were confirmed by real-time RT-PCR. In addition, MAP kinase pathways and focal adhesion kinase (FAK) activation downstream of ephrin-B were investigated by immunoblotting and fluorescence microscopy.RESULTS: Stimulation of the ephrin-B reverse signaling pathway in IEC-6 cells induces predominant expression of genes known to be involved into wound healing/cell migration, antiapoptotic pathways, host defense and inflammation. Cox-2, c-Fos, Egr-1, Egr-2, and MCP-1 were found among the most significantly regulated genes.Furthermore, we show that the expression of repairrelated genes is also accompanied by activation of the ERK1/2 MAP kinase pathway and FAK, two key regulators of epithelial restitution.CONCLUSION: Stimulation of the ephrin-B reverse signaling pathway induces a phenotype characterized by upregulation of repair-related genes, which may partially be mediated by ERK1/2 pathways. | Christian Hafner Stefanie Meyer Ilja Hagen Bernd Becker Alexander Roesch Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，29： | 2 |
| 19 | Three-dimensional vision enhances task performance independently of the surgical method显示文摘 | O. Wagner M. Hagen A. Kurmann S. Horgan D. Candinas S. Vorburger | 2012 | Surgical Endoscopy2012，，10： | 2 |
| 20 | Expression and prognostic significance of thymidylate synthase (TS) in pancreatic head and periampullary cancer显示文摘 | J.A. van der Zee C.H.J. van Eijck W.C.J. Hop H. van Dekken B.M. Dicheva A.L.B. Seynhaeve G.A. Koning A.M.M. Eggermont T.L.M. ten Hagen | 2012 | European Journal of Surgical Oncology2012，，11： | 2 |
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