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| 1 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 2 | Dai- ly interruption of sedative infusions in critically ill patients un- dergoing mechanical ventilation显示文摘 | John P Kress Anne S Pohlman Miehael F O'Connor etal | 2000 | The New England Journal of Medicine2000，342，20： | 1 |
| 3 | Plant availabilityof inorganic and organic selenium fertilizer as influencedby soil organic matter content and pH显示文摘 | Susanne E G Trine A S Anne F O | 2007 | NutrientCycling in Agroecosystems2007，79，3： | 1 |
| 4 | Peer-led sex education-characteristics of peer educators and their perceptions of the impact on them of participation in a peer education programme显示文摘 | Vicki S Simon F Ann O | 2002 | Health Educ Res2002，17，3： | 1 |
| 5 | Plant availability of inorganic and organic selenium fertilizer as influenced by soil organic matter content and pH显示文摘 | Susanne E G Trine A S Anne F O | 2007 | Nutrient Cycling in Agroecosystems2007，79，3： | 1 |
| 6 | Trends in molecular diagnostics 显示文摘 | FODINGER M SUNDER-PLASSM ANN G WAGNER O F | 1999 | Wien Klin Wochenschr1999，111，8： | 1 |
| 7 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 1 |
| 8 | Degradation of chloroform by photoassisted heterogeneous catalysis in dilute aqueous suspensions of titanium dioxide显示文摘 | Ann Lorette Pruden David F O | 1983 | Environ Sci Technol1983，17，： | 1 |
| 9 | Improving access to analgesic drugs for patients with cancer in sub-Saharan Africa显示文摘 | Megan O’Brien Faith Mwangi-Powell Isaac F Adewole Olaitan Soyannwo Jacinto Amandua Elizabeth Ogaja Mary Okpeseyi Zipporah Ali Rose Kiwanuka Anne Merriman | 2013 | Lancet Oncology2013，，4： | 1 |
| 10 | 癫痫:从儿童至成年的医疗过渡——来自安大略省癫痫执行工作组的建议显示文摘从儿童到成人的医疗保健系统的转变对许多患有癫痫的年轻人及其家庭来说是一个挑战。最近,加拿大安大略省卫生部和长期医疗部门成立了一个过渡工作组(Transition working group,TWG),为安大略省癫痫患者的过渡提出建议。在此对这项工作做出总结。TWG包括儿科和成人癫痫病专家、精神科医生和来自学术界和社区的家庭医生,从事儿童和成人癫痫项目的社区医师、护士和社会工作者,以及青少年内科医师、律师、职业治疗师、社区癫痫机构的代表、癫痫患者和患者父母。该小组主要解决3个领域的问题:(1)癫痫的诊断和管理;(2)癫痫患者心理健康和社会心理需求;(3)癫痫患者经济、社会和法律支持。目前虽然还没有对过渡方案的结果进行系统研究,但TWG能早期识别处于过渡失败风险的青少年,在实际过渡之前即应协调儿童和成人神经科医师以及其他专家。过渡期是重新思考诊断和重复诊断检测(特别是基因检测,现有技术较多年前可发现更多病因)的理想时期。在转至成人医疗系统后部分筛查应重复。文章提出的7个步骤可以促进过渡,从而有助于为青少年癫痫患者转出儿童保健系统提供持续且合理的医疗服务。 | Danielle M.Andrade Anne S.Bassett Eduard Bercovici Borlot F Bui E Camfield P Clozza GQ Cohen E Gofine T Graves L Greenaway J Guttman B Guttman-Slater M Hassan A Henze M Kaufman M Lawless B Lee H Lindzon L Lomax LB McAndrews MP Menna-Dack D Minassian BA Mulligan J Nabbout R Nejm T Secco M Sellers L Shapiro M Slegr M Smith R Szatmari P Tao L Vogt A Whiting S Carter Snead O 3rd 刘旭 熊维希 慕洁 | 2018 | 癫痫杂志2018，4，4： | 0 |
| 11 | Obesity is associated with decreased risk of microscopic colitis in women显示文摘BACKGROUND Microscopic colitis is a leading cause of diarrhea in the older adults.There is limited information about risk factors.We hypothesized that obesity would be associated with microscopic colitis.AIM To examine the association between obesity and microscopic colitis in men and women undergoing colonoscopy.METHODS We conducted a case-control study at the University of North Carolina Hospitals.We identified and enrolled men and women referred for elective,outpatient colonoscopy for chronic diarrhea.We excluded patients with a past diagnosis of Crohn’s disease or ulcerative colitis.A research pathologist reviewed biopsies on every patient and classified them as microscopic colitis cases or non-microscopic colitis controls.Patients provided information on body weight,height and exposure to medications via structured interviews or Internet based forms.The analysis included 110 patients with microscopic colitis(cases)and 252 nonmicroscopic colitis controls.Multivariable analyses were performed using logistic regression to estimate odds ratios and 95%confidence intervals.RESULTS Cases were older and more likely than controls to be white race.Study subjects were well educated,but cases were better educated than controls.Cases with microscopic colitis had lower body mass index than controls and reported more weight loss after the onset of diarrhea.Compared to patients who were normal or under-weight,obese(BMI>30 kg/m2)patients were substantially less likely to have microscopic colitis after adjusting for age and education,adjusted OR(aOR)0.35,95%confidence interval(CI)0.18-0.66).When stratified by sex,the association was limited to obese women,aOR 0.21,95%CI:0.10-0.45.Patients with microscopic colitis were more likely to report weight loss after the onset of diarrhea.After stratifying by weight loss,there remained a strong inverse association between obesity and microscopic colitis,aOR 0.33,95%CI:0.10-1.11 among the patients who did not lose weight.Ever use of birth control pills was associated with lower risk of microscopic colitis after adjusting for age,education and BMI,aOR 0.38,95%CI:0.17-0.84.CONCLUSION Compared to controls also seen for diarrhea,microscopic colitis cases were less likely to be obese.Mechanisms are unknown but could involve hormonal effects of obesity or the gut microbiome. | Robert S Sandler Temitope O Keku John T Woosley Dale P Sandler Joseph A Galanko Anne F Peery | 2022 | World Journal of Gastroenterology2022，28，2： | 0 |
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