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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 3 | Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial显示文摘 | Guglielmo Ronco Paolo Giorgi-Rossi Francesca Carozzi Massimo Confortini Paolo Dalla Palma Annarosa Del Mistro Bruno Ghiringhello Salvatore Girlando Anna Gillio-Tos Laura De Marco Carlo Naldoni Paola Pierotti Raffaella Rizzolo Patrizia Schincaglia Manuel Z | 2010 | Lancet Oncology2010，，3： | 3 |
| 4 | Mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones显示文摘AIM An increased viscosity of gallbladder bile has been considered an important factor in the pathogenesis of gallstone disease. Besides lipids and proteins, mucin has been suggested to affect the viscosity of bile. To further clarify these issues we compared mucin, protein and the lipid components of hepatic and gallbladder bile and its viscosity in patients with gallstones.METHODS Viscosity of bile ( mpa. s ) wasmeasured using rotation viscosimetry in regard to the non-Newtonian property of bile at law shear rates.RESULTS Biliary viscosity was markedly higher in gallbladder bile of patients with cholesterol (5.00 ± 0.60 mpa. s, mean ± SEM, n --28) and mixed stones (3.50±0.68 mPa. s; n =8) compared to hepatic bile (0.92 ± 0.06 mpa. s,n -6). A positive correlation between mucin and viscosity was found in gallbladder biles (r=0.65; P<0.001) but not in hepatic biles. The addition of physiologic and supraphysiologic amounts of mucin to gallbladder bile resulted in a dose dependent non linear increase of its viscosity. A positive correlation was determined between phospholipid concentration and viscosity (r = 0.34, P<0.005) in gallbladder biles. However, no correlation was found between total protein or the other lipid concentrations and viscosity in both gallbladder and hepatic biles.CONCLUSION The viscosity of gallbladder bile is markedly higher than that of hepatic bile in patients with gallstones. The concentration of mucin is the major determinant of biliary viscosity and may contribute by this mechanism to the role of mucin in the pathogenesis of gallstones. | Dieter Jüngst Anna Niemeyer Iris Müller Benedikta Zündt Günther Meyer Martin Wilhelmi Reginalddel Pozo | 2001 | World Journal of Gastroenterology2001，7，2： | 2 |
| 5 | Transatrial approach of acquired posterior ventrieular septal rupture and double orifice technique in tricuspid valve repair 显示文摘 | MARIO Z ANNA M ERNESTO T | 2003 | The Annals of Thoracic Surgery2003，76，： | 1 |
| 6 | Differential MMP and TIMP production by human marrow and peripheral blood CD34 + cells in response to chemokines显示文摘 | Anna Janowska-Wieczorek Leah A Marquez Adrian Dobrowsky Mariusz Z Ratajczak Maria Luisa Cabuhat | 2000 | Experimental Hematology2000，，11： | 1 |
| 7 | Deep sequencing of the zebrafish transcriptome response to mycobacterium infection显示文摘 | Zoltan H Anna Z Vilmos C A | 2009 | Molecular Immunology2009，，46： | 1 |
| 8 | Treatment of Fourteen Chronic Active HBSAg^+ ,HBeAg^+ Hepatitis Patients with Low Dose Nature Human Interferon Alpha Administered Orally 显示文摘 | Wladyslawa Z Jacek P Anna K | 1993 | Arch lmmunol Ther Exp1993，41，： | 1 |
| 9 | Simplified forms of computerized reasoning with distance semantics显示文摘 | OFER A ANNA Z | 2010 | Journal of Applied Logic2010，9，1： | 1 |
| 10 | Enzymatic activity ofPhlebiopsis gigantea isolates 显示文摘 | Anna Z Teresa AK Zbigniew S Helena I | 2008 | Acta Mycologica2008，43，1： | 1 |
| 11 | Effects of bacterial cell surface structure and hydrophobie on attachment to activated sludge floes 显示文摘 | Anna Z Malte H | 1997 | Applied and Environment Microbiology1997，63，3： | 1 |
| 12 | Heparin/PF4 anti- bodies formation after heparin treatment: Temporal aspects and long-term follow-up显示文摘 | ANNA VM LORENZO B MAURO Z | 2009 | Am Heart J2009，157，3： | 1 |
| 13 | Effect of thenumber of arms on the association of amphiphilic star-Block copolymers 显示文摘 | SATU S ANNA Z ANATOLY A D | 2008 | Macromolecules2008，41，： | 1 |
| 14 | Deep sequencing of the zebrafish transeriptome response to mycobaeterium infection显示文摘 | Zoltdn H Anna Z Vilmos C A | 2009 | Molecular Immunology2009，46，： | 1 |
| 15 | Notch inhibits osteoblast differentiation and causes osteopenia 显示文摘 | Stefano Z Anna SR Lisa S | 2008 | Endocrinology2008，149，8： | 1 |
| 16 | A review of subclavian steal syndrome with clinical correlation显示文摘 | Stephen O Anna Z Jerzy G | 2012 | Med Sci Monit2012，18，5： | 1 |
| 17 | Carotid intima-media thickness, hs-CRP and TNF-a are inde- pendently associated with cardiovascular event risk in patients with atherosclemtic occlusive disease 显示文摘 | ANNA K Z | 2011 | Atheroselerosis2011，21，4： | 1 |
| 18 | Immunohistochemical expression of TGF-β1, p21WAF1, p53, Ki67, and angiogenesis in gastric carcinomas 显示文摘 | Vassliki Z Anna B Athanassias C T | 2002 | International Journal of Gastrointestinal Cancer2002，32，23： | 1 |
| 19 | The adsorption properties of short chain alcohols and Triton X-100 mixtures at the water-air interface 显示文摘 | Anna Z | 2009 | Journal of Colloid and Interface Science2009，335，2： | 1 |
| 20 | TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is reg- ulated by epigenetic modifications显示文摘 | Anna Z Xiao QZ Zeng LF | 2006 | Biochem Biophys Res Commun2006，347，1： | 1 |
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